Acute and chronic nicotinic interactions with dopamine systems and working memory performance.

abstract：:The observations described herein allow us to make several inferences about PKC and regulation of normal and CF Cl- channels. FIGURE 5 shows a model that summarizes these observations. In this model, for the sake of clarity, we refer to the channel as a single entity, but note that it may consist of multiple subunits ...

journal_title：Annals of the New York Academy of Sciences

authors： Welsh MJ,Li M,McCann JD,Clancy JP,Anderson MP

更新日期：1989-01-01 00:00:00

abstract：:Ibogaine, an alkaloid extracted from Tabemanthe iboga, is being studied as a potential long-acting treatment for oploid and stimulant abuse as well as for alcoholism and smoking. Studies in this laboratory have used animal models to characterize ibogaine's interactions with drugs of abuse, and to investigate the mecha...

journal_title：Annals of the New York Academy of Sciences

authors： Glick SD,Maisonneuve IS

更新日期：1998-05-30 00:00:00

abstract：:Syndrome X is a clinical syndrome in which multiple risks cluster in an individual, and it is a common basis of vascular disease in the industrial countries. The molecular basis of Syndrome X, however, has not been elucidated. We have analyzed body fat distribution using CT scan and have shown that people who have acc...

journal_title：Annals of the New York Academy of Sciences

authors： Matsuzawa Y,Funahashi T,Nakamura T

更新日期：1999-11-18 00:00:00

abstract：:Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical...

journal_title：Annals of the New York Academy of Sciences

authors： Talukdar FR,di Pietro M,Secrier M,Moehler M,Goepfert K,Lima SSC,Pinto LFR,Hendricks D,Parker MI,Herceg Z

更新日期：2018-12-01 00:00:00

abstract：:Nuclear receptors are transcription factors that are activated by ligands and subsequently bind to regulatory regions in target genes, thereby modulating their expression. Nuclear receptors thus allow the organism to integrate signals coming from the environment and to adapt by modifying the expression levels of relev...

journal_title：Annals of the New York Academy of Sciences

authors： Bocher V,Pineda-Torra I,Fruchart JC,Staels B

更新日期：2002-06-01 00:00:00

abstract：:Sleep deprivation severely compromises the ability of human beings to respond to stimuli in a timely fashion. These deficits have been attributed in large part to failures of vigilant attention, which many theorists believe forms the bedrock of the other more complex components of cognition. One of the leading paradig...

journal_title：Annals of the New York Academy of Sciences

authors： Lim J,Dinges DF

更新日期：2008-01-01 00:00:00

abstract：:While each region of the world faces unique public health challenges, environmental threats to vulnerable populations in Asia constitute a significant global public health challenge. Environmental threats to health are widespread and are increasing as nations in the region undergo rapid industrial development. One of ...

journal_title：Annals of the New York Academy of Sciences

authors： Suk WA,Davis EA

更新日期：2008-10-01 00:00:00

abstract：:We have examined the expression of several genes whose transcripts have increased levels in Alzheimer's disease and have found heterogeneity in these levels in different patients with this condition. The level of expression of these genes was compared to different clinical and pathological aspects of the disease. A ca...

journal_title：Annals of the New York Academy of Sciences

authors： Duguid JR,Trzepacz C,Kemper T,Tourtellote WW,Volicer L

更新日期：1993-05-28 00:00:00

abstract：:Disorientation may draw attention from other activities and its impact on cognition may cause pilot error and problems of concentration in dizzy patients. Tasks used to study the impact of disorientation include number processing, intelligence scales and Brookes matrices (reproduction of 2xD patterns of numbers vs. no...

journal_title：Annals of the New York Academy of Sciences

authors： Gresty MA,Golding JF

更新日期：2009-05-01 00:00:00

abstract：:The availability of computer-controlled artificial hearts, kidneys, and lungs, as well as the possibility of implanting human embryos in ex vivo uterus models or an artificial endometrium, presents new perspectives for creating an artificial uterus. Survival rates have also improved, with fetuses surviving from as ear...

journal_title：Annals of the New York Academy of Sciences

authors： Bulletti C,Palagiano A,Pace C,Cerni A,Borini A,de Ziegler D

更新日期：2011-03-01 00:00:00

abstract：:Rewards can be viewed as probability distributions of reward values. Besides expected (mean) value, a key parameter of such distributions is variance (or standard deviation), which constitutes a measure of risk. Single neurons in orbitofrontal cortex signal risk mostly separately from value. Comparable risk signals in...

journal_title：Annals of the New York Academy of Sciences

authors： Schultz W,O'Neill M,Tobler PN,Kobayashi S

更新日期：2011-12-01 00:00:00

abstract：:A summary is provided of the early history of research on the flow of nonrenewable energy resources through the economy and of the flow of renewable energy resources through a natural ecosystem. The techniques are similar, and many specific applications are provided. A combined economic and ecological technique is als...

journal_title：Annals of the New York Academy of Sciences

authors： Hannon B

更新日期：2010-01-01 00:00:00

abstract：:Recent work in the field of atherosclerosis has greatly expanded our knowledge of the pathogenesis of this disease. Scavenger receptors, including CD36, are thought to be most important early in the disease progression during macrophage uptake of modified LDL and foam cell formation. Genetically engineered murine mode...

journal_title：Annals of the New York Academy of Sciences

authors： Nicholson AC,Han J,Febbraio M,Silversterin RL,Hajjar DP

更新日期：2001-12-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stress than do normal c...

journal_title：Annals of the New York Academy of Sciences

authors： Suh DH,Kim MK,Kim HS,Chung HH,Song YS

更新日期：2012-10-01 00:00:00

abstract：:Chronic exposure to arsenic causes health problems, including peripheral neuropathy. Oxidative stress is one of the mechanisms underlying arsenic-induced neurotoxicity. For this report, we studied the protective effect of N-acetylcysteine (NAC) on arsenic-induced oxidative injury in dorsal root ganglion (DRG) explants...

journal_title：Annals of the New York Academy of Sciences

authors： Chao PL,Fan SF,Chou YH,Lin AM

更新日期：2007-12-01 00:00:00

abstract：:The existence of a covalent intermediate in topoisomerase I catalysis allows uncoupling of the cleavage and ligation half-reactions on partially single-stranded DNA substrates containing a highly preferred interaction site. Using this model DNA substrate system we have demonstrated that the cleavage reaction requires ...

journal_title：Annals of the New York Academy of Sciences

authors： Christiansen K,Westergaard O

更新日期：1996-12-13 00:00:00

abstract：:Parkinson's disease is a neurodegenerative process characterized by progressive degeneration of the substantia nigra and concurrent loss of neuromelanin in these structures. The present hypothesis suggests that progression of Parkinson's disease may be reduced by enhancing the regional levels of neuroprotective factor...

journal_title：Annals of the New York Academy of Sciences

authors： Halabe Bucay A

更新日期：2008-11-01 00:00:00

abstract：:Protein crystallography, which has a growing role in the human genome project, is one of the most powerful techniques in modern biology. However, it can only be applied providing suitable crystals can be obtained. The ability to produce suitable crystals is currently the major bottleneck to structure determination. Mi...

journal_title：Annals of the New York Academy of Sciences

authors： Chayen NE,Helliwell JR

更新日期：2002-10-01 00:00:00

abstract：:Stroke is a common and serious disease. Most studies have shown that basic public knowledge about what a stroke is, symptoms of a stroke, and the proper reaction to a stroke is quite deficient. The fact that a stroke affects cognitive, communicative, and motor functions may partially explain the poor reaction to acute...

journal_title：Annals of the New York Academy of Sciences

authors： Alberts MJ

更新日期：2012-09-01 00:00:00

abstract：:According to the redusome hypothesis, the aging of an organism is determined by the shortening of chronomeres (small perichromosomal linear DNA molecules). In this paper, a presumptive role for infradian hormonal rhythms is considered. Endogenous infradian rhythms are supposed to actively interact with those hormonal ...

journal_title：Annals of the New York Academy of Sciences

authors： Olovnikov A

更新日期：2005-12-01 00:00:00

abstract：:Gonad-stimulating substance (GSS) is the first invertebrate gonadotropic neuropeptide hormone identified in a marine invertebrate, the starfish. Here, we show expression and distribution of GSS in various organs of the starfish Asterina pectinifera. Levels of GSS were high in the radial nerves and nerve ring. GSS was ...

journal_title：Annals of the New York Academy of Sciences

authors： Mita M,Ito C,Kubota E,Nagahama Y,Shibata Y

更新日期：2009-04-01 00:00:00

abstract：:While liver enzyme changes are frequently reported in hyperthyroidism, liver dysfunction itself can lead to alterations in thyroid hormone metabolism. However, the exact relationship between hyperthyroidism and liver dysfunction is unclear. We report an 11-year-old boy presenting with acute hepatitis of unknown etiolo...

journal_title：Annals of the New York Academy of Sciences

authors： Yeliosof O,Marshall I

更新日期：2020-09-23 00:00:00

abstract：:Animal studies have already shown the possibility to modulate insulin action by changing not only the amount of total fat, but also the type of fat. In these studies, saturated fat significantly increased insulin resistance, long- and short-chain omega(3) fatty acids significantly improved it, whereas the effects of m...

journal_title：Annals of the New York Academy of Sciences

authors： Rivellese AA,De Natale C,Lilli S

更新日期：2002-06-01 00:00:00

abstract：:tRNA prepared from cells of E. coli B that had been incubated with 0.5% DL-ethionine (Ethio sRNA) was found to accept methyl groups from 14CH3-S-adenosyl-methionine in the enzymatic reaction catalyzed in vitro by tRNA methyl transferases from untreated cells of the same organism. tRNA from cells that were not exposed ...

journal_title：Annals of the New York Academy of Sciences

authors： Wainfan E,Maschio FA

更新日期：1975-08-08 00:00:00

abstract：:The quasibiennial oscillation (QBO) dominates the variability of the equatorial stratosphere and also affects the circulation and temperature of the extratropical region. In this paper we review previous work showing that the mid- to high-latitude circulation is weaker (stronger) when QBO easterlies (westerlies) domin...

journal_title：Annals of the New York Academy of Sciences

authors： Peña-Ortiz C,García-Herrera R,Ribera P,Calvo N

更新日期：2008-12-01 00:00:00

abstract：:Release of the amyloid precursor protein (APP) of Alzheimer's disease from Swiss 3T3 fibroblasts was stimulated in a concentration-dependent manner by phorbol 12-myristate 13-acetate. In fibroblasts overexpressing protein kinase C alpha (PKC alpha), the EC50 for this response was 7 nM, while in control cells the EC50 ...

journal_title：Annals of the New York Academy of Sciences

authors： Slack BE,Nitsch RM,Livneh E,Kunz GM Jr,Eldar H,Wurtman RJ

更新日期：1993-09-24 00:00:00

abstract：:It is known that hepatocytes show the different morphology depending on the surface condition of cultural substratum. The cells form a floating cell-aggregate called spheroid on proteoglycan-coated or positively charged dishes. The liver cell functions are generally high and maintained for the long-term in the spheroi...

journal_title：Annals of the New York Academy of Sciences

authors： Kamihira M,Yamada K,Hamamoto R,Iijima S

更新日期：1997-12-31 00:00:00

abstract：:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Does common genetic variation at human TH alter autonomic activity and predispose to cardiovascular disease? We undertook systematic polymorphism discovery at the TH locus, and then tested variants for contributions to sympathetic fun...

journal_title：Annals of the New York Academy of Sciences

authors： Rao F,Zhang L,Wessel J,Zhang K,Wen G,Kennedy BP,Rana BK,Das M,Rodriguez-Flores JL,Smith DW,Cadman PE,Salem RM,Mahata SK,Schork NJ,Taupenot L,Ziegler MG,O'Connor DT

更新日期：2008-12-01 00:00:00

abstract：:SOX8 is a transcription factor that belongs to the SoxE group of high mobility group (HMG) superfamily of genes. As Sox8 is widely expressed during development, and has male-specific expression at the critical period for sex determination, it was initially hypothesized that its inactivation would result in abnormal se...

journal_title：Annals of the New York Academy of Sciences

authors： Kennedy CL,Koopman P,Mishina Y,O'Bryan MK

更新日期：2007-12-01 00:00:00

abstract：:Hereditary episodic ataxia (EA) syndromes are rare monogenic disorders that are phenotypically and genetically heterogeneous. The number of identified EA phenotypes is expanding. So far, mutations have been identified in four genes, all coding for membrane proteins including ion channels and transporters. The study of...

journal_title：Annals of the New York Academy of Sciences

authors： Jen JC

更新日期：2008-10-01 00:00:00