How youth mentoring relationships end and why it matters: a mixed-methods, multi-informant study.

abstract：:The rates and properties of new mutations affecting fitness have implications for a number of outstanding questions in evolutionary biology. Obtaining estimates of mutation rates and effects has historically been challenging, and little theory has been available for predicting the distribution of fitness effects (DFE)...

journal_title：Annals of the New York Academy of Sciences

authors： Bataillon T,Bailey SF

更新日期：2014-07-01 00:00:00

abstract：UNLABELLED:Hepatocarcinogenesis is a multistep process characterized by hepatocyte inflammation, regeneration, and proliferation. These changes are believed to depend on the aberrant expression of various tumor suppressor genes, oncogenes and growth factors. Several studies have shown the involvement of cyclooxygenase-...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Ingrao S,Soresi M,Florena AM,La Spada E,Sandonato L,D'Alessandro N,Cervello M,Montalto G

更新日期：2009-02-01 00:00:00

abstract：:It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of agin...

journal_title：Annals of the New York Academy of Sciences

authors： Hodes RJ,Sierra F,Austad SN,Epel E,Neigh GN,Erlandson KM,Schafer MJ,LeBrasseur NK,Wiley C,Campisi J,Sehl ME,Scalia R,Eguchi S,Kasinath BS,Halter JB,Cohen HJ,Demark-Wahnefried W,Ahles TA,Barzilai N,Hurria A,Hunt PW

更新日期：2016-12-01 00:00:00

abstract：:The interleukin (IL)-2 receptor has proved an attractive target for T cell-directed therapies. Agents including monoclonal antibodies, single-chain antibody immunoconjugates, radioimmunoconjugates, and, most recently, ligand fusion toxins have demonstrated activity in vitro and in clinical trials in both hematologic m...

journal_title：Annals of the New York Academy of Sciences

authors： Foss FM

更新日期：2001-09-01 00:00:00

abstract：:Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase-2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention stra...

journal_title：Annals of the New York Academy of Sciences

authors： Nelson MA,Goulet AC,Jacobs ET,Lance P

更新日期：2005-11-01 00:00:00

abstract：:In the past few years it has been shown that, like many other non-neuroendocrine cells, adipocytes possess a mechanism for triggered exocytosis. Endocytosis and exocytosis affect the plasma membrane surface area, which can be directly monitored with electrophysiological patch-clamp techniques by measuring membrane cap...

journal_title：Annals of the New York Academy of Sciences

authors： Chowdhury HH,Grilc S,Zorec R

更新日期：2005-06-01 00:00:00

abstract：:The term "steroid- or glucocorticoid-resistant (GR) asthma" has been used to describe a group of asthmatics who demonstrate persistent airway obstruction and inflammation despite treatment with high doses of systemic glucocorticoids (GCs). There are at least two forms of GR asthma. The first group of patients has an a...

journal_title：Annals of the New York Academy of Sciences

authors： Leung DY,de Castro M,Szefler SJ,Chrousos GP

更新日期：1998-05-01 00:00:00

abstract：:A summary is provided of the early history of research on the flow of nonrenewable energy resources through the economy and of the flow of renewable energy resources through a natural ecosystem. The techniques are similar, and many specific applications are provided. A combined economic and ecological technique is als...

journal_title：Annals of the New York Academy of Sciences

authors： Hannon B

更新日期：2010-01-01 00:00:00

abstract：:Locomotion control uses proprioceptive, visual, and vestibular signals. Previously, we analyzed the visual contribution with visual motion stimulation in roll while participants kept their heads in a normal upright orientation. In this study we applied the same visual disturbance in a head-upright and a nose-down cond...

journal_title：Annals of the New York Academy of Sciences

authors： Bardins S,Schneider E

更新日期：2009-05-01 00:00:00

abstract：:We discuss the relevance of studying ecology within the framework of Complexity Science from a statistical mechanics approach. Ecology is concerned with understanding how systems level properties emerge out of the multitude of interactions among large numbers of components, leading to ecosystems that possess the proto...

journal_title：Annals of the New York Academy of Sciences

authors： Jensen HJ,Arcaute E

更新日期：2010-05-01 00:00:00

abstract：:Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap be...

journal_title：Annals of the New York Academy of Sciences

authors： Hill C,Khashab MA,Kalloo AN,Kumbhari V

更新日期：2018-01-01 00:00:00

abstract：:Opsoclonus-myoclonus syndrome (OMS) is a rare neurologic disorder comprising the main symptoms of eye-movement disturbances, muscle jerks, and severe ataxia. In children and adults, some cases are associated with a tumor as a paraneoplastic syndrome, whereas in children the paraneoplastic form is almost exclusively as...

journal_title：Annals of the New York Academy of Sciences

authors： Kirsten A,Beck S,Fühlhuber V,Kaps M,Kreutz T,Korfei M,Schmitt S,Preissner KT,Blaes F

更新日期：2007-09-01 00:00:00

abstract：:Apoptosis in T and B lymphocytes is a major element controlling the immune response. Activation induced cell death (AICD) in T cells is a main mechanism for maintaining peripheral tolerance and for limiting an ongoing immune response. AICD is initiated by antigen reengagement of the T cell receptor (TCR), and mediated...

journal_title：Annals of the New York Academy of Sciences

authors： Delgado M,Ganea D

更新日期：2000-01-01 00:00:00

abstract：:The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this dis...

journal_title：Annals of the New York Academy of Sciences

authors： Lee MH,Surh YJ

更新日期：2009-08-01 00:00:00

abstract：:Social behavior in most human societies is characterized by the following of moral rules explicitly justified by religious belief systems. These systems constitute the diverse domain of human sacred values. Supernatural entities as founders or warranty of moral principles may be seen as a form of "conversation stopper...

journal_title：Annals of the New York Academy of Sciences

authors： Tófalvy T,Viciana H

更新日期：2009-06-01 00:00:00

abstract：:Chronic purulent rhinosinusitis (CPR) is an inflammatory condition of unknown origin. Although various medical and surgical treatment modalities are available, 5-10% of patients remain refractory. Immune deficiency is one of the underlying risk factors for this disease. Earlier studies demonstrated disturbances in cel...

journal_title：Annals of the New York Academy of Sciences

authors： Dalm VA,de Wit H,Drexhage HA

更新日期：2012-10-01 00:00:00

abstract：:The vast majority of what is known about the neural underpinnings of human cognition comes from studies limited to racially, ethnically, and socioeconomically homogeneous samples. Furthermore, although most studies include both males and females in their samples, sex differences in patterns of brain activity and perfo...

journal_title：Annals of the New York Academy of Sciences

authors： Dotson VM,Duarte A

更新日期：2020-03-01 00:00:00

abstract：:Previous studies have established that methanolic extracts of bovine brain and lung possess CDS activity with an agonist-like profile at alpha(2)-adrenoceptor binding sites (i.e., greater potency against [(3)H]-clonidine sites than against [(3)H]-RX-821001 sites). Following prolonged reflux in ethylacetate, monovalent...

journal_title：Annals of the New York Academy of Sciences

authors： Pinthong D,Kendall DA,Wilson VG

更新日期：2003-12-01 00:00:00

abstract：:While each region of the world faces unique public health challenges, environmental threats to vulnerable populations in Asia constitute a significant global public health challenge. Environmental threats to health are widespread and are increasing as nations in the region undergo rapid industrial development. One of ...

journal_title：Annals of the New York Academy of Sciences

authors： Suk WA,Davis EA

更新日期：2008-10-01 00:00:00

abstract：:Social motor coordination (SMC) pertains to the timing of contingent movements during social interactions and is of high relevance for successful social and musical interactions. Semi-automated, objective methods are increasingly being used to analyze SMC, though it is unclear if these methods are feasible in naturali...

journal_title：Annals of the New York Academy of Sciences

authors： Pfeiffer R,Wallace M,Lense M

更新日期：2018-05-04 00:00:00

abstract：:Antioxidant activity of Maillard reaction products (MRPs) derived from four sugar-amino acid Maillard reaction model systems (glucose [Glc] or ribose [Rib] reacted with glycine [Gly] and L-lysine [Lys]) were examined in terms of chemical properties and molecular weight fractionation of reaction products. Rib-amino aci...

journal_title：Annals of the New York Academy of Sciences

authors： Chen XM,Kitts DD

更新日期：2008-04-01 00:00:00

abstract：:Catecholamines (CAs) are significantly involved in the regulation of homeostasis of the organism at rest and especially during stressful situations. Stress induces increases in plasma CA (epinephrine and norepinephrine) levels and prolactin (PRL) release from the adenopituitary. We have recently observed that salsolin...

journal_title：Annals of the New York Academy of Sciences

authors： Bodnar I,Mravec B,Kubovcakova L,Fekete MI,Nagy GM,Kvetnansky R

更新日期：2004-06-01 00:00:00

abstract：:Relaxin has been validated as a cardiotropic hormone, being produced by the heart and acting on specific heart receptors. Evidence is accumulating that it could hamper the pathophysiologic mechanisms of ischemic heart disease. Time is ripe to study relaxin as a cardiotropic drug, as recombinant human relaxin (hrRLX) i...

journal_title：Annals of the New York Academy of Sciences

authors： Bani D,Nistri S,Sacchi TB,Bigazzi M

更新日期：2005-05-01 00:00:00

abstract：:Nonpathogenic enteric bacterial species initiate and perpetuate experimental colitis in interleukin-10 geneeficient mice (IL-10(-/-)). Bacteria-specific effects on the epithelium are difficult to distinguish because of the complex nature of the gut microflora. We showed that IL-10(-/-) mice compared to wild-type mice ...

journal_title：Annals of the New York Academy of Sciences

authors： Ruiz PA,Shkoda A,Kim SC,Sartor RB,Haller D

更新日期：2006-08-01 00:00:00

abstract：:Studies of the ability of the EPR spin trap DEPMPO to detect both superoxide and hydroxyl radicals produced by systems in vitro and in vivo are presented. Experiments using free radical-generating systems confirmed the suitability of the EPR spin trapping technique but also revealed the existence of an undesirable con...

journal_title：Annals of the New York Academy of Sciences

authors： Mojović M,Vuletić M,Bacić GG

更新日期：2005-06-01 00:00:00

abstract：:Homogenate of 30 sarcoid lymph nodes was injected into the footpads of mice and 42% of the mice showed epitheloid-cell granulomas in the sites. However, the control lymph-node homogenates obtained from nonsarcoid patients also provoked similar granulomatous changes, although the positive rate was somewhat lower. In th...

journal_title：Annals of the New York Academy of Sciences

authors： Iwai K,Takahashi S

更新日期：1976-01-01 00:00:00

abstract：:We propose a model for signaling events induced by fluid shear stress that incorporates many of the features discussed in this paper (FIG. 4). First, heterotrimeric G-proteins, as well as a small G-proteins, are activated by flow. Indeed, a G protein appears to be required for ERK1/2 activation by flow because ERK1/2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Ishida T,Takahashi M,Corson MA,Berk BC

更新日期：1997-04-15 00:00:00

abstract：:We have been interested in the consequences of foreign DNA insertion into established mammalian genomes and have initially studied this problem in adenovirus type 12 (Ad12)-transformed cells or in Ad12-induced hamster tumors. Since integrates are frequently methylated de novo, it appears that they might be modified by...

journal_title：Annals of the New York Academy of Sciences

authors： Doerfler W,Hohlweg U,Müller K,Remus R,Heller H,Hertz J

更新日期：2001-09-01 00:00:00

abstract：:Osteocytes are derived from osteoblasts and make up over 90% of the cells in bone. However, the mechanisms that control the differentiation of osteoblasts into osteocytes embedded in bone matrix are not well understood. With the recent developments of transgenic models for manipulating gene expression in osteocytes an...

journal_title：Annals of the New York Academy of Sciences

authors： Dallas SL,Bonewald LF

更新日期：2010-03-01 00:00:00

abstract：:According to the fetal origin of adult diseases hypothesis, the intrauterine environment through developmental plasticity may permanently influence long-term health and disease. Therefore, intrauterine growth restriction (IUGR), due either to maternal, placental, or genetic factors, may permanently alter the endocrine...

journal_title：Annals of the New York Academy of Sciences

authors： Kanaka-Gantenbein C

更新日期：2010-09-01 00:00:00