Genetic variation among hepatitis B and related viruses.

Abstract:

:Hepatitis B virus (HBV) of man has several characteristics that distinguish it from viruses of other groups. These include its ultrastructure, viral DNA size and structure, a virion DNA polymerase which repairs a single-stranded region in the viral DNA, liver tropism, character of persistent infection, and association with hepatitis and hepatocellular carcinoma. Recently three other viruses have been found in other animal species that appear to share these characteristics although the viruses are not identical. HBV, Woodchuck hepatitis virus (WHV), ground squirrel hepatitis virus (GSHV), and duck hepatitis virus (DHV) appear to be members of a new virus group that might be designated the Hepadna virus group. Genetic variation among hepatitis B viruses includes the antigenic variation in the surface antigen (HBsAg) which constitutes the known HBsAg subtypes. There is also frequent variation in DNA base sequence among HBVs isolated from different patients.

journal_name

Ann N Y Acad Sci

authors

Robinson WS

doi

10.1111/j.1749-6632.1980.tb27978.x

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

371-8

eissn

0077-8923

issn

1749-6632

journal_volume

354

pub_type

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