Peripheral Nerve Dysmyelination Due to P0 Glycoprotein Overexpression Is Dose-Dependent.

abstract：:The nearly neutral theory represents a development of Kimura's neutral theory of molecular evolution that makes testable predictions that go beyond a mere null model. Recent evidence has strongly supported several of these predictions, including the prediction that slightly deleterious variants will accumulate in a sp...

journal_title：Annals of the New York Academy of Sciences

authors： Hughes AL

更新日期：2008-01-01 00:00:00

abstract：:SPAG-1, a sporozoite surface antigen of T. annulata, has previously been shown to elicit partial protection when used, as an hepatitis B core antigen fusion, to immunize cattle. The objective of this study was to try and improve the protective capacity of this antigen by enlisting different vaccine strategies. Cattle ...

journal_title：Annals of the New York Academy of Sciences

authors： Boulter NR,Brown CG,Kirvar E,Glass E,Campbell J,Morzaria S,Nene V,Musoke A,D'Oliveira C,Gubbels MJ,Jongejan F,Hall FR

更新日期：1998-06-29 00:00:00

abstract：:This paper discusses the repatriation of human remains to indigenous peoples in Australia and the United States and the role anthropologists play in the construction of past, present, and future identities for contemporary indigenous peoples. Using examples from both countries, I suggest that many of the participants ...

journal_title：Annals of the New York Academy of Sciences

authors： Cantwell AM

更新日期：2000-01-01 00:00:00

abstract：:The current research has demonstrated that MPP+ can induce lipid peroxidation in the nigrostriatal system of rat in vivo. Antioxidant agent U-78517F and .OH scavenger DMSO may protect against MPP+ toxicity through the inhibition of .OH radical-mediated oxidative injury in the substantia nigra. These findings indicate ...

journal_title：Annals of the New York Academy of Sciences

authors： Wu RM,Mohanakumar KP,Murphy DL,Chiueh CC

更新日期：1994-11-17 00:00:00

abstract：:Sophisticated imaging and fetal sampling techniques have defined the natural history and pathophysiologic characteristics of many previously mysterious conditions of newborn. Although most prenatally diagnosed malformations are best managed by appropriate medical and surgical therapy after delivery, an increasing numb...

journal_title：Annals of the New York Academy of Sciences

authors： Albanese CT,Harrison MR

更新日期：1998-06-18 00:00:00

abstract：:The discovery of the adenylyl cyclase signaling mechanism (ACSM) of insulin and related peptides allows for advancing the hypothesis of its participation in regulatory action on cell growth, apoptosis, and metabolism. The following evidences were obtained: (1) The order of efficiency of insulin and IGF-I growth-promot...

journal_title：Annals of the New York Academy of Sciences

authors： Pertseva MN

更新日期：2005-04-01 00:00:00

abstract：:Three patients with the clinical diagnosis of Wallenberg's syndrome caused by acute unilateral ischemic infarctions, which included the vestibular nucleus in the medullary brain stem and afferent vestibular pathways, were examined by positron emission tomography (PET) during caloric vestibular stimulation. They all ha...

journal_title：Annals of the New York Academy of Sciences

authors： Dieterich M,Bense S,Stephan T,Brandt T,Schwaiger M,Bartenstein P

更新日期：2005-04-01 00:00:00

abstract：:The use of animal cells, tissues, or organs for humans is being investigated as an alternative to allotransplantation and as therapy for a broad range of disease states including diabetes, Parkinson's disease, and neurologic pain control. The risk of transmitting novel infections with these tissues, xenozoonoses, has ...

journal_title：Annals of the New York Academy of Sciences

authors： Michaels M

更新日期：1998-12-30 00:00:00

abstract：:The kinetics of the E(2) --> E(1) conformational change of unphosphorylated Na(+),K(+)-ATPase from rabbit kidney were investigated via the stopped-flow technique using the fluorescent label RH421 (pH 7.4, 24 degrees C). The enzyme was preequilibrated in a solution containing 25 mM histidine and 0.1 mM EDTA to initiall...

journal_title：Annals of the New York Academy of Sciences

authors： Clarke RJ,Humphrey PA,Lüpfert C,Apell HJ,Cornelius F

更新日期：2003-04-01 00:00:00

abstract：:Gastrointestinal peptides play important roles regulating feeding and energy homeostasis. Most gastrointestinal peptides including glucagon like peptide-1, peptide YY, amylin, and oxytomodulin are anorectic, and only ghrelin is an orexigenic peptide. Ghrelin increases appetite, modulates energy balance, suppresses inf...

journal_title：Annals of the New York Academy of Sciences

authors： Ueno H,Shiiya T,Nakazato M

更新日期：2010-07-01 00:00:00

abstract：:In adult Lurcher mice virtually all cerebellar Purkinje cells have degenerated as a direct consequence of mutant gene action, providing a natural model for studying the effect of cerebellar cortical lesions on the generation of compensatory eye movements. Lurcher mice possess both optokinetic (OKR) and vestibular (VOR...

journal_title：Annals of the New York Academy of Sciences

authors： Van Alphen AM,Schepers T,Luo C,De Zeeuw CI

更新日期：2002-12-01 00:00:00

abstract：:Severely inflamed colonic sections of IL-2 (-/-) mice showed up to 19-fold increased iNOS mRNA levels. The level of iNOS protein expression corresponded to the increased iNOS mRNA levels as detected by means of Western blot analysis. There was a clear, positive relationship between the level of iNOS expression and the...

journal_title：Annals of the New York Academy of Sciences

authors： Harren M,Schönfelder G,Paul M,Horak I,Riecken EO,Wiedenmann B,John M

更新日期：1998-11-17 00:00:00

abstract：:This paper is dedicated to the transient liquid crystal technique measurements for multiple view access by using a novel digital recording and image processing system. The transient liquid crystal technique is widely used for heat transfer investigations in turbomachinery. It has been applied in our laboratory in seve...

journal_title：Annals of the New York Academy of Sciences

authors： Vogel G,Boelcs A

更新日期：2001-05-01 00:00:00

abstract：:The fatty acid (FA) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (TG) were determined in the hereditary hypertriglyceridemic (HTG) rat, a nonobese animal model of the insulin resistance syndrome. Four groups of HTG rats and four groups of...

journal_title：Annals of the New York Academy of Sciences

authors： Bohov P,Seböková E,Gasperíková D,Langer P,Klimes I

更新日期：1997-09-20 00:00:00

abstract：:We showed the presence of glucocorticoid (GR) and mineralocorticoid (MR) receptors in different populations of Xenopus laevis melanotrope cells and revealed their downregulation (MR) and upregulation (GR) during dark background adaptation. Corticosterone did not affect short-term intracellular calcium dynamics and alp...

journal_title：Annals of the New York Academy of Sciences

authors： Roubos EW,Kuribara M,Kuipers-Kwant FJ,Coenen TA,Meijer KH,Cruijsen PM,Denver RJ

更新日期：2009-04-01 00:00:00

abstract：:Entomopathogenic fungi are promising alternatives to chemical acaricides in controlling tick populations; however, biological formulations are required to improve conidial performance of these pathogens in the field. This study evaluated the effect of in vitro treatment of Rhipicephalus sanguineus with conidial formul...

journal_title：Annals of the New York Academy of Sciences

authors： Reis RC,Fernandes EK,Bittencourt VR

更新日期：2008-12-01 00:00:00

abstract：:Human female reproductive aging consists of multiple processes and interacts with other physiological systems in unique ways. Here we discuss eight recent longitudinal, epidemiologic studies of female reproductive aging that include endocrine data to highlight their contributions to our understanding of these various ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrell RJ,Sowers M

更新日期：2010-08-01 00:00:00

abstract：:In Wegener's granulomatosis (WG), antiproteinase 3 (PR3) autoantibodies (PR3-ANCA) are crucial in the development of generalized vasculitis. Wegener's pathognomonic lesion, a granulomatous inflammation of the upper and lower respiratory tract, contains abundant lymphocytes and macrophages. Lymphocyte clusters in germi...

journal_title：Annals of the New York Academy of Sciences

authors： Voswinkel J,Müller A,Lamprecht P

更新日期：2005-06-01 00:00:00

abstract：:The recent identification of tumor-associated antigens (TAA) and TAA-derived peptides presented by MHC molecules to T cells has provided the tools to design and test clinical vaccines for treating human malignancies, such as melanoma. While the most effective adjuvant for use in vaccine formulation remains unclear, au...

journal_title：Annals of the New York Academy of Sciences

authors： Zitvogel L,Couderc B,Mayordomo JI,Robbins PD,Lotze MT,Storkus WJ

更新日期：1996-10-31 00:00:00

abstract：:Developmental dyslexia is associated with problems in a range of linguistic and non-linguistic skills. Some of those problems have been attributed to dysfunction of the cerebellum and its associated neural systems. Two studies of cerebellar structure were undertaken by our group. In Study 1, white and grey matter volu...

journal_title：Annals of the New York Academy of Sciences

authors： Laycock SK,Wilkinson ID,Wallis LI,Darwent G,Wonders SH,Fawcett AJ,Griffiths PD,Nicolson RI

更新日期：2008-12-01 00:00:00

abstract：:Esophageal symptoms are common, and can arise from mucosal, motor, functional, and neoplastic processes, among others. Judicious use of diagnostic testing can help define the etiology of symptoms and can direct management. Endoscopy, esophageal high-resolution manometry (HRM), ambulatory pH or pH-impedance manometry, ...

journal_title：Annals of the New York Academy of Sciences

authors： Gyawali CP,de Bortoli N,Clarke J,Marinelli C,Tolone S,Roman S,Savarino E

更新日期：2018-12-01 00:00:00

abstract：:Stationary-phase mutation (a subset of which was previously called adaptive mutation) occurs in apparently nondividing, stationary-phase cells exposed to a nonlethal genetic selection. In one experimental system, stationary-phase reversion of an Escherichia coli F'-borne lac frameshift mutation occurs by a novel molec...

journal_title：Annals of the New York Academy of Sciences

authors： Lombardo MJ,Torkelson J,Bull HJ,McKenzie GJ,Rosenberg SM

更新日期：1999-05-18 00:00:00

abstract：:The hemorrhagic strokes, intracerebral (ICH) and subarachnoid hemorrhage (SAH), often have poor outcomes. Indeed, the most common hemorrhagic stroke, ICH, has the highest mortality and morbidity rates of any stroke subtype. In this report, we discuss the evidence for the staging of red blood cell removal after ICH and...

journal_title：Annals of the New York Academy of Sciences

authors： Wagner KR,Dwyer BE

更新日期：2004-03-01 00:00:00

abstract：:We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but ...

journal_title：Annals of the New York Academy of Sciences

authors： Jiang Q,Wong J,Ames BN

更新日期：2004-12-01 00:00:00

abstract：:We have previously shown that bone marrow will seed and proliferate in normal recipients. Transfusion of 50 million cells on each of 4 or 5 consecutive days, a total of 200-250 million cells, resulted in the recipient's marrow being 20-40% of donor origin. The present paper reported on the marked enhancement of prolif...

journal_title：Annals of the New York Academy of Sciences

authors： Brecher G,Mulcahy K,Tjio JH,Raveché E

更新日期：1985-01-01 00:00:00

abstract：:Pheochromocytomas (PCCs) are neuroendocrine tumors of chromaffin tissue that produce catecholamines. They are usually located in the adrenal medulla, although in about 10% the tumors arise from extra-adrenal chromaffin tissue. The majority of PCCs arise sporadically, but PCCs occur also in the context of hereditary ca...

journal_title：Annals of the New York Academy of Sciences

authors： Korpershoek E,Van Nederveen FH,Dannenberg H,Petri BJ,Komminoth P,Perren A,Lenders JW,Verhofstad AA,De Herder WW,De Krijger RR,Dinjens WN

更新日期：2006-08-01 00:00:00

abstract：:The HLA genotype DRB1*03,DQB1*0201/DRB1*04,DQB1*0302 confers a 25-fold increase in the risk of type 1 diabetes. In persons with this genotype, DRB1*0405, *0402, and *0401 subtypes have been reported to further increase risk, whereas the *0403 and *0406 alleles confer a relative protection. We compared the frequencies ...

journal_title：Annals of the New York Academy of Sciences

authors： Rewers A,Babu S,Wang TB,Bugawan TL,Barriga K,Eisenbarth GS,Erlich HA

更新日期：2003-11-01 00:00:00

abstract：:The endogenous serum metabolite of vitamin D (calcitriol, 1,25(OH)2 D3 ) is considered a true steroid hormone (D hormone), and like glucocorticoids (GCs) and gonadal hormones, may exert several immunomodulatory activities. Serum vitamin D deficiency (25(OH) D), and therefore reduced 1,25(OH)2 D3 availability, is consi...

journal_title：Annals of the New York Academy of Sciences

authors： Cutolo M,Paolino S,Sulli A,Smith V,Pizzorni C,Seriolo B

更新日期：2014-05-01 00:00:00

abstract：:To investigate the role of poliovirus (PV) infection in the development of the post-polio syndrome (PPS), we studied the serum, spinal fluid, peripheral blood lymphocytes, and muscle from 47 patients with PPS. We found high titers of IgM PV antibodies (up to 1:250) in the serum of 6 patients, compared to very low tite...

journal_title：Annals of the New York Academy of Sciences

authors： Leon-Monzon ME,Dalakas MC

更新日期：1995-05-25 00:00:00

abstract：:The potential of a transdisciplinary research method--Quali-Quantitative Analysis (QQA)--for delivering better evidence for healthy aging is explored. Illustrative reviews from the literature on healthy aging are summarized, as are papers on methodology by Charles Ragin and colleagues. The evidence needs for healthy a...

journal_title：Annals of the New York Academy of Sciences

authors： Bell E

更新日期：2007-10-01 00:00:00