Abstract:
:Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase-2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention strategies with selenium compounds represent a viable option to reduce colon cancer. Here we discuss epidemiologic studies and ongoing clinical trials with selenium. In addition, we discuss preclinical mechanistic studies that provide insights into the biochemical and molecular bases for the anticancer effects of selenomethionine.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Nelson MA,Goulet AC,Jacobs ET,Lance Pdoi
10.1196/annals.1339.016subject
Has Abstractpub_date
2005-11-01 00:00:00pages
26-32eissn
0077-8923issn
1749-6632pii
1059/1/26journal_volume
1059pub_type
杂志文章,评审abstract::Congenital myasthenia (CM) constitutes a heterogeneous group of disorders with different underlying defects. The authors investigated a case of CM, presenting with congenital contractures. Endplate studies in the first year of life showed a developmental disorder of postsynaptic membranes. Clinical follow-up demonstra...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1987.tb51303.x
更新日期:1987-01-01 00:00:00
abstract::Bioterrorism includes possible use of Weapons of Mass Destruction (WMD), preferably biological agents, by non-state terrorist groups as well as criminal clusters. The threat from terrorists to utilize biological agents to achieve goals is not new, but the threshold to realize the threats seems to be lower than previou...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::We and others recently showed that fever induced by intravenously or intraperitoneally injected lipopolysaccharide (LPS) may involve brain signaling via hepatic vagal afferents. This suggests that LPS fever may be initiated by mediators released mainly by cells in the liver, presumably macrophages (Kupffer cells, Kc)....
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1998.tb08318.x
更新日期:1998-09-29 00:00:00
abstract::Our recently developed method, TranSIESTA, enables modelling of molecular electronic devices under operation conditions. The method is based on density functional theory, and calculates the self-consistent electronic structure of a nanostructure coupled to three-dimensional electrodes with different electrochemical po...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1292.014
更新日期:2003-12-01 00:00:00
abstract::Endometrial carcinoma is the most common cancer of the female reproductive organs in the United States. International comparisons reveal that the incidence of endometrial cancer vary widely between different countries with the highest rates observed in North America and Northern Europe, intermediate rates in Eastern E...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2001.tb03811.x
更新日期:2001-09-01 00:00:00
abstract::In our study, we present a purely statistical observations-based model-free analysis that provides evidence about Granger causality (GC) from long-lived radiative forcings (LLRFs) to the climate trend (CT). This relies on having locally ordered breaks in the slopes of the trend functions of LLRF and the CT, with the b...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/nyas.13923
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abstract::The rapid (IKr) and slow (IKs) delayed rectifier K+ currents are key regulators of cardiac repolarization. HERG encodes the Kr channel, and KVLQT1 and hminK encode subunits that coassemble to form Ks channels. Mutations in any one of these genes cause Romano-Ward syndrome, an autosomal dominant form of long QT syndrom...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1999.tb11302.x
更新日期:1999-04-30 00:00:00
abstract::Lesion, stimulation, and pharmacological studies point to separate hypothalamic control of pulsatile FSH and LH secretion. LH release is controlled by a region extending from the preoptic area to the anterior and mid-median eminence, whereas FSH release is controlled by a region extending from the dorsal anterior hypo...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1993.tb43853.x
更新日期:1993-05-28 00:00:00
abstract::The National Institutes of Health's Clinical and Translational Science Award (CTSA) program has had a profound impact on clinical research and training methods at the University of California, Davis (UC Davis). UC Davis was among the first 12 institutions to receive NIH funding for this award, and created its Clinical...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.05257.x
更新日期:2010-03-01 00:00:00
abstract::There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2008.03664.x
更新日期:2009-04-01 00:00:00
abstract::The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chic...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1999.tb07858.x
更新日期:1999-01-01 00:00:00
abstract::This study measured on-road driving behavior in subjects with bilateral vestibular loss (BVL). Data included point-of-regard (what the driver is looking at and attending to), gaze stability (the performance of the vestibulo-ocular reflex), and head movement, during complex maneuvers such as changing lanes, cornering, ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2008.03733.x
更新日期:2009-05-01 00:00:00
abstract::This paper presents a video-based eye-tracking method, ideally deployed via a mobile device or laptop-based webcam, as a tool for measuring brain function. Eye movements and pupillary motility are tightly regulated by brain circuits, are subtly perturbed by many disease states, and are measurable using video-based met...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/nyas.13305
更新日期:2017-01-01 00:00:00
abstract::The data presented above suggest that one possible clinical use of TGF-beta would be to protect the bone marrow from the effects of myelosuppressive chemotherapeutic drugs by preventing entry or removing primitive stem cells from the cell cycle. It may also have the additional benefit of reducing the drug-induced neut...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1991.tb17220.x
更新日期:1991-01-01 00:00:00
abstract::1. One can accurately predict the contribution of each inhibitor to the total inactivation of an enzyme in plasma once its pseudo-first-order reaction rate constant and concentration are known. 2. Because the mechanism of augmentation of the inactivation rate of an enzyme by ATIII occurs via formation of an ATIII-hepa...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1989.tb22493.x
更新日期:1989-01-01 00:00:00
abstract::In an effort to identify novel targets for the development of nonhormonal male contraceptives, genome-wide transcriptional profiling of the rat testis was performed. Specifically, enzymatically purified spermatogonia plus early spermatocyctes, pachytene spermatocytes, round spermatids, and Sertoli cells was analyzed a...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1411.014
更新日期:2007-12-01 00:00:00
abstract::Content differentiation models posit that different areas of the prefrontal cortex perform similar operations but differ in terms of the content that is operated on. For example, it has been suggested that the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC) perform similar working memory or i...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1401.012
更新日期:2007-12-01 00:00:00
abstract::Departing from the functional parallelism that undoubtedly exists between the nervous and immune system, we suggest that the latter also counts with means for information exchange that may result in a mutual influence of immune processes between nearby individuals. Our concept relies on a molecular interface that is c...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.04920.x
更新日期:2009-09-01 00:00:00
abstract::Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2012.06614.x
更新日期:2012-09-01 00:00:00
abstract::The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harn...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/nyas.12113
更新日期:2013-05-01 00:00:00
abstract::There is a growing interest in the effectiveness of mindfulness meditation for sleep disturbed populations. Our study sought to evaluate the effect of mindfulness meditation interventions on sleep quality. To assess for relative efficacy, comparator groups were restricted to specific active controls (such as evidenced...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1111/nyas.13996
更新日期:2019-06-01 00:00:00
abstract::Prolactin (PL) is a mammotropic neuropeptide produced by the pituitary and extrapituitary cells existing as several isoforms and belongs to the growth and lactogenic hormone family, which includes growth hormone and placental lactogens. The secretion of pituitary PL is under hypothalamic control. The cytokines IL-1, I...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1999.tb07629.x
更新日期:1999-06-22 00:00:00
abstract::Locomotion control uses proprioceptive, visual, and vestibular signals. Previously, we analyzed the visual contribution with visual motion stimulation in roll while participants kept their heads in a normal upright orientation. In this study we applied the same visual disturbance in a head-upright and a nose-down cond...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.03846.x
更新日期:2009-05-01 00:00:00
abstract::Bacterial, plasmid, and synthetic DNA containing unmethylated CpG dinucleotides in specific sequence contexts activate the vertebrate innate immune system. A pattern recognition receptor (PRR), toll-like receptor 9 (TLR9), recognizes CpG DNA and activates signaling cascade leading to the secretion of a number of cytok...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1281.005
更新日期:2003-12-01 00:00:00
abstract::After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found. In this review, basic and clinical evidence is presented that assembles and hypothetically explains most of the key pathologic events associated with the development of AD. These pathologic events are triggered in AD by impai...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2000.tb05572.x
更新日期:2000-01-01 00:00:00
abstract::Angiogenesis is a prerequisite for tumor expansion and metastasis. The angiogenic potential of the heparin-binding growth factors acidic fibroblast growth factor (FGF) and basic FGF has been demonstrated in various publications. We studied the inhibitory effects of suramin and the polysulfated heparinoids pentosan pol...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1999.tb09427.x
更新日期:1999-01-01 00:00:00
abstract::The measurement of autoantibodies specific for double-stranded DNA (anti-dsDNA) is a useful tool for the diagnosis and the prognosis of systemic lupus erythematosus (SLE). A new quantitative enzyme-linked immunosorbent assay (ELISA), ORG anti-dsDNA, is recently available for the determination of anti-dsDNA antibodies....
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1398.057
更新日期:2007-08-01 00:00:00
abstract::This review discusses the available clinical trials in which steroids have been used in the (adjuvant) treatment of rheumatoid arthritis. Glucocorticosteroids have a positive effect on symptoms and signs of inflammation, but probably not on structural damage. Therefore glucocorticosteroids should be used as part of a ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1999.tb07659.x
更新日期:1999-06-22 00:00:00
abstract::Sophisticated imaging and fetal sampling techniques have defined the natural history and pathophysiologic characteristics of many previously mysterious conditions of newborn. Although most prenatally diagnosed malformations are best managed by appropriate medical and surgical therapy after delivery, an increasing numb...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1998.tb08928.x
更新日期:1998-06-18 00:00:00
abstract::Cytotoxic T lymphocytes (CTL) play a central role in successful control of HIV. Induction of effective CTL responses may therefore be an essential requirement of HIV vaccines. Knowledge of CTL epitopes targeted either in natural infection or following vaccination will be critical to understanding the anti-HIV immune r...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2000.tb05502.x
更新日期:2000-11-01 00:00:00