Cardiovascular MRI in thalassemia major.

abstract：:The selective expression of a gene is achieved through the interaction of protein transcription factors with characteristic DNA sequences located in the regulatory region of the gene, which is usually distinct from the coding region. These proteins contain domains that bind specifically to the DNA sites (or response e...

journal_title：Annals of the New York Academy of Sciences

authors： Klug A

更新日期：1995-06-30 00:00:00

abstract：:We have demonstrated a far more widespread and selective ischemic cell damage than previously thought. In area CA3, a distinct subpopulation of interneurons, characterized by their spiny dendrites and their calretinin content, was selectively vulnerable in the absence of any other CA3 involvement. In the dentate hilus...

journal_title：Annals of the New York Academy of Sciences

authors： Hsu M,Sik A,Gallyas F,Horváth Z,Buzsáki G

更新日期：1994-11-14 00:00:00

abstract：:The gain of function phenotypes exhibited by the heterozygous Tr, Tr-J, and CMT1A mutations indicate that these mutations interfere with more than the function of a single PMP22 allele. The identification of proteins that interact with PMP22 and that are sensitive both to stoichiometry and the effects of the mutations...

journal_title：Annals of the New York Academy of Sciences

authors： Snipes GJ,Orfali W,Fraser A,Dickson K,Colby J

更新日期：1999-09-14 00:00:00

abstract：:Pregnant female Sprague-Dawley rats were injected with either 40 mg/kg (-)cocaine hydrochloride or an equivalent volume of 0.9% saline, subcutaneously (s.c.), once daily from gestational day 12 (GD 12) to GD 21. Gestational cocaine exposure had no effect on maternal weight gain, length of gestation, birthweight, fetal...

journal_title：Annals of the New York Academy of Sciences

authors： Choi SJ,Mazzio E,Soliman KF

更新日期：1998-05-30 00:00:00

abstract：:Content differentiation models posit that different areas of the prefrontal cortex perform similar operations but differ in terms of the content that is operated on. For example, it has been suggested that the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC) perform similar working memory or i...

journal_title：Annals of the New York Academy of Sciences

authors： Zald DH

更新日期：2007-12-01 00:00:00

abstract：:The nonpregnant uterus shows uterine activity throughout the menstrual cycle. This uterine activity was detected both by single strep tissue and by using intrauterine pressure recordings in vitro and in vivo. Today, ultrasound has made it possible to study this activity with a noninvasive approach and to assess uterin...

journal_title：Annals of the New York Academy of Sciences

authors： Bulletti C,DE Ziegler D,Setti PL,Cicinelli E,Polli V,Flamigni C

更新日期：2004-12-01 00:00:00

abstract：:Cystic fibrosis (CF) is associated with abnormal lipid metabolism, intense respiratory tract (RT) infection, and inflammation, eventually resulting in lung tissue destruction and respiratory failure. The CF RT inflammatory milieu, as reflected by airway secretions, includes a complex array of inflammatory mediators, b...

journal_title：Annals of the New York Academy of Sciences

authors： Eiserich JP,Yang J,Morrissey BM,Hammock BD,Cross CE

更新日期：2012-07-01 00:00:00

abstract：:In recent years calcium channel blockers have emerged as a new class of antiarrhythmic agents for the control of certain supraventricular and ventricular arrhythmias. Electrophysiologically, they are heterogeneous but their main action is mediated through a depressant effect on the slow calcium channel in cardiac musc...

journal_title：Annals of the New York Academy of Sciences

authors： Nademanee K,Singh BN

更新日期：1988-01-01 00:00:00

abstract：:We compared the expression of target genes of Hedgehog/Patched signaling in ovarian fibromas and ovarian dermoids. We noted that high levels of SHH appear almost regularly, especially in dermoids, usually accompanied by increased expression of SMO. GLI overexpression does not coincide with that of PTCH. Loss of hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Levanat S,Musani V,Komar A,Oreskovic S

更新日期：2004-12-01 00:00:00

abstract：:Isolation of Coxiella Burnetii in the standard laboratory setting is hazardous; therefore most diagnoses are based on retrospective detection of a rising antibody titer to C. burnetti. As a result, this disease is usually undiagnosed or misdiagnosed. Methods for the rapid detection of C. burnetti have now been develop...

journal_title：Annals of the New York Academy of Sciences

authors： Frazier ME,Mallavia LP,Samuel JE,Baca OG

更新日期：1990-01-01 00:00:00

abstract：:To develop new treatments for beta-thalassemia, it is essential to identify the genes involved in the relevant pathophysiological processes. Iron metabolism in thalassemia mice being investigated, focusing on the expression of a gene called hepcidin (Hamp), which is expressed in the liver and whose product (Hamp) is s...

journal_title：Annals of the New York Academy of Sciences

authors： Breda L,Gardenghi S,Guy E,Rachmilewitz EA,Weizer-Stern O,Adamsky K,Amariglio N,Rechavi G,Giardina PJ,Grady RW,Rivella S

更新日期：2005-01-01 00:00:00

abstract：:The purpose of this article is to review recent findings regarding the mechanisms by which GM1 may mimic or potentiate certain actions of neurotrophic factors, including promotion of neuronal survival. It is proposed that the neuroprotective activity of GM1 is due, at least in part, to its ability to favor the dimeriz...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari G,Greene LA

更新日期：1998-06-19 00:00:00

abstract：:The conspicuous similarities between Cushing's syndrome and the Metabolic Syndrome X open up the possibility that hypercortisolemia is involved also in the latter. Salivary cortisol is possible to measure during undisturbed conditions including perceived stressful events during everyday life. Such measurements clearly...

journal_title：Annals of the New York Academy of Sciences

authors： Björntorp P,Rosmond R

更新日期：1999-11-18 00:00:00

abstract：:Although much work has been done in the field of circulating DNA, no definitive information on sequencing data of total circulating DNA is available. Characterization of total circulating DNA by sequence analysis may give valuable information about the origin and function of these nucleic acid molecules. Circulating D...

journal_title：Annals of the New York Academy of Sciences

authors： van der Vaart M,Pretorius PJ

更新日期：2008-08-01 00:00:00

abstract：:A host of missense mutations in muscle nicotinic receptor subunits have been identified as the cause of congenital myasthenic syndromes (CMS). Two classes of CMS phenotypes have been identified: slow channel myasthenic syndromes (SCCMSs) and fast channel myasthenic syndromes (FCCMSs). Although both have similar phenot...

journal_title：Annals of the New York Academy of Sciences

authors： Sine SM,Wang HL,Ohno K,Shen XM,Lee WY,Engel AG

更新日期：2003-09-01 00:00:00

abstract：:The discovery of the adenylyl cyclase signaling mechanism (ACSM) of insulin and related peptides allows for advancing the hypothesis of its participation in regulatory action on cell growth, apoptosis, and metabolism. The following evidences were obtained: (1) The order of efficiency of insulin and IGF-I growth-promot...

journal_title：Annals of the New York Academy of Sciences

authors： Pertseva MN

更新日期：2005-04-01 00:00:00

abstract：:The use of animal cells, tissues, or organs for humans is being investigated as an alternative to allotransplantation and as therapy for a broad range of disease states including diabetes, Parkinson's disease, and neurologic pain control. The risk of transmitting novel infections with these tissues, xenozoonoses, has ...

journal_title：Annals of the New York Academy of Sciences

authors： Michaels M

更新日期：1998-12-30 00:00:00

abstract：:In two series of antiarrhythmic drugs tested, as the octanol/water partition coefficient increases so do the following: elimination from the body by biotransformation, first-pass biotransformation in the liver and gastrointestinal tract after oral administration, protein binding to some extent, and penetration into br...

journal_title：Annals of the New York Academy of Sciences

authors： Drayer DE

更新日期：1984-01-01 00:00:00

abstract：:A meta-analysis of 14 clinical studies with RRR- or all-rac-alpha-tocopherol (83,800 subjects) was performed to evaluate whether RRR and all-rac differ in cardiovascular efficacy based on those clinical endpoints that are most consistently documented in the publications of the studies. Odds ratios of treatment versus ...

journal_title：Annals of the New York Academy of Sciences

authors： Kraemer K,Koch W,Hoppe PP

更新日期：2004-12-01 00:00:00

abstract：:Regulation of pulmonary oxygen uptake (VO2p) during exercise depends on cellular energy demand, blood flow, ventilation, oxygen exchange across membranes, and oxygen utilization in the contracting skeletal muscle. In human and animal studies of metabolic processes that control cellular respiration in working skeletal ...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou H,Lai N,Saidel GM,Cabrera ME

更新日期：2008-03-01 00:00:00

abstract：:The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk. ...

journal_title：Annals of the New York Academy of Sciences

authors： Greiner DL,Brehm MA,Hosur V,Harlan DM,Powers AC,Shultz LD

更新日期：2011-12-01 00:00:00

abstract：:There has been renewed interest in the role of strategies in sensorimotor learning. The combination of new behavioral methods and computational methods has begun to unravel the interaction between processes related to strategic control and processes related to motor adaptation. These processes may operate on very diff...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor JA,Ivry RB

更新日期：2012-03-01 00:00:00

abstract：:This article reviews research on the Finnish model of peer-group mentoring (PGM). The theoretical foundation of the model is based on the constructivist theory of learning, the concept of autonomy in teaching profession, peer learning, and narrative identity work. The model has been disseminated nationwide in the educ...

journal_title：Annals of the New York Academy of Sciences

authors： Tynjälä P,Pennanen M,Markkanen I,Heikkinen HLT

更新日期：2021-01-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide that has several functions, including the regulation of water and electrolyte secretion, hormone and cytokine release, bronchodilitation, and neurogenesis. VIP effects are mediated by specific G-protein coupled receptors. Three distinct receptor subtypes, ...

journal_title：Annals of the New York Academy of Sciences

authors： Karacay B,O'Dorisio MS,Summers M,Bruce J

更新日期：2000-01-01 00:00:00

abstract：:The current research has demonstrated that MPP+ can induce lipid peroxidation in the nigrostriatal system of rat in vivo. Antioxidant agent U-78517F and .OH scavenger DMSO may protect against MPP+ toxicity through the inhibition of .OH radical-mediated oxidative injury in the substantia nigra. These findings indicate ...

journal_title：Annals of the New York Academy of Sciences

authors： Wu RM,Mohanakumar KP,Murphy DL,Chiueh CC

更新日期：1994-11-17 00:00:00

abstract：:Peripheral sympathetic nerve terminals in many tissues, but not all, are endowed with beta-adrenoceptors. Activation of these result in an enhancement of noradrenaline release evoked by electrical nerve stimulation. These so-called presynaptic beta-adrenoceptors are possibly located on the outer surface of the varicos...

journal_title：Annals of the New York Academy of Sciences

authors： Nedergaard OA,Abrahamsen J

更新日期：1990-01-01 00:00:00

abstract：:The formation of bone is a continual process in vertebrate development, initiated during fetal development and persisting in adulthood in the form of remodeling and repair. The remarkable capacity of skeletal tissues to regenerate has led to the hypothesis that the molecular signaling pathways regulating skeletogenesi...

journal_title：Annals of the New York Academy of Sciences

authors： Ferguson CM,Miclau T,Hu D,Alpern E,Helms JA

更新日期：1998-10-23 00:00:00

abstract：:Although the evidence for oxidative stress for air pollution in the human lung is fragmentary, the hypothesis that oxidative stress is an important, if not the sole, mechanism of toxicity of oxidizing air pollutants and tobacco smoke is compelling and growing. First, biochemical mechanisms have been worked out for oxi...

journal_title：Annals of the New York Academy of Sciences

authors： Menzel DB

更新日期：1992-09-30 00:00:00

abstract：:Metacommunity ecology combines local (e.g., environmental filtering and biotic interactions) and regional (e.g., dispersal and heterogeneity) processes to understand patterns of species abundance, occurrence, composition, and diversity across scales of space and time. As such, it has a great potential to generalize an...

journal_title：Annals of the New York Academy of Sciences

authors： Chase JM,Jeliazkov A,Ladouceur E,Viana DS

更新日期：2020-06-01 00:00:00

abstract：:Questions about music's evolution and functions have long excited interest among scholars. More recent theoretical accounts have stressed the importance of music's social origins and functions. Autism and Williams syndrome, neurodevelopmental disorders supposedly characterized by contrasting social and musical phenoty...

journal_title：Annals of the New York Academy of Sciences

authors： Heaton P,Allen R

更新日期：2009-07-01 00:00:00