Protein kinases and addiction.

abstract：:The aim of this study was to evaluate a novel third-generation enzyme-linked immunosorbent assay (ELISA) for the high-sensitivity detection of autoantibodies to proteinase-3 (PR3) in patients with Wegener's granulomatosis (WG). First- and second-generation ELISA for the detection of antineutrophil cytoplasmic antibodi...

journal_title：Annals of the New York Academy of Sciences

authors： Roggenbuck D,Buettner T,Hoffmann L,Schmechta H,Reinhold D,Conrad K

更新日期：2009-09-01 00:00:00

abstract：:One of the most remarkable aspects of the immune system is its ability to fashion an immune response most appropriate to the activating stimulus. Although the immune system possesses a number of adaptations to accomplish this, an important theme is local immune regulation by site-specific expression of receptors and l...

journal_title：Annals of the New York Academy of Sciences

authors： Shao L,Allez M,Park MS,Mayer L

更新日期：2006-08-01 00:00:00

abstract：:Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan...

journal_title：Annals of the New York Academy of Sciences

authors： Cervi J,Marotta F,Bater C,Masulair K,Minelli E,Harada M,Marandola P

更新日期：2006-05-01 00:00:00

abstract：:The lobster stomatogastric ganglion contains 30 neurons and when modulated can produce two distinct rhythmic motor patterns--the gastric mill and the pyloric. The complete neural circuitry underlying both patterns is well known. Without modulatory input no patterns are produced, and the neurons fire tonically or are s...

journal_title：Annals of the New York Academy of Sciences

authors： Selverston A,Elson R,Rabinovich M,Huerta R,Abarbanel H

更新日期：1998-11-16 00:00:00

abstract：:Mice deficient for complement factors C3, C4, or C5 are resistant to experimental autoimmune myasthenia gravis (EAMG). Acetylcholine receptor (AChR) immune lymph node cells (LNC) of C3 deficient mice produce less interleukin 6 (IL-6), and EAMG-resistant IL-6 deficient mice have less serum C3. Increased serum C1q-circu...

journal_title：Annals of the New York Academy of Sciences

authors： Christadoss P,Tüzün E,Li J,Saini SS,Yang H

更新日期：2008-01-01 00:00:00

abstract：:GABAA receptor heterogeneity is based on the combinatorial assembly of a large family of subunits into distinct receptor subtypes. A neuron-specific expression pattern of receptor subtypes has been demonstrated in adult rat brain, which can be reproduced in vitro in primary neuron cultures. This suggests that genetic ...

journal_title：Annals of the New York Academy of Sciences

authors： Penschuck S,Paysan J,Giorgetta O,Fritschy JM

更新日期：1999-04-30 00:00:00

abstract：:Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and we...

journal_title：Annals of the New York Academy of Sciences

authors： Joffe RT,Sawka AM,Marriott MJ,MacQueen GM,Gernstein HC

更新日期：2004-12-01 00:00:00

abstract：:We have established several tumor T cell lines, both from the skin and from the blood of a patient with an MHC class II-/class I+, CD4+ cutaneous T cell lymphoma (CTCL). These cell lines, like the initial tumor cells, had a CD3+CD4+CD8- phenotype. We also isolated two cytotoxic T lymphocyte clones from the tumor site ...

journal_title：Annals of the New York Academy of Sciences

authors： Bagot M,Nikolova M,Schirm-Chabanette F,Wechsler J,Boumsell L,Bensussan A

更新日期：2001-09-01 00:00:00

abstract：:We studied hearing impairment and cochlear ultrastructure in C57BL/6J mice containing the cpk mutant gene. Heterozygous cpk/+ mutant mice, 6-8 months old, showed a marked hearing loss as demonstrated by auditory evoked potentials with some showing hearing loss at 90 db sound pressure. Ultrastructural studies of first ...

journal_title：Annals of the New York Academy of Sciences

authors： Cho H,Buchanan J,Strong D,Yamada Y,Yoo TJ

更新日期：1991-01-01 00:00:00

abstract：:Organophosphorus pesticides (OPs) and nerve agents (NAs) are highly toxic chemicals that pose a significant threat to human health worldwide. These compounds induce status epilepticus (SE) by irreversibly blocking the ability of acetylcholinesterase to break down acetylcholine at neural synapses. Animal models of orga...

journal_title：Annals of the New York Academy of Sciences

authors： McCarren HS,McDonough JH Jr

更新日期：2016-06-01 00:00:00

abstract：:Increasing data indicate that polymorphic variants of nuclear loci can affect rate and quality of aging in humans. However, the mitochondrial genome is another good candidate, because of the central role played by mitochondrial genes in oxidative phosphorylation (OXPHOS) and cell metabolism. A characteristic of the mi...

journal_title：Annals of the New York Academy of Sciences

authors： de Benedictis G,Carrieri G,Varcasia O,Bonafè M,Franceschi C

更新日期：2000-06-01 00:00:00

abstract：:Nuclear receptors are transcription factors that are activated by ligands and subsequently bind to regulatory regions in target genes, thereby modulating their expression. Nuclear receptors thus allow the organism to integrate signals coming from the environment and to adapt by modifying the expression levels of relev...

journal_title：Annals of the New York Academy of Sciences

authors： Bocher V,Pineda-Torra I,Fruchart JC,Staels B

更新日期：2002-06-01 00:00:00

abstract：:We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

journal_title：Annals of the New York Academy of Sciences

authors： Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

更新日期：1998-05-01 00:00:00

abstract：:Comparative studies of proteins often face the problem of distinguishing a true orthologue (species homologue) from a paralogue (a gene duplicate). This identification task is particularly challenging for endocrine peptides and neuropeptides because they are short and usually have several invariant positions. For some...

journal_title：Annals of the New York Academy of Sciences

authors： Larhammar D,Sundström G,Dreborg S,Daza DO,Larsson TA

更新日期：2009-04-01 00:00:00

abstract：:Our earlier studies of translation have led us to a specific numeric coding of nucleotides (A = 0, C = 1, G = 2, and U = 3)--that is, a quaternary numeric system; to ordering of digrams and codons (read right to left: .yx and Z.yx) as ordinal numbers from 000 to 111; and to seek hypothetic transformation of mRNA to 20...

journal_title：Annals of the New York Academy of Sciences

authors： Damjanović ZM,Rakocević MM

更新日期：2005-06-01 00:00:00

abstract：:Although Lyme disease (LD) is the most common tick-borne disease in the United States, little is known about the frequency of and risk factors for infection with Borrelia burgdorferi in occupational groups. In 1986, we recruited primarily outdoor workers from six employee groups in southeastern New York where LD is en...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PF,Benach JL,White DJ,Stroup DF,Morse DL

更新日期：1988-01-01 00:00:00

abstract：:Nicotine has been found to improve memory performance in a variety of tests in rats, monkeys, and humans. Interactions of nicotinic systems with dopamine (DA) systems may be important for this effect. We conducted a series of studies of nicotinic agonist and antagonist interactions with DA systems using rats in a win-...

journal_title：Annals of the New York Academy of Sciences

authors： Levin ED,Rose JE

更新日期：1995-05-10 00:00:00

abstract：:Recent studies have reported an association between exposure to childhood abuse or neglect and alterations in brain structure or function. One limitation of these studies is that they are correlational and do not provide evidence of a cause-effect relationship. Preclinical studies on the effects of exposure to early l...

journal_title：Annals of the New York Academy of Sciences

authors： Teicher MH,Tomoda A,Andersen SL

更新日期：2006-07-01 00:00:00

abstract：:alpha-Melanocyte stimulating hormone (alpha-MSH) modulates all forms of inflammation by acting on peripheral inflammatory cells, glial inflammatory cells, and on CNS receptors that activate descending antiinflammatory neural pathways. The multiple actions of this ancient peptide suggest that there is no singular bioch...

journal_title：Annals of the New York Academy of Sciences

authors： Lipton JM,Zhao H,Ichiyama T,Barsh GS,Catania A

更新日期：1999-10-20 00:00:00

abstract：:Liquid diffusion experiments conducted on the MIR space station using the Canadian Space Agency QUELD II processing facility and the microgravity isolation mount (MIM) showed that g-jitter significantly increased the measured solute diffusion coefficients. In some experiments, milli-g forced vibration was superimposed...

journal_title：Annals of the New York Academy of Sciences

authors： Smith RW,Yang BJ,Huang WD

更新日期：2004-11-01 00:00:00

abstract：:Sensorimotor learning requires knowledge of the relationship between movements and sensory effects: a sensorimotor map. Generally, these mappings are not innate but have to be learned. During learning, the challenge is to build a continuous map from a set of discrete observations, that is, predict locations of novel t...

journal_title：Annals of the New York Academy of Sciences

authors： van Vugt FT,Ostry DJ

更新日期：2018-03-03 00:00:00

abstract：:In epithelial and endothelial cell layers tight junctions form selective apicolateral paracellular barriers separating luminal and extracellular spaces from the underlying tissues. Within the tight junctions the tetraspan transmembrane proteins occludin, claudins, and tricellulin form anastomosing strands of protein c...

journal_title：Annals of the New York Academy of Sciences

authors： Dörfel MJ,Westphal JK,Huber O

更新日期：2009-05-01 00:00:00

abstract：:Apoptosis in T and B lymphocytes is a major element controlling the immune response. Activation induced cell death (AICD) in T cells is a main mechanism for maintaining peripheral tolerance and for limiting an ongoing immune response. AICD is initiated by antigen reengagement of the T cell receptor (TCR), and mediated...

journal_title：Annals of the New York Academy of Sciences

authors： Delgado M,Ganea D

更新日期：2000-01-01 00:00:00

abstract：:This paper presents a review of the publicly available knowledge base concerning turbine blade tip heat transfer, from the early fundamental research which laid the foundations of our knowledge, to current experimental and numerical studies utilizing engine-scaled blade cascades and turbine rigs. Focus is placed on hi...

journal_title：Annals of the New York Academy of Sciences

authors： Bunker RS

更新日期：2001-05-01 00:00:00

abstract：:Reactive oxygen species have been known to cause DNA damage and induce apoptosis. During DNA damage, DNA repair proteins Ku70 and Ku80 prevent cell death, but severe DNA damage beyond the repair capacity of the DNA repair proteins triggers necrosis or apoptosis. Recent reports have shown that NF-kappaB plays a critica...

journal_title：Annals of the New York Academy of Sciences

authors： Song JY,Lim JW,Kim H,Kim KH

更新日期：2003-12-01 00:00:00

abstract：:We studied the role of the peptide substance P, signaling through the neurokinin-1 (NK-1) receptor, on methamphetamine-induced loss of dopamine transporter sites, a well-documented marker of toxicity in the striatum of the mouse brain, because this peptide is under dynamic regulation by the neurotransmitter dopamine. ...

journal_title：Annals of the New York Academy of Sciences

authors： Yu J,Allison S,Ibrahim D,Cadet JL,Angulo JA

更新日期：2002-06-01 00:00:00

abstract：:A recent study showed a significant association between schizophrenia in European samples and the glutamate cysteine ligase modifier (GCLM) subunit gene, which is the key glutathione (GSH)-synthesizing enzyme. Since the symptoms of methamphetamine (METH)-induced psychosis are similar to those of schizophrenia, the GCL...

journal_title：Annals of the New York Academy of Sciences

authors： Kishi T,Ikeda M,Kitajima T,Yamanouchi Y,Kinoshita Y,Kawashima K,Inada T,Harano M,Komiyama T,Hori T,Yamada M,Iyo M,Sora I,Sekine Y,Ozaki N,Ujike H,Iwata N

更新日期：2008-10-01 00:00:00

abstract：:Mitochondrial dysfunction is implicated in many forms of cell death, particularly in the central nervous system. The mitochondria are required at the same time to generate adenosine 5'-triphosphate (ATP) for the cell, sequester excess cytoplasmic Ca(2+), and both produce and detoxify superoxide free radicals. The elec...

journal_title：Annals of the New York Academy of Sciences

authors： Nicholls DG

更新日期：2008-12-01 00:00:00

abstract：:One hundred years after Santiago Ramon y Cajal provided critical evidence for the "neuron doctrine," his cellular view of the brain remains the basis of modern neural science. This article begins with a review of how the early work of Ramon y Cajal, Charles Sherrington, and John Eccles and their contemporaries laid ...

journal_title：Annals of the New York Academy of Sciences

authors： Albright TD,Jessell TM,Kandell ER,Posner MI

更新日期：2001-04-01 00:00:00

abstract：:Caloric restriction (CR) remains the only nongenetic intervention that reproducibly extends mean and maximal life span in short-lived mammalian species. This nutritional intervention also delays the onset, or slows the progression, of many age-related disease processes. The diverse effects of CR have been demonstrated...

journal_title：Annals of the New York Academy of Sciences

authors： Lane MA,Black A,Handy A,Tilmont EM,Ingram DK,Roth GS

更新日期：2001-04-01 00:00:00