Abstract:
:Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41 degrees C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Kraft DC,Deocaris CC,Rattan SIdoi
10.1196/annals.1354.028subject
Has Abstractpub_date
2006-05-01 00:00:00pages
224-7eissn
0077-8923issn
1749-6632pii
1067/1/224journal_volume
1067pub_type
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