Status of the Standard Model.

abstract：:Dopaminergic signaling in the brain is primarily modulated by dopamine transporters (DATs), which actively translocate extraneuronal dopamine back into dopaminergic neurons. Transporter proteins are highly dynamic, continuously trafficking between plasmalemmal and endosomal membranes. Changes in DAT membrane trafficki...

journal_title：Annals of the New York Academy of Sciences

authors： Schmitt KC,Reith ME

更新日期：2010-02-01 00:00:00

abstract：:Higher levels of body fat are associated with increased risk for development of numerous adverse health conditions. Phytochemicals are potential agents to inhibit differentiation of preadipocytes, stimulate lipolysis, and induce apoptosis of existing adipocytes, thereby reducing adipose tissue mass. Resveratrol decrea...

journal_title：Annals of the New York Academy of Sciences

authors： Baile CA,Yang JY,Rayalam S,Hartzell DL,Lai CY,Andersen C,Della-Fera MA

更新日期：2011-01-01 00:00:00

abstract：:Development of tick vaccines provides new opportunities for control of tick infestations and tick-borne diseases. Recently, the tick-protective protein, subolesin, was identified in a cell line derived from Ixodes scapularis by expression library immunization and a mouse model of tick infestations. While subolesin was...

journal_title：Annals of the New York Academy of Sciences

authors： Blouin EF,Manzano-Roman R,de la Fuente J,Kocan KM

更新日期：2008-12-01 00:00:00

abstract：:The course of 1,487 patients with myasthenia gravis followed between 1940 and 1985 for a mean of 18 years provides further evidence that the distribution, severity, and outcome of the disease are determined during the first 1 to 3 (occasionally 5) years after onset, suggesting that injury to acetylcholine receptors oc...

journal_title：Annals of the New York Academy of Sciences

authors： Grob D,Arsura EL,Brunner NG,Namba T

更新日期：1987-01-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenocortical (HPA) axis is a major neuroendocrine system involved in the regulation of numerous physiological processes and in adaptation to stress. A wide range of variability can be observed in all the components of the system, and the contribution of genetic factors has been shown in th...

journal_title：Annals of the New York Academy of Sciences

authors： Mormede P,Foury A,Barat P,Corcuff JB,Terenina E,Marissal-Arvy N,Moisan MP

更新日期：2011-03-01 00:00:00

abstract：:While the tumor necrosis factor (TNF) family members RANKL and TNF-alpha are critical regulators of osteoclast formation, functions of other TNFs in bone are poorly understood. Here we consider the roles in regulating bone turnover of TNF receptors (TNF-R) also expressed by osteoblasts and osteoblast precursors. TNF r...

journal_title：Annals of the New York Academy of Sciences

authors： Robinson LJ,Borysenko CW,Blair HC

更新日期：2007-11-01 00:00:00

abstract：:Basal phagocytosis of neutrophils, a crucial component of non-specific immunity, is an eminently circadian parameter. In mice and rats, rates of phagocytosis peak in the second half of the dark span. A lipopolysaccharide-induced phagocytic response challenged in this period appears the most significant in amplitude an...

journal_title：Annals of the New York Academy of Sciences

authors： Hriscu ML

更新日期：2005-12-01 00:00:00

abstract：:The relationship between the concentration of cell-free DNA (cfDNA) and the number of proliferating/apoptotic lymphocytes in peripheral blood of premature newborns of different gestation age and full-term newborns was determined. The experiments were performed using fluorescent spectrophotometry (with Hoechst 33342), ...

journal_title：Annals of the New York Academy of Sciences

authors： Tuaeva NO,Abramova ZI,Sofronov VV

更新日期：2008-08-01 00:00:00

abstract：:A majority of incidentally found adrenal tumors derive from the adrenal cortex. The aim of our study was evaluation of the incidence of chromaffin tumors in a group of 1,111 patients with adrenal incidentalomas. In this group there were 803 women and 308 men, aged 10-87 years. Clinical examination, imaging studies (ul...

journal_title：Annals of the New York Academy of Sciences

authors： Kasperlik-Zaluska AA,Roslonowska E,Slowinska-Srzednicka J,Otto M,Cichocki A,Cwikla J,Slapa R,Eisenhofer G

更新日期：2006-08-01 00:00:00

abstract：:Several orphan G-protein-coupled receptors (GPCRs), LGR7 and LGR8, GPCR135 and GPCR142, were recently identified as putative, native receptors for different relaxin-family peptides, and their cell signaling mechanisms were elucidated in stably transfected cell lines. Anatomic studies have demonstrated that discrete po...

journal_title：Annals of the New York Academy of Sciences

authors： Ortinau S,Lin F,Wade JD,Tregear GW,Bathgate RA,Gundlach AL

更新日期：2005-05-01 00:00:00

abstract：:Evidence is emerging that calcium-activated neutral proteinases (CANPs) not only participate in intracellular protein turnover but help to regulate the functional reorganization of cytoskeletal proteins in response to calcium and second-messenger stimulation. The high concentration of CANPs in certain neurons has sugg...

journal_title：Annals of the New York Academy of Sciences

authors： Nixon RA

更新日期：1989-01-01 00:00:00

abstract：:The loop between transmembrane helices 6 and 7 (L6/7) of P-type ATPases has been suggested to be important for the functional linkage of ion binding and enzyme phosphorylation or to be a site of initial cation binding. To investigate the role of L6/7 in Na,K-ATPase, alanine substitutions were made for charged and cons...

journal_title：Annals of the New York Academy of Sciences

authors： Xu G,Farley RA,Kane DJ,Faller LD

更新日期：2003-04-01 00:00:00

abstract：:We demonstrate that task relevance dissociates between visual awareness and knowledge activation to create a state of seeing without knowing-visual awareness of familiar stimuli without recognizing them. We rely on the fact that in order to experience a Kanizsa illusion, participants must be aware of its inducers. Whi...

journal_title：Annals of the New York Academy of Sciences

authors： Eitam B,Shoval R,Yeshurun Y

更新日期：2015-03-01 00:00:00

abstract：:The New York Stem Cell Foundation's "Fifth Annual Translational Stem Cell Research Conference" convened on October 12-13, 2010 at the Rockefeller University in New York City. The conference attracted over 400 scientists, patient advocates, and stem cell research supporters from 16 countries. In addition to poster and ...

journal_title：Annals of the New York Academy of Sciences

authors： Marshall C,Wang GK,Cimetta E,Talchai C,Egli D,Shim JW,Martin I,Ahmad F,Sproul A,Chen T,Fossati V,McKeon D,Smith K,Solomon SL

更新日期：2011-05-01 00:00:00

abstract：:Approximately 90% of all cancer deaths arise from metastasis formation. Hence, understanding the molecular mechanisms underlying tumor progression, local invasion, and the formation of tumor metastases represents one of the great challenges in exploratory cancer research. Recent experimental results indicate that chan...

journal_title：Annals of the New York Academy of Sciences

authors： Cavallaro U,Christofori G

更新日期：2004-04-01 00:00:00

abstract：:During food shortage, organisms activate defense mechanisms to maximize their chance of survival. At least in part, these responses are triggered by changes in hormonal status and neural status during starvation. The hypothalamus is organized as a collection of distinct autonomously active nuclei and is considered to ...

journal_title：Annals of the New York Academy of Sciences

authors： Chiba T,Fujita S,Kubota H,Inoue D,Mizuno A,Komatsu T,Yamaza H,Higami Y,Shimokawa I

更新日期：2007-11-01 00:00:00

abstract：:T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Falk LA Jr,Byington R,Silva DP

更新日期：1984-01-01 00:00:00

abstract：:Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen-sensitive transcription factors including the hypoxia-inducible factor (HIF) and nuclear factor-kappaB (NF-kappaB). Hypoxia-dependent gene expression can have important physiologic or pathophysiologic co...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor CT,Cummins EP

更新日期：2009-10-01 00:00:00

abstract：:Statistical learning is a set of cognitive mechanisms allowing for extracting regularities from the environment and segmenting continuous sensory input into discrete units. The current study used functional magnetic resonance imaging (fMRI) (N = 25) in conjunction with an artificial language learning paradigm to provi...

journal_title：Annals of the New York Academy of Sciences

authors： Ordin M,Polyanskaya L,Soto D

更新日期：2020-05-01 00:00:00

abstract：:The physiological status of presynaptic receptors, regulating sympathetic neurotransmitter release, remains subject to debate. Nevertheless, pharmacological techniques have shown presynaptic alpha-adrenoceptors, mediating a negative feedback inhibition of neuronal noradrenaline (NA) release, and presynaptic beta-adren...

journal_title：Annals of the New York Academy of Sciences

authors： Borkowski KR

更新日期：1990-01-01 00:00:00

abstract：:Chronic exposure to arsenic causes health problems, including peripheral neuropathy. Oxidative stress is one of the mechanisms underlying arsenic-induced neurotoxicity. For this report, we studied the protective effect of N-acetylcysteine (NAC) on arsenic-induced oxidative injury in dorsal root ganglion (DRG) explants...

journal_title：Annals of the New York Academy of Sciences

authors： Chao PL,Fan SF,Chou YH,Lin AM

更新日期：2007-12-01 00:00:00

abstract：:This paper represents a unique effort to elucidate the dynamics of two major types of politically motivated hostage takers. The data presented are derived from an ongoing research project that is gathering extensive interview and psychological test materials from prisoners convicted of politically motivated crimes, bo...

journal_title：Annals of the New York Academy of Sciences

authors： Knutson JN

更新日期：1980-01-01 00:00:00

abstract：:It is now generally accepted that it is not possible to design iron(III)-selective hexadentate chelators with high oral bioavailability. In order to achieve suitable levels of oral activity for the treatment of systemic iron overload either tridentate or bidentate molecules need to be investigated. There are a number ...

journal_title：Annals of the New York Academy of Sciences

authors： Hider RC,Zhou T

更新日期：2005-01-01 00:00:00

abstract：:Regulation of carbohydrate and fat utilization by skeletal muscle at rest and during exercise has been the subject of investigation since the early 1960s when Randle et al. proposed the so-called glucose-fatty acid cycle to explain the reciprocal relationship between carbohydrate and fat metabolism. The suggested mech...

journal_title：Annals of the New York Academy of Sciences

authors： Jeukendrup AE

更新日期：2002-06-01 00:00:00

abstract：:In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

journal_title：Annals of the New York Academy of Sciences

authors： Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

更新日期：2021-01-12 00:00:00

abstract：:Rapid advances in the biomedical sciences are producing new means of intervention against many of the major tropical diseases. The discovery of new drugs, vaccines and diagnostic tests, however, is only the first, though important, step down an often long and difficult road to their effective deployment in disease con...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PG

更新日期：1989-01-01 00:00:00

abstract：:The nature and regulation of juvenile hormone (JH) biosynthesis have been investigated in isolated corpora allata (CA) of adult males and females, and larvae of the tomato moth Lacanobia oleracea (Noctuidae). Larval CA (Vth day 1 to VIth day 1) appear to synthesize JH at very low rates (< 0.5 fmol/pr/h). This synthesi...

journal_title：Annals of the New York Academy of Sciences

authors： Audsley N,Weaver RJ,Edwards JP

更新日期：1999-01-01 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:The human ABO(H) blood group phenotypes arise from the evolutionarily oldest genetic system found in primate populations. While the blood group antigen A is considered the ancestral primordial structure, under the selective pressure of life-threatening diseases blood group O(H) came to dominate as the most frequently ...

journal_title：Annals of the New York Academy of Sciences

authors： Arend P

更新日期：2018-08-01 00:00:00

abstract：:This paper is a progress report on our present understanding of iron nutrition in man, particularly in developing countries. We will be concerned with the quantitative aspects of iron balance and in particular with the availability of dietary iron, the recognition of iron deficiency and its prevalence, the effects of ...

journal_title：Annals of the New York Academy of Sciences

authors： Finch CA

更新日期：1977-11-30 00:00:00