Role of glial cell line-derived neurotrophic factor in germ-line stem cell fate.

Abstract:

:The overall goal of this study is to unravel the role(s) played by glial cell line-derived neurotrophic factor (GDNF) in the fate of spermatogonial stem cells. There is great interest in the biology of spermatogonial stem cells, or A(single) spermatogonia, because of their importance in the treatment of infertility, the development of contraceptives, and the understanding of the etiology of testicular cancer, particularly seminoma. In the mouse, spermatogonial stem cells express GFRalpha-1, the receptor for GDNF, and respond to this growth factor in vivo and in vitro. GDNF is produced by the adjacent Sertoli cells, which are part of the germ-line stem cell niche in vertebrates. We specifically isolated GFRalpha-1-positive spermatogonia using an immunomagnetic bead technique. We then stimulated the cells with 100 ng/mL of rGDNF for 10 hours; unstimulated cells served as negative controls. Microarray analysis, immunocytochemistry, and Western blotting revealed that Numb, a regulator of the Notch pathway, is upregulated by GDNF in spermatogonial stem cells. There are indications that in rats, mice, and humans, the Notch pathway promotes spermatogonial differentiation. We observed that an increase in Numb expression is concomitant with Notch degradation in these cells. Thus, through Numb, GDNF might inhibit differentiation and allows the maintenance of the stem cell pool in the mouse seminiferous epithelium.

journal_name

Ann N Y Acad Sci

authors

Braydich-Stolle L,Nolan C,Dym M,Hofmann MC

doi

10.1196/annals.1336.010

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

94-9

eissn

0077-8923

issn

1749-6632

pii

1061/1/94

journal_volume

1061

pub_type

杂志文章
  • Therapy of presymptomatic FeLV-induced immunodeficiency syndrome with AZT in combination with alpha interferon.

    abstract::AZT inhibited replication of an immunodeficiency-inducing strain of feline leukemia virus (FeLV-FAIDS) in vitro at concentrations as low as 0.005 microgram/mL. This antiviral activity was augmented an additional 25-30% when AZT was combined with human recombinant alpha-interferon (2b) (IFN alpha). Administration of AZ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1990.tb17846.x

    authors: Hoover EA,Zeidner NS,Mullins JI

    更新日期:1990-01-01 00:00:00

  • Occurrence and fate of organic and inorganic contaminants in marine animals.

    abstract::Most chemical contaminants occur in highest concentrations in coastal waters, often maximized in very localized areas. In general, this situation represents the exposure pattern for marine animals. However, the availability of contaminant to an organism depends not only on its concentration but also on its chemical na...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1977.tb19254.x

    authors: Whittle KJ,Hardy R,Holden AV,Johnston R,Pentreath RJ

    更新日期:1978-09-29 00:00:00

  • Perceiving prosody in speech. Effects of music lessons.

    abstract::In two experiments, musically trained and untrained adults were tested on their ability to match spoken utterances with their tonal analogues (tone sequences that retained the pitch and temporal patterns of the utterances). In both cases, musical training was associated with superior performance, indicating an enhance...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1284.067

    authors: Thompson WF,Schellenberg EG,Husain G

    更新日期:2003-11-01 00:00:00

  • Neurophysiological models for new treatment development in schizophrenia: early sensory approaches.

    abstract::Schizophrenia is a major mental disorder associated with core neurocognitive impairments. The ability to recreate these deficits in animal models is limited, hampering ongoing translational drug development efforts. This paper reviews the use of electroencephalography (EEG)-based neurophysiological measures, such as e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.12689

    authors: Javitt DC

    更新日期:2015-05-01 00:00:00

  • Parachlamydia acanthamoeba is endosymbiotic or lytic for Acanthamoeba polyphaga depending on the incubation temperature.

    abstract::Parachlamydiaceae are potential emerging pathogens that naturally infect free-living amoebae. We investigated the affects of incubation temperature on the growth and cytopathic effect of P. acanthamoeba in Acanthamoeba polyphaga. A. polyphaga were infected with P. acanthamoeba and incubated at different temperatures f...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07437.x

    authors: Greub G,La Scola B,Raoult D

    更新日期:2003-06-01 00:00:00

  • Adolescent brain development and animal models.

    abstract::Research examining brain development during adolescence is escalating rapidly along multiple dimensions, as illustrated by the remarkable diversity of trans-disciplinary work shown in this symposium. Ontogenetic transitions characteristics of adolescence are common among mammalian species. Although no other species de...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1308.002

    authors: Spear LP

    更新日期:2004-06-01 00:00:00

  • Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors.

    abstract::The DNase activity and circulating DNA (cirDNA) concentration in blood plasma of healthy donors, patients with chronic prostatitis, and patients with prostate tumors were analyzed. The concentration of the cirDNA from plasma was determined by PicoGreen fluorescent assay. DNase activity in blood was measured using the ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1448.016

    authors: Cherepanova AV,Tamkovich SN,Bryzgunova OE,Vlassov VV,Laktionov PP

    更新日期:2008-08-01 00:00:00

  • Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy.

    abstract::Despite the documented association between apolipoprotein E genotype and cerebral amyloid angiopathy (CAA), a substantial proportion of CAA-related hemorrhages occur in patients without known risks for this disorder. Two other factors implicated in the pathogenesis of CAA are the amyloid-beta peptide (preferentially d...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06361.x

    authors: Greenberg SM,Cho HS,O'Donnell HC,Rosand J,Segal AZ,Younkin LH,Younkin SG,Rebeck GW

    更新日期:2000-04-01 00:00:00

  • Long-term antibody production is sustained by antibody-secreting cells in the bone marrow following acute viral infection.

    abstract::Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1996.tb52958.x

    authors: Slifka MK,Ahmed R

    更新日期:1996-10-25 00:00:00

  • Interaction of fibrinogen with staphylococcal clumping factor and with platelets.

    abstract::Fibrinogen, a clottable plasma glycoprotein, participates in cell adhesion phenomena involving prokaryotic cells, e.g. staphylococci, and eukaryotic cell fragments, e.g. platelets. Among the three chains (alpha, beta, gamma) of human fibrinogen, the gamma chain bears the main site recognizing the staphylococcal clumpi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb23270.x

    authors: Hawiger J,Kloczewiak M,Timmons S,Strong D,Doolittle RF

    更新日期:1983-06-27 00:00:00

  • Stress, heat shock proteins, and autoimmunity: how immune responses to heat shock proteins are to be used for the control of chronic inflammatory diseases.

    abstract::Especially since the (re-)discovery of T cell subpopulations with specialized regulatory activities, mechanisms of anti-inflammatory T cell regulation are studied very actively and are expected to lead to the development of novel immunotherapeutic approaches, especially in chronic inflammatory diseases. Heat shock pro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1391.020

    authors: Van Eden W,Wick G,Albani S,Cohen I

    更新日期:2007-10-01 00:00:00

  • Experimental and clinical results in shock lung treatment with vitamin E.

    abstract::The adult respiratory distress syndrome (ARDS) is not confined only to late shock states but is a typical finding in intoxications with such oxidizing agents as O3, NO2, chlorate, or paraquat. Under experimental conditions, alpha-tocopherol in a high enteric dosage (2 x 50 mg/kg) was able to prevent alterations of pul...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1749-6632.1982.tb31278.x

    authors: Wolf HR,Seeger HW

    更新日期:1982-01-01 00:00:00

  • Role of transforming growth factor-beta 1 in regulation of hematopoiesis.

    abstract::The data presented above suggest that one possible clinical use of TGF-beta would be to protect the bone marrow from the effects of myelosuppressive chemotherapeutic drugs by preventing entry or removing primitive stem cells from the cell cycle. It may also have the additional benefit of reducing the drug-induced neut...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1991.tb17220.x

    authors: Ruscetti FW,Jacobsen SE,Birchenall-Roberts M,Broxmeyer HE,Engelmann GL,Dubois C,Keller JR

    更新日期:1991-01-01 00:00:00

  • Clara cell secretory protein (CC16): features as a peripheral lung biomarker.

    abstract::Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb05520.x

    authors: Broeckaert F,Clippe A,Knoops B,Hermans C,Bernard A

    更新日期:2000-01-01 00:00:00

  • Parallel ascending vestibular pathways: anatomical localization and functional specialization.

    abstract::Information from the vestibular nuclei ascending through the brainstem to the oculomotor and trochlear nuclei (NIII, NIV), the interstitial nucleus of Cajal (INC), the pretectum, or thalamus, is thought to be distributed in at least five different pathways. They include the medial longitudinal fasciculus (MLF), the as...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.04461.x

    authors: Zwergal A,Strupp M,Brandt T,Büttner-Ennever JA

    更新日期:2009-05-01 00:00:00

  • Coagulation and splenectomy: an overview.

    abstract::Venous thromboembolic events, such as pulmonary embolism, deep venous thrombosis, and portal vein thrombosis, have been observed in adult thalassemia patients, mainly in beta-thalassemia intermedia. The clinical findings are consistent with the observation of several alterations that indicate a state of activation of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1345.039

    authors: Cappellini MD,Grespi E,Cassinerio E,Bignamini D,Fiorelli G

    更新日期:2005-01-01 00:00:00

  • Prologue: mind over molecule: activating biological demons.

    abstract::The new vogue for systems biology is an important development. It is time to complement reductionist molecular biology by integrative approaches. But this welcome development is in danger of losing its way. Many of the early implementations of the approach are very low level, in some cases hardly more than an extensio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1420.000

    authors: Noble D

    更新日期:2008-03-01 00:00:00

  • Hypothalamic origin of the metabolic syndrome X.

    abstract::The conspicuous similarities between Cushing's syndrome and the Metabolic Syndrome X open up the possibility that hypercortisolemia is involved also in the latter. Salivary cortisol is possible to measure during undisturbed conditions including perceived stressful events during everyday life. Such measurements clearly...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb07803.x

    authors: Björntorp P,Rosmond R

    更新日期:1999-11-18 00:00:00

  • A natural toxic defense system: cardenolides in butterflies versus birds.

    abstract::We have verified that wild birds can become conditioned to reject naturally toxic insects either visually (experiment 1) or by taste (experiment 2). We have also verified, however, that unconditioned taste rejection of noxious chemicals by wild birds also occurs (experiment 3). Such unconditioned responses to the apos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb27072.x

    authors: Brower LP,Fink LS

    更新日期:1985-01-01 00:00:00

  • Comparative DNA microarray analysis of host cell transcriptional responses to infection by Coxiella burnetii or Chlamydia trachomatis.

    abstract::DNA microarray analysis was conducted to investigate the transcriptional responses of the human monocytic leukemia cell line THP-1 to infection by Chlamydia trachomatis or Coxiella burnetii. RNA was isolated from mock infected cells and cells infected for 36 hours using TRIzol reagent. Biotinylated probes synthesized ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07447.x

    authors: Ren Q,Robertson SJ,Howe D,Barrows LF,Heinzen RA

    更新日期:2003-06-01 00:00:00

  • Reverse-engineering transcriptional modules from gene expression data.

    abstract::"Module networks" are a framework to learn gene regulatory networks from expression data using a probabilistic model in which coregulated genes share the same parameters and conditional distributions. We present a method to infer ensembles of such networks and an averaging procedure to extract the statistically most s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03943.x

    authors: Michoel T,De Smet R,Joshi A,Marchal K,Van de Peer Y

    更新日期:2009-03-01 00:00:00

  • Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells.

    abstract::Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with de...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1377.007

    authors: Kajiyama H,Shibata K,Terauchi M,Ino K,Nawa A,Kikkawa F

    更新日期:2006-11-01 00:00:00

  • The biological embedding of early experience and its effects on health in adulthood.

    abstract::Explanations of the socioeconomic gradient in health status must account for the observations that the gradient cuts across a wide range of disease processes and is capable of replicating itself on new disease processes as they emerge in society. Understanding this pattern requires an understanding of how human organi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb08107.x

    authors: Hertzman C

    更新日期:1999-01-01 00:00:00

  • Density-driven instabilities of variable-viscosity miscible fluids in a capillary tube.

    abstract::A linear stability analysis is presented for variable-viscosity miscible fluids in an unstable configuration; that is, a heavier fluid placed above a lighter one in a vertically oriented capillary tube. The initial interface thickness is treated as a parameter to the problem. The analysis is based on the three-dimensi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1324.032

    authors: Meiburg E,Vanaparthy SH,Payr MD,Wilhelm D

    更新日期:2004-11-01 00:00:00

  • Rickettsiosis of the genus Rickettsia in South America.

    abstract::In South America, human cases of infection by the genus Rickettsia have been described in several countries in the last twenty years. The role of international organizations, such as the Centers for Disease Control and Prevention in Atlanta, Georgia, USA and the World Health Organization Collaborating Center for Tropi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07337.x

    authors: Galvão MA,Mafra CL,Moron C,Anaya E,Walker DH

    更新日期:2003-06-01 00:00:00

  • T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells.

    abstract::T cell protein tyrosine phosphatase (TCPTP) dephosphorylates a number of substrates, including JAK-STAT (signal transducer and activator of transcription) signaling proteins, which are activated by interferon (IFN)-γ, a major proinflammatory cytokine involved in conditions such as inflammatory bowel disease. A critica...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13439

    authors: Krishnan M,McCole DF

    更新日期:2017-10-01 00:00:00

  • Prosodic and melodic processing in adults and children. Behavioral and electrophysiologic approaches.

    abstract::The results of a series of experiments aimed at directly comparing the prosodic level of processing in language with the melodic level of processing in music are reported. The first series of experiments was conducted on adults, musicians and nonmusicians, and the second one on 7- to 9-year-old musician and nonmusicia...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1284.056

    authors: Magne C,Schön D,Besson M

    更新日期:2003-11-01 00:00:00

  • Collectibles and collections for comparative and evolutionary neurobiological research in Africa.

    abstract::The scientific investigation of brains of different vertebrates, both extant and extinct, is of interest for several reasons: for translating medical research on rodent models into practice, for understanding the animals investigated in order to improve conservation and management strategies, and for understanding the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2010.05948.x

    authors: Manger PR

    更新日期:2011-05-01 00:00:00

  • Absorption and metabolism of antioxidative polyphenolic compounds in red wine.

    abstract::We have shown that drinking red wine reduces oxidation of LDL. This reduction in oxidation has been attributed to the polyphenolic compounds in red wine, but the mechanisms of absorption and metabolism of these compounds has been unclear. We therefore investigated the absorption and metabolism of polyphenols using rat...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb02934.x

    authors: Yamashita S,Sakane T,Harada M,Sugiura N,Koda H,Kiso Y,Sezaki H

    更新日期:2002-05-01 00:00:00

  • Measles infection in HIV-infected African infants.

    abstract::Measles infection remains a serious threat to child survival in the developing world despite vaccination and treatment with vitamin A. This report reviews the epidemiology of measles in HIV-infected children in Africa. In hospitalized infants, the rate of malnutrition before measles and the rate of death after measles...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb05511.x

    authors: Perry RT,Mmiro F,Ndugwa C,Semba RD

    更新日期:2000-11-01 00:00:00