Strategies for addressing global environmental health concerns.

abstract：:T cell protein tyrosine phosphatase (TCPTP) dephosphorylates a number of substrates, including JAK-STAT (signal transducer and activator of transcription) signaling proteins, which are activated by interferon (IFN)-γ, a major proinflammatory cytokine involved in conditions such as inflammatory bowel disease. A critica...

journal_title：Annals of the New York Academy of Sciences

authors： Krishnan M,McCole DF

更新日期：2017-10-01 00:00:00

abstract：:Because of the relatively high prevalence of both hepatitis C virus (HCV) infection and autoimmune disorders (ADs), it is not rare to encounter in daily clinical practice patients with ADs also carrying HCV. Corticosteroids and/or immunosuppressant drugs are needed to treat ADs, but they place HCV-infected patients at...

journal_title：Annals of the New York Academy of Sciences

authors： Galeazzi M,Bellisai F,Giannitti C,Manganelli S,Morozzi G,Sebastiani GD

更新日期：2007-09-01 00:00:00

abstract：:Content differentiation models posit that different areas of the prefrontal cortex perform similar operations but differ in terms of the content that is operated on. For example, it has been suggested that the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC) perform similar working memory or i...

journal_title：Annals of the New York Academy of Sciences

authors： Zald DH

更新日期：2007-12-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have an increased incidence of vascular disease, and oxidative stress is recognized as an important feature in this condition, despite the underlying mechanisms not being fully understood. In these patients, an interaction between lipoproteins and the immune system has ...

journal_title：Annals of the New York Academy of Sciences

authors： Batuca JR,Ames PR,Isenberg DA,Alves JD

更新日期：2007-06-01 00:00:00

abstract：:The dentate gyrus of the rat forms in three developmental phases, each of which is characterized by neuronal birth, migration and death. Recent evidence indicates that adrenal steroids regulate neuronal birth, death, and possibly migration throughout the life of the animal. However, the observation that very few neuro...

journal_title：Annals of the New York Academy of Sciences

authors： Gould E

更新日期：1994-11-14 00:00:00

abstract：:The receptive field of a direction-selective unit of any type consists of an excitatory center 3 degrees -5 degrees in size, a near inhibitory surround and a far surround upon which illumination exerts an influence for both spontaneous activity and specific cell response. ...

journal_title：Annals of the New York Academy of Sciences

authors： Golovkin M,Gorbunov V,Maximova E,Maximov V

更新日期：2005-06-01 00:00:00

abstract：:Increasing evidence suggests that the tight junction is a dynamically regulated structure. Cytoskeletal reorganization, particularly myosin light chain phosphorylation--induced actomyosin contraction, has increasingly been recognized as a mediator of physiological and pathophysiological tight junction regulation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Shen L

更新日期：2012-07-01 00:00:00

abstract：:Fibrinogen, a clottable plasma glycoprotein, participates in cell adhesion phenomena involving prokaryotic cells, e.g. staphylococci, and eukaryotic cell fragments, e.g. platelets. Among the three chains (alpha, beta, gamma) of human fibrinogen, the gamma chain bears the main site recognizing the staphylococcal clumpi...

journal_title：Annals of the New York Academy of Sciences

authors： Hawiger J,Kloczewiak M,Timmons S,Strong D,Doolittle RF

更新日期：1983-06-27 00:00:00

abstract：:All blood cells are derived from multipotent stem cells, the so-called hematopoietic stem cells (HSCs), that in adults reside in the bone marrow. Most types of blood cells also develop there, with the notable exception of T lymphocytes that develop in the thymus. For both HSCs and developing T cells, interactions with...

journal_title：Annals of the New York Academy of Sciences

authors： Roozen PP,Brugman MH,Staal FJ

更新日期：2012-08-01 00:00:00

abstract：:To test a hypothesis about how otoliths resolve roll-tilts from translations, we measured human ocular torsion position [ocular counterrolling (OCR)] to maintained linear acceleration stimuli. All subjects (n = 8) were tested in two conditions where the same magnitude of shear along an interaural axis was generated in...

journal_title：Annals of the New York Academy of Sciences

authors： MacDougall HG,Curthoys IS,Betts GA,Burgess AM,Halmagyi GM

更新日期：1999-05-28 00:00:00

abstract：:Type 2 diabetes and obesity are major global public health problems, with migrant populations in high-income countries being particularly affected. Type 2 diabetes and obesity are also major threats in low- and middle-income countries, from which most migrant populations originate. Transitioning of societies and the r...

journal_title：Annals of the New York Academy of Sciences

authors： Agyemang C,Beune E,Meeks K,Addo J,Aikins AD,Bahendeka S,Danquah I,Mockenhaupt FP,Schulze MB,Klipstein-Grobusch K,Smeeth L,Stronks K

更新日期：2017-03-01 00:00:00

abstract：:Intracellular foreign protein (beta-galactosidase) expression in recombinant CHO cell lines in continuous culture was analyzed by developing a mathematical model that includes the effects of metabolic burden and cell cycle dependence of intracellular foreign protein expression. This combined growth kinetic and cell cy...

journal_title：Annals of the New York Academy of Sciences

authors： Gu MB,Todd P,Kompala DS

更新日期：1994-05-02 00:00:00

abstract：:Expression analysis and epidemiologic studies have provided indirect evidence that proteinases and growth factors play a role in the development of atherosclerosis and complications such as aneurysm formation and plaque rupture. Studies using genetically altered mice have proven to be an elegant tool to study the caus...

journal_title：Annals of the New York Academy of Sciences

authors： Luttun A,Carmeliet P

更新日期：2001-12-01 00:00:00

abstract：:The formation of bone is a continual process in vertebrate development, initiated during fetal development and persisting in adulthood in the form of remodeling and repair. The remarkable capacity of skeletal tissues to regenerate has led to the hypothesis that the molecular signaling pathways regulating skeletogenesi...

journal_title：Annals of the New York Academy of Sciences

authors： Ferguson CM,Miclau T,Hu D,Alpern E,Helms JA

更新日期：1998-10-23 00:00:00

abstract：:Altered calcium homeostasis may play a key role in the pathophysiology of human heart failure. Levels of sarcoplasmic reticulum (SR) proteins and sarcolemmal Na(+)-Ca2+ exchanger were analyzed by Western blot in failing and nonfailing human myocardium and related to myocardial function. Levels of the SR calcium releas...

journal_title：Annals of the New York Academy of Sciences

authors： Lehnart SE,Schillinger W,Pieske B,Prestle J,Just H,Hasenfuss G

更新日期：1998-09-16 00:00:00

abstract：:This chapter considers violence prevention programs in light of aggression and violence directed toward girls and women. More specifically, current violence prevention programs, directed toward young children and/or their caregivers, are discussed with a special consideration for the Adults and Children Together (ACT)...

journal_title：Annals of the New York Academy of Sciences

authors： Guttman M,Mowder B,Yasik A

更新日期：2006-11-01 00:00:00

abstract：:Many risk factors have been identified as having either a protective or a negative effect on the development of fibroids, but due to methodological issues and a lack of long-term studies, the exact effect of these factors is ambiguous. In similar dispute is the proper treatment of fibroids. Recent technological advanc...

journal_title：Annals of the New York Academy of Sciences

authors： Moorehead ME,Conard CJ

更新日期：2001-12-01 00:00:00

abstract：:Acute phase proteins (APPs) are a group of serum proteins that undergo dramatic changes in concentration during times of inflammation. Many APPs are heavily glycosylated, and their sugar content and complexity change in the presence of cancer-induced chronic inflammation. These changes in glycosylation are currently b...

journal_title：Annals of the New York Academy of Sciences

authors： Dempsey E,Rudd PM

更新日期：2012-04-01 00:00:00

abstract：:An extended parallel is developed between musical and prosodic structures, using the author's cognitively oriented music theory and recent work in generative phonology. For illustration, the sounds of a short poem by Robert Frost are treated entirely in musical terms. The poem is assigned a phonological stress grid an...

journal_title：Annals of the New York Academy of Sciences

authors： Lerdahl F

更新日期：2001-06-01 00:00:00

abstract：:The aim of this study was to examine the role of activating pathways of plasminogen in the natural history of abdominal aortic aneurysms (AAA). To fulfill this objective 70 male patients with small AAA (> 3 cm) were interviewed and examined. Their blood samples were taken at diagnosis. The patients were scanned annual...

journal_title：Annals of the New York Academy of Sciences

authors： Lindholt JS

更新日期：2006-11-01 00:00:00

abstract：:More than 10% of postmenopausal women in the United States receive thyroid hormone replacement therapy and up to 20% of these women are over-replaced inducing subclinical hyperthyroidism. Because hyperthyroidism and post menopausal osteoporosis overlap in women of advancing age, it is urgent to understand the effect o...

journal_title：Annals of the New York Academy of Sciences

authors： Abe E,Sun L,Mechanick J,Iqbal J,Yamoah K,Baliram R,Arabi A,Moonga BS,Davies TF,Zaidi M

更新日期：2007-11-01 00:00:00

abstract：:A new model for spatial convective transport processes conjugated with the measured or calculated realistic quasi-steady microaccelerations is presented. Rotation around the mass center, including accelerated rotation, gravity gradient, and aerodynamical drag are taken into account. New results of the effect on mixing...

journal_title：Annals of the New York Academy of Sciences

authors： Polezhaev VI,Nikitin SA

更新日期：2009-04-01 00:00:00

abstract：:Prostate and breast cancer are hormone-dependent malignancies of the aging male and female and require the local production of androgens and estrogens to stimulate cell proliferation. Aldo-keto reductases (AKR) play key roles in this process. In the prostate, AKR1C3 (type 5 17beta-HSD) reduces Delta(4)-androstene-3,17...

journal_title：Annals of the New York Academy of Sciences

authors： Penning TM,Byrns MC

更新日期：2009-02-01 00:00:00

abstract：:We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in suscep...

journal_title：Annals of the New York Academy of Sciences

authors： Goldhaber JI,Henderson SA,Reuter H,Pott C,Philipson KD

更新日期：2005-06-01 00:00:00

abstract：:In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of t...

journal_title：Annals of the New York Academy of Sciences

authors： Borman RA,Burleigh DE

更新日期：1997-05-30 00:00:00

abstract：:The SET domain, first identified within and named after proteins encoded by three Drosophila genes [Su(var)3-9, E(z), and Trithorax], is recognized as a signature motif for histone methyltransferases that are involved in epigenetic processes. The SUV39H family of SET domain proteins methylate specifically the residue ...

journal_title：Annals of the New York Academy of Sciences

authors： Zhao Z,Shen WH

更新日期：2004-12-01 00:00:00

abstract：:Hyperinsulinemia and hyperglycemia have been associated with vascular injury such as atherosclerosis in diabetes mellitus. Recently, annexin II, a member of annexin family proteins, has been found to work as co-receptor on endothelial cells for plasminogen and tissue plasminogen activator, facilitating plasmin generat...

journal_title：Annals of the New York Academy of Sciences

authors： Ishii H,Yoshida M,Hajjar KA,Tanaka A,Yasukochi Y,Shimokado K,Numano F

更新日期：2001-12-01 00:00:00

abstract：:The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and...

journal_title：Annals of the New York Academy of Sciences

authors： Wagner KR,Dwyer BE

更新日期：2004-03-01 00:00:00

abstract：:Growing evidence from clinical and epidemiological studies points to a synchronized increase in the incidence of male reproductive problems, such as genital abnormalities, testicular cancer, reduced semen quality, and subfertility. Together these male reproductive problems may reflect the existence of one common entit...

journal_title：Annals of the New York Academy of Sciences

authors： Boisen KA,Main KM,Rajpert-De Meyts E,Skakkebaek NE

更新日期：2001-12-01 00:00:00

abstract：:We previously showed that pituitary adenylate cyclase-activating polypeptide (PACAP) potently stimulates insulin secretion in vivo in mice without altering glucose disposal. Such a combination of results would be explained if epinephrine released by PACAP counteracts the action of insulin and, therefore, that the gluc...

journal_title：Annals of the New York Academy of Sciences

authors： Ahrén B,Filipsson K

更新日期：2000-01-01 00:00:00