Balance before reason in rats and humans.

Abstract:

:Considerable clinical and experimental evidence indicates that loss of vestibular function results in cognitive deficits, especially deficits in spatial memory. These studies demonstrate the importance of balance for the most fundamental of cognitive processes and suggest that information about head acceleration and orientation must have been critical to the evolution of brain structures such as the hippocampus. Studies of animals with bilateral vestibular lesions have shown that theta rhythm and the activity of hippocampal place cells are severely disrupted; recent human studies show that bilateral vestibular loss is even associated with hippocampal atrophy. While it is conceivable that the effects of vestibular lesions on the hippocampus are due to chronic stress and increased glucocorticoid levels, at present there is little evidence to support this hypothesis. It is also possible that the hippocampal changes are due to a reduction in exploration and active behavior; however, in rats, at least, bilateral vestibular lesions cause hyperactivity rather than hypoactivity. Alternatively, the hippocampus may have developed a special dependence upon the vestibular system during evolution, since it was the first sensory system to reliably indicate gravitational vertical.

journal_name

Ann N Y Acad Sci

authors

Smith PF,Brandt T,Strupp M,Darlington CL,Zheng Y

doi

10.1111/j.1749-6632.2008.03726.x

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

127-33

eissn

0077-8923

issn

1749-6632

pii

NYAS03726

journal_volume

1164

pub_type

杂志文章
  • How to design a therapeutic study in patients with the post-polio syndrome. Methodological concerns and status of present therapies.

    abstract::The innervation of muscles in patients with the post-polio syndrome (PPS) may differ from limb to limb or even within the same limb because of the segmental nature of the initial involvement and the varying degree of subsequent recovery. Consequently, the compensatory effort of the neighboring muscles varies even in t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1995.tb27557.x

    authors: Dalakas MC

    更新日期:1995-05-25 00:00:00

  • Hematoma removal, heme, and heme oxygenase following hemorrhagic stroke.

    abstract::The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1306.020

    authors: Wagner KR,Dwyer BE

    更新日期:2004-03-01 00:00:00

  • Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified mice.

    abstract::We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in suscep...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1341.011

    authors: Goldhaber JI,Henderson SA,Reuter H,Pott C,Philipson KD

    更新日期:2005-06-01 00:00:00

  • Different vaccine strategies used to protect against Theileria annulata.

    abstract::SPAG-1, a sporozoite surface antigen of T. annulata, has previously been shown to elicit partial protection when used, as an hepatitis B core antigen fusion, to immunize cattle. The objective of this study was to try and improve the protective capacity of this antigen by enlisting different vaccine strategies. Cattle ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb11054.x

    authors: Boulter NR,Brown CG,Kirvar E,Glass E,Campbell J,Morzaria S,Nene V,Musoke A,D'Oliveira C,Gubbels MJ,Jongejan F,Hall FR

    更新日期:1998-06-29 00:00:00

  • The role of input-output analysis of energy and ecologic systems. In the early development of ecological economics--a personal perspective.

    abstract::A summary is provided of the early history of research on the flow of nonrenewable energy resources through the economy and of the flow of renewable energy resources through a natural ecosystem. The techniques are similar, and many specific applications are provided. A combined economic and ecological technique is als...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.05165.x

    authors: Hannon B

    更新日期:2010-01-01 00:00:00

  • Exposure of human diploid fibroblasts to hypoxia extends proliferative life span.

    abstract::Normal human mitotic cells do not proliferate indefinitely in culture but undergo a limited number of divisions and progressively reach a state of irreversible growth arrest, a process termed replicative senescence. Hypoxia is a situation of reduced oxygen concentration that relates to many physiological and pathophys...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1404.025

    authors: Poulios E,Trougakos IP,Chondrogianni N,Gonos ES

    更新日期:2007-11-01 00:00:00

  • Measurement and interpretation of hemoglobin concentration in clinical and field settings: a narrative review.

    abstract::Anemia affects over 800 million women and children globally. Defined as a limited or insufficient functional red blood cell supply in peripheral blood, anemia causes a reduced oxygen supply to tissues and can have serious health consequences for women and children. Hemoglobin (Hb) concentration is most commonly measur...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.14003

    authors: Karakochuk CD,Hess SY,Moorthy D,Namaste S,Parker ME,Rappaport AI,Wegmüller R,Dary O,HEmoglobin MEasurement (HEME) Working Group.

    更新日期:2019-08-01 00:00:00

  • Antioxidant vitamins and prevention of lung disease.

    abstract::Although the evidence for oxidative stress for air pollution in the human lung is fragmentary, the hypothesis that oxidative stress is an important, if not the sole, mechanism of toxicity of oxidizing air pollutants and tobacco smoke is compelling and growing. First, biochemical mechanisms have been worked out for oxi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1992.tb17095.x

    authors: Menzel DB

    更新日期:1992-09-30 00:00:00

  • Visual skills and cross-modal plasticity in deaf readers: possible implications for acquiring meaning from print.

    abstract::Most research on reading skill acquisition in deaf individuals has been conducted from the perspective of a hearing child learning to read. This approach may limit our understanding of how a deaf child approaches the task of learning to read and successfully acquires reading skills. An alternative approach is to consi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1416.013

    authors: Dye MW,Hauser PC,Bavelier D

    更新日期:2008-12-01 00:00:00

  • Sexually dimorphic actions of glucocorticoids: beyond chromosomes and sex hormones.

    abstract::Sexual dimorphism is a well-documented phenomenon that is observed at all levels of the animal kingdom. Historically, sex hormones (testosterone and estrogen) have been implicated as key players in a wide array of pathologies displaying sexual dimorphism in their etiology and progression. While these hormones clearly ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12425

    authors: Quinn M,Ramamoorthy S,Cidlowski JA

    更新日期:2014-05-01 00:00:00

  • Rare tumors of esophageal squamous mucosa.

    abstract::In spite of increasing incidence of esophageal adenocarcinoma in the last few decades, esophageal squamous cell carcinoma (SCC) still remains the dominant subtype of esophageal cancer worldwide. Apart from conventional SCC, some rare unconventional tumors of esophageal squamous mucosa are also well known. This study p...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13108

    authors: Tripathi M,Swanson PE

    更新日期:2016-10-01 00:00:00

  • Characterization and discrimination of three Theileria parva stabilates involved in East Coast fever vaccination.

    abstract::Three vaccine stabilates of Theileria parva, of which sporozoites are being used against East Coast fever, were characterized by immunological and molecular biology techniques before being used for a national vaccination campaign in Kenya. T. parva Marikebuni stabilates 316 and 3014, and T. parva Lanet were used in th...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb11034.x

    authors: Sparagano OA,Zanaa O,Ambrose N

    更新日期:1998-06-29 00:00:00

  • Extracellular heat shock proteins in cell signaling and immunity.

    abstract::Extracellular stress proteins including heat shock proteins (Hsps) and glucose-regulated proteins (Grps) are emerging as important mediators of intercellular signaling and transport. Release of such proteins from cells is triggered by physical trauma and behavioral stress as well as exposure to immunological "danger s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,收录出版,评审

    doi:10.1196/annals.1391.019

    authors: Calderwood SK,Mambula SS,Gray PJ Jr

    更新日期:2007-10-01 00:00:00

  • eEF1A2 as a putative oncogene.

    abstract::The first evidence for the role of the protein elongation factor eEF1A2 in tumorigenesis was reported by Anand and colleagues who demonstrated that eEF1A2 is overexpressed in about 30% of ovarian tumors and some established ovarian cancer cells. This abnormal expression correlates with a poor prognosis. Since this dis...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04909.x

    authors: Lee MH,Surh YJ

    更新日期:2009-08-01 00:00:00

  • Factor XIII prevents development of myocardial edema in children undergoing surgery for congenital heart disease.

    abstract::In a prospective investigation of perioperative cardiac edema formation requiring a delayed sternal closure, we identified thrombin increase combined with a simultaneous decrease of factor XIII as a probable cause. After experimental studies additionally revealed that factor XIII could protect endothelial barrier func...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1749-6632.2001.tb03549.x

    authors: Wozniak G,Noll T,Akintürk H,Thul J,Müller M

    更新日期:2001-01-01 00:00:00

  • Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I.

    abstract::GEM 231 is a second-generation antisense oligonucleotide targeted against the RIalpha regulatory subunit of cAMP-dependent protein kinase type I (PKA-I). Excessive expression of PKA-I is associated with cell proliferation and transformation, and increased levels of secreted extracellular PKA (ECPKA) are found in the s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1281.028

    authors: Mani S,Goel S,Nesterova M,Martin RM,Grindel JM,Rothenberg ML,Zhang R,Tortora G,Cho-Chung YS

    更新日期:2003-12-01 00:00:00

  • Thrombin activates NF-kappa B through thrombin receptor and results in proliferation of vascular smooth muscle cells: role of thrombin in atherosclerosis and restenosis.

    abstract::We investigated the role of thrombin in the pathogenesis in atherosclerosis and restenosis. First we examined the effect of thrombin on cultured human vascular smooth muscle cells (VSMC). We showed that thrombin acts as a mitogen on VSMC through thrombin receptor. The expression of thrombin receptor was increased in t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb52024.x

    authors: Maruyama I,Shigeta K,Miyahara H,Nakajima T,Shin H,Ide S,Kitajima I

    更新日期:1997-04-15 00:00:00

  • Developmental Exposure to Methamphetamine: A Neonatal Model in the Rata.

    abstract::Taking into account that methamphetamine (MA) is a popular recreational drug among young adult women, i.e., in gestational age, the present model aims to assess the effects of its exposure during development. In this experimental model, MA effects are assessed in the rat during the first month of life, regarding both ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb08245.x

    authors: Gomes-DA-Silva J,Silva MC,Tavares MA

    更新日期:1998-05-01 00:00:00

  • Vaccines developed for H5 highly pathogenic avian influenza in China.

    abstract::Since the first detection of highly pathogenic H5N1 avian influenza virus from sick goose in Guangdong province in China in 1996, scientists in China started to develop vaccines for avian influenza pandemic preparedness. An H5N2 inactivated vaccine was produced from a low pathogenic virus, A/turkey/England/N-28/73, an...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1373.022

    authors: Qiao C,Tian G,Jiang Y,Li Y,Shi J,Yu K,Chen H

    更新日期:2006-10-01 00:00:00

  • The effect of fasting and vitamin E on insulin action in obese type 2 diabetes mellitus.

    abstract::The influence of either short-term fasting or vitamin E administration on insulin action was studied in two groups of obese Type 2 diabetic patients. Twelve patients underwent 7 days of fasting (group A), whereas 600 mg of vitamin E was administered daily during 3 months in 9 diabetic patients (group B). Insulin actio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb51870.x

    authors: Skrha J,Sindelka G,Hilgertová J

    更新日期:1997-09-20 00:00:00

  • Indications of centromere movement during interphase and differentiation.

    abstract::Mouse and human DNA sequences from centromeric and ribosomal domains were labeled with biotinylated deoxynucleotides and hybridized in situ to paraformaldehyde-fixed tissue culture cells. Centromeres were widely dispersed in most of these interphase nuclei. At late G2 phases of the cell cycle, centromeres appeared to ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb21494.x

    authors: Manuelidis L

    更新日期:1985-01-01 00:00:00

  • Perspectives of regional paleoclimate modeling.

    abstract::Regional climate modeling bridges the gap between the coarse resolution of current global climate models and the regional-to-local scales, where the impacts of climate change are of primary interest. Here, we present a review of the added value of the regional climate modeling approach within the scope of paleoclimate...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13865

    authors: Ludwig P,Gómez-Navarro JJ,Pinto JG,Raible CC,Wagner S,Zorita E

    更新日期:2019-01-01 00:00:00

  • The role of strategies in motor learning.

    abstract::There has been renewed interest in the role of strategies in sensorimotor learning. The combination of new behavioral methods and computational methods has begun to unravel the interaction between processes related to strategic control and processes related to motor adaptation. These processes may operate on very diff...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06430.x

    authors: Taylor JA,Ivry RB

    更新日期:2012-03-01 00:00:00

  • Comparative effects of NO-synthase inhibitor and NMDA antagonist on generation of nitric oxide and release of amino acids and acetylcholine in the rat brain elicited by amphetamine neurotoxicity.

    abstract::The aim of this study was to clarify the role of nitric oxide (NO) and lipid peroxidation (LPO) processes as well as the contribution of various neurotransmitters in pathophysiological mechanisms of neurotoxicity induced by amphetamine (AMPH). NO level was determined directly in brain tissues using electron paramagnet...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1316.027

    authors: Bashkatova V,Kraus MM,Vanin A,Hornick A,Prast H

    更新日期:2004-10-01 00:00:00

  • Major genomic events and their consequences for vertebrate evolution and endocrinology.

    abstract::Comparative studies of proteins often face the problem of distinguishing a true orthologue (species homologue) from a paralogue (a gene duplicate). This identification task is particularly challenging for endocrine peptides and neuropeptides because they are short and usually have several invariant positions. For some...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2008.03659.x

    authors: Larhammar D,Sundström G,Dreborg S,Daza DO,Larsson TA

    更新日期:2009-04-01 00:00:00

  • The role of thymomas in the development of myasthenia gravis.

    abstract::Thymic pathology occurs in 80-90% of myasthenia gravis patients. Significant associations between different thymic alterations and clinical findings are discussed. To highlight peculiarities in thymoma-associated myasthenia gravis, we briefly review myasthenia gravis associated with thymic lymphofollicular hyperplasia...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1254.025

    authors: Marx A,Müller-Hermelink HK,Ströbel P

    更新日期:2003-09-01 00:00:00

  • Early maternal deprivation in rats: a proposed animal model for the study of developmental neuroimmunoendocrine interactions.

    abstract::Adult animals that had been subjected to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alterations that resemble specific symptoms of schizophrenia. Moreover, at adolescence MD rats showed depressive-like behavior and altered motor responses. Accordi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03979.x

    authors: De la Fuente M,Llorente R,Baeza I,De Castro NM,Arranz L,Cruces J,Viveros MP

    更新日期:2009-02-01 00:00:00

  • Epicenter location by analysis of interictal spikes: a case study for the use of artificial neural networks in biomedical engineering.

    abstract::Artificial neural network (ANN) technology is finding increasing application in medicine and biomedical engineering. This paper supplies necessary background in ANN technology for researchers unfamiliar with this rapidly emerging discipline. This introduction to ANN application is cast in the context of epileptic seiz...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04907.x

    authors: Hand C

    更新日期:2002-12-01 00:00:00

  • Difference in enzymatic properties between "staphylothrombin" and free alpha-thrombin.

    abstract::Bacterial protein, staphylocoagulase, binds stoichiometrically to human prothrombin resulting in a coagulant complex, staphylothrombin. The enzymatic properties of staphylothrombin differ from those of alpha-thrombin in their substrate specificities toward natural and synthetic substrates, in addition to their interac...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb34565.x

    authors: Kawabata S,Morita T,Miyata T,Kaida S,Igarashi H,Iwanaga S

    更新日期:1986-01-01 00:00:00

  • Studies on the metabolism and biological function of APLP2.

    abstract::Amyloid precursor proteins (APP) are a member of a larger family of proteins that include the amyloid precursor-like proteins (APLP) APLPI and APLP2. We have examined the expression and metabolism of APLP2 and document that APLP2 is expressed at high levels in the nervous system and in peripheral tissues. Furthermore,...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb34404.x

    authors: Sisodia SS,Thinakaran G,Slunt HH,Kitt CA,Von Koch CS,Reed RR,Zheng H,Price DL

    更新日期:1996-01-17 00:00:00