Congenital lymphatic malformations.

abstract：:Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signa...

journal_title：Annals of the New York Academy of Sciences

authors： Lee AM,Messing RO

更新日期：2008-10-01 00:00:00

abstract：:The constitution of platelet-fibrin(ogen) contacts, the separation of the platelets initially aggregated, and the rearrangement of the platelet cytoskeleton during clot formation (0.5 to 60 minutes after thrombin stimulation) were investigated using ultrastructural and immunocytochemical techniques. After aggregation,...

journal_title：Annals of the New York Academy of Sciences

authors： Morgenstern E,Daub M,Dierichs R

更新日期：2001-01-01 00:00:00

abstract：:In rats, arginine vasopressin augments bradycardia associated with baroreflex activation. We investigated whether modulation of peripheral cardiac parasympathetic nerve function by AVP may play a role in this effect. To accomplish this we utilized an in vivo model with which we previously demonstrated both adrenergic ...

journal_title：Annals of the New York Academy of Sciences

authors： Pardini BJ,Lund DD,Schmid PG

更新日期：1993-07-22 00:00:00

abstract：:Rituximab (RTX) is currently used in many diseases, but its efficacy and safety in juvenile systemic lupus erythematosus (SLEj) is still unknown. In this chapter we present four case reports of children treated with RTX: three SLE and one immune thrombocytopenic purpura (ITP). Two of the three SLEj patients had class ...

journal_title：Annals of the New York Academy of Sciences

authors： Polido-Pereira J,Ferreira D,Rodrigues AM,Nascimento C,Costa P,Almeida M,da Silva JE,Simão C,Stone R,Ramos F,Neto A,da Costa JC,Melo-Gomes J,Gomes-Pedro J,Viana-Queiroz M,Canhão H,Fonseca JE

更新日期：2009-09-01 00:00:00

abstract：:In natural tissues, cells form multiple attachment sites to their extracellular matrix. By means of those attachments, cells deform as the tissue deforms in response to the natural mechanical stresses and strains that the tissue must sustain during function. These mechanical forces are the energy input that instruct t...

journal_title：Annals of the New York Academy of Sciences

authors： Urry DW,Pattanaik A

更新日期：1997-12-31 00:00:00

abstract：:Thymic pathology occurs in 80-90% of myasthenia gravis patients. Significant associations between different thymic alterations and clinical findings are discussed. To highlight peculiarities in thymoma-associated myasthenia gravis, we briefly review myasthenia gravis associated with thymic lymphofollicular hyperplasia...

journal_title：Annals of the New York Academy of Sciences

authors： Marx A,Müller-Hermelink HK,Ströbel P

更新日期：2003-09-01 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is an increasingly popular noninvasive neuromodulatory tool in the fields of cognitive and clinical neuroscience and psychiatry. It is an inexpensive, painless, and safe brain-stimulation technique that has proven to be effective in modulating cognitive and sensory-percep...

journal_title：Annals of the New York Academy of Sciences

authors： Sellaro R,Nitsche MA,Colzato LS

更新日期：2016-04-01 00:00:00

abstract：:Enhanced levels of plasminogen activator inhibitor-1 (PAI-1) are considered to be a risk factor for pathological conditions associated with hypoxia or hyperinsulinemia. The expression of the PAI-1 gene is increased by insulin in different cells, although, the molecular mechanisms behind insulin-induced PAI-1 expressio...

journal_title：Annals of the New York Academy of Sciences

authors： Dimova EY,Kietzmann T

更新日期：2006-12-01 00:00:00

abstract：:The endogenous serum metabolite of vitamin D (calcitriol, 1,25(OH)2 D3 ) is considered a true steroid hormone (D hormone), and like glucocorticoids (GCs) and gonadal hormones, may exert several immunomodulatory activities. Serum vitamin D deficiency (25(OH) D), and therefore reduced 1,25(OH)2 D3 availability, is consi...

journal_title：Annals of the New York Academy of Sciences

authors： Cutolo M,Paolino S,Sulli A,Smith V,Pizzorni C,Seriolo B

更新日期：2014-05-01 00:00:00

abstract：:Evidence is reviewed that suggests a central role for telomeres in one major model of biological aging, namely, proliferative senescence. Telomeric shortening with each cell division does not only act as a biological clock, but appears to trigger the ultimate loss of proliferative ability via activation of the p53-dep...

journal_title：Annals of the New York Academy of Sciences

authors： von Zglinicki T

更新日期：1998-11-20 00:00:00

abstract：:The damaging effects of superoxide in mitochondria leading to pathological disorders and aging are well documented and usually ascribed to superoxide's role as a precursor of reactive free radical species. However, the latest findings point out the importance of the nucleophilic properties of superoxide and its abilit...

journal_title：Annals of the New York Academy of Sciences

authors： Afanas'Ev IB

更新日期：2004-06-01 00:00:00

abstract：:We have established several tumor T cell lines, both from the skin and from the blood of a patient with an MHC class II-/class I+, CD4+ cutaneous T cell lymphoma (CTCL). These cell lines, like the initial tumor cells, had a CD3+CD4+CD8- phenotype. We also isolated two cytotoxic T lymphocyte clones from the tumor site ...

journal_title：Annals of the New York Academy of Sciences

authors： Bagot M,Nikolova M,Schirm-Chabanette F,Wechsler J,Boumsell L,Bensussan A

更新日期：2001-09-01 00:00:00

abstract：:Early dissemination, blood circulation, or homing of single tumor cells in bone marrow and other organs is usually undetectable at primary diagnosis, even by high resolution imaging technologies. However, ultrasensitive approaches now enable the detection of "occult" tumor cells. Many researchers are currently focusin...

journal_title：Annals of the New York Academy of Sciences

authors： Riethdorf S,Pantel K

更新日期：2010-10-01 00:00:00

abstract：:Expression of human prolactin in the mammary gland, one of the main target organs of this hormone, leads to the formation of an autocrine-paracrine proliferative loop in this tissue. Involvement of prolactin in normal and neoplastic mammary development triggered the interest in transcriptional regulation of the human ...

journal_title：Annals of the New York Academy of Sciences

authors： Baudhuin A,Manfroid I,Van De Weerdt C,Martial JA,Muller M

更新日期：2002-11-01 00:00:00

abstract：:The Ca2+-pump ATPase of human RBC membranes appears to be exquisitely sensitive to a variety of amphipathic molecules. The acidic protein calmodulin (CaM) activates the enzyme some three- to fivefold with an apparent Kd of approximately 1-5 nM. A variety of other amphipathic anions, such as acidic phospholipids, free ...

journal_title：Annals of the New York Academy of Sciences

authors： Vincenzi FF

更新日期：1982-01-01 00:00:00

abstract：:It is well known that hemodynamic load is one of the most important determinants of cardiac structure and function. Circadian variations in blood pressure (BP) values are usually accompanied by consensual changes in peripheral resistance and/or cardiac output. In recent years, in hypertensive patients with left ventri...

journal_title：Annals of the New York Academy of Sciences

authors： Rizzoni D,Agabiti-Rosei E

更新日期：1996-08-15 00:00:00

abstract：:In the pancreatic islets, pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed in beta cells and autonomic nerve terminals; the majority of these nerve terminals are parasympathetic. PACAP binds to three types of G protein-coupled receptors (GPCRs): VPAC1 receptors, VPAC2 receptors, and PAC1 recepto...

journal_title：Annals of the New York Academy of Sciences

authors： Ahrén B

更新日期：2008-11-01 00:00:00

abstract：:The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors that mediate the biological properties of the NGF family of neurotrophins. This family of growth factors includes in addition to NGF, BDNF, NT-3, and NT-4. TrkA is the NGF receptor. TrkB serves as a receptor for both BDNF and...

journal_title：Annals of the New York Academy of Sciences

authors： Barbacid M

更新日期：1995-09-07 00:00:00

abstract：:Data have been presented to document that the human newborn is a conditionable organism. Babies in the first days of life possess sensitivity to stimulation in all sensory modalities, an unconditioned repertoire of responses to some of these sensory stimuli, and a capacity for associating simultaneously presented stim...

journal_title：Annals of the New York Academy of Sciences

authors： Lipsitt LP

更新日期：1990-01-01 00:00:00

abstract：:Clinically potent skeletal muscle relaxants are used primarily for their effects on the central nervous system. But they also have direct effects on muscle contraction that possibly involve Ca2+ channels. We compared the effects of dantrolene, an agent known to have a direct action on vertebrate skeletal muscle, with ...

journal_title：Annals of the New York Academy of Sciences

authors： Helland LA,Lopez JR,Taylor SR,Trube G,Wanek LA

更新日期：1988-01-01 00:00:00

abstract：:It has been proposed that spacetime should be regarded as an evolving block universe, bounded to the future by the present time, which continually extends to the future. This future boundary is defined at each time by measuring proper time along Ricci eigenlines from the start of the universe. A key point, then, is th...

journal_title：Annals of the New York Academy of Sciences

authors： Ellis GF

更新日期：2014-10-01 00:00:00

abstract：:Metastasis is the main cause of human cancer deaths, and cell motility is one key component of the process of metastasis. The ERK mitogen-activated protein kinase (MAPK) signaling pathway is probably one of the most commonly activated in malignant human cancers. We describe the molecular mechanisms by which ERK MAPK s...

journal_title：Annals of the New York Academy of Sciences

authors： Viala E,Pouysségur J

更新日期：2004-12-01 00:00:00

abstract：:Curcumin (diferuloylmethane) is a nontoxic dietary pigment in tumeric and curry and a potent inhibitor of the common transcription factor Nuclear Factor kappaB (NF-kappaB) in several cell types. It is well established that some of the catabolic effects of the proinflammatory cytokines interleukin-1beta (IL-1beta) and ...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze-Tanzil G,Mobasheri A,Sendzik J,John T,Shakibaei M

更新日期：2004-12-01 00:00:00

abstract：:This paper reviews a series of my heat transfer studies of on the so-called "self-rewetting" fluids, in which the Marangoni effect due to concentration gradient and the thermocapillary flow cooperatively result in a strong liquid inflow at the nucleation sites in the course of boiling. First of all, the background of ...

journal_title：Annals of the New York Academy of Sciences

authors： Abe Y

更新日期：2006-09-01 00:00:00

abstract：:Research in the area of adolescent alcohol use is progressing rapidly, as exemplified by the chapters in this section. Basic animal research in rodents has revealed adolescents to be more sensitive than adults to ethanol-induced disruptions in brain plasticity, although adolescents conversely are relatively insensitiv...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:The SERMs currently in clinical practice or in late stages of clinical development have been studied primarily for their effects on the breast, cardiovascular, bone, and reproductive systems. The effect of SERMs on the hypothalamic-pituitary-gonadal (HPG) axis has not been the primary focus of the studies conducted th...

journal_title：Annals of the New York Academy of Sciences

authors： Plouffe L Jr,Siddhanti S

更新日期：2001-12-01 00:00:00

abstract：:Glycoxidation and lipoxidation reactions contribute to the chemical modification of proteins during the Maillard reaction. Reactive oxygen species, produced during the oxidation of sugars and lipids in these processes, irreversibly oxidize proteins. Methionine is particularly susceptible to oxidation, yielding the oxi...

journal_title：Annals of the New York Academy of Sciences

authors： Brock JW,Cotham WC,Ames JM,Thorpe SR,Baynes JW

更新日期：2005-06-01 00:00:00

abstract：:There is growing interest in the use of statins, HMG-CoA reductase inhibitors, for treating specific neurodegenerative diseases (e.g., cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis) and possibly traumatic brain injury. Neither is there a consensus on the efficacy of statins in t...

journal_title：Annals of the New York Academy of Sciences

authors： Wood WG,Eckert GP,Igbavboa U,Müller WE

更新日期：2010-06-01 00:00:00

abstract：:Gene therapy for beta-globinopathies, particularly beta-thalassemia and sickle cell anemia, hold much promise for the future, as a one time cure for these common and debilitating disorders. Correction of the beta-globinopathies using lentivirus vectors (LV) carrying the beta- or gamma-globin genes and elements of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Perumbeti A,Malik P

更新日期：2010-08-01 00:00:00

abstract：:We have previously shown that increased dosage of the mouse protein zero gene (Mpz) causes a dysmyelinating neuropathy in transgenic (Tg80) mice. To ask whether the dysmyelination is dose dependent, we inbred one of the Tg80 lines and compared the resulting phenotype in homozygous and heterozygous mice. Whereas hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Quattrini A,Feltri ML,Previtali S,Fasolini M,Messing A,Wrabetz L

更新日期：1999-10-01 00:00:00