PPARs: transcription factors controlling lipid and lipoprotein metabolism.

Abstract:

:Nuclear receptors are transcription factors that are activated by ligands and subsequently bind to regulatory regions in target genes, thereby modulating their expression. Nuclear receptors thus allow the organism to integrate signals coming from the environment and to adapt by modifying the expression levels of relevant genes. The peroxisome proliferator-activated receptors (PPARs) alpha, beta/delta, and gamma constitute a subfamily of nuclear receptors. PPARalpha has been shown to bind and to be activated by leukotriene B4 and the hypolipidemic drugs of the fibrate class; PPARbeta/delta ligands are polyunsaturated fatty acids and prostaglandins; while prostaglandin J2 derivatives and the antidiabetic glitazones are, respectively, natural and synthetic ligands for PPARgamma. Upon binding and activation by their ligands, they regulate the transcription of numerous genes involved in intracellular lipid metabolism, lipoprotein metabolism, and reverse cholesterol transport in a subtype- and tissue-specific manner. PPARs therefore constitute interesting targets for the development of therapeutic compounds useful in the treatment of disorders of lipid and lipoprotein metabolism.

journal_name

Ann N Y Acad Sci

authors

Bocher V,Pineda-Torra I,Fruchart JC,Staels B

doi

10.1111/j.1749-6632.2002.tb04258.x

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

7-18

eissn

0077-8923

issn

1749-6632

journal_volume

967

pub_type

杂志文章,评审
  • Analysis of factors for the prediction of the response to xenotransplantation.

    abstract::Predicting the response to xenotransplantation is difficult, but can be based upon (i) past clinical experience, (ii) opinion surveys and focus groups, (iii) predictable variables, and (iv) the allotransplant experience. Baby Fae, the Pittsburgh baboon liver transplants, and the Jeff Getty baboon marrow transplant hav...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09141.x

    authors: Daar AS

    更新日期:1998-12-30 00:00:00

  • Differential phosphorylation of occludin and tricellulin by CK2 and CK1.

    abstract::In epithelial and endothelial cell layers tight junctions form selective apicolateral paracellular barriers separating luminal and extracellular spaces from the underlying tissues. Within the tight junctions the tetraspan transmembrane proteins occludin, claudins, and tricellulin form anastomosing strands of protein c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04043.x

    authors: Dörfel MJ,Westphal JK,Huber O

    更新日期:2009-05-01 00:00:00

  • T-cell receptor V-region usage and antigen specificity. The cytochrome c model system.

    abstract::Investigations of the I-Ek-restricted, cytochrome c-specific T-cell response in mice show that both T-cell receptor V alpha and V beta CDR3 residues and the use of particular V alpha s and V beta s are necessary for recognition. Data strongly suggest that specific CDR3 residues are important in contacting the peptide....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1995.tb44477.x

    authors: Davis MM,McHeyzer-Williams M,Chien YH

    更新日期:1995-07-07 00:00:00

  • Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells.

    abstract::Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties. While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood. Although specifi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05533.x

    authors: Kundu GC,Zhang Z,Mantile-Selvaggi G,Mandal A,Yuan CJ,Mukherjee AB

    更新日期:2000-01-01 00:00:00

  • Biological significance of protein modifications in aging and calorie restriction.

    abstract::By virtue of the progress in proteomics, the involvement of posttranslational modifications in aging has been more clearly demonstrated in recent years. We describe here that (1) carbonylation, a hallmark of protein oxidation in general, is paradoxically decreased in histone with aging and increased by calorie restric...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05374.x

    authors: Nakamura A,Kawakami K,Kametani F,Nakamoto H,Goto S

    更新日期:2010-06-01 00:00:00

  • The avian song system in comparative perspective.

    abstract::The song system of oscine birds has become a versatile model system that is used to study diverse problems in neurobiology. Because the song system is often studied with the intention of applying the results to mammalian systems, it is important to place song system brain nuclei in a broader context and to understand ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1298.007

    authors: Farries MA

    更新日期:2004-06-01 00:00:00

  • Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis.

    abstract::The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1354.038

    authors: Crivello A,Giacalone A,Scola L,Forte GI,Nuzzo D,Giacconi R,Cipriano C,Candore G,Mocchegiani E,Colonna-Romano G,Lio D,Caruso C

    更新日期:2006-05-01 00:00:00

  • Proteome and proteomics for the research on protein alterations in aging.

    abstract::Functional decline of tissues in aged animals is a result of cellular aging. Though any process of somatic cell aging basically depends on genomic instructions, phenotypes of aged cells are expressed in a given internal environment of each cell type that was made with translated proteins and post-translationally modif...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05637.x

    authors: Toda T

    更新日期:2001-04-01 00:00:00

  • Monoclonal antibodies recognizing the secreted and membrane domains of the IgA dimer receptor.

    abstract::The receptor that mediates the specific uptake and intracellular transport of dimeric immunoglobulin A (IgA dimer) in mucosal and glandular epithelia is identical with a transmembrane precursor of secreted secretory component. During transport, the IgA dimer receptor (membrane SC) is cleaved into two domains, a membra...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb26914.x

    authors: Kühn LC,Kraehenbuhl JP

    更新日期:1983-06-30 00:00:00

  • A psychosocial perspective. Growing up with thalassemia, a chronic disorder.

    abstract::Thalassemia influences individual and family psychosocial functioning. Parental reaction to diagnosis affects the parent-child relationship, parents' roles, and family resources for coping. A child frequently translates parental reactions into personal attitudes of dependency and lowered self-esteem. In coping with on...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1990.tb24331.x

    authors: Nash KB

    更新日期:1990-01-01 00:00:00

  • The alpha-ketoglutarate dehydrogenase complex.

    abstract::The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known. Th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb07818.x

    authors: Sheu KF,Blass JP

    更新日期:1999-01-01 00:00:00

  • The effects of calories and types of supplements on postpartum amenorrhea in the Philippines.

    abstract::Data on 3080 mother-infant pairs from Cebu in the Philippines were used to conduct a logistics hazards analysis to determine the effect of supplemental calories and the types of supplements that the infant ingests on return to menses. Breast feeding had a significant reduced odds of the mother returning to menses (od...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1994.tb30406.x

    authors: Zohoori N

    更新日期:1994-02-18 00:00:00

  • Mitochondrial dysfunction via disruption of complex II activity during iron chelation-induced senescence-like growth arrest of Chang cells.

    abstract::When cells are deprived of iron, their growth is invariably inhibited. However, the mechanism involved remains largely unclear. Recently, we have reported that subcytotoxic concentration of deferoxamine mesylate (DFO), an iron chelator, specifically inhibited transition of Chang cell, a normal hepatocyte cell line, fr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1007/978-3-662-41088-2_13

    authors: Yoon YS,Cho H,Lee JH,Yoon G

    更新日期:2004-04-01 00:00:00

  • Fetal sex identification in maternal plasma by means of short tandem repeats on chromosome x.

    abstract::Analysis of fetal DNA in maternal plasma has recently been introduced as a new method for noninvasive prenatal diagnosis. In the majority of cases, the Y chromosome-specific sequences are commonly used as a fetus-specific marker with a high risk of false-negative cases. We attempted to develop a sensitive and reliable...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1448.038

    authors: Vecchione G,Tomaiuolo M,Sarno M,Colaizzo D,Petraroli R,Matteo M,Greco P,Grandone E,Margaglione M

    更新日期:2008-08-01 00:00:00

  • Self-rewetting fluids: beneficial aqueous solutions.

    abstract::This paper reviews a series of my heat transfer studies of on the so-called "self-rewetting" fluids, in which the Marangoni effect due to concentration gradient and the thermocapillary flow cooperatively result in a strong liquid inflow at the nucleation sites in the course of boiling. First of all, the background of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1362.026

    authors: Abe Y

    更新日期:2006-09-01 00:00:00

  • Blood elements at surfaces: platelets.

    abstract::This brief review is designed to highlight the limitations of our knowledge given the difficulties in simulating the in vivo condition in models established in vitro and ex vivo. Despite this uncertainty, mounting evidence indicates that the GPIIb-IIIa receptor mediates crucial platelet functions and that control over...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1987.tb33056.x

    authors: Coller BS

    更新日期:1987-01-01 00:00:00

  • Saturable binding of anesthetics to nicotinic acetylcholine receptors. A possible mechanism of anesthetic action.

    abstract::Recent controversies in the existence of saturable binding of general anesthetics in brain tissues prompted a careful examination of specific binding of anesthetics to neural receptors. We examined the binding of both local and general anesthetics using electron spin resonance and radioligand criteria. Our results sug...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1991.tb33897.x

    authors: Lin L,Koblin DD,Wang HH

    更新日期:1991-01-01 00:00:00

  • The esophageal mucosa and submucosa: immunohistology in GERD and Barrett's esophagus.

    abstract::This paper presents commentaries on the microscopic morphology of esophageal squamous epithelium; the frequency of duplication of the muscularis mucosae (MM) in Barrett's esophagus (BE); the significance of multilayered epithelium; whether cells in the lamina propria reflect those in the epithelium; how stem cells are...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12241

    authors: Appelman HD,Streutker C,Vieth M,Neumann H,Neurath MF,Upton MP,Sagaert X,Wang HH,El-Zimaity H,Abraham SC,Bellizzi AM

    更新日期:2013-10-01 00:00:00

  • Dopamine, acetylcholine, and glutamate interactions in aging. Behavioral and neurochemical correlates.

    abstract::Aging, hypoxia, and thiamin deficiency diminish motor performance. Similar alterations of ACh, DA, and glutamate metabolism accompany hypoxia, thiamin deficiency, and aging. Both aging and hypoxia reduce ACh release and stimulate DA and glutamate release. Presynaptic enhancement of DA and glutamate release may be impo...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1988.tb32984.x

    authors: Freeman GB,Gibson GE

    更新日期:1988-01-01 00:00:00

  • New pathogens, new tricks: emerging, drug-resistant fungal pathogens and future prospects for antifungal therapeutics.

    abstract::Fungal pathogens are a growing threat to public health. As human immunodeficiency becomes increasingly common, fungal infections are becoming more prevalent. The use of antifungal agents for prophylaxis and treatment of fungal infections has favored the emergence of previously rare or unidentified species of drug-resi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13739

    authors: Geddes-McAlister J,Shapiro RS

    更新日期:2019-01-01 00:00:00

  • Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients.

    abstract::TT virus (TTV) is a recently described circular DNA virus of about 3.8 kb, which is related to the circoviridae viruses. It is commonly detected in healthy subjects and no association with any specific disease has been established. TTV was initially thought to be hepatotropic, but subsequent reports have shown that it...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03868.x

    authors: Zhong S,Yeo W,Tang MW,Lin XR,Mo F,Ho WM,Hui P,Johnson PJ

    更新日期:2001-09-01 00:00:00

  • In vitro clonal analysis of cardiac outflow tract mesenchyme.

    abstract::In vitro clonal analyses were performed to gain insight into the mechanisms that control development of neural crest-derived cardiac outflow tract mesenchyme of quail embryos. The cardiac neural crest originates from the posterior rhombencephalic neural tube. The cells leave the neural tube and migrate through the pos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb17409.x

    authors: Sieber-Blum M,Ito K

    更新日期:1995-03-27 00:00:00

  • From organ to molecules: steps and consequences.

    abstract::The classic cardiac research programs revolved around measurable properties such as pressures, work done, vascular blood flow, electrical propagation, and other such parameters that defined the global heart functions in health and decease. Consistently, the first Henry Goldberg Workshop, held in Haifa in 1984, focused...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1341.001

    authors: Beyar R

    更新日期:2005-06-01 00:00:00

  • Corticotropin and corticosteroids in generalized myasthenia gravis: comparative studies and role in management.

    abstract::The effect of 310 courses of corticotropin, methylprednisolone, prednisone, and dexamethasone were studied in 62 patients with generalized myasthenia gravis who were poorly responsive to anticholinesterase medication and most of whom required assisted respiration. Improvement in strength and response to anticholinest...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1976.tb47717.x

    authors: Brunner NG,Berger CL,Namba T,Grob D

    更新日期:1976-01-01 00:00:00

  • Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders.

    abstract::Melatonin is a hormone secreted by the pineal gland, mostly in the dark period of the light/dark cycle, with corresponding fluctuations reflected in the plasma melatonin levels. This hormone plays a critical role in the regulation of various neural and endocrine processes that are synchronized with daily change in pho...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1332.014

    authors: Lahiri DK,Chen D,Lahiri P,Rogers JT,Greig NH,Bondy S

    更新日期:2004-12-01 00:00:00

  • Spheroid formation of hepatocytes using synthetic polymer.

    abstract::It is known that hepatocytes show the different morphology depending on the surface condition of cultural substratum. The cells form a floating cell-aggregate called spheroid on proteoglycan-coated or positively charged dishes. The liver cell functions are generally high and maintained for the long-term in the spheroi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb52213.x

    authors: Kamihira M,Yamada K,Hamamoto R,Iijima S

    更新日期:1997-12-31 00:00:00

  • Variation in stress responses within a bacterial species and the indirect costs of stress resistance.

    abstract::Bacteria can exhibit high levels of resistance to one or more environmental stresses such as temperature, osmolarity, radiation, pH, starvation, as well as resistance to noxious chemicals and antibiotics. Yet evolution has not optimized stress resistance in all bacteria to all stresses. Even within a species like Esch...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1391.003

    authors: Ferenci T,Spira B

    更新日期:2007-10-01 00:00:00

  • Effects of buoyancy-driven convection on nucleation and growth of protein crystals.

    abstract::Protein crystallization has been studied in presence or absence of buoyancy-driven convection. Gravity-driven flow was created, or suppressed, in protein solutions by means of vertically directed density gradients that were caused by generating suitable temperature gradients. The presence of enhanced mixing was demons...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1324.001

    authors: Nanev CN,Penkova A,Chayen N

    更新日期:2004-11-01 00:00:00

  • Role of nitric oxide and alcohol on gonadotropin release in vitro and in vivo.

    abstract::Alcohol suppresses reproduction in humans, monkeys, and small rodents by suppressing release of luteinizing hormone (LH). The major action is on the hypothalamus to decrease release of LH-releasing hormone (LHRH). The release of LHRH is controlled by nitric oxide (NO) as determined by in vivo and in vitro experiments....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb09562.x

    authors: Rettori V,McCann SM

    更新日期:1998-05-01 00:00:00

  • Multi-scale model of O2 transport and metabolism: response to exercise.

    abstract::Regulation of pulmonary oxygen uptake (VO2p) during exercise depends on cellular energy demand, blood flow, ventilation, oxygen exchange across membranes, and oxygen utilization in the contracting skeletal muscle. In human and animal studies of metabolic processes that control cellular respiration in working skeletal ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1420.021

    authors: Zhou H,Lai N,Saidel GM,Cabrera ME

    更新日期:2008-03-01 00:00:00