Developmental Exposure to Methamphetamine: A Neonatal Model in the Rata.

abstract：:Preeclampsia is the disorder of pregnancy with the highest rate of both maternal and neonatal morbidity and mortality. The maternal syndrome is characterized by oxidative stress and activation of the vascular endothelium that may originate from placental release of lipid peroxidation products, cytokines, and micropart...

journal_title：Annals of the New York Academy of Sciences

authors： Poston L,Raijmakers M,Kelly F

更新日期：2004-12-01 00:00:00

abstract：:The temporal and spatial regulation of intracellular calcium concentration ([Ca(2+)](i)) is very crucial for maintaining calcium ion homeostasis within cells, and consequently in the regulation of cellular functions such as beta cell replication and differentiation, insulin secretion, and apoptosis. Calcium ion regula...

journal_title：Annals of the New York Academy of Sciences

authors： Parkash J

更新日期：2008-12-01 00:00:00

abstract：:Research examining brain development during adolescence is escalating rapidly along multiple dimensions, as illustrated by the remarkable diversity of trans-disciplinary work shown in this symposium. Ontogenetic transitions characteristics of adolescence are common among mammalian species. Although no other species de...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:Many features of these gastric vesicles satisfy the requirements for the gastric H+ pump. For example, we have: (a) K+ requirement, (b) KA for K+ of about 30 mM; (c) identical cation sequence for tissue and vesicles, (d) similar anion sequence, (e) localization at the microvillus of the secretory canaliculus, (f) TI+ ...

journal_title：Annals of the New York Academy of Sciences

authors： Sachs G,Berglindh T,Rabon E,Stewart HB,Barcellona ML,Wallmark B,Saccomani G

更新日期：1980-01-01 00:00:00

abstract：:The complex dielectric properties of canine skeletal muscles were measured at 25 degrees C during ischemia in the frequency range from 50 Hz to 200 MHz. The dielectric spectrum of skeletal muscle shows an alpha-dispersion below 1 kHz and a beta-dispersion with a relaxation frequency of about 100 kHz. The alpha-dispers...

journal_title：Annals of the New York Academy of Sciences

authors： Schäfer M,Kirlum HJ,Schlegel C,Gebhard MM

更新日期：1999-04-20 00:00:00

abstract：:We studied the effects of change of head position in the pitch plane on the ability to hold horizontal eccentric gaze in five patients with cerebellar disorders. All patient showed a change in the time constant of horizontal centripetal drift when the head was pitched forward or back. This result suggests that otolith...

journal_title：Annals of the New York Academy of Sciences

authors： Wilson E,Sng K,Somers JT,Reschke MF,Leigh RJ

更新日期：2005-04-01 00:00:00

abstract：:Our studies have indicated that normal human placental cytosol contains a complex mixture of nucleoside kinase enzymes, some of which conform to previously characterized activities. Deoxyadenosine is phosphorylated by deoxycytidine kinase, adenosine kinase, and two as yet uncharacterized activities. Deoxyguanosine pho...

journal_title：Annals of the New York Academy of Sciences

authors： Hurley MC,Fox IH

更新日期：1985-01-01 00:00:00

abstract：:The overall goal of this study is to unravel the role(s) played by glial cell line-derived neurotrophic factor (GDNF) in the fate of spermatogonial stem cells. There is great interest in the biology of spermatogonial stem cells, or A(single) spermatogonia, because of their importance in the treatment of infertility, t...

journal_title：Annals of the New York Academy of Sciences

authors： Braydich-Stolle L,Nolan C,Dym M,Hofmann MC

更新日期：2005-12-01 00:00:00

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:Overt aggression in its various forms is the most prevalent symptom presenting to pediatric mental health providers, regardless of setting. It is a behavior with a heterogeneous etiology and requires a comprehensive approach to evaluation and treatment. Evaluation of the aggressive child must assess medical, neurologi...

journal_title：Annals of the New York Academy of Sciences

authors： Connor DF,Steingard RJ

更新日期：1996-09-20 00:00:00

abstract：:Human alpha 2-antiplasmin (alpha 2AP) is the primary inhibitor of plasmin-mediated fibrinolysis and is an efficient substrate of activated factor XIII (FXIIIa). Among 452 amino acid residues in alpha 2AP, Gln2 is believed to be the sole FXIIIa-reactive site that participates in crosslinking alpha 2AP to fibrin. We stu...

journal_title：Annals of the New York Academy of Sciences

authors： Lee KN,Lee CS,Tae WC,Jackson KW,Christiansen VJ,McKee PA

更新日期：2001-01-01 00:00:00

abstract：:Phospholemman (PLM) is the first sequenced member of the FXYD family of regulators of ion transport. The mature protein has 72 amino acids and consists of an extracellular N terminus containing the signature FXYD motif, a single transmembrane (TM) domain, and a cytoplasmic C-terminal domain containing four potential s...

journal_title：Annals of the New York Academy of Sciences

authors： Cheung JY,Rothblum LI,Moorman JR,Tucker AL,Song J,Ahlers BA,Carl LL,Wang J,Zhang XQ

更新日期：2007-03-01 00:00:00

abstract：:The study of music perception and cognition is one of the oldest topics in experimental psychology. The last 20 years have seen an increased interest in understanding the functional neuroanatomy of music processing in humans, using a variety of technologies including fMRI, PET, ERP, MEG, and lesion studies. We review ...

journal_title：Annals of the New York Academy of Sciences

authors： Levitin DJ,Tirovolas AK

更新日期：2009-03-01 00:00:00

abstract：:Nanotechnology provides multifunctional agents for in vivo use that increasingly blur the distinction between pharmaceuticals and medical devices. Realization of such therapeutic nanodevices requires multidisciplinary effort that is difficult for individual device developers to sustain, and identification of appropria...

journal_title：Annals of the New York Academy of Sciences

authors： Lee SC,Bhalerao K,Ferrari M

更新日期：2004-05-01 00:00:00

abstract：:This study measured on-road driving behavior in subjects with bilateral vestibular loss (BVL). Data included point-of-regard (what the driver is looking at and attending to), gaze stability (the performance of the vestibulo-ocular reflex), and head movement, during complex maneuvers such as changing lanes, cornering, ...

journal_title：Annals of the New York Academy of Sciences

authors： MacDougall HG,Moore ST,Black RA,Jolly N,Curthoys IS

更新日期：2009-05-01 00:00:00

abstract：:Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. The use of herbal drugs is once more escalating in the form of complementary and alternative medicine. The past century...

journal_title：Annals of the New York Academy of Sciences

authors： Cragg GM,Newman DJ

更新日期：2001-12-01 00:00:00

abstract：:It is well established for both rat and man that the total testosterone concentration within the testis is far higher than that in serum. We know for the rat that intratesticular testosterone can be reduced by 50-60% without an adverse effect on spermatogenesis but that the required intratesticular testosterone concen...

journal_title：Annals of the New York Academy of Sciences

authors： Jarow JP,Zirkin BR

更新日期：2005-12-01 00:00:00

abstract：:Congenital myasthenia (CM) constitutes a heterogeneous group of disorders with different underlying defects. The authors investigated a case of CM, presenting with congenital contractures. Endplate studies in the first year of life showed a developmental disorder of postsynaptic membranes. Clinical follow-up demonstra...

journal_title：Annals of the New York Academy of Sciences

authors： Smit LM,Veldman H,Jennekens FG,Molenaar PC,Oen BS

更新日期：1987-01-01 00:00:00

abstract：:Previous reports have shown that there are age-related reductions in muscarinic receptor (mAChR) sensitivity to agonist stimulation. Our research has elucidated the mechanisms involved in this loss. These studies have shown that this decline is the result of decreases in mAChR concentration, reductions in the number o...

journal_title：Annals of the New York Academy of Sciences

authors： Joseph JA,Cutler R,Roth GS

更新日期：1993-09-24 00:00:00

abstract：:Recognizing the self-activity of matter through complexification can lead to seeing evolution as a process of union. This process approach emphasizes a metaphysics of becoming rather than of being. Advances in the science of thermodynamics lead to understanding chemical self-organization as a stage in this process of ...

journal_title：Annals of the New York Academy of Sciences

authors： Salmon JF

更新日期：2003-05-01 00:00:00

abstract：:G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...

journal_title：Annals of the New York Academy of Sciences

authors： Benimetskaya L,Lai JC,Khvorova A,Wu S,Miller P,Stein CA

更新日期：2005-11-01 00:00:00

abstract：:The development of ustekinumab as a first-in-class anti-interleukin (IL) 12/23p40 therapeutic agent for psoriasis represents an important example of modern and rational drug design and development. Psoriasis is a chronic, systemic, immune-mediated skin disorder with considerable clinical, psychosocial, and economic bu...

journal_title：Annals of the New York Academy of Sciences

authors： Yeilding N,Szapary P,Brodmerkel C,Benson J,Plotnick M,Zhou H,Goyal K,Schenkel B,Giles-Komar J,Mascelli MA,Guzzo C

更新日期：2011-03-01 00:00:00

abstract：:In Wegener's granulomatosis (WG), antiproteinase 3 (PR3) autoantibodies (PR3-ANCA) are crucial in the development of generalized vasculitis. Wegener's pathognomonic lesion, a granulomatous inflammation of the upper and lower respiratory tract, contains abundant lymphocytes and macrophages. Lymphocyte clusters in germi...

journal_title：Annals of the New York Academy of Sciences

authors： Voswinkel J,Müller A,Lamprecht P

更新日期：2005-06-01 00:00:00

abstract：:Corticosteroids have potent immunosuppressive and anti-inflammatory effects. Although corticosteroids are an important weapon in the clinical arsenal for treating inflammatory episodes, the mechanisms underlying the actions and regulation of endogenous corticosteroids remain obscure. In the late 1980s and early 1990s,...

journal_title：Annals of the New York Academy of Sciences

authors： Harbuz MS,Chover-Gonzalez AJ,Jessop DS

更新日期：2003-05-01 00:00:00

abstract：:Our previous studies of anti-DNA antibodies in SLE have demonstrated a preferential use of V kappa I and V lambda II gene families to encode light chains of antibodies that express the anti-DNA-associated 3I and 8.12 idiotypes, respectively. In this study, we employed PCR to obtain V kappa I and V lambda II germline g...

journal_title：Annals of the New York Academy of Sciences

authors： Manheimer-Lory A,Irigoyen M,Gaynor B,Monhian R,Splaver A,Diamond B

更新日期：1995-09-29 00:00:00

abstract：:The sense of smell shows a diminution with age as measured by the University of Pennsylvania Smell Identification Test (UPSIT). To ascertain whether the volumes of the olfactory bulbs and tracts (OBTs) and the temporal lobes (TL) declined in parallel to smell function, we examined 36 individuals from ages 22 to 78 who...

journal_title：Annals of the New York Academy of Sciences

authors： Yousem DM,Geckle RJ,Bilker WB,Doty RL

更新日期：1998-11-30 00:00:00

abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of the neuromuscular synapse. About half of LEMS patients have an associated small cell lung carcinoma (SCLC), which is usually detected after diagnosis of LEMS. This short review summarizes clinical and serological markers shown to predict the presenc...

journal_title：Annals of the New York Academy of Sciences

authors： Lipka AF,Verschuuren JJ,Titulaer MJ

更新日期：2012-12-01 00:00:00

abstract：:The Mediterranean diet is now recognized as being both limited in toxicity and abundant in nutrient and non-nutrient protective factors. A large body of basic, clinical and epidemiological studies have been developed in recent years to provide evidence of the benefits of the Mediterranean diet or its components on hea...

journal_title：Annals of the New York Academy of Sciences

authors： Covas MI,Marrugat J,Fitó M,Elosua R,de la Torre-Boronat C

更新日期：2002-05-01 00:00:00

abstract：:Differentiation of embryonic stem (ES) cells in vitro yields abundant hematopoietic progenitors, but achieving stable hematopoietic engraftment of irradiated mice has proven difficult, begging the question of whether ES cells give rise to hematopoietic stem cells in vitro, and limiting the application of ES cells as e...

journal_title：Annals of the New York Academy of Sciences

authors： Daley GQ

更新日期：2003-05-01 00:00:00

abstract：:Recent controversies in the existence of saturable binding of general anesthetics in brain tissues prompted a careful examination of specific binding of anesthetics to neural receptors. We examined the binding of both local and general anesthetics using electron spin resonance and radioligand criteria. Our results sug...

journal_title：Annals of the New York Academy of Sciences

authors： Lin L,Koblin DD,Wang HH

更新日期：1991-01-01 00:00:00