A phenotypic perspective on Mammalian oxygen sensor candidates.

abstract：:The discrepancy between dynamical mass measures of objects such as galaxies and the observed distribution of luminous matter in the universe is typically explained by invoking an unseen "dark matter" component. Dark matter must necessarily be nonbaryonic. We introduce a simple hypothesis to do away with the necessity ...

journal_title：Annals of the New York Academy of Sciences

authors： Kinney WH,Brisudova M

更新日期：2001-06-01 00:00:00

abstract：:Perhaps the greatest mystery is why the universe exists in the first place. How is it possible for something to emerge from nothing, or has a universe in some form always existed? This question of origins-both of the universe as a whole and of the fundamental laws of physics-raises profound scientific, philosophical, ...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Albert D,Holt J,Turok N

更新日期：2015-12-01 00:00:00

abstract：:Modest changes in gene expression of three-fold or less might be expected after mild to moderate neurotoxic exposure to classes of compounds, such as the substituted amphetamines, or at time points that are weeks after more severe neurotoxic exposures. When many genes appear to change expression by less than two-fold,...

journal_title：Annals of the New York Academy of Sciences

authors： Delongchamp RR,Harris AJ,Bowyer JF

更新日期：2003-05-01 00:00:00

abstract：:Intracellular foreign protein (beta-galactosidase) expression in recombinant CHO cell lines in continuous culture was analyzed by developing a mathematical model that includes the effects of metabolic burden and cell cycle dependence of intracellular foreign protein expression. This combined growth kinetic and cell cy...

journal_title：Annals of the New York Academy of Sciences

authors： Gu MB,Todd P,Kompala DS

更新日期：1994-05-02 00:00:00

abstract：:The primate orbitofrontal cortex (OFC) is often treated as a single entity, but architectonic and connectional neuroanatomy indicate that it has distinguishable parts. Nevertheless, few studies have attempted to dissociate the functions of its subregions. Here we review findings from recent neuropsychological and neur...

journal_title：Annals of the New York Academy of Sciences

authors： Rudebeck PH,Murray EA

更新日期：2011-12-01 00:00:00

abstract：:A number of important themes emerge from our compartmental analyses of Na,K-ATPase biosynthesis in response to ionic stimuli. The ubiquitous alpha 1 beta 1 type sodium pump evolved to generate and maintain transmembrane Na+ and K+ gradients, and there are cell-type specific mechanisms of increasing synthesis and decre...

journal_title：Annals of the New York Academy of Sciences

authors： McDonough AA,Azuma KK,Lescale-Matys L,Tang MJ,Nakhoul F,Hensley CB,Komatsu Y

更新日期：1992-11-30 00:00:00

abstract：:A human T-T hybridoma was produced, which was a fusion product between and HGPRT-deficient T-cell line, Jurkat 3, and an OKT4+ activated peripheral blood T-cell. The hybrid expressed a receptor for IgM Fc and was negative for IgA Fc. It was shown to produce a factor capable of specifically enhancing IgA production and...

journal_title：Annals of the New York Academy of Sciences

authors： Mayer L,Fu SM,Kunkel HG

更新日期：1983-06-30 00:00:00

abstract：:Adhesive interactions are recognized requirements for cellular proliferation, migration and differentiation during normal morphogenesis as well as disease. By differential cloning, osteopontin was identified as an adhesive protein upregulated during vascular remodeling and neointima formation in both rat models and hu...

journal_title：Annals of the New York Academy of Sciences

authors： Giachelli CM,Liaw L,Murry CE,Schwartz SM,Almeida M

更新日期：1995-04-21 00:00:00

abstract：:Our earlier studies of translation have led us to a specific numeric coding of nucleotides (A = 0, C = 1, G = 2, and U = 3)--that is, a quaternary numeric system; to ordering of digrams and codons (read right to left: .yx and Z.yx) as ordinal numbers from 000 to 111; and to seek hypothetic transformation of mRNA to 20...

journal_title：Annals of the New York Academy of Sciences

authors： Damjanović ZM,Rakocević MM

更新日期：2005-06-01 00:00:00

abstract：:Results from two similar experimental systems that attempt to create laboratory geophysical analogs in spherical geometry are presented. In the first system, real time holographic interferometry and shadowgraph visualization are used to study convection in the fluid between two concentric spheres when two distinct buo...

journal_title：Annals of the New York Academy of Sciences

authors： Hegseth J,Amara K

更新日期：2002-10-01 00:00:00

abstract：:Landesberg and Sideman's four state model of the cardiac cross-bridge (XB) hypothesizes a feedback of force development to Ca(2+) binding by troponin C (TnC). We have further modeled this behavior and observed that the force (F)-Ca(2+) relationship as well as the F-sarcomere length (SL) relationship and the time cours...

journal_title：Annals of the New York Academy of Sciences

authors： Ter Keurs HE,Wakayama Y,Miura M,Stuyvers BD,Boyden PA,Landesberg A

更新日期：2005-06-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) play a central role in successful control of HIV. Induction of effective CTL responses may therefore be an essential requirement of HIV vaccines. Knowledge of CTL epitopes targeted either in natural infection or following vaccination will be critical to understanding the anti-HIV immune r...

journal_title：Annals of the New York Academy of Sciences

authors： Goulder PJ

更新日期：2000-11-01 00:00:00

abstract：:Bacterial protein, staphylocoagulase, binds stoichiometrically to human prothrombin resulting in a coagulant complex, staphylothrombin. The enzymatic properties of staphylothrombin differ from those of alpha-thrombin in their substrate specificities toward natural and synthetic substrates, in addition to their interac...

journal_title：Annals of the New York Academy of Sciences

authors： Kawabata S,Morita T,Miyata T,Kaida S,Igarashi H,Iwanaga S

更新日期：1986-01-01 00:00:00

abstract：:We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

journal_title：Annals of the New York Academy of Sciences

authors： Romano AG,Harvey JA

更新日期：1998-06-21 00:00:00

abstract：:The cell surface antigen recognized by monoclonal antibody W7C5 is expressed at low levels on human CD34(+) and CD34(-) bone marrow stem cell populations but at high levels on fetal liver CD34(+) cells. To identify the recognized antigen, we performed partial amino acid sequence and MALDI analysis of purified W7C5 ant...

journal_title：Annals of the New York Academy of Sciences

authors： Giesert C,Marxer A,Sutherland DR,Schuh AC,Kanz L,Buhring HJ

更新日期：2003-05-01 00:00:00

abstract：:Recent studies have shown that cirazoline, an alpha 1-adrenoceptor agonist, has greater affinity than do other imidazoline or guanidinium compounds at imidazoline recognition sites. In this report we used [3H]cirazoline as a probe to characterize imidazoline recognition sites present in membrane homogenates of rat bra...

journal_title：Annals of the New York Academy of Sciences

authors： Angel I,Le Rouzic M,Pimoule C,Graham D,Arbilla S

更新日期：1995-07-12 00:00:00

abstract：:T cell protein tyrosine phosphatase (TCPTP) dephosphorylates a number of substrates, including JAK-STAT (signal transducer and activator of transcription) signaling proteins, which are activated by interferon (IFN)-γ, a major proinflammatory cytokine involved in conditions such as inflammatory bowel disease. A critica...

journal_title：Annals of the New York Academy of Sciences

authors： Krishnan M,McCole DF

更新日期：2017-10-01 00:00:00

abstract：:Chemical hypoxia produces depletion of ATP, intracellular Ca2+ overload, and cell death. The role of Na+/Ca2+ exchanger (NCX), the major plasma membrane Ca2+ extruding system, has been explored in chemical hypoxia using BHK cells stably transfected with the three mammalian NCX isoforms: NCX1, NCX2, and NCX3. Here we r...

journal_title：Annals of the New York Academy of Sciences

authors： Secondo A,Staiano IR,Scorziello A,Sirabella R,Boscia F,Adornetto A,Canzoniero LM,Di Renzo G,Annunziato L

更新日期：2007-03-01 00:00:00

abstract：:Tight junction (TJ) properties are determined by membrane protein complexes of neighboring cells that form both a barrier and a selective pathway for paracellular substrate transport. Our previous work supports the view that paracellular permeability changes in the thick ascending limb (TAL) may underlie the mechanism...

journal_title：Annals of the New York Academy of Sciences

authors： Shan Q,Himmerkus N,Hou J,Goodenough DA,Bleich M

更新日期：2009-05-01 00:00:00

abstract：:First we remind general considerations concerning biodiversity on earth and particularly the loss of genetic biodiversity that seems irreversible whether its origin is directly or indirectly linked to human activities. Urgent and considerable efforts must be made from now on to cataloge, understand, preserve, and enha...

journal_title：Annals of the New York Academy of Sciences

authors： Maillard JC,Gonzalez JP

更新日期：2006-10-01 00:00:00

abstract：:Flow cytometry was used to separate Xenopus melanotrope cells according to their size. The cells were then submitted to real-time RT-PCR to determine the level of POMC-gene expression. The results show a positive correlation between cell size and gene expression for cells from black-background (but not white-backgroun...

journal_title：Annals of the New York Academy of Sciences

authors： Corstens GJ,Roubos EW,Jenks BG,Van Erp PE

更新日期：2005-04-01 00:00:00

abstract：:"Vascular anomalies" represents a spectrum of vascular lesions, of unclear etiology and often with unpredictable behavior. Patients with vascular anomalies represent a unique population, in that they have focal aberrations of vascular development (in vascular malformations) or vascular proliferation (in hemangiomas). ...

journal_title：Annals of the New York Academy of Sciences

authors： Blei F

更新日期：2008-01-01 00:00:00

abstract：:Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield...

journal_title：Annals of the New York Academy of Sciences

authors： Ashe KH

更新日期：2000-01-01 00:00:00

abstract：:Phosphorus nuclear magnetic resonance studies of various normal and dystrophic muscles have demonstrated differences in phosphodiester contents. Dystrophic chicken pectoralis muscle contains elevated levels of the diester SEP, and Duchenne dystrophic human leg muscle lacks the diester GPC. It is shown that SEP may be ...

journal_title：Annals of the New York Academy of Sciences

authors： Chalovich JM,Burt CT,Danon MJ,Glonek T,Bárány M

更新日期：1979-01-01 00:00:00

abstract：:Entomopathogenic fungi are promising alternatives to chemical acaricides in controlling tick populations; however, biological formulations are required to improve conidial performance of these pathogens in the field. This study evaluated the effect of in vitro treatment of Rhipicephalus sanguineus with conidial formul...

journal_title：Annals of the New York Academy of Sciences

authors： Reis RC,Fernandes EK,Bittencourt VR

更新日期：2008-12-01 00:00:00

abstract：:Tocopherols and tocotrienols (vitamin E) and ascorbic acid (vitamin C) as well as the carotenoids react with free radicals, notably peroxyl radicals, and with singlet molecular oxygen (1O2), this being the basis of their function as antioxidants. RRR-alpha-tocopherol is the major peroxyl radical scavenger in biologica...

journal_title：Annals of the New York Academy of Sciences

authors： Sies H,Stahl W,Sundquist AR

更新日期：1992-09-30 00:00:00

abstract：:Tight junctions (TJs) regulate paracellular barriers and claudins (Cld) form the backbone of TJ strands. To elucidate the molecular mechanism of claudin polymer formation, TJs were reconstituted by claudin transfection of TJ-free HEK293 cells. Therewith, typical TJ stands can be found at cell-cell contacts. In additio...

journal_title：Annals of the New York Academy of Sciences

authors： Rossa J,Lorenz D,Ringling M,Veshnyakova A,Piontek J

更新日期：2012-06-01 00:00:00

abstract：:Propagation and prolongation of rapid neuronal discharge underlies the epilepsies. However, episodic focal rapid neuronal discharges limited to discrete nuclei and pathways of the amygdala-hippocampal-septal-hypothalamic networks are the language of physiologic message systems for endocrine regulation and reproductive...

journal_title：Annals of the New York Academy of Sciences

authors： Stevens JR

更新日期：1999-06-29 00:00:00

abstract：:Auditory brainstem potentials were recorded from various scalp and nasopharyngeal sites referenced both to a noncephalic site and to certain scalp locations in normal humans. The distribution of amplitudes and latencies of the components were defined. There were significant amplitude, polarity, and latency asymmetries...

journal_title：Annals of the New York Academy of Sciences

authors： Starr A,Squires K

更新日期：1982-01-01 00:00:00

abstract：:Several years of survey data indicate that illicit drug use among U.S. youth was at its highest level in 1979. Generally, the use of some illicit drugs declined progressively throughout the 1980s, stabilized, and then decreased slightly. Reducing illicit drug use among U.S. youth continues to be a priority of federal,...

journal_title：Annals of the New York Academy of Sciences

authors： Banken JA

更新日期：2004-10-01 00:00:00