Abstract:
:Alterations in brain distribution of 11C-MAP, 14C-MAP, and 123I-IMP in MAP- and cocaine-sensitized animals were examined to investigate the mechanism involved in increased dopaminergic transmission and behavioral sensitization. First, a significant increase in 11C-MAP radioactivity in the striatum and hypothalamus was found in the mice pretreated with MAP for 7 days. Secondly, in MAP-sensitized rats, marked increases in 14C-MAP radioactivity were found in the striatum and limbic forebrain, respectively (370% and 650%). These findings may propose a new hypothesis that subchronic MAP administration may result in a long-term change in the presynaptic cell membrane at the nerve terminal which may in turn cause an increase in both MAP and DA uptake accompanied by an increased release of DA at the synaptic cleft.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Numachi Y,Yoshida S,Inosaka T,Sato M,Mizugaki M,Kimura K,Hishinuma Tdoi
10.1111/j.1749-6632.1992.tb25964.xsubject
Has Abstractpub_date
1992-06-28 00:00:00pages
153-9eissn
0077-8923issn
1749-6632journal_volume
654pub_type
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journal_title:Annals of the New York Academy of Sciences
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