IgA specific T-cell factor produced by a human T-T hybridoma.

Abstract:

:A human T-T hybridoma was produced, which was a fusion product between and HGPRT-deficient T-cell line, Jurkat 3, and an OKT4+ activated peripheral blood T-cell. The hybrid expressed a receptor for IgM Fc and was negative for IgA Fc. It was shown to produce a factor capable of specifically enhancing IgA production and secretion by isolated human B-cells. The factor exerts its effect directly on B-cells and appears to be different from T-cell-replacing factors previously described.

journal_name

Ann N Y Acad Sci

authors

Mayer L,Fu SM,Kunkel HG

doi

10.1111/j.1749-6632.1983.tb26873.x

subject

Has Abstract

pub_date

1983-06-30 00:00:00

pages

238-42

eissn

0077-8923

issn

1749-6632

journal_volume

409

pub_type

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