Abstract:
:The past three decades of clinical disappointments in treating stroke must compel us to rethink our strategy. Given the enormous complexity of the clinical disease, the "one size fits all" approach to stroke treatment is unlikely to succeed. The effective treatment of stroke aimed at reversing ischemic injury will require monitoring of tissue injury and response to therapeutic interventions, perhaps the use of multiple drugs, sequentially administered in a timely manner. The proposed sequential intra-arterial therapy for stroke (SITS) relies on the development of novel intra-arterial treatments of ischemic brain injury in the magnetic resonance imaging environment. However, translating SITS protocol from bench to bedside could greatly benefit from the advances in optical technologies. Compared to magnetic resonance imaging, optical sensing technology promises to be quicker, cheaper, simpler, and more versatile, and thus is ideally suited for investigating the fast kinetics and monitoring the pharmacological effects of intra-arterial drugs.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Joshi S,Agarwal Sdoi
10.1111/j.1749-6632.2009.05381.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
149-57eissn
0077-8923issn
1749-6632pii
NYAS5381journal_volume
1199pub_type
杂志文章abstract::The present experiments were conducted to determine the effects of neurotensin on secretion of a variety of anterior pituitary hormones. Conscious rats with indwelling cannulae in the third ventricle and external jugular vein were used and the effects on plasma hormone levels measured by radioimmunoassay. Neurotensin ...
journal_title:Annals of the New York Academy of Sciences
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doi:10.1111/j.1749-6632.1982.tb31567.x
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abstract::Amyloid precursor proteins (APP) are a member of a larger family of proteins that include the amyloid precursor-like proteins (APLP) APLPI and APLP2. We have examined the expression and metabolism of APLP2 and document that APLP2 is expressed at high levels in the nervous system and in peripheral tissues. Furthermore,...
journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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更新日期:1983-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2003-09-01 00:00:00