Molecular evidence of Coxiella-like microorganism harbored by Haemaphysalis concinnae ticks in the Russian Far East.

abstract：:The purpose of this article is to review recent findings regarding the mechanisms by which GM1 may mimic or potentiate certain actions of neurotrophic factors, including promotion of neuronal survival. It is proposed that the neuroprotective activity of GM1 is due, at least in part, to its ability to favor the dimeriz...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari G,Greene LA

更新日期：1998-06-19 00:00:00

abstract：:Autophagy is a phylogenetically conserved process that plays a critical role in the degradation of oxidatively damaged proteins and organelle turnover. The role of oxidative stress and apoptosis in methamphetamine (METH)-induced neurotoxicity is well known; however, the potential contribution of autophagy to METH-indu...

journal_title：Annals of the New York Academy of Sciences

authors： Kanthasamy A,Anantharam V,Ali SF,Kanthasamy AG

更新日期：2006-08-01 00:00:00

abstract：:The mechanism of action of tocopherol transfer protein (TTP) and its role in the intracellular processing of vitamin E were investigated using confocal fluorescence microscopy. The results from this work suggest that TTP functions by transporting vitamin E from endocytic organelles to other locations in the cell. ...

journal_title：Annals of the New York Academy of Sciences

authors： Qian J,Wilson K,Nava P,Morley S,Atkinson J,Manor D

更新日期：2004-12-01 00:00:00

abstract：:The intracellular bacterium, Ehrlichia ruminantium, is the causative agent of heartwater, a tick-borne disease of livestock. Because vaccines need to incorporate components from several virulent isolates, it is essential to have information on the extent of genetic variation among isolates. We therefore amplified and ...

journal_title：Annals of the New York Academy of Sciences

authors： Allsopp M,Steyn H,Zweygarth E,Allsopp B

更新日期：2005-12-01 00:00:00

abstract：:In the study reported in this paper, we characterized PACAP in the human fetal adrenal gland and we investigated the effect of PACAP on steroid secretion from cultured fetal adrenal cells. The adrenal gland from 20-week-old fetuses contained substantial concentrations of PACAP-immunoreactive material (88.6 ng/g wet ti...

journal_title：Annals of the New York Academy of Sciences

authors： Breault L,Yon L,Montéro M,Chouinard L,Contesse V,Delarue C,Fournier A,Lehoux JG,Vaudry H,Gallo-Payet N

更新日期：2000-01-01 00:00:00

abstract：:Diverse mutations in the gene encoding the copper transporter ATP7A lead to X-linked recessive Menkes disease or occipital horn syndrome. Recently, two unique ATP7A missense mutations, T994I and P1386S, were shown to cause isolated adult-onset distal motor neuropathy. These mutations induce subtle defects in ATP7A int...

journal_title：Annals of the New York Academy of Sciences

authors： Yi L,Kaler S

更新日期：2014-05-01 00:00:00

abstract：:In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

journal_title：Annals of the New York Academy of Sciences

authors： Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

更新日期：2021-01-12 00:00:00

abstract：:Developmental robustness, the capacity to stay "on track" despite the myriad vicissitudes that inevitably plague a developing organism, is, I argue, a prerequisite for natural selection and key to our understanding of the evolution of developmental processes. But how is such robustness achieved? And how can we reconci...

journal_title：Annals of the New York Academy of Sciences

authors： Keller EF

更新日期：2002-12-01 00:00:00

abstract：:The nonpregnant uterus shows uterine activity throughout the menstrual cycle. This uterine activity was detected both by single strep tissue and by using intrauterine pressure recordings in vitro and in vivo. Today, ultrasound has made it possible to study this activity with a noninvasive approach and to assess uterin...

journal_title：Annals of the New York Academy of Sciences

authors： Bulletti C,DE Ziegler D,Setti PL,Cicinelli E,Polli V,Flamigni C

更新日期：2004-12-01 00:00:00

abstract：:According to the redusome hypothesis, the aging of an organism is determined by the shortening of chronomeres (small perichromosomal linear DNA molecules). In this paper, a presumptive role for infradian hormonal rhythms is considered. Endogenous infradian rhythms are supposed to actively interact with those hormonal ...

journal_title：Annals of the New York Academy of Sciences

authors： Olovnikov A

更新日期：2005-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic joint inflammation and continuous immune cell infiltration in the synovium. These changes are linked to inflammatory cytokine release, leading to eventual destruction of cartilage and bone. During the last decade new therapeutic modalities ha...

journal_title：Annals of the New York Academy of Sciences

authors： Marti L,Golmia R,Golmia AP,Paes AT,Guilhen DD,Moreira-Filho CA,Scheinberg M

更新日期：2009-09-01 00:00:00

abstract：:Converging lines of evidence indicate that withdrawal from prolonged exposure to stimulants and alcohol results in synaptic deficits of both dopamine (DA) and serotonin (5-HT). According to the dual deficit model proposed by the authors, DA dysfunction during cocaine or alcohol withdrawal underlies anhedonia and psych...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman RB,Partilla JS,Dersch CM,Carroll FI,Rice KC,Baumann MH

更新日期：2000-09-01 00:00:00

abstract：:Sexual dimorphism is a well-documented phenomenon that is observed at all levels of the animal kingdom. Historically, sex hormones (testosterone and estrogen) have been implicated as key players in a wide array of pathologies displaying sexual dimorphism in their etiology and progression. While these hormones clearly ...

journal_title：Annals of the New York Academy of Sciences

authors： Quinn M,Ramamoorthy S,Cidlowski JA

更新日期：2014-05-01 00:00:00

abstract：:Extension of mammalian health and life span has been achieved using various dietary interventions. We previously reported that restricting dietary methionine (MET) content extends life span only when growth hormone signaling is intact (no life span increase in GH deficiency or GH resistance). To understand the metabol...

journal_title：Annals of the New York Academy of Sciences

authors： Brown-Borg HM,Rakoczy S,Wonderlich JA,Borg KE,Rojanathammanee L

更新日期：2018-04-01 00:00:00

abstract：:There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes...

journal_title：Annals of the New York Academy of Sciences

authors： Do Rego JL,Seong JY,Burel D,Luu-The V,Larhammar D,Tsutsui K,Pelletier G,Tonon MC,Vaudry H

更新日期：2009-04-01 00:00:00

abstract：:Na+/Ca2+-K+ exchangers (NCKX) are plasma membrane transporters that are thought to mainly mediate Ca2+ extrusion (along with K+) at the expense of the Na+ electrochemical gradient. However, because they are bidirectional, most assays have relied on measuring their activity in the reverse (Ca2+ import) mode. Herein we ...

journal_title：Annals of the New York Academy of Sciences

authors： Altimimi HF,Schnetkamp PP

更新日期：2007-03-01 00:00:00

abstract：:The potential of a transdisciplinary research method--Quali-Quantitative Analysis (QQA)--for delivering better evidence for healthy aging is explored. Illustrative reviews from the literature on healthy aging are summarized, as are papers on methodology by Charles Ragin and colleagues. The evidence needs for healthy a...

journal_title：Annals of the New York Academy of Sciences

authors： Bell E

更新日期：2007-10-01 00:00:00

abstract：:Research examining brain development during adolescence is escalating rapidly along multiple dimensions, as illustrated by the remarkable diversity of trans-disciplinary work shown in this symposium. Ontogenetic transitions characteristics of adolescence are common among mammalian species. Although no other species de...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:Evolutionary theory is undergoing an intense period of discussion and reevaluation. This, contrary to the misleading claims of creationists and other pseudoscientists, is no harbinger of a crisis but rather the opposite: the field is expanding dramatically in terms of both empirical discoveries and new ideas. In this ...

journal_title：Annals of the New York Academy of Sciences

authors： Pigliucci M

更新日期：2009-06-01 00:00:00

abstract：:In all patients and volunteers, the levels of immunoreactive SP measured in saliva were about 100 times higher than the levels measured in plasma. SP per mg protein was consistently lower in both plasma and saliva of chronic pain patients than in healthy volunteers. These findings suggest that a simple noninvasive obj...

journal_title：Annals of the New York Academy of Sciences

authors： Parris WC,Sastry BV,Kambam JR,Naukam RJ,Johnson BW

更新日期：1993-09-20 00:00:00

abstract：:Experimental evidence confirms that the matrix metalloproteinases (MMPs) play a fundamental role in a wide variety of pathologic conditions that involve connective tissue destruction including osteoarthritis and rheumatoid arthritis, tumor metastasis and angiogenesis, corneal ulceration, multiple sclerosis, periodonta...

journal_title：Annals of the New York Academy of Sciences

authors： Skotnicki JS,Zask A,Nelson FC,Albright JD,Levin JI

更新日期：1999-06-30 00:00:00

abstract：:Conventional and thiophosphonate-derivatized oligonucleotides were employed to specifically regulate functional gene expression in murine T-cell hybridomas. For example, induction of apoptotic cell death following activation of T-cell hybridomas was examined using antisense oligonucleotides corresponding to several pr...

journal_title：Annals of the New York Academy of Sciences

authors： Green DR,Zheng H,Shi Y

更新日期：1992-10-28 00:00:00

abstract：:TGF beta is a cytokine which is involved with the regulation of different aspects of host defense responses to injury. Overexpression of TGF beta can lead to the conversion of its protective functions to pathogenetic manifestations. TGF beta is a potent factor in promoting anabolic aspects in connective tissue metabol...

journal_title：Annals of the New York Academy of Sciences

authors： Lotz M,Seth P

更新日期：1993-06-23 00:00:00

abstract：:Physicians have used various forms of antipyretic therapy since antiquity to lower the temperature of febrile patients. Nevertheless, it has yet to be determined whether the benefits of antipyretic therapy outweigh its risks. It is not known, for example, if core temperatures encountered during the febrile state ever ...

journal_title：Annals of the New York Academy of Sciences

authors： Mackowiak PA,Plaisance KI

更新日期：1998-09-29 00:00:00

abstract：:Frontal lobe functions include a range of cognitive, emotional, and social abilities that enable goal-directed behavior. Although a number of studies have plotted the development of frontal lobe functions in childhood, few have extended into the adolescent years. There is also little information on which cognitive and...

journal_title：Annals of the New York Academy of Sciences

authors： Rosso IM,Young AD,Femia LA,Yurgelun-Todd DA

更新日期：2004-06-01 00:00:00

abstract：:Functional decline of tissues in aged animals is a result of cellular aging. Though any process of somatic cell aging basically depends on genomic instructions, phenotypes of aged cells are expressed in a given internal environment of each cell type that was made with translated proteins and post-translationally modif...

journal_title：Annals of the New York Academy of Sciences

authors： Toda T

更新日期：2001-04-01 00:00:00

abstract：:Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cong Y,Liu C,Weaver CT,Elson CO

更新日期：2004-12-01 00:00:00

abstract：:Vaccinia virus encodes secretory proteins termed virokines. One of the major virokines encoded by the N1L open reading frame is the 13.8 kDa protein. A recombinant virus, termed vGK5, lacking this protein when injected intracranially into mice, has one of the highest levels of in vivo attenuation achieved by deletion ...

journal_title：Annals of the New York Academy of Sciences

authors： Billings B,Smith SA,Zhang Z,Lahiri DK,Kotwal GJ

更新日期：2004-12-01 00:00:00

abstract：:We study the linear coupling between the Marangoni and Cowley-Rosensweig instabilities for a thin layer of ferrofluid subjected to a temperature gradient and a magnetic field. Both are perpendicular to the reference horizontal boundaries, one of which is a rigid plate, while the other is a free surface remaining flat ...

journal_title：Annals of the New York Academy of Sciences

authors： Hennenberg M,Slavtchev S,Weyssow B

更新日期：2009-04-01 00:00:00

abstract：:We have earlier shown that monkeys reared with daily alternating monocular occlusion for the first few months of life develop large horizontal strabismus, A/V patterns, dissociated vertical deviation (DVD), and dissociated horizontal deviation (DHD). Here, we present results from neurophysiological experiments that sh...

journal_title：Annals of the New York Academy of Sciences

authors： Das VE

更新日期：2011-09-01 00:00:00