Abstract:
:We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of heterozygosity findings in the PTCH locus and increased expression of several genes in the pathway strongly suggest that the pathway is involved in both ovarian fibroma and dermoids.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Levanat S,Musani V,Komar A,Oreskovic Sdoi
10.1196/annals.1329.017subject
Has Abstractpub_date
2004-12-01 00:00:00pages
134-43eissn
0077-8923issn
1749-6632pii
1030/1/134journal_volume
1030pub_type
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