Anticonvulsant discovery through animal models of status epilepticus induced by organophosphorus nerve agents and pesticides.

abstract：:In the early 1970s carbohydrates (CHOs) were believed to induce overconsumption and excess fat deposition. They are now perceived to protect against these consequences. This paper evaluates the evidence for this change of interpretation by considering (1) the energy content of CHOs, (2) the energetic efficiency with w...

journal_title：Annals of the New York Academy of Sciences

authors： Stubbs RJ,Prentice AM,James WP

更新日期：1997-05-23 00:00:00

abstract：:Endometriosis is often a perplexing medical condition for both the physician and the patient. Accordingly, development of treatment strategies based on the needs of the individual patient is highly desirable. Although endometriosis has been part of the clinical practice for almost a century, many questions remain rela...

journal_title：Annals of the New York Academy of Sciences

authors： Valle RF,Sciarra JJ

更新日期：2003-11-01 00:00:00

abstract：:Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan...

journal_title：Annals of the New York Academy of Sciences

authors： Cervi J,Marotta F,Bater C,Masulair K,Minelli E,Harada M,Marandola P

更新日期：2006-05-01 00:00:00

abstract：:Donepezil, a choline esterase inhibitor, has been widely used as a medicine for Alzheimer's disease. Recently, a study showed that donepezil inhibited addictive behaviors induced by cocaine, including cocaine-conditioned place preference (CPP) and locomotor sensitization to cocaine. In the present study, we investigat...

journal_title：Annals of the New York Academy of Sciences

authors： Takamatsu Y,Yamanishi Y,Hagino Y,Yamamoto H,Ikeda K

更新日期：2006-08-01 00:00:00

abstract：:The emission factors for indoor straw combustion are a major data gap for estimating the polycyclic aromatic hydrocarbon (PAH) emissions in China. The emission factors for open-fire straw burning were borrowed from our previous study and a rough estimate was developed. As one of the most important emission sources in ...

journal_title：Annals of the New York Academy of Sciences

authors： Zhang Y,Dou H,Chang B,Wei Z,Qiu W,Liu S,Liu W,Tao S

更新日期：2008-10-01 00:00:00

abstract：:Megadose haploidentical transplants, mismatched at three HLA loci, engraft rapidly and durably without induction of graft-versus-host disease (GVHD). In vitro studies suggest that veto cells, contained in the population of hematopoietic progenitors, facilitate this favorable outcome. Cytotoxic T cells, not reactive ag...

journal_title：Annals of the New York Academy of Sciences

authors： Reisner Y

更新日期：2001-06-01 00:00:00

abstract：:The ocular motor system provides several advantages for studying the brain, including well-defined populations of neurons that contribute to specific eye movements. Generation of rapid eye movements (saccades) depends on excitatory burst neurons (EBN) and omnipause neurons (OPN) within the brainstem, both types of cel...

journal_title：Annals of the New York Academy of Sciences

authors： Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ

更新日期：2015-04-01 00:00:00

abstract：:The concepts of the ventral striatopallidal system and extended amygdala have significantly improved our understanding of basal forebrain organization. As a result of these and other advances during the last twenty years, many of the most prominent basal forebrain structures, including the nucleus accumbens, olfactory...

journal_title：Annals of the New York Academy of Sciences

authors： de Olmos JS,Heimer L

更新日期：1999-06-29 00:00:00

abstract：:One of the most remarkable aspects of the immune system is its ability to fashion an immune response most appropriate to the activating stimulus. Although the immune system possesses a number of adaptations to accomplish this, an important theme is local immune regulation by site-specific expression of receptors and l...

journal_title：Annals of the New York Academy of Sciences

authors： Shao L,Allez M,Park MS,Mayer L

更新日期：2006-08-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a structurally highly conserved neuropeptide and displays pleiotropic activity, including functioning as a neurotransmitter, neuromodulator, and neurotrophic factor. A series of recent experiments, including genetic manipulation of PACAP and its receptors, ...

journal_title：Annals of the New York Academy of Sciences

authors： Hashimoto H,Shintani N,Baba A

更新日期：2006-07-01 00:00:00

abstract：:Without landmarks, navigation is based on information about self-velocity, which is transformed to position or orientation by a process called path integration. Simple path integration tasks, such as reaching a previously seen goal by blindfolded locomotion, were often considered to be automatic and not influenced by ...

journal_title：Annals of the New York Academy of Sciences

authors： Glasauer S,Stein A,Günther AL,Flanagin VL,Jahn K,Brandt T

更新日期：2009-05-01 00:00:00

abstract：:Stroke is a common and often fatal event, and, in survivors, it is accompanied by a high risk of recurrence. Ischemic stroke is associated with abnormal platelet activity and thrombus formation. In addition to their roles in the development of acute thrombi, platelets serve as a bridge for leukocytes within the vascul...

journal_title：Annals of the New York Academy of Sciences

authors： Franks ZG,Campbell RA,Weyrich AS,Rondina MT

更新日期：2010-10-01 00:00:00

abstract：:Several reports indicate the presence of infection with Anaplasma phagocytophila in Europe. The first case with confirmed human granulocytic ehrlichiosis was reported from Slovenia in 1997. By 2002, 13 patients have been discovered in a prospective study on the etiology of febrile illnesses occurring within six weeks ...

journal_title：Annals of the New York Academy of Sciences

authors： Lotric-Furlan S,Petrovec M,Avsic-Zupanc T,Strle F

更新日期：2003-06-01 00:00:00

abstract：:Potato products contain high amounts of acrylamide, which sometimes exceeds the concentration of 1 mg/L. However, many strategies for acrylamide reduction in potato products are possible. In this work, the different approaches for reducing acrylamide formation have been reviewed, keeping in mind that in the applicatio...

journal_title：Annals of the New York Academy of Sciences

authors： Morales F,Capuano E,Fogliano V

更新日期：2008-04-01 00:00:00

abstract：:In this paper, we develop an agent-based model of social influence on body weight. The model's assumptions are grounded in theory and evidence from physiology, social psychology, and behavioral science, and its outcomes are tested against longitudinal data from American youth. We discuss the implementation of the mode...

journal_title：Annals of the New York Academy of Sciences

authors： Hammond RA,Ornstein JT

更新日期：2014-12-01 00:00:00

abstract：:The development of animal and mathematical models for several forms of acquired nystagmus has led to more comprehensive knowledge of these disorders. In the best understood forms, such as periodic alternating nystagmus, our range of knowledge includes an animal model, the neurotransmitters involved, and effective trea...

journal_title：Annals of the New York Academy of Sciences

authors： Leigh RJ,Das VE,Seidman SH

更新日期：2002-04-01 00:00:00

abstract：:Fructosamine-3-kinase (FN3K) and the more recently discovered fructosamine-3-kinase-related protein (FN3KRP) appear to protect proteins from nonenzymatic glycation. To gain a better understanding of these enzymes we performed a series of investigations including (1) in silico comparisons of their promoters; (2) real-t...

journal_title：Annals of the New York Academy of Sciences

authors： Conner JR,Beisswenger PJ,Szwergold BS

更新日期：2005-06-01 00:00:00

abstract：:In a retrospective studies of spontaneous abortion, bias can arise if the investigator restricts attention to the outcome of the most recent pregnancy. Bias happens because couples tend to replace spontaneous abortions with other pregnancies until they achieve a live birth, after which they may avoid conception for a ...

journal_title：Annals of the New York Academy of Sciences

authors： Weinberg CR,Baird DD,Wilcox AJ

更新日期：1994-02-18 00:00:00

abstract：:Autophagy is a major intracellular pathway for the degradation and recycling of long-lived proteins and cytoplasmic organelles. Like apoptotic programmed cell death, autophagy is an essential part of growth regulation and maintenance of homeostasis in multicellular organisms. Autophagic vacuole formation is also activ...

journal_title：Annals of the New York Academy of Sciences

authors： Kelekar A

更新日期：2005-12-01 00:00:00

abstract：:The characterization of the molecular mechanisms involved in low-oxygen chemotransduction has been an active field of research since the first description of an oxygen-sensitive K(+) channel in rabbit carotid body (CB) chemoreceptor cells. As a result, a large number of components of the transduction cascade, from O(2...

journal_title：Annals of the New York Academy of Sciences

authors： Gonzalez C,Vaquero LM,López-López JR,Pérez-García MT

更新日期：2009-10-01 00:00:00

abstract：:The results of this study indicate that the presence of plants did enhance TNT and TNB removal from IAAP groundwater. Most effective at 25 degrees C were reed canary grass, coontail and pondweed. Groundwater and plant tissue analyses indicate that in presence of the plants tested TNT is degraded to reduced by-products...

journal_title：Annals of the New York Academy of Sciences

authors： Best EP,Zappi ME,Fredrickson HL,Sprecher SL,Larson SL,Ochman M

更新日期：1997-11-21 00:00:00

abstract：:Evidence gathered to date from topographic data, geophysical data, well logs, and drill-core samples indicates that the buried Chicxulub basin, the source crater for the approximately 65 Ma Cretaceous-Tertiary (K/T) boundary deposits, is approximately 300 km in diameter. A prominent topographic ridge and a ring of gra...

journal_title：Annals of the New York Academy of Sciences

authors： Sharpton VL,Marin LE

更新日期：1997-05-30 00:00:00

abstract：:Adrenocortical androgens, including dehydroepiandrosterone (DHEA), are produced in the inner zone of the adrenal cortex that is in direct contact with the neural crest-derived catecholamine-producing chromaffin cells. DHEA has recently been identified as a crucial regulator of neuronal stem cell proliferation. Thus, D...

journal_title：Annals of the New York Academy of Sciences

authors： Ziegler CG,Sicard F,Sperber S,Ehrhart-Bornstein M,Bornstein SR,Krug AW

更新日期：2006-08-01 00:00:00

abstract：:The National Institutes of Health's Clinical and Translational Science Award (CTSA) program has had a profound impact on clinical research and training methods at the University of California, Davis (UC Davis). UC Davis was among the first 12 institutions to receive NIH funding for this award, and created its Clinical...

journal_title：Annals of the New York Academy of Sciences

authors： Kasim-Karakas S,Hyson D,Halsted C,van Loan M,Chedin E,Berglund L

更新日期：2010-03-01 00:00:00

abstract：:Marisa cornuarietis (Mollusc), Hyalella azteca (Crustacean), and Paracentrotus lividus (Echinoderm) demonstrated the ability to metabolize androgens through different pathways catalyzed by 5alpha-reductases (5alpha-R), hydroxysteroid dehydrogenases (HSD), hydroxylases, sulfotransferases (SULT), and fatty-acid acyl-CoA...

journal_title：Annals of the New York Academy of Sciences

authors： Janer G,Leblanc GA,Porte C

更新日期：2005-04-01 00:00:00

abstract：:Previous studies in postmenopausal women have reported that estrogen treatment (ET) modulates the risk for developing Alzheimer's disease (AD). It has recently been hypothesized that there may be a "critical period" around the time of menopause during which the prescription of ET may reduce the risk of developing AD i...

journal_title：Annals of the New York Academy of Sciences

authors： Craig MC,Murphy DG

更新日期：2010-09-01 00:00:00

abstract：:The smooth muscle myosin heavy chain (MHC) gene and its isoforms are excellent molecular markers that reflect smooth muscle phenotypes. The SMemb/Nonmuscle Myosin Heavy Chain B (NMHC-B) is a distinct MHC gene expressed predominantly in phenotypically modulated SMCs (synthetic-type SMC). To dissect the molecular mechan...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai R,Suzuki T,Aizawa K,Miyamoto S,Amaki T,Kawai-Kowase K,Sekiguchi KI,Kurabayashi M

更新日期：2001-12-01 00:00:00

abstract：:Posttranscriptional control of gene expression plays a key role in regulating gene expression in cells undergoing apoptosis. Cyclooxygenase-2 (COX-2) is a crucial enzyme in the conversion of arachidonic acid to prostaglandin E2 (PGE(2)) and is significantly upregulated in many types of adenocarcinomas. COX-2 overexpre...

journal_title：Annals of the New York Academy of Sciences

authors： Mukhopadhyay D,Jung J,Murmu N,Houchen CW,Dieckgraefe BK,Anant S

更新日期：2003-12-01 00:00:00

abstract：:The theme of this presentation has been to show that the control of transmitter release at the neuromuscular synapse is achieved by extracellular and intracellular calcium. For the fast information transfer represented by the end-plate potential, the electrochemical gradient for calcium across the presynaptic membrane...

journal_title：Annals of the New York Academy of Sciences

authors： Rahamimoff R,Erulkar SD,Lev-Tov A,Meiri H

更新日期：1978-04-28 00:00:00

abstract：:We evaluated immune and endocrine status following antituberculosis treatment in HIV-negative patients with newly diagnosed tuberculosis (TB). Treatment led to a decrease in IL-6, IL-1β, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after 4 months, but changes ...

journal_title：Annals of the New York Academy of Sciences

authors： Bongiovanni B,Díaz A,D'Attilio L,Santucci N,Dídoli G,Lioi S,Nannini LJ,Gardeñez W,Bogue C,Besedovsky H,del Rey A,Bottasso O,Bay ML

更新日期：2012-07-01 00:00:00