Complex interaction of alpha(2)-adrenoceptor binding sites with bovine brain and lung extracts containing clonidine-displacing substance.

abstract：:The last decade has witnessed a surge in studies on steroid hormones of maternal origin present in avian eggs and affecting offspring development. The value of such studies for the understanding of maternal effects and individual differentiation is endorsed and a series of methodological and conceptual issues in the c...

journal_title：Annals of the New York Academy of Sciences

authors： Groothuis TG,von Engelhardt N

更新日期：2005-06-01 00:00:00

abstract：:Advanced glycation endproducts (AGEs) and oxidative stress (OS) contribute to the development and progression of diabetic complications. We have reported that dietary AGEs and OS induce acute endothelial dysfunction in vivo, but little is known about their effects on adipokines. Twenty inpatients with type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Stirban A,Negrean M,Götting C,Uribarri J,Gawlowski T,Stratmann B,Kleesiek K,Koschinsky T,Vlassara H,Tschoepe D

更新日期：2008-04-01 00:00:00

abstract：:The homeostasis of skeletal tissues requires tight regulation of a variety of signaling pathways, and the onset and progression of skeletal diseases are often caused by signaling abnormalities. MicroRNAs (miRNAs) are short noncoding RNA molecules that have emerged as a new dimension of gene regulation. MiRNAs have bee...

journal_title：Annals of the New York Academy of Sciences

authors： Zhao W,Zhang S,Wang B,Huang J,Lu WW,Chen D

更新日期：2016-11-01 00:00:00

abstract：:In visual working memory tasks, memory for an item is enhanced if participants are told that the item is relatively more valuable than others presented within the same trial. Experiment 1 explored whether these probe value boosts (termed prioritization effects in previous literature) are affected by probe frequency (i...

journal_title：Annals of the New York Academy of Sciences

authors： Atkinson AL,Berry EDJ,Waterman AH,Baddeley AD,Hitch GJ,Allen RJ

更新日期：2018-07-01 00:00:00

abstract：:Posttranscriptional control of gene expression plays a key role in regulating gene expression in cells undergoing apoptosis. Cyclooxygenase-2 (COX-2) is a crucial enzyme in the conversion of arachidonic acid to prostaglandin E2 (PGE(2)) and is significantly upregulated in many types of adenocarcinomas. COX-2 overexpre...

journal_title：Annals of the New York Academy of Sciences

authors： Mukhopadhyay D,Jung J,Murmu N,Houchen CW,Dieckgraefe BK,Anant S

更新日期：2003-12-01 00:00:00

abstract：:Undernutrition and inadequate stimulation both negatively influence child health and development and have a long-term impact on school attainment and income. This paper reports data from India and Pakistan looking at how families interact, play with, and feed children; their expectations of growth and development; and...

journal_title：Annals of the New York Academy of Sciences

authors： Lingam R,Gupta P,Zafar S,Hill Z,Yousafzai A,Iyengar S,Sikander S,Haq Zu,Mehta S,Skordis-Worrel J,Rahman A,Kirkwood B

更新日期：2014-01-01 00:00:00

abstract：:Mitochondrial dysfunction, due to either environmental or genetic factors, can result in excessive production of reactive oxygen species, triggering the apoptotic death of dopaminergic cells in Parkinson's disease. Mitochondrial free radical production is promoted by the inhibition of electron transport at any point d...

journal_title：Annals of the New York Academy of Sciences

authors： Fiskum G,Starkov A,Polster BM,Chinopoulos C

更新日期：2003-06-01 00:00:00

abstract：:Athletic women are at risk for developing ovulatory dysfunction, which presents variably as menstrual irregularity or absence. Initially characterized as an isolated disruption of hypothalamic gonadotropin-releasing hormone (GnRH) release, athletic amenorrhea, a form of hypogonadotropic hypogonadism, is invariably acc...

journal_title：Annals of the New York Academy of Sciences

authors： Pauli SA,Berga SL

更新日期：2010-09-01 00:00:00

abstract：:Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infe...

journal_title：Annals of the New York Academy of Sciences

authors： Hwang K,Yatsenko AN,Jorgez CJ,Mukherjee S,Nalam RL,Matzuk MM,Lamb DJ

更新日期：2010-12-01 00:00:00

abstract：:Our earlier studies of translation have led us to a specific numeric coding of nucleotides (A = 0, C = 1, G = 2, and U = 3)--that is, a quaternary numeric system; to ordering of digrams and codons (read right to left: .yx and Z.yx) as ordinal numbers from 000 to 111; and to seek hypothetic transformation of mRNA to 20...

journal_title：Annals of the New York Academy of Sciences

authors： Damjanović ZM,Rakocević MM

更新日期：2005-06-01 00:00:00

abstract：:Nanotechnology provides multifunctional agents for in vivo use that increasingly blur the distinction between pharmaceuticals and medical devices. Realization of such therapeutic nanodevices requires multidisciplinary effort that is difficult for individual device developers to sustain, and identification of appropria...

journal_title：Annals of the New York Academy of Sciences

authors： Lee SC,Bhalerao K,Ferrari M

更新日期：2004-05-01 00:00:00

abstract：:Sensorimotor learning requires knowledge of the relationship between movements and sensory effects: a sensorimotor map. Generally, these mappings are not innate but have to be learned. During learning, the challenge is to build a continuous map from a set of discrete observations, that is, predict locations of novel t...

journal_title：Annals of the New York Academy of Sciences

authors： van Vugt FT,Ostry DJ

更新日期：2018-03-03 00:00:00

abstract：:Many studies have now indicated that micronutrients, such as the carotenoids, tocopherols, and ascorbic acid, can prevent mutagenesis, genotoxic effects, or malignant transformation in bacteria and mammalian tissue, either in cell culture or in organ culture. In addition, multiple papers report that some of these micr...

journal_title：Annals of the New York Academy of Sciences

authors： Krinsky NI

更新日期：1993-05-28 00:00:00

abstract：:The Sm-2Fe molten alloy with 1:2 molar ratio was unidirectionally solidified in both microgravity and normal gravity in concurrence with a magnetic flux (0-0.12 T). The compound SmFe2 was produced by the unidirectional solidification in microgravity with a magnetic flux of 0T and exhibited a lamellar microstructure. T...

journal_title：Annals of the New York Academy of Sciences

authors： Okutani T,Nagai H,Mamiya M,Shibuya M,Castillo M

更新日期：2006-09-01 00:00:00

abstract：:The Women's Health Initiative (WHI) hormone trials have been widely interpreted as demonstrating that combined menopausal hormone therapy (HT) fails to protect against-and may increase-cardiovascular disease (CVD), stroke, and dementia in menopausal women, regardless of whether initiated early in the menopause or late...

journal_title：Annals of the New York Academy of Sciences

authors： Harman SM,Naftolin F,Brinton EA,Judelson DR

更新日期：2005-06-01 00:00:00

abstract：:Protection against stress by glucocorticoids is discussed in relation to their permissive and suppressive actions. Evidence from the last decade is summarized regarding the physiological nature of the suppressive actions, and the hypothesis that they prevent stress-activated defense mechanisms from overshooting and da...

journal_title：Annals of the New York Academy of Sciences

authors： Munck A,Náray-Fejes-Tóth A

更新日期：1994-11-30 00:00:00

abstract：:A number of important themes emerge from our compartmental analyses of Na,K-ATPase biosynthesis in response to ionic stimuli. The ubiquitous alpha 1 beta 1 type sodium pump evolved to generate and maintain transmembrane Na+ and K+ gradients, and there are cell-type specific mechanisms of increasing synthesis and decre...

journal_title：Annals of the New York Academy of Sciences

authors： McDonough AA,Azuma KK,Lescale-Matys L,Tang MJ,Nakhoul F,Hensley CB,Komatsu Y

更新日期：1992-11-30 00:00:00

abstract：:Studies in humans and in animal models have demonstrated that the receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal skeletal growth and maturation. Investigations were undertaken to address which consequences of vitamin D receptor deficiency are a direct result of impaired receptor-dependen...

journal_title：Annals of the New York Academy of Sciences

authors： Demay MB

更新日期：2006-04-01 00:00:00

abstract：:Significant advances have recently been made in understanding the regulation of Ca(2+)-ATPase by phospholamban and in modeling their structures. However, these insights would be furthered by determining the 3-D structure of both proteins within the membrane, thus revealing the structural basis for their interaction. T...

journal_title：Annals of the New York Academy of Sciences

authors： Young HS,Reddy LG,Jones LR,Stokes DL

更新日期：1998-09-16 00:00:00

abstract：:In thalassemia, iron overload is the joint outcome of excessive iron absorption and transfusional siderosis. While iron absorption is limited by a physiologic ceiling of about 3 mg/d, plasma iron turnover in thalassemia may be 10 to 15 times normal, caused by the wasteful, ineffective erythropoiesis of an enormously e...

journal_title：Annals of the New York Academy of Sciences

authors： Hershko C,Link G,Cabantchik I

更新日期：1998-06-30 00:00:00

abstract：:Metastasis is the main cause of human cancer deaths, and cell motility is one key component of the process of metastasis. The ERK mitogen-activated protein kinase (MAPK) signaling pathway is probably one of the most commonly activated in malignant human cancers. We describe the molecular mechanisms by which ERK MAPK s...

journal_title：Annals of the New York Academy of Sciences

authors： Viala E,Pouysségur J

更新日期：2004-12-01 00:00:00

abstract：:Clumps of corona cells were separated from oocytes at the moment of fertilization control and were subsequently processed and cut into 1-mu sections to study their general morphologic patterns. This study revealed an extensive phagocytosis of spermatozoa by corona cells. Clumps of mural granulosa cells of comparable s...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnenborg R,Gordts S,Ongkowidjojo R,Brosens I

更新日期：1985-01-01 00:00:00

abstract：:Conventional and thiophosphonate-derivatized oligonucleotides were employed to specifically regulate functional gene expression in murine T-cell hybridomas. For example, induction of apoptotic cell death following activation of T-cell hybridomas was examined using antisense oligonucleotides corresponding to several pr...

journal_title：Annals of the New York Academy of Sciences

authors： Green DR,Zheng H,Shi Y

更新日期：1992-10-28 00:00:00

abstract：:Previous studies, which included predominantly Caucasian populations, examined psychiatric and physical illness and associated suicide risk. We used a nationwide database to reassess the findings in an Asian population, and also analyzed the influence of different onset timing of psychiatric and physical illness and t...

journal_title：Annals of the New York Academy of Sciences

authors： Chang CF,Yeh MK,Chien WC,Chung CH,Li TT,Lai EC

更新日期：2020-02-01 00:00:00

abstract：:Azathioprine may be tried for treatment of severe myasthenia gravis, in a dose of 2 mg/kg BW. With careful monitoring the side reactions may be controlled. The therapeutic response will occur after a time delay of 4-8 months. About one-third of patients with type II MG (severe, late onset, HLA B8-) will proceed to a c...

journal_title：Annals of the New York Academy of Sciences

authors： Matell G

更新日期：1987-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGF-R) has been implicated in the growth of endometrial cancer. In the present study, immunostaining of EGF-R was investigated in different endometrial cancer histotypes. For this purpose 34 surgical samples of primary endometrial carcinoma were studied using monoclonal anti-EGF-R ant...

journal_title：Annals of the New York Academy of Sciences

authors： Jasonni VM,Santini D,Amadori A,Ceccarelli C,Naldi S

更新日期：1994-09-30 00:00:00

abstract：:The benefits of estrogen replacement therapy in postmenopausal women include increased quality of life, relief from specific symptoms, and the prevention of osteoporosis, genitourinary atrophy, and cardiovascular diseases. Despite these advantages, this therapy has been reported to be associated with an increased freq...

journal_title：Annals of the New York Academy of Sciences

authors： De Cecco L,Leone M,Gerbaldo D,Venturini PL,Rissone R,Messeni Leone M

更新日期：1991-01-01 00:00:00

abstract：:Internuclear ophthalmoparesis (INO) is the most common saccadic eye movement disorder observed in patients with multiple sclerosis (MS). It is characterized by slowing of the adducting eye during horizontal saccades, and most commonly results from a demyelinating lesion in the medial longitudinal fasciculus (MLF) with...

journal_title：Annals of the New York Academy of Sciences

authors： Frohman TC,Davis SL,Frohman EM

更新日期：2011-09-01 00:00:00

abstract：:The historical reasons for the introduction of tick control during the nineteenth century are reviewed. Background and concepts for the choice between long-term tick control and tick eradication are compared. Case studies of large-scale tick control or eradication programs in Africa, Australia, the United States, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Pegram RG,Wilson DD,Hansen JW

更新日期：2000-01-01 00:00:00

abstract：:Apoptosis plays a critical role in acetaminophen (AAP)-induced hepatic injury, since inhibiting apoptosis also prevents the development of acute liver failure. In this study, the mechanism of apoptosis induction by AAP was investigated in the human hepatoblastoma cell line HuH7. AAP caused marked cytotoxicity in HuH7 ...

journal_title：Annals of the New York Academy of Sciences

authors： Kass GE,Macanas-Pirard P,Lee PC,Hinton RH

更新日期：2003-12-01 00:00:00