Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline).

abstract：:The present study was aimed at finding neural correlates of aesthetic versus descriptive listening of the same musical cadences. Results showed that aesthetic listening generated greater right frontocentral negativities than did descriptive listening, indicating distinct cortical mechanisms for aesthetic versus descri...

journal_title：Annals of the New York Academy of Sciences

authors： Brattico E,Jacobsen T,De Baene W,Nakai N,Tervaniemi M

更新日期：2003-11-01 00:00:00

abstract：:It has been hypothesized that a central even in the early pathogenesis of sporadic Alzheimer disease (SAD) is the dysfunction of the neuronal insulin receptor signal transduction. To prove this, this receptor was inhibited by a triplicate icv application of STZ. Insulin binding sites were upregulated as in SAD. With r...

journal_title：Annals of the New York Academy of Sciences

authors： Hoyer S,Lee SK,Löffler T,Schliebs R

更新日期：2000-01-01 00:00:00

abstract：:Fifteen patients with coccidioidal meningitis were treated with high doses of ketoconazole for up to 4 years. Five patients were treated with ketoconazole alone. One clinically failed, one developed hepatotoxicity, and three achieved remission of meningitis. One patient received intrathecal AMB in addition to ketocona...

journal_title：Annals of the New York Academy of Sciences

authors： Graybill JR,Stevens DA,Galgiani JN,Sugar AM,Craven PC,Gregg C,Huppert M,Cloud G,Dismukes WE

更新日期：1988-01-01 00:00:00

abstract：:Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cas...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai S,Kurebayashi Y,Koyasu S

更新日期：2013-03-01 00:00:00

abstract：:The objectives of ExoMars are to inject an orbiter around Mars and to land a rover on the surface to look for possible traces of life. During the first stages of the feasibility analysis, the mass margin of the orbiter was very small for a direct transfer in the Soyuz/Fregat scenario. An analysis of the combined use o...

journal_title：Annals of the New York Academy of Sciences

authors： Gil-Fernández J,Van Damme CC,Graziano M,Amata GB,Cogo F,Perino MA

更新日期：2005-12-01 00:00:00

abstract：:A growing body of literature has investigated the effects of playing video games on brain function and behavior. One key takeaway from this literature has been that not all entertainment video games are created equal with respect to their effects on cognitive functioning. The majority of the research to date has contr...

journal_title：Annals of the New York Academy of Sciences

authors： Dale G,Joessel A,Bavelier D,Green CS

更新日期：2020-03-01 00:00:00

abstract：:Despite the high prevalence of adolescent smoking, few studies have examined nicotine sensitivity during this developmental period. In the present study we examined adolescent and adult rats' preference/aversion for a flavor previously paired with nicotine. Paired (nicotine + Kool-Aid) and unpaired (Kool-Aid) solution...

journal_title：Annals of the New York Academy of Sciences

authors： Wilmouth CE,Spear LP

更新日期：2004-06-01 00:00:00

abstract：:From the time Dan was 12 years old to the present, he always was the explorer of life. He was very fortunate in having an opportunity to see how life exists in several human societies around the world. His many professional foreign travels are presented. Dan went to a 1959 meeting in Argentina, to England in 1963, and...

journal_title：Annals of the New York Academy of Sciences

authors： Gilbert C,Gilbert RL

更新日期：2000-01-01 00:00:00

abstract：:Propagation of a kerosene spray formed by a prefilming airblast atomizer within a pulsating flame has been investigated. The measurements were performed in a 400 kW single combustor rig at typical engine conditions of up to 0.8 MPa inlet pressure and 673 K inlet temperature. The homogeneity of the fuel spray propagati...

journal_title：Annals of the New York Academy of Sciences

authors： Schober P,Meier R,Schäfer O,Wittig S

更新日期：2002-10-01 00:00:00

abstract：:Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation respo...

journal_title：Annals of the New York Academy of Sciences

authors： Kraft DC,Deocaris CC,Rattan SI

更新日期：2006-05-01 00:00:00

abstract：:Vitamin E and essential fatty acid status were examined in two groups of patients, one receiving fat-free total parenteral nutrition (TPN) with intravenous all-rac-alpha-tocopherol for vitamin E deficiency and the other receiving routine intravenous fat (Intralipid, 10%) emulsions with TPN to supply both fatty acid an...

journal_title：Annals of the New York Academy of Sciences

authors： Thurlow PM,Grant JP

更新日期：1982-01-01 00:00:00

abstract：:The research presented at this conference, including a series of excellent posters from junior investigators, documents the pervasive importance of affiliation and other social behaviors. Affiliative behaviors interact with, but are distinct from reproductive and aggressive behaviors. Patterns of social behaviors tend...

journal_title：Annals of the New York Academy of Sciences

authors： Carter CS,Lederhendler I,Kirkpatrick B

更新日期：1997-01-15 00:00:00

abstract：:The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis...

journal_title：Annals of the New York Academy of Sciences

authors： Crivello A,Giacalone A,Scola L,Forte GI,Nuzzo D,Giacconi R,Cipriano C,Candore G,Mocchegiani E,Colonna-Romano G,Lio D,Caruso C

更新日期：2006-05-01 00:00:00

abstract：:Ginkgo biloba extract EGb 761 has been used for many years to treat age-related cognitive disorders including Alzheimer's disease. EGb 761 given shortly after initiating mitochondrial damage by sodium nitroprusside (nitric oxide donor) improved the mitochondrial membrane potential of PC12 cells significantly and dose ...

journal_title：Annals of the New York Academy of Sciences

authors： Eckert A,Keil U,Scherping I,Hauptmann S,Müller WE

更新日期：2005-11-01 00:00:00

abstract：:Electroporation was used to transform the methylotrophic bacterium Methylobacterium extorquens with broad-host-range plasmid pLA2917, which contains a gene specifying resistance to kanamycin. Plasmid DNA was introduced into M. extorquens in the presence of an electric pulse, and kanamycin-resistant transformants were ...

journal_title：Annals of the New York Academy of Sciences

authors： Ueda S,Matsumoto S,Shimizu S,Yamane T

更新日期：1991-12-27 00:00:00

abstract：:One of the most striking changes in the primary lymphoid organs during human aging is the progressive involution of the thymus. As a consequence, the rate of naïve T cell output dramatically declines with age and the peripheral T cell pool shrinks. These changes lead to increased incidence of severe infections and dec...

journal_title：Annals of the New York Academy of Sciences

authors： Pfister G,Weiskopf D,Lazuardi L,Kovaiou RD,Cioca DP,Keller M,Lorbeg B,Parson W,Grubeck-Loebenstein B

更新日期：2006-05-01 00:00:00

abstract：:Sarcopenia is the involuntary loss of skeletal muscle mass and strength that occurs with aging, resulting in physical frailty. One potential explanation for sarcopenia is the failure of muscle to regenerate after damage, some of which may be due to changes in the function of satellite cells. Recent studies have identi...

journal_title：Annals of the New York Academy of Sciences

authors： Machida S,Narusawa M

更新日期：2006-05-01 00:00:00

abstract：:The authors report their experience in the surgical treatment of bone deformities in osteogenesis imperfecta, based upon 45 operations in 13 severely affected patients. Three different procedures were used. Fragmentation and temporary fixation by means of a wire does not guarantee a sufficient protection of the bone a...

journal_title：Annals of the New York Academy of Sciences

authors： Brunelli PC,Frediani P

更新日期：1988-01-01 00:00:00

abstract：:Starling's law and the end-systolic pressure-volume relationship (ESPVR) reflect the effect of sarcomere length (SL) on the development of stress (sigma) and shortening by myocytes in the uniform ventricle. We show here that tetanic contractions of rat cardiac trabeculae exhibit a sigma-SL relationship at saturating [...

journal_title：Annals of the New York Academy of Sciences

authors： Ter Keurs HE,Shinozaki T,Zhang YM,Wakayama Y,Sugai Y,Kagaya Y,Miura M,Boyden PA,Stuyvers BD,Landesberg A

更新日期：2008-03-01 00:00:00

abstract：:The autonomic nervous system (ANS) plays a role in a wide range of somatic and mental diseases. Whereas the role of the ANS in the regulation of the cardiovascular system seems evident, its role in the regulation of other systems associated with allostasis is less clear. Using a model of neurovisceral integration we d...

journal_title：Annals of the New York Academy of Sciences

authors： Thayer JF,Sternberg E

更新日期：2006-11-01 00:00:00

abstract：:The role of the potent proinflammatory cytokine IL-1 in disease could clinically be investigated with the development of the IL-1 blocking agent anakinra (Kineret), a recombinant IL-1 receptor antagonist. It was first tested in patients with sepsis without much benefit but was later FDA approved for the treatment of p...

journal_title：Annals of the New York Academy of Sciences

authors： Goldbach-Mansky R

更新日期：2009-12-01 00:00:00

abstract：:The elderly, often defined as those 65 years or older, are the most rapidly growing segment of the population, and onset of epilepsy is higher in this age group than in any other. This paper reviews recent developments, including a new proposed definition of epilepsy, a transgenic mouse model of Alzheimer's disease th...

journal_title：Annals of the New York Academy of Sciences

authors： Leppik IE,Birnbaum AK

更新日期：2010-01-01 00:00:00

abstract：:Modern neurostimulation approaches in humans provide controlled inputs into the operations of cortical regions, with highly specific behavioral consequences. This enables causal structure-function inferences, and in combination with neuroimaging, has provided novel insights into the basic mechanisms of action of neuro...

journal_title：Annals of the New York Academy of Sciences

authors： Bestmann S,Feredoes E

更新日期：2013-08-01 00:00:00

abstract：:This article focuses on the importance of social engagement and the behavioral and neurophysiological mechanisms that allow individuals to reduce psychological and physical distance. A model of social engagement derived from the Polyvagal Theory is presented. The model emphasizes phylogeny as an organizing principle a...

journal_title：Annals of the New York Academy of Sciences

authors： Porges SW

更新日期：2003-12-01 00:00:00

abstract：:Aberrations in estrogen signaling increase breast cancer risk. Molecular mechanisms that impact breast cancer initiation, promotion, and progression can be investigated using genetically engineered mouse models. Increasing estrogen receptor alpha (ERα) expression levels twofold is sufficient to initiate and promote br...

journal_title：Annals of the New York Academy of Sciences

authors： Furth PA,Cabrera MC,Díaz-Cruz ES,Millman S,Nakles RE

更新日期：2011-07-01 00:00:00

abstract：:Air particulate activity over all of the Northern Hemisphere reached its highest levels since the termination of nuclear weapons testing--sometimes up to 1 million times higher than before the Chernobyl contamination. There were essential changes in the ionic, aerosol, and gas structure of the surface air in the heavi...

journal_title：Annals of the New York Academy of Sciences

authors： Yablokov AV,Nesterenko VB,Nesterenko AV

更新日期：2009-11-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChRs) play an important role in various processes involved in regulating systemic blood pressure. These receptors are expressed at excitatory cholinergic synapses between sympathetic preganglionic neurons and postganglionic sympathetic neurons and link the integrative activities of...

journal_title：Annals of the New York Academy of Sciences

authors： Cooper E

更新日期：2001-06-01 00:00:00

abstract：:Neuroendocrine tumors are very heterogeneous, develop from a variety of tissues, and can be difficult to diagnose. Without the clinical manifestation of metastases, it is often difficult to characterize them as malignant. Even so-called completely (R0) resected tumors can spread clinically visible metastases within a ...

journal_title：Annals of the New York Academy of Sciences

authors： Koch CA,Gimm O,Vortmeyer AO,Al-Ali HK,Lamesch P,Ott R,Kluge R,Bierbach U,Tannapfel A

更新日期：2006-08-01 00:00:00

abstract：:Posttranscriptional control of gene expression plays a key role in regulating gene expression in cells undergoing apoptosis. Cyclooxygenase-2 (COX-2) is a crucial enzyme in the conversion of arachidonic acid to prostaglandin E2 (PGE(2)) and is significantly upregulated in many types of adenocarcinomas. COX-2 overexpre...

journal_title：Annals of the New York Academy of Sciences

authors： Mukhopadhyay D,Jung J,Murmu N,Houchen CW,Dieckgraefe BK,Anant S

更新日期：2003-12-01 00:00:00

abstract：:The identification of immunologic biomarkers associated with clinical response after immune intervention for cancer is an area of intensive investigation. The field would benefit from a more systemic and directed approach for biomarker identification and evaluation. Lessons can be learned from other fields, such as ca...

journal_title：Annals of the New York Academy of Sciences

authors： Dang Y,Disis ML

更新日期：2009-09-01 00:00:00