Studies into the anticancer effects of selenomethionine against human colon cancer.

Abstract:

:Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase-2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention strategies with selenium compounds represent a viable option to reduce colon cancer. Here we discuss epidemiologic studies and ongoing clinical trials with selenium. In addition, we discuss preclinical mechanistic studies that provide insights into the biochemical and molecular bases for the anticancer effects of selenomethionine.

journal_name

Ann N Y Acad Sci

authors

Nelson MA,Goulet AC,Jacobs ET,Lance P

doi

10.1196/annals.1339.016

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

26-32

eissn

0077-8923

issn

1749-6632

pii

1059/1/26

journal_volume

1059

pub_type

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