Abstract:
:Homogenate of 30 sarcoid lymph nodes was injected into the footpads of mice and 42% of the mice showed epitheloid-cell granulomas in the sites. However, the control lymph-node homogenates obtained from nonsarcoid patients also provoked similar granulomatous changes, although the positive rate was somewhat lower. In the granulomas a small amount of dust pigment remained, but no polarizing crystals were found in the sites or in the homogenate of either groups. No acid-fast bacilli, fungi, or other aerobic organisms were cultivated from the homogenate. Granuloma-formation activity remained after the homogenate had been sterilized in several ways and it existed in sediments of centrifugation of less than 2200 x g, but not in the supernate. The results seem to indicate that the granuloma formed in the footpads were the result of a local immunological reaction to the degenerated heterogenic protein of the injected and persistent homogenate.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Iwai K,Takahashi Sdoi
10.1111/j.1749-6632.1976.tb47036.xsubject
Has Abstractpub_date
1976-01-01 00:00:00pages
249-59eissn
0077-8923issn
1749-6632journal_volume
278pub_type
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