Reverse-engineering transcriptional modules from gene expression data.

abstract：:The development of animal and mathematical models for several forms of acquired nystagmus has led to more comprehensive knowledge of these disorders. In the best understood forms, such as periodic alternating nystagmus, our range of knowledge includes an animal model, the neurotransmitters involved, and effective trea...

journal_title：Annals of the New York Academy of Sciences

authors： Leigh RJ,Das VE,Seidman SH

更新日期：2002-04-01 00:00:00

abstract：:Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS). Although a number of therapeutic strategies have been initiated, their success has been limited largely due to an incomplete ...

journal_title：Annals of the New York Academy of Sciences

authors： Deitch EA

更新日期：2010-10-01 00:00:00

abstract：:Extracellular DNA in the plasma or serum of cancer patients has been recently proposed as a source of analyzable cancer-related gene sequences (qualitative approach). Furthermore, patients with different tumor types show high levels of cell-free circulating DNA both in plasma and serum (quantitative approach) at the t...

journal_title：Annals of the New York Academy of Sciences

authors： Frattini M,Gallino G,Signoroni S,Balestra D,Battaglia L,Sozzi G,Leo E,Pilotti S,Pierotti MA

更新日期：2006-09-01 00:00:00

abstract：:This review focuses on the importance of bradykinin in myocardial preservation during ischemic arrest. Bradykinin is released from the heart spontaneously in response to ischemic stress, which may be viewed as a survival signal of the heart against ischemia. Bradykinin appears to function as a signaling molecule by co...

journal_title：Annals of the New York Academy of Sciences

authors： Sato M,Das DK,Engelman RM

更新日期：1999-06-30 00:00:00

abstract：:In order to identify rate and stability of remission induced by low-dose prednisone comedication in early rheumatoid arthritis (RA), we evaluated patients with early RA (<1 year) who were randomized to receive (P) or not (non-P) low-dose prednisone in association with step-up disease-modifying antirheumatic drug thera...

journal_title：Annals of the New York Academy of Sciences

authors： Todoerti M,Scirè CA,Boffini N,Bugatti S,Montecucco C,Caporali R

更新日期：2010-04-01 00:00:00

abstract：:Force and shortening in striated muscle are driven by a structural working stroke in the globular portion of the myosin molecules-the myosin head-that cross-links the myosin-containing filaments and the actin-containing filaments. We use time-resolved X-ray diffraction in single fibers from frog skeletal muscle to lin...

journal_title：Annals of the New York Academy of Sciences

authors： Reconditi M,Linari M,Lucii L,Stewart A,Sun YB,Narayanan T,Irving T,Piazzesi G,Irving M,Lombardi V

更新日期：2005-06-01 00:00:00

abstract：:Managed care organizations and their affiliated group practices approach technology evaluation in a methodical way. This paper reviews the factors used in analysis of ultrasound for the diagnosis of fetal anomalies. It includes one group practice's strategies for ultrasound management while supporting the use of the s...

journal_title：Annals of the New York Academy of Sciences

authors： Buechler EJ

更新日期：1998-06-18 00:00:00

abstract：:In this paper, I describe the development of the Irie Classroom Toolbox, a school-based violence prevention, teacher training program for use with children aged 3-6 years. In-depth interviews were conducted with Jamaican preschool teachers, who had participated in a trial of a classroom behavior management program, at...

journal_title：Annals of the New York Academy of Sciences

authors： Baker-Henningham H

更新日期：2018-05-01 00:00:00

abstract：:A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 ag...

journal_title：Annals of the New York Academy of Sciences

authors： Nakajima S,Tohda Y,Ohkawa K,Chihara J,Nagasaka Y

更新日期：1993-06-23 00:00:00

abstract：:The preventive effects of the phytoalexin trans-resveratrol toward cancer have been largely described at the cellular and molecular levels in both in vivo and in vitro models; however, its primary targets are still poorly identified. In this review, we show the crucial role of cell membrane microdomains, that is, lipi...

journal_title：Annals of the New York Academy of Sciences

authors： Delmas D,Aires V,Colin DJ,Limagne E,Scagliarini A,Cotte AK,Ghiringhelli F

更新日期：2013-07-01 00:00:00

abstract：:In humans any effects of dietary saturated fats or omega-6 polyunsaturates on blood pressure appear to be mediated by changes in caloric intake and long-term weight changes. In contrast, omega-3 fatty acids have a mild antihypertensive effect which is seen most clearly in untreated subjects with higher blood pressures...

journal_title：Annals of the New York Academy of Sciences

authors： Beilin LJ

更新日期：1993-06-14 00:00:00

abstract：:Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen-sensitive transcription factors including the hypoxia-inducible factor (HIF) and nuclear factor-kappaB (NF-kappaB). Hypoxia-dependent gene expression can have important physiologic or pathophysiologic co...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor CT,Cummins EP

更新日期：2009-10-01 00:00:00

abstract：:Endometriosis is often a perplexing medical condition for both the physician and the patient. Accordingly, development of treatment strategies based on the needs of the individual patient is highly desirable. Although endometriosis has been part of the clinical practice for almost a century, many questions remain rela...

journal_title：Annals of the New York Academy of Sciences

authors： Valle RF,Sciarra JJ

更新日期：2003-11-01 00:00:00

abstract：:Analysis of the protein profile of mitochondria and its age-dependent variation is a promising approach to unravel mechanisms involved in aging and age-related diseases. Our studies focus on the mammalian mitochondrial membrane proteome, especially of the inner mitochondrial membrane with the respiratory chain complex...

journal_title：Annals of the New York Academy of Sciences

authors： Dencher NA,Frenzel M,Reifschneider NH,Sugawa M,Krause F

更新日期：2007-04-01 00:00:00

abstract：:Septic shock is a systemic response to severe bacterial infections, generally caused by Gram-negative bacterial endotoxins, with multiple manifestations such as hypotension, tissue injury, disseminated intravascular coagulation, and multi-organ failure. All these effects, are induced by the generation of pro-inflammat...

journal_title：Annals of the New York Academy of Sciences

authors： Martínez C,Arranz A,Juarranz Y,Abad C,García-Gómez M,Rosignoli F,Leceta J,Gomariz RP

更新日期：2006-07-01 00:00:00

abstract：:Chronic hypoxic stimulation in mammals can induce several phenotypic changes, such as polycythemia, pulmonary vascular changes, pulmonary hypertension, and carotid body (CB) enlargement. These phenotypic alterations provide a tool to test whether an oxygen sensor candidate is involved in an organism's response to envi...

journal_title：Annals of the New York Academy of Sciences

authors： Baysal BE

更新日期：2006-08-01 00:00:00

abstract：:This review will focus on the free radical signaling mechanism of preconditioning. The results from our laboratory as well as studies from other laboratories suggest that reactive oxygen species function as second messenger during myocardial adaptation to ischemia. This review provides evidence for the first time that...

journal_title：Annals of the New York Academy of Sciences

authors： Das DK,Engelman RM,Maulik N

更新日期：1999-06-30 00:00:00

abstract：:The present study investigates the impact of emotional deficits on implicit and explicit memory for musical stimuli in patients with Alzheimer's disease and elderly depressed patients. Results showed that unlike Alzheimer's patients, depressed patients were unable to develop a positive affective bias of judgment for p...

journal_title：Annals of the New York Academy of Sciences

authors： Quoniam N,Ergis AM,Fossati P,Peretz I,Samson S,Sarazin M,Allilaire JF

更新日期：2003-11-01 00:00:00

abstract：:There is a growing interest in the effectiveness of mindfulness meditation for sleep disturbed populations. Our study sought to evaluate the effect of mindfulness meditation interventions on sleep quality. To assess for relative efficacy, comparator groups were restricted to specific active controls (such as evidenced...

journal_title：Annals of the New York Academy of Sciences

authors： Rusch HL,Rosario M,Levison LM,Olivera A,Livingston WS,Wu T,Gill JM

更新日期：2019-06-01 00:00:00

abstract：:Humans can discriminate whether a change in the direction of gravito-inertial force (GIF) is caused by body tilt or by linear translation. This ability, attributed to vestibular sensory fusion, is often examined by asking subjects to adjust an indicator to match their subjective earth-fixed vertical (SV). We used two ...

journal_title：Annals of the New York Academy of Sciences

authors： Guenther AL,Bartl K,Nauderer J,Schneider E,Huesmann A,Brandt T,Glasauer S

更新日期：2009-05-01 00:00:00

abstract：:We recently isolated a novel bHLH/PAS protein, CLIF (cycle like factor), by yeast two-hybrid screening of human umbilical endothelial cell cDNA library. CLIF is preferentially expressed in endothelial and neuronal cells. Because CLIF is expressed in vascular endothelial cells and forms a heterodimer with CLOCK, the ke...

journal_title：Annals of the New York Academy of Sciences

authors： Maemura K,Layne MD,Watanabe M,Perrell MA,Nagai R,Lee ME

更新日期：2001-12-01 00:00:00

abstract：:To examine whether treatment with cardiopulmonary bypass (CPB), which causes transient cellular immunity depression, influences tuberculin skin testing (TST) interpretation. The study was also aimed to assess the degree of cellular immunity depression following open heart surgery. Fifteen children from developing coun...

journal_title：Annals of the New York Academy of Sciences

authors： Stein M,Sela-Razon B,Linder I,Somekh E

更新日期：2007-08-01 00:00:00

abstract：:Most ecological economists believe that the transition to a steady-state economy is necessary to ensure ecological sustainability and to maximize a nation's economic welfare. While some observers agree with the necessity of the steady-state economy, they are nonetheless critical of the suggestion made by ecological ec...

journal_title：Annals of the New York Academy of Sciences

authors： Lawn P

更新日期：2011-02-01 00:00:00

abstract：:We measured plasma concentration of alpha-melanocyte-stimulating hormone (alpha-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. alp...

journal_title：Annals of the New York Academy of Sciences

authors： Catania A,Airaghi L,Garofalo L,Cutuli M,Lipton JM

更新日期：1998-05-01 00:00:00

abstract：:A trial was carried out in alpacas (Lama pacos) and llamas (Lama glama) to determine the economic benefits of controlling both external and internal parasites by the use of ivermectin ("Ivomec," Merck Sharp & Dohme). After four months the treated male alpacas gained on average 3.1 kg more than the untreated males, and...

journal_title：Annals of the New York Academy of Sciences

authors： Windsor RS,Windsor RH,Teran M

更新日期：1992-06-16 00:00:00

abstract：:Our objective was to learn the prevalence of spotted fever group (SFG) Rickettsia detected in ticks in La Rioja, in the north of Spain. From 2001 to 2005, 496 ticks representing 7 tick species were analysed at the Hospital de La Rioja. Ticks were removed from humans with or without rickettsial syndrome (n = 59) or col...

journal_title：Annals of the New York Academy of Sciences

authors： Oteo JA,Portillo A,Santibáñez S,Pérez-Martínez L,Blanco JR,Jiménez S,Ibarra V,Pérez-Palacios A,Sanz M

更新日期：2006-10-01 00:00:00

abstract：:To minimize technical problems relating to excessive size (600-800 mu in diameter) of standard alginate microcapsules (CSM) for pancreatic islet graft immunoisolation, we have developed two novel minimal volume, chemically identical, capsule prototypes (MVC): 1) coherent microcapsules (CM), and 2) medium-size microcap...

journal_title：Annals of the New York Academy of Sciences

authors： Calafiore R,Basta G,Luca G,Boselli C,Bufalari A,Bufalari A,Cassarani MP,Giustozzi GM,Brunetti P

更新日期：1999-06-18 00:00:00

abstract：:Nanotechnology provides multifunctional agents for in vivo use that increasingly blur the distinction between pharmaceuticals and medical devices. Realization of such therapeutic nanodevices requires multidisciplinary effort that is difficult for individual device developers to sustain, and identification of appropria...

journal_title：Annals of the New York Academy of Sciences

authors： Lee SC,Bhalerao K,Ferrari M

更新日期：2004-05-01 00:00:00

abstract：:Regardless of how creative, innovative, and elegant our computational methods, the ultimate proof of an algorithm's worth is the experimentally validated quality of its predictions. Unfortunately, this truism is hard to reduce to practice. Usually, modelers produce hundreds to hundreds of thousands of predictions, mos...

journal_title：Annals of the New York Academy of Sciences

authors： Stolovitzky G,Prill RJ,Califano A

更新日期：2009-03-01 00:00:00

abstract：:The adrenergic system has long been known to be activated in a situation of stress and thus during opiate withdrawal. A method for detoxification that decreases the stimulation of the sympathetic nervous system will prevent changes of catecholamine levels. Some of such methods have been developed. One of them uses dir...

journal_title：Annals of the New York Academy of Sciences

authors： Macedo TR,Relvas J,Fontes Ribeiro CA,Pacheco F,Morgadinho MT,Pinto CM,Gomes PC,Ventura M,Henriques V,Nunes SV,Ruis GR,Ramalheira C,Boto I,Vale LL

更新日期：2000-09-01 00:00:00