Structural and functional properties of the TRK family of neurotrophin receptors.

abstract：:Interleukin (IL)-17-producing helper T (Th17) cells serve as a Th subset involved in epithelial cell- and neutrophil-mediated immune responses against extracellular microbes and in the development of various autoimmune diseases. The differentiation of Th17 cells is controlled by a number of intracellular signaling cas...

journal_title：Annals of the New York Academy of Sciences

authors： Nagai S,Kurebayashi Y,Koyasu S

更新日期：2013-03-01 00:00:00

abstract：:Considerable clinical and experimental evidence indicates that loss of vestibular function results in cognitive deficits, especially deficits in spatial memory. These studies demonstrate the importance of balance for the most fundamental of cognitive processes and suggest that information about head acceleration and o...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PF,Brandt T,Strupp M,Darlington CL,Zheng Y

更新日期：2009-05-01 00:00:00

abstract：:Potato products contain high amounts of acrylamide, which sometimes exceeds the concentration of 1 mg/L. However, many strategies for acrylamide reduction in potato products are possible. In this work, the different approaches for reducing acrylamide formation have been reviewed, keeping in mind that in the applicatio...

journal_title：Annals of the New York Academy of Sciences

authors： Morales F,Capuano E,Fogliano V

更新日期：2008-04-01 00:00:00

abstract：:Although pancreatic adenocarcinoma has become one of the best characterized malignant diseases, severe diagnostic and therapeutic problems are still associated with this disease. The establishment of a molecular model of pancreatic carcinogenesis may provide tools that could result in earlier diagnosis of this disease...

journal_title：Annals of the New York Academy of Sciences

authors： Jesnowski R,Müller P,Schareck W,Liebe S,Löhr M

更新日期：1999-06-30 00:00:00

abstract：:Early dissemination, blood circulation, or homing of single tumor cells in bone marrow and other organs is usually undetectable at primary diagnosis, even by high resolution imaging technologies. However, ultrasensitive approaches now enable the detection of "occult" tumor cells. Many researchers are currently focusin...

journal_title：Annals of the New York Academy of Sciences

authors： Riethdorf S,Pantel K

更新日期：2010-10-01 00:00:00

abstract：:The intracellular bacterium, Ehrlichia ruminantium, is the causative agent of heartwater, a tick-borne disease of livestock. Because vaccines need to incorporate components from several virulent isolates, it is essential to have information on the extent of genetic variation among isolates. We therefore amplified and ...

journal_title：Annals of the New York Academy of Sciences

authors： Allsopp M,Steyn H,Zweygarth E,Allsopp B

更新日期：2005-12-01 00:00:00

abstract：:Globally, increasing acquired antimicrobial resistance among pathogenic bacteria presents an urgent challenge to human and animal health. As a result, significant efforts, such as the One Health Initiative, are underway to curtail and optimize the use of critically important antimicrobials for human medicine in all ap...

journal_title：Annals of the New York Academy of Sciences

authors： Scott HM,Acuff G,Bergeron G,Bourassa MW,Gill J,Graham DW,Kahn LH,Morley PS,Salois MJ,Simjee S,Singer RS,Smith TC,Storrs C,Wittum TE

更新日期：2019-04-01 00:00:00

abstract：:The proper function of skeletal muscles relies on their ability to process signals derived from motor neurons, transmit stimuli along the muscle fibers, contract, and regenerate efficiently after injury. The dystrophin-glycoprotein complex (DGC; also called the dystrophin-associated protein complex) plays a central ro...

journal_title：Annals of the New York Academy of Sciences

authors： Gawor M,Prószyński TJ

更新日期：2018-01-01 00:00:00

abstract：:The fate of a neuron in the developing brain to multiply, differentiate, or die in an apoptotic manner depends on the expression of genes that are involved in regulating the cell cycle. Recent studies determined the involvement of several genes, including cyclin A and B2, in dopamine-induced apoptosis in cultured chic...

journal_title：Annals of the New York Academy of Sciences

authors： Porat S,Simantov R

更新日期：1999-01-01 00:00:00

abstract：:Birds, the most species-rich monophyletic group of land vertebrates, have been subject to some of the most intense sequencing efforts to date, making them an ideal case study for recent developments in genomics research. Here, we review how our understanding of bird genomes has changed with the recent sequencing of mo...

journal_title：Annals of the New York Academy of Sciences

authors： Kapusta A,Suh A

更新日期：2017-02-01 00:00:00

abstract：:Sm-p80-based vaccine efficacy for Schistosoma mansoni was evaluated in a baboon model of infection and disease. The study was designed to replicate a human vaccine implementation scenario for endemic regions in which vaccine would be administered following drug treatment of infected individuals. In our study, the Sm-p...

journal_title：Annals of the New York Academy of Sciences

authors： Siddiqui AJ,Molehin AJ,Zhang W,Ganapathy PK,Kim E,Rojo JU,Redman WK,Sennoune SR,Sudduth J,Freeborn J,Hunter D,Kottapalli KR,Kottapalli P,Wettashinghe R,van Dam GJ,Corstjens PLAM,Papin JF,Carey D,Torben W,Ahmad G,S

更新日期：2018-08-01 00:00:00

abstract：:The role of gamma-glutamyl-carboxylated growth arrest-specific 6 (cGas6) in mediating the beneficial effect of vitamin K (VK) on regulating glucose metabolism remains elusive. We took a three-pronged approach-evaluating human type 2 diabetes (T2D), high-fat diet (HFD)-fed mice, and in vitro cultured myotubes-to addres...

journal_title：Annals of the New York Academy of Sciences

authors： Dihingia A,Ozah D,Borah T,Kalita J,Manna P

更新日期：2020-02-01 00:00:00

abstract：:Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS). Although a number of therapeutic strategies have been initiated, their success has been limited largely due to an incomplete ...

journal_title：Annals of the New York Academy of Sciences

authors： Deitch EA

更新日期：2010-10-01 00:00:00

abstract：:Depressive disorders are associated with significant psychosocial impairment and disability. Depression should be thoroughly evaluated, as should current and past suicidality and potential risk factors for suicide. Mortality by suicide characterizes the course of major affective disorders in approximately 15% of those...

journal_title：Annals of the New York Academy of Sciences

authors： Nemeroff CB,Compton MT,Berger J

更新日期：2001-04-01 00:00:00

abstract：:Galanin is widely distributed in enteric nerves and nerve terminals throughout the gastrointestinal (GI) tract. Within the GI tract galanin is best known for its ability to alter smooth muscle contractility and regulate intestinal motility. However, recent studies also indicate that galanin can modulate epithelial ion...

journal_title：Annals of the New York Academy of Sciences

authors： Benya RV,Matkowskyj KA,Danilkovich A,Hecht G

更新日期：1998-12-21 00:00:00

abstract：:Access to food is essential to optimal development and function in children and adults. Food security, food insecurity, and hunger have been defined and a U.S. Food Security Scale was developed and is administered annually by the Census Bureau in its Current Population Survey. The eight child-referenced items now make...

journal_title：Annals of the New York Academy of Sciences

authors： Cook JT,Frank DA

更新日期：2008-01-01 00:00:00

abstract：:Epidemiological studies have suggested that excess body weight gain may be a major risk factor for colon and breast cancer. A positive energy balance creates metabolic stresses, including the excess production of reactive oxygen species (ROS), hyperinsulinemia, the elevated adipokine secretion, and increased gut perme...

journal_title：Annals of the New York Academy of Sciences

authors： Sung MK,Yeon JY,Park SY,Park JH,Choi MS

更新日期：2011-07-01 00:00:00

abstract：:Our cumulative experience continues to validate the fetal nucleated erythrocyte as the target fetal cell type of choice, primarily because it reflects the cytogenetic status of the current pregnancy. Additional cell types, such as the granulocyte, await further study. Quantitative PCR is a sensitive and useful new met...

journal_title：Annals of the New York Academy of Sciences

authors： Bianchi DW

更新日期：1994-09-07 00:00:00

abstract：:Members of the steroid receptor superfamily, like other transcription factors, can function as transcriptional inducers as well as repressors of transcription. The mechanisms by which repression is achieved seem to be specific for the factors and [table: see text] regulatory sequences involved. Many and perhaps all of...

journal_title：Annals of the New York Academy of Sciences

authors： Renkawitz R

更新日期：1993-06-11 00:00:00

abstract：:The ocular motor system provides several advantages for studying the brain, including well-defined populations of neurons that contribute to specific eye movements. Generation of rapid eye movements (saccades) depends on excitatory burst neurons (EBN) and omnipause neurons (OPN) within the brainstem, both types of cel...

journal_title：Annals of the New York Academy of Sciences

authors： Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ

更新日期：2015-04-01 00:00:00

abstract：:The purpose of this article is to review recent findings regarding the mechanisms by which GM1 may mimic or potentiate certain actions of neurotrophic factors, including promotion of neuronal survival. It is proposed that the neuroprotective activity of GM1 is due, at least in part, to its ability to favor the dimeriz...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari G,Greene LA

更新日期：1998-06-19 00:00:00

abstract：:Thromboembolic and infectious events were found to be major complications of long-term total artificial heart implantation in two patients. Similar complications have been reported in other patients, as well as in animal studies. The thromboembolic events and the infectious complications appear to be interrelated. On ...

journal_title：Annals of the New York Academy of Sciences

authors： Ward RA,Wellhausen SR,Dobbins JJ,Johnson GS,DeVries WC

更新日期：1987-01-01 00:00:00

abstract：:Healthy CD45 KO mice show a Th2-type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1-type profile, suggesting that diet can alter cytokine secretion. ...

journal_title：Annals of the New York Academy of Sciences

authors： Lópeza MC,Holmes N

更新日期：2004-12-01 00:00:00

abstract：:An extended parallel is developed between musical and prosodic structures, using the author's cognitively oriented music theory and recent work in generative phonology. For illustration, the sounds of a short poem by Robert Frost are treated entirely in musical terms. The poem is assigned a phonological stress grid an...

journal_title：Annals of the New York Academy of Sciences

authors： Lerdahl F

更新日期：2001-06-01 00:00:00

abstract：:Research in the area of adolescent alcohol use is progressing rapidly, as exemplified by the chapters in this section. Basic animal research in rodents has revealed adolescents to be more sensitive than adults to ethanol-induced disruptions in brain plasticity, although adolescents conversely are relatively insensitiv...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:Neuropathologic examination in elderly individuals and patients with Parkinson's disease with and without dementia reveals abundant isocortical amyloid deposits with no or only a few neuritic plaques, neuropil threads (NT), and neurofibrillary tangles (NFT), whereas NT and NFT may be present only in the entorhinal reg...

journal_title：Annals of the New York Academy of Sciences

authors： Jellinger K,Braak H,Braak E,Fischer P

更新日期：1991-01-01 00:00:00

abstract：:The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this dis...

journal_title：Annals of the New York Academy of Sciences

authors： Lee MH,Surh YJ

更新日期：2009-08-01 00:00:00

abstract：:First we remind general considerations concerning biodiversity on earth and particularly the loss of genetic biodiversity that seems irreversible whether its origin is directly or indirectly linked to human activities. Urgent and considerable efforts must be made from now on to cataloge, understand, preserve, and enha...

journal_title：Annals of the New York Academy of Sciences

authors： Maillard JC,Gonzalez JP

更新日期：2006-10-01 00:00:00

abstract：:The Sex combs reduced gene of the Antennapedia complex specifics the identities of the anterior thoracic and posterior head segments, including the primordium of the larval salivary gland. The Sex combs reduced transcription unit spans over 30 kb of genomic DNA, with another 40 kb of upstream cis-regulatory sequences....

journal_title：Annals of the New York Academy of Sciences

authors： Kennison JA,Vázquez M,Brizuela BJ

更新日期：1998-04-15 00:00:00

abstract：:The most common ototoxic compounds in clinical practice are aminoglycoside antibiotics, cisplatin, and loop diuretics (ethacrynic acid and furosemide). These agents also have substantial renal effects in the form of nephrotoxicity or diuresis. The understanding of these renal effects may provide insight into ototoxic ...

journal_title：Annals of the New York Academy of Sciences

authors： Humes HD

更新日期：1999-11-28 00:00:00