Steroid hormone transforming aldo-keto reductases and cancer.

abstract：:The membrane domain of the Na(+)/Ca(2+) exchanger (NCX) contains two conserved internal repeat sequences, designated the alpha-1 and alpha-2 repeats. We have studied the topological disposition of residues in the alpha repeats and a neighboring region by substituted cysteine accessibility scanning as well as the funct...

journal_title：Annals of the New York Academy of Sciences

authors： Shigekawa M,Iwamoto T,Uehara A,Kita S

更新日期：2002-11-01 00:00:00

abstract：:The purpose of this study was to test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9NC), administered in a liposome formulation (L-9NC) in aerosol to mice with subcutaneous xenografts of three human cancers and in mice with murine melanoma and human osteosarcoma pul...

journal_title：Annals of the New York Academy of Sciences

authors： Knight V,Kleinerman ES,Waldrep JC,Giovanella BC,Gilbert BE,Koshkina NV

更新日期：2000-01-01 00:00:00

abstract：:The present paper reviews the major modes of action of estrogen on the molecular, cellular, tissue, and neurobehavioral levels of mammalian physiology, with an emphasis on the brain as an estrogen target tissue. We draw a distinction between receptor- and nonreceptor-mediated actions, as well as delineate the range of...

journal_title：Annals of the New York Academy of Sciences

authors： Scallet AC

更新日期：1999-01-01 00:00:00

abstract：:There are two types of escapes in conservative dynamical systems with two degrees of freedom: escapes to infinity and escapes to certain singular points at a finite distance. In both cases the areas on a surface of section are not preserved. We consider the basins of escape to infinity in simple Hamiltonian systems. T...

journal_title：Annals of the New York Academy of Sciences

authors： Contopoulos G,Harsoula M

更新日期：2005-06-01 00:00:00

abstract：:As recently as ten years ago, the nature of the T-cell receptor for antigen was a mystery, as was the precise role of histocompatibility molecules in antigen-presentation to T cells. Although T-cell receptors have now been cloned and crystal structures of MHC/peptide molecules exist, our understanding of the parameter...

journal_title：Annals of the New York Academy of Sciences

authors： Boniface JJ,Davis MM

更新日期：1995-09-07 00:00:00

abstract：:Although stress is tightly connected with elevated levels of catecholamines, stress effects on target structures of catecholamine action--adrenoceptors (ARs)--has not been deeply studied yet. Similarly, very little is known about changes of muscarinic receptors (MRs) during stress. We determined changes in these recep...

journal_title：Annals of the New York Academy of Sciences

authors： Myslivecek J,Tillinger A,Novakova M,Kvetnanský R

更新日期：2008-12-01 00:00:00

abstract：:These initial studies show that deregulated expression of ALG7 affects diverse cellular functions crucial to development, including proliferation, differentiation, and morphogenesis. Furthermore, the data suggest multiple genetic targets for ALG7 and provide the basis for future dissection of these developmentally rel...

journal_title：Annals of the New York Academy of Sciences

authors： Lennon K,Bird A,Kukuruzinska MA

更新日期：1998-04-15 00:00:00

abstract：:Most risk assessments assume uncertainty may be decomposed into variability and incertitude. Language is often overlooked as a source of uncertainty, but linguistic uncertainty may be pervasive in workshops, committees, and other face-to-face language-based settings where it can result in misunderstanding and arbitrar...

journal_title：Annals of the New York Academy of Sciences

authors： Carey JM,Burgman MA

更新日期：2008-04-01 00:00:00

abstract：:Jopock (Jpk), a transacting factor associated with the position-specific regulatory element of murine Hoxa-7, has shown to induce cell death in both prokaryotic and eukaryotic cells when introduced and overexpressed. Since Jpk protein harbors a transmembrane domain (TM) and a putative endoplasmic reticulum (ER) -reten...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HS,Kong KA,Chung H,Park S,Kim MH

更新日期：2007-01-01 00:00:00

abstract：:Reports on patients with hemiparalysis indicate the importance of the nervous system for the pathophysiology of rheumatoid arthritis (RA) or osteoarthritis (OA). Norepinephrine (NE) and opioids seem to be more antiinflammatory neurotransmitters whereas substance P is proinflammatory. The study aimed to investigate the...

journal_title：Annals of the New York Academy of Sciences

authors： Miller LE,Wessinghage D,Müller-Ladner U,Schölmerich J,Falk W,Kerner T,Straub RH

更新日期：1999-06-22 00:00:00

abstract：:The action of a medicinal spray that contains anti-inflammatory and bacterio-static drugs integrated with the penetrating and potentiating agent DMSO has been evaluated clinically in 60 infants with acute respiratory obstruction. A dose of 2 ml of this spray is applied in the posterior pharynx and the tonsil region; 1...

journal_title：Annals of the New York Academy of Sciences

authors： Zúñiga A,Burdach R,Rubio S

更新日期：1975-01-27 00:00:00

abstract：:Information from the vestibular nuclei ascending through the brainstem to the oculomotor and trochlear nuclei (NIII, NIV), the interstitial nucleus of Cajal (INC), the pretectum, or thalamus, is thought to be distributed in at least five different pathways. They include the medial longitudinal fasciculus (MLF), the as...

journal_title：Annals of the New York Academy of Sciences

authors： Zwergal A,Strupp M,Brandt T,Büttner-Ennever JA

更新日期：2009-05-01 00:00:00

abstract：:We studied the role of the peptide substance P, signaling through the neurokinin-1 (NK-1) receptor, on methamphetamine-induced loss of dopamine transporter sites, a well-documented marker of toxicity in the striatum of the mouse brain, because this peptide is under dynamic regulation by the neurotransmitter dopamine. ...

journal_title：Annals of the New York Academy of Sciences

authors： Yu J,Allison S,Ibrahim D,Cadet JL,Angulo JA

更新日期：2002-06-01 00:00:00

abstract：:Although alloxan-resistant (ALR) mice share 70% of the NOD genome, ALR islets are remarkably resistant to oxidative stress and autoimmunity. Using 2D PAGE comparative analysis, we have characterized 55 proteins that are differentially expressed between the NOD and ALR islet proteome. Ten proteins were found to be high...

journal_title：Annals of the New York Academy of Sciences

authors： Yang P,Li M,Guo D,Gong F,Adam BL,Atkinson MA,Wang CY

更新日期：2008-12-01 00:00:00

abstract：:Endometrial carcinoma is the most common cancer of the female reproductive organs in the United States. International comparisons reveal that the incidence of endometrial cancer vary widely between different countries with the highest rates observed in North America and Northern Europe, intermediate rates in Eastern E...

journal_title：Annals of the New York Academy of Sciences

authors： Akhmedkhanov A,Zeleniuch-Jacquotte A,Toniolo P

更新日期：2001-09-01 00:00:00

abstract：:Pathophysiological events in biological tissue are characterized by a shift in electrical impedance spectra of the tissue under study. In this paper, techniques based on electrical impedance are reviewed with emphasis on their possible role in evaluating the skin reactivity of an individual, including results from imp...

journal_title：Annals of the New York Academy of Sciences

authors： Nyrén M,Hagströmer L,Emtestam L

更新日期：1999-04-20 00:00:00

abstract：:This paper presents a review of the publicly available knowledge base concerning turbine blade tip heat transfer, from the early fundamental research which laid the foundations of our knowledge, to current experimental and numerical studies utilizing engine-scaled blade cascades and turbine rigs. Focus is placed on hi...

journal_title：Annals of the New York Academy of Sciences

authors： Bunker RS

更新日期：2001-05-01 00:00:00

abstract：:Clinical research has demonstrated that increased or decreased estradiol 2-hydroxylation can easily be achieved with a number of experimental approaches. In contrast, estradiol 16 alpha-hydroxylation, which may have potentially deleterious effects in estrogen-dependent tissues, cannot be readily altered. Predictable h...

journal_title：Annals of the New York Academy of Sciences

authors： Michnovicz JJ,Bradlow HL

更新日期：1990-01-01 00:00:00

abstract：:Insulin-related peptides (IRPs) from ganglions of mollusk, Anodonta cygnea, were purified and characterized (IRP1-IRP13) using insulin and insulin-like growth factor-I (IGF-I) radioreceptor test systems. The IRPs were able to bind to insulin and IGF-I receptors. Dose-dependent curve slopes indicated that most IRPs bin...

journal_title：Annals of the New York Academy of Sciences

authors： Shipilov VN,Shpakov AO,Rusakov YI

更新日期：2005-04-01 00:00:00

abstract：:The loss of mucus coat continuity and apoptosis have been shown in Helicobacter pylori (H. pylori)-infected gastric tissues. Blockade of p38 mitogen-activated kinase (MAPK) produced reversal in the LPS-induced reduction in mucin synthesis and apoptosis in gastric epithelial cells. This study investigates whether H. py...

journal_title：Annals of the New York Academy of Sciences

authors： Kim H,Seo JH,Kim KH

更新日期：2003-12-01 00:00:00

abstract：:Some characteristics of the effects of brief and prolonged stress on tail-flick latency are described. The pharmacological profiles of the latency responses to 30 sec and 30 min footshock are strikingly different. Thus, the increase of tail-flick latency after 30 sec shock is unaffected by naloxone and enhanced by dru...

journal_title：Annals of the New York Academy of Sciences

authors： Curzon G,Hutson PH,Kennett GA,Marcou M,Gower A,Tricklebank MD

更新日期：1986-01-01 00:00:00

abstract：:Chemical hypoxia produces depletion of ATP, intracellular Ca2+ overload, and cell death. The role of Na+/Ca2+ exchanger (NCX), the major plasma membrane Ca2+ extruding system, has been explored in chemical hypoxia using BHK cells stably transfected with the three mammalian NCX isoforms: NCX1, NCX2, and NCX3. Here we r...

journal_title：Annals of the New York Academy of Sciences

authors： Secondo A,Staiano IR,Scorziello A,Sirabella R,Boscia F,Adornetto A,Canzoniero LM,Di Renzo G,Annunziato L

更新日期：2007-03-01 00:00:00

abstract：:To develop new treatments for beta-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is s...

journal_title：Annals of the New York Academy of Sciences

authors： Breda L,Gardenghi S,Guy E,Rachmilewitz EA,Weizer-Stern O,Adamsky K,Amariglio N,Rechavi G,Giardina PJ,Grady RW,Rivella S

更新日期：2005-01-01 00:00:00

abstract：:To test the utility of the UCLA posttraumatic stress disorder (PTSD) Index for DSM-IV (U-PTSD-I)(c) for predicting PTSD diagnosis in children with and without medical illnesses. The U-PTSD-I and a standard psychiatric interview were administered to medically ill children (n = 76) and children who experienced other tra...

journal_title：Annals of the New York Academy of Sciences

authors： Shemesh E,Annunziato RA,Newcorn JH,Rockmore L,Bierer LM,Cohen JA,Schmeidler J,Yehuda R

更新日期：2006-07-01 00:00:00

abstract：:The human serum resistance-associated (SRA) gene was identified in 28 (80%) of the 35 T.b. rhodesiense trypanosomes from parasitologically confirmed sleeping sickness cases, using the primers designed by Radwanska and in 27 (77.1%) of the same 35 T.b. rhodesiense trypanosomes using the primers designed by Gibson. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Enyaru JC,Matovu E,Nerima B,Akol M,Sebikali C

更新日期：2006-10-01 00:00:00

abstract：:Saliva is an underused fluid with considerable promise for biomedical testing. Its potential is particularly great for monitoring small-molecule analytes since these are often present in saliva at concentrations that correlate well with their free levels in blood. We describe the development of a prototype diagnostic ...

journal_title：Annals of the New York Academy of Sciences

authors： Fu E,Chinowsky T,Nelson K,Johnston K,Edwards T,Helton K,Grow M,Miller JW,Yager P

更新日期：2007-03-01 00:00:00

abstract：:As studied by single cell RT-PCR of pituitary hormones, we demonstrated that the pituitaries of rats and mice contain a subpopulation of cells that express two or more hormone phenotypes typically belonging to lineages that are branched separately early during embryonic development, such as glycoprotein hormone alpha-...

journal_title：Annals of the New York Academy of Sciences

authors： Denef C,Pals K,Hauspie A,Vankelecom H,Seuntjens E

更新日期：2005-04-01 00:00:00

abstract：:We studied the translational vestibulo-ocular reflex (tVOR) in four healthy human subjects during complex, unpredictable sum-of-sines head motion (combination of 0.73, 1.33, 1.93, and 2.93 Hz), while subjects viewed a target 15 cm away. Ideal eye velocity was calculated from recorded head motion; actual eye velocity w...

journal_title：Annals of the New York Academy of Sciences

authors： Walker M,Liao K

更新日期：2011-09-01 00:00:00

abstract：:The CD27(+) IgD(+) B cell population, known as IgM memory, reduces with age. It is thought that this population is responsible for pneumococcal polysaccharide T-independent responses, and that the age-related reduction might be partially responsible for the increased susceptibility of older people to bacterial pathoge...

journal_title：Annals of the New York Academy of Sciences

authors： Martin V,Wu YC,Kipling D,Dunn-Walters DK

更新日期：2015-12-01 00:00:00

abstract：:Reactive oxygen species have been known to cause DNA damage and induce apoptosis. During DNA damage, DNA repair proteins Ku70 and Ku80 prevent cell death, but severe DNA damage beyond the repair capacity of the DNA repair proteins triggers necrosis or apoptosis. Recent reports have shown that NF-kappaB plays a critica...

journal_title：Annals of the New York Academy of Sciences

authors： Song JY,Lim JW,Kim H,Kim KH

更新日期：2003-12-01 00:00:00