Potential mechanisms for reduced delivery of nitric oxide to peripheral tissues in diabetes mellitus.

abstract：:The extensive literature and the work from our laboratory illustrate the large number of complex processes affected by estrogen that might contribute to the striking ability of 17-beta estradiol (E2) and its derivatives to inhibit clinical and histological signs of experimental autoimmune encephalomyelitis (EAE) in mi...

journal_title：Annals of the New York Academy of Sciences

authors： Offner H,Polanczyk M

更新日期：2006-11-01 00:00:00

abstract：:Risk factors for esophageal cancer include genetic factors (such as tylosis) and infectious agents. A variety of organisms have been implicated in esophageal carcinogenesis, either directly or indirectly. In this review, we explore the normal esophageal flora and how it may be controlled, and also the variety of organ...

journal_title：Annals of the New York Academy of Sciences

authors： El-Zimaity H,Di Pilato V,Novella Ringressi M,Brcic I,Rajendra S,Langer R,Dislich B,Tripathi M,Guindi M,Riddell R

更新日期：2018-12-01 00:00:00

abstract：:This publication provides a brief summary of a presentation given at the NICHD Anniversary Symposium that was designed to describe the research progress of the O'Malley laboratory over the past 30 years of its NICHD funding. It highlights a few of the lab's major discoveries during the course of the pursuit of its lon...

journal_title：Annals of the New York Academy of Sciences

authors： O'Malley BW

更新日期：2004-12-01 00:00:00

abstract：:The serologic and molecular characterization of four monoclonal antibodies to human gastric cancer cells and to CEA were described and the immunohistologic patterns of reactions with freshly obtained gastrointestinal tissues were examined. Monoclonal antibody YK004, which was secreted by the hybridoma constructed with...

journal_title：Annals of the New York Academy of Sciences

authors： Yachi A,Imai K,Moriya Y,Fujita H,Tanda M,Nishi S,Kawaharada M

更新日期：1983-01-01 00:00:00

abstract：:Glucagon and the glucagon-like peptides (GLP-1 and GLP-2) share a common evolutionary origin and are triplication products of an ancestral glucagon exon. In mammals, a standard scenario is found where only a single proglucagon-derived peptide set exists. However, fish and amphibians have either multiple proglucagon ge...

journal_title：Annals of the New York Academy of Sciences

authors： Ng SY,Lee LT,Chow BK

更新日期：2010-07-01 00:00:00

abstract：:Cardiac afferent neurons are activated in the setting of myocardial ischemia and mediate the sensation of angina. However, the precise stimuli and receptive molecules responsible are not completely understood. To further investigate the molecular components involved, cardiac afferents were isolated in dissociated cult...

journal_title：Annals of the New York Academy of Sciences

authors： Benson CJ,Sutherland SP

更新日期：2001-06-01 00:00:00

abstract：:TGF beta is a cytokine which is involved with the regulation of different aspects of host defense responses to injury. Overexpression of TGF beta can lead to the conversion of its protective functions to pathogenetic manifestations. TGF beta is a potent factor in promoting anabolic aspects in connective tissue metabol...

journal_title：Annals of the New York Academy of Sciences

authors： Lotz M,Seth P

更新日期：1993-06-23 00:00:00

abstract：:Twenty female imago of Haemaphysalis concinnae ticks collected from wild vegetation in May of 2001 in the Obor region near Khabarovsk in the Russian Far East were studied. DNA was extracted with commercially available kits following manufacturer's instructions. We used broad range primers SFG3 and SFG6 proposed for am...

journal_title：Annals of the New York Academy of Sciences

authors： Mediannikov O,Ivanov L,Nishikawa M,Saito R,Sidelnikov YN,Zdanovskaya NI,Tarasevich IV,Suzuki H

更新日期：2003-06-01 00:00:00

abstract：:Astrocytes and serotoninergic neurons play a role in central nervous system (CNS) development, probably through serotonin (5HT) stimulation of the glial 5HT(1A) receptor. Activation of 5HT(1A) receptors causes the release of S-100 beta, a glial derived growth factor. In vitro, astrocytes are profoundly altered by chro...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos AJ,Evrard SG,Tagliaferro P,Tricárico MV,Brusco A

更新日期：2002-06-01 00:00:00

abstract：:Congenital myasthenia (CM) constitutes a heterogeneous group of disorders with different underlying defects. The authors investigated a case of CM, presenting with congenital contractures. Endplate studies in the first year of life showed a developmental disorder of postsynaptic membranes. Clinical follow-up demonstra...

journal_title：Annals of the New York Academy of Sciences

authors： Smit LM,Veldman H,Jennekens FG,Molenaar PC,Oen BS

更新日期：1987-01-01 00:00:00

abstract：:Dopaminergic signaling in the brain is primarily modulated by dopamine transporters (DATs), which actively translocate extraneuronal dopamine back into dopaminergic neurons. Transporter proteins are highly dynamic, continuously trafficking between plasmalemmal and endosomal membranes. Changes in DAT membrane trafficki...

journal_title：Annals of the New York Academy of Sciences

authors： Schmitt KC,Reith ME

更新日期：2010-02-01 00:00:00

abstract：:High demand of neoplastic tissues for glutamine (Gln) is met by its active transport across cell membranes. Chronic treatment with acrylamide in rodents is associated with an increased incidence of neoplasms, including astrocytomas. In this study, 24-h acrylamide treatment significantly increased the initial rate of l...

journal_title：Annals of the New York Academy of Sciences

authors： Wu Q,Sidoryk M,Mutkus L,Zielińska M,Albrecht J,Aschner M

更新日期：2005-08-01 00:00:00

abstract：:Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organi...

journal_title：Annals of the New York Academy of Sciences

authors： Hertzman C

更新日期：1999-01-01 00:00:00

abstract：:Achalasia is a primary motility disorder of the esophagus, and while there are several treatment options, there is no consensus regarding them. When therapeutic intervention for achalasia fails, a careful evaluation of the cause of the persistent or recurrent symptoms using upper endoscopy, esophageal manometry, and c...

journal_title：Annals of the New York Academy of Sciences

authors： Felix VN,Murayama KM,Bonavina L,Park MI

更新日期：2020-12-01 00:00:00

abstract：:Although very few measurements have appeared in the open literature and there seems to be a controversy about the existence of the NDR phenomenon in molecules, the prospects of building such systems have attracted significant attention. In the work reported in this paper we used a model based on DFT calculations of th...

journal_title：Annals of the New York Academy of Sciences

authors： Simón-Manso Y,Gonzalez C,Mujica V,Aray Y,Marquez M

更新日期：2003-12-01 00:00:00

abstract：:Uncertainty in exposure assessment and uncertainty in kinetic models of early effects after exposure to a toxin are addressed in this paper. Sources of uncertainty in the determination of exposure of workers in chemical industry exposed to dioxins are exhibited and a simple kinetic model for biomonitor measurements of...

journal_title：Annals of the New York Academy of Sciences

authors： Edler L

更新日期：1999-01-01 00:00:00

abstract：:In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

journal_title：Annals of the New York Academy of Sciences

authors： Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

更新日期：2021-01-12 00:00:00

abstract：:The action of a medicinal spray that contains anti-inflammatory and bacterio-static drugs integrated with the penetrating and potentiating agent DMSO has been evaluated clinically in 60 infants with acute respiratory obstruction. A dose of 2 ml of this spray is applied in the posterior pharynx and the tonsil region; 1...

journal_title：Annals of the New York Academy of Sciences

authors： Zúñiga A,Burdach R,Rubio S

更新日期：1975-01-27 00:00:00

abstract：:We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Levanat S,Musani V,Komar A,Oreskovic S

更新日期：2004-12-01 00:00:00

abstract：:Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spine...

journal_title：Annals of the New York Academy of Sciences

authors： Wallace M,Frankfurt M,Arellanos A,Inagaki T,Luine V

更新日期：2007-02-01 00:00:00

abstract：:The receptive field of a direction-selective unit of any type consists of an excitatory center 3 degrees -5 degrees in size, a near inhibitory surround and a far surround upon which illumination exerts an influence for both spontaneous activity and specific cell response. ...

journal_title：Annals of the New York Academy of Sciences

authors： Golovkin M,Gorbunov V,Maximova E,Maximov V

更新日期：2005-06-01 00:00:00

abstract：:A hallmark of success for early career biomedical researchers is the acquisition of research funding. There are marked disparities among principal investigators who submit grants and the likelihood of receiving national funding. The National Research Mentoring Network was funded by the National Institutes of Health to...

journal_title：Annals of the New York Academy of Sciences

authors： Harwood EM,Jones AR,Erickson D,Buchwald D,Johnson-Hemming J,Jones HP,Manson S,McGee R,Smith A,Steer CJ,Vishwanatha JK,Weber-Main AM,Okuyemi KS

更新日期：2019-06-01 00:00:00

abstract：:The key pathologic mechanism in rheumatoid arthritis (RA) is the destruction of cartilage by fibroblasts. In a severe combined immunodeficient (SCID) mouse model, this process can be modulated by gene transfer using invasive LS48 fibroblasts. This study aims to investigate the effect of interleukins (IL) -11 and -12 o...

journal_title：Annals of the New York Academy of Sciences

authors： Sack U,Sehm B,Kahlenberg F,Murr A,Lehmann J,Tannapfel A,Uberla K,Moessner A,Dietrich A,Emmrich F,Lange F,Jungel A,Braun JM,Anderegg U

更新日期：2005-06-01 00:00:00

abstract：:The research presented at this conference, including a series of excellent posters from junior investigators, documents the pervasive importance of affiliation and other social behaviors. Affiliative behaviors interact with, but are distinct from reproductive and aggressive behaviors. Patterns of social behaviors tend...

journal_title：Annals of the New York Academy of Sciences

authors： Carter CS,Lederhendler I,Kirkpatrick B

更新日期：1997-01-15 00:00:00

abstract：:Carnitine acyltransferases catalyze the exchange of acyl groups between carnitine and coenzyme A (CoA). These enzymes include carnitine acetyltransferase (CrAT), carnitine octanoyltransferase (CrOT), and carnitine palmitoyltransferases (CPTs). CPT-I and CPT-II are crucial for the beta-oxidation of long-chain fatty aci...

journal_title：Annals of the New York Academy of Sciences

authors： Jogl G,Hsiao YS,Tong L

更新日期：2004-11-01 00:00:00

abstract：:A survey of rodents and hematophagous flies was conducted on three farms located in an area endemic for vesicular stomatitis to determine the species composition of each zoological group occurring in these areas. Eleven species of small rodents were collected and identified. Individuals from forty-nine species of hema...

journal_title：Annals of the New York Academy of Sciences

authors： Jimenez AE,Vargas Herrera F,Salman M,Herrero MV

更新日期：2000-01-01 00:00:00

abstract：:This study examined the functional response to human relaxin 2 (H2 relaxin), human relaxin 3 (H3 relaxin), porcine relaxin, and human INSL3 in the cytosensor microphysiometer, using CHO-K1 cells stably expressing human GPCR135. CHO-K1 cells stably expressing GPCR135 were generated by the serial dilution method and rec...

journal_title：Annals of the New York Academy of Sciences

authors： Van der Westhuizen ET,Sexton PM,Bathgate RA,Summers RJ

更新日期：2005-05-01 00:00:00

abstract：:Cardiac muscle relies highly on aerobic metabolism. Heart muscle has a high oxygen uptake at resting conditions, which increases many fold during exhaustive physical exercise. Such a high rate of oxidative metabolism is often associated with enhanced production of reactive oxygen metabolites. A single bout of strenuou...

journal_title：Annals of the New York Academy of Sciences

authors： Atalay M,Sen CK

更新日期：1999-06-30 00:00:00

abstract：:Learning to play a musical instrument requires complex multimodal skills involving simultaneous perception of several sensory modalities: auditory, visual, and somatosensory as well as the motor system. Musical training thus provides an adequate neuroscientific model to study multimodal integration and plasticity in m...

journal_title：Annals of the New York Academy of Sciences

authors： Pantev C,Lappe C,Herholz SC,Trainor L

更新日期：2009-07-01 00:00:00

abstract：:G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...

journal_title：Annals of the New York Academy of Sciences

authors： Benimetskaya L,Lai JC,Khvorova A,Wu S,Miller P,Stein CA

更新日期：2005-11-01 00:00:00