Profile of patients with colorectal cancer at a tertiary care cancer hospital in Pakistan.

abstract：:The historical reasons for the introduction of tick control during the nineteenth century are reviewed. Background and concepts for the choice between long-term tick control and tick eradication are compared. Case studies of large-scale tick control or eradication programs in Africa, Australia, the United States, and ...

journal_title：Annals of the New York Academy of Sciences

authors： Pegram RG,Wilson DD,Hansen JW

更新日期：2000-01-01 00:00:00

abstract：:Pain is a subjective symptom whose prevalence can be grossly underestimated. The high proportion of adults with thalassemia who experience chronic pain is evident from recent surveys. However, pain has not received enough attention in the overall management of thalassemia. The association of pain with the type and tre...

journal_title：Annals of the New York Academy of Sciences

authors： Lal A

更新日期：2016-03-01 00:00:00

abstract：:Alterations in brain distribution of 11C-MAP, 14C-MAP, and 123I-IMP in MAP- and cocaine-sensitized animals were examined to investigate the mechanism involved in increased dopaminergic transmission and behavioral sensitization. First, a significant increase in 11C-MAP radioactivity in the striatum and hypothalamus was...

journal_title：Annals of the New York Academy of Sciences

authors： Numachi Y,Yoshida S,Inosaka T,Sato M,Mizugaki M,Kimura K,Hishinuma T

更新日期：1992-06-28 00:00:00

abstract：:The multiple actions of somatostatin are mediated by specific membrane-bound receptors present in all somatostatin target tissues, such as brain, pituitary, pancreas, gastrointestinal tract, and kidney. For instance, in the human gastrointestinal tract, three different types of tissue compartments express somatostatin...

journal_title：Annals of the New York Academy of Sciences

authors： Reubi JC,Laissue J,Waser B,Horisberger U,Schaer JC

更新日期：1994-09-15 00:00:00

abstract：:The new vogue for systems biology is an important development. It is time to complement reductionist molecular biology by integrative approaches. But this welcome development is in danger of losing its way. Many of the early implementations of the approach are very low level, in some cases hardly more than an extensio...

journal_title：Annals of the New York Academy of Sciences

authors： Noble D

更新日期：2008-03-01 00:00:00

abstract：:The purpose of the Big Data to Knowledge initiative is to develop methods for discovering new knowledge from large amounts of data. However, if the resulting knowledge is so large that it resists comprehension, referred to here as Big Knowledge (BK), how can it be used properly and creatively? We call this secondary c...

journal_title：Annals of the New York Academy of Sciences

authors： Perl Y,Geller J,Halper M,Ochs C,Zheng L,Kapusnik-Uner J

更新日期：2017-01-01 00:00:00

abstract：:Neuromodulation denotes controlled electrical stimulation of the central or peripheral nervous system. The three forms of neuromodulation described in this paper-deep brain stimulation, vagus nerve stimulation, and transcranial magnetic stimulation-were chosen primarily for their demonstrated or potential clinical use...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2003-05-01 00:00:00

abstract：:Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [(18)F]6-fluroro-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understa...

journal_title：Annals of the New York Academy of Sciences

authors： Chu Y,Kordower JH

更新日期：2010-01-01 00:00:00

abstract：:Apoptosis plays a critical role in acetaminophen (AAP)-induced hepatic injury, since inhibiting apoptosis also prevents the development of acute liver failure. In this study, the mechanism of apoptosis induction by AAP was investigated in the human hepatoblastoma cell line HuH7. AAP caused marked cytotoxicity in HuH7 ...

journal_title：Annals of the New York Academy of Sciences

authors： Kass GE,Macanas-Pirard P,Lee PC,Hinton RH

更新日期：2003-12-01 00:00:00

abstract：:The arterial baroreflex has two important functions. First, the arterial baroreflex is a negative feedback reflex that regulates arterial pressure around a preset value called a set or operating point. Second, the arterial baroreflex also establishes the prevailing systemic arterial pressure when the operating point i...

journal_title：Annals of the New York Academy of Sciences

authors： DiCarlo SE,Bishop VS

更新日期：2001-06-01 00:00:00

abstract：:Carnitine and its congeners may regulate the immune networks, and their influence on functions of immune cells predominantly or exclusively relies on carnitine-dependent energy production from fatty acids. A reduced pool of carnitines has been demonstrated in either serum or tissues, or both, from patients with a wide...

journal_title：Annals of the New York Academy of Sciences

authors： Famularo G,De Simone C,Trinchieri V,Mosca L

更新日期：2004-11-01 00:00:00

abstract：:Transmission of HIV from mothers to children may occur through the transplacental, intrapartum, or breastfeeding routes. Adequate nutritional status may reduce vertical transmission by affecting several maternal or fetal and child risk factors for transmission including enhancing systemic immune function in the mother...

journal_title：Annals of the New York Academy of Sciences

authors： Fawzi W

更新日期：2000-11-01 00:00:00

abstract：:Endothelial cells produce and bind to multiple basement membrane components. Fibronectin and interstitial collagens seem to promote migration and proliferation, whereas basement membrane collagen and laminin stimulate attachment and differentiation. Human umbilical vein endothelial cells will rapidly form capillary-li...

journal_title：Annals of the New York Academy of Sciences

authors： Grant DS,Kleinman HK,Martin GR

更新日期：1990-01-01 00:00:00

abstract：:The identification of sensitive assay formats capable of distinguishing islet autoreactive T cells directly ex vivo in blood is a major goal in type 1 diabetes research. Whereas much effort has been made to identify suitable assay formats, relatively little attention has been paid to optimizing the quality of cell pre...

journal_title：Annals of the New York Academy of Sciences

authors： Tree TI,Roep BO,Peakman M

更新日期：2004-12-01 00:00:00

abstract：:Understanding how the gulf between prokaryotic and eukaryotic cellular design arose is a major challenge. The viral eukaryogenesis (VE) hypothesis addresses the challenge of eukaryotic origins by suggesting the first eukaryotic cell was a multimember consortium consisting of a viral ancestor of the nucleus, an archaea...

journal_title：Annals of the New York Academy of Sciences

authors： Bell PJ

更新日期：2009-10-01 00:00:00

abstract：:GABAA receptor heterogeneity is based on the combinatorial assembly of a large family of subunits into distinct receptor subtypes. A neuron-specific expression pattern of receptor subtypes has been demonstrated in adult rat brain, which can be reproduced in vitro in primary neuron cultures. This suggests that genetic ...

journal_title：Annals of the New York Academy of Sciences

authors： Penschuck S,Paysan J,Giorgetta O,Fritschy JM

更新日期：1999-04-30 00:00:00

abstract：:Activated platelets and leukocytes release potent vasoactive factors that may modulate vascular tone. Activation of normal platelets produces dilatation of normal arteries. Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. In atherosc...

journal_title：Annals of the New York Academy of Sciences

authors： Kaul S,Padgett RC,Heistad DD

更新日期：1994-04-18 00:00:00

abstract：:After the initial dramatic effects, observed in a Lewis lung carcinoma animal model, using a combination of thymosin alpha 1 (Talpha1) and interferon (IFN) after cyclophosphamide, a number of other preclinical models in mice (Friend erythroleukemia and B16 melanoma) and in rats (DHD/K12 colorectal cancer liver metasta...

journal_title：Annals of the New York Academy of Sciences

authors： Garaci E,Favalli C,Pica F,Sinibaldi Vallebona P,Palamara AT,Matteucci C,Pierimarchi P,Serafino A,Mastino A,Bistoni F,Romani L,Rasi G

更新日期：2007-09-01 00:00:00

abstract：:The understanding and control of embryo implantation represents the major challenge for assisted reproductive technologies. Along with developments in basic research and efforts to optimize embryo quality, the improvement of noninvasive and reliable methods to assess uterine receptivity constitutes an important step t...

journal_title：Annals of the New York Academy of Sciences

authors： Fanchin R

更新日期：2001-09-01 00:00:00

abstract：:In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of t...

journal_title：Annals of the New York Academy of Sciences

authors： Borman RA,Burleigh DE

更新日期：1997-05-30 00:00:00

abstract：:The temporal and spatial regulation of intracellular calcium concentration ([Ca(2+)](i)) is very crucial for maintaining calcium ion homeostasis within cells, and consequently in the regulation of cellular functions such as beta cell replication and differentiation, insulin secretion, and apoptosis. Calcium ion regula...

journal_title：Annals of the New York Academy of Sciences

authors： Parkash J

更新日期：2008-12-01 00:00:00

abstract：:Drug addiction is a chronic relapsing brain disorder characterized by neurobiological changes that lead to a compulsion to take a drug with loss of control over drug intake. The hypothesis outlined here is that knowledge of the neurochemical systems involved in the transition from drug use to the compulsive use of add...

journal_title：Annals of the New York Academy of Sciences

authors： Koob GF

更新日期：2000-01-01 00:00:00

abstract：:Delayed type hypersensitivity (DTH) reactions represent cell-mediated immune responses that exert important immunoprotective (resistance to viruses, bacteria, and fungi) or immunopathologic (allergic or autoimmune hypersensitivity) effects. We have used the skin DTH response as an in vivo model to study neuro-endocrin...

journal_title：Annals of the New York Academy of Sciences

authors： Dhabhar FS

更新日期：2003-05-01 00:00:00

abstract：:In preindustrial settings, biological, economic, and social mechanisms caused fertility to respond to feedback signals from population size variation in such a way as to steer populations toward equilibrium levels. It is unlikely that the relevant signal was population density; more plausibly the signal was economic w...

journal_title：Annals of the New York Academy of Sciences

authors： Lee R

更新日期：1994-02-18 00:00:00

abstract：:A summary is provided of the early history of research on the flow of nonrenewable energy resources through the economy and of the flow of renewable energy resources through a natural ecosystem. The techniques are similar, and many specific applications are provided. A combined economic and ecological technique is als...

journal_title：Annals of the New York Academy of Sciences

authors： Hannon B

更新日期：2010-01-01 00:00:00

abstract：:The kinetics of the E(2) --> E(1) conformational change of unphosphorylated Na(+),K(+)-ATPase from rabbit kidney were investigated via the stopped-flow technique using the fluorescent label RH421 (pH 7.4, 24 degrees C). The enzyme was preequilibrated in a solution containing 25 mM histidine and 0.1 mM EDTA to initiall...

journal_title：Annals of the New York Academy of Sciences

authors： Clarke RJ,Humphrey PA,Lüpfert C,Apell HJ,Cornelius F

更新日期：2003-04-01 00:00:00

abstract：:Bacterial protein, staphylocoagulase, binds stoichiometrically to human prothrombin resulting in a coagulant complex, staphylothrombin. The enzymatic properties of staphylothrombin differ from those of alpha-thrombin in their substrate specificities toward natural and synthetic substrates, in addition to their interac...

journal_title：Annals of the New York Academy of Sciences

authors： Kawabata S,Morita T,Miyata T,Kaida S,Igarashi H,Iwanaga S

更新日期：1986-01-01 00:00:00

abstract：:Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signa...

journal_title：Annals of the New York Academy of Sciences

authors： Lee AM,Messing RO

更新日期：2008-10-01 00:00:00

abstract：:The NFkappaB factor Bcl-3 influences the survival of T cells when they are activated to take part in immune responses. Because treatment of mice with adjuvant results in the increased expression of Bcl-3 in T cells, where it has survival-promoting effects, Bcl-3 may be an important, limiting factor that is supplied to...

journal_title：Annals of the New York Academy of Sciences

authors： Mitchell TC,Thompson BS,Trent JO,Casella CR

更新日期：2002-12-01 00:00:00

abstract：:Clumps of corona cells were separated from oocytes at the moment of fertilization control and were subsequently processed and cut into 1-mu sections to study their general morphologic patterns. This study revealed an extensive phagocytosis of spermatozoa by corona cells. Clumps of mural granulosa cells of comparable s...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnenborg R,Gordts S,Ongkowidjojo R,Brosens I

更新日期：1985-01-01 00:00:00