Different vaccine strategies used to protect against Theileria annulata.

Abstract:

:SPAG-1, a sporozoite surface antigen of T. annulata, has previously been shown to elicit partial protection when used, as an hepatitis B core antigen fusion, to immunize cattle. The objective of this study was to try and improve the protective capacity of this antigen by enlisting different vaccine strategies. Cattle were immunized with SPAG-1, as a fusion protein with a His6 tag, either incorporated into ISCOMs, with or without the merozoite antigens TAMS 1-1 and 1-2, or with RWL as adjuvant three times at monthly intervals. Another group of cattle were immunized with p67, the T. parva sporozoite antigen, in RWL to assess whether any cross-protection could be induced. The animals were then challenged with an estimated LD50 of T. annulata sporozoites, and their ability to resist the infection was investigated. Serum responses and T-cell proliferative responses were analyzed throughout the trial. Post-challenge analyses included lymph node biopsies and blood smears to check for the presence of parasites, routine hematological parameters, and observation for clinical manifestations of the disease. The results of this trial will be discussed.

journal_name

Ann N Y Acad Sci

authors

Boulter NR,Brown CG,Kirvar E,Glass E,Campbell J,Morzaria S,Nene V,Musoke A,D'Oliveira C,Gubbels MJ,Jongejan F,Hall FR

doi

10.1111/j.1749-6632.1998.tb11054.x

subject

Has Abstract

pub_date

1998-06-29 00:00:00

pages

234-46

eissn

0077-8923

issn

1749-6632

journal_volume

849

pub_type

杂志文章
  • Self-rewetting fluids: beneficial aqueous solutions.

    abstract::This paper reviews a series of my heat transfer studies of on the so-called "self-rewetting" fluids, in which the Marangoni effect due to concentration gradient and the thermocapillary flow cooperatively result in a strong liquid inflow at the nucleation sites in the course of boiling. First of all, the background of ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1362.026

    authors: Abe Y

    更新日期:2006-09-01 00:00:00

  • Leukemia inhibitory factor and human embryo implantation.

    abstract::The success of embryonic implantation relies on an ideal cross-talk between the embryo and the receptive endometrium. This article focuses on the role of leukemia inhibitory factor (LIF) and its receptors in human embryo implantation. LIF is a secreted glycoprotein first described as a factor that induced the differen...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1335.020

    authors: Aghajanova L

    更新日期:2004-12-01 00:00:00

  • Autologous hematopoietic stem cell transplantation for type 1 diabetes.

    abstract::In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Ho...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1447.048

    authors: Voltarelli JC,Couri CE,Stracieri AB,Oliveira MC,Moraes DA,Pieroni F,Barros GM,Madeira MI,Malmegrim KC,Foss-Freitas MC,Simões BP,Foss MC,Squiers E,Burt RK

    更新日期:2008-12-01 00:00:00

  • Circulating fetal RNA in maternal plasma.

    abstract::The discovery of cell-free nucleic acids in plasma has opened up new possibilities for noninvasive clinical diagnosis. We demonstrate the presence of cell-free fetal RNA in maternal plasma, indicating that plasma fetal RNA might be used as a marker for noninvasive prenatal diagnosis. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2001.tb03887.x

    authors: Poon LL,Leung TN,Lau TK,Lo YM

    更新日期:2001-09-01 00:00:00

  • Renal tubule sodium transporter abundance profiling in rat kidney: response to aldosterone and variations in NaCl intake.

    abstract::Based on extensive physiological study of sodium transport mechanisms along the renal tubule, complementary DNAs for all of the major transporters and channels responsible for renal tubular sodium reabsorption have been cloned over the past decade. There is now a comprehensive set of cDNA and antibody probes that can ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07254.x

    authors: Knepper MA,Kim GH,Masilamani S

    更新日期:2003-04-01 00:00:00

  • Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke.

    abstract::Stroke is a common and often fatal event, and, in survivors, it is accompanied by a high risk of recurrence. Ischemic stroke is associated with abnormal platelet activity and thrombus formation. In addition to their roles in the development of acute thrombi, platelets serve as a bridge for leukocytes within the vascul...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2010.05733.x

    authors: Franks ZG,Campbell RA,Weyrich AS,Rondina MT

    更新日期:2010-10-01 00:00:00

  • The substance P and somatostatin interferon-gamma immunoregulatory circuit.

    abstract::Murine schistosomiasis mansoni is a parasitic disease in which flukes living in the portal vein of the host produce ova that deposit in the liver and intestines. In these organs, ova release antigens that induce chronic, focal granulomatous inflammation. IFN-gamma is an inflammatory cytokine important in macrophage ac...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09592.x

    authors: Weinstock JV,Elliott D

    更新日期:1998-05-01 00:00:00

  • Molecular evidence of Coxiella-like microorganism harbored by Haemaphysalis concinnae ticks in the Russian Far East.

    abstract::Twenty female imago of Haemaphysalis concinnae ticks collected from wild vegetation in May of 2001 in the Obor region near Khabarovsk in the Russian Far East were studied. DNA was extracted with commercially available kits following manufacturer's instructions. We used broad range primers SFG3 and SFG6 proposed for am...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb07367.x

    authors: Mediannikov O,Ivanov L,Nishikawa M,Saito R,Sidelnikov YN,Zdanovskaya NI,Tarasevich IV,Suzuki H

    更新日期:2003-06-01 00:00:00

  • Production of neurotoxic factors by brain endothelium in Alzheimer's disease.

    abstract::The cerebral vasculature is central to the maintenance of the neuronal microenvironment. We have previously demonstrated that brain microvessels in Alzheimer's disease produce high, potentially toxic, levels of nitric oxide. It is our hypothesis that neuronal injury in Alzheimer's disease occurs because an abnormal en...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1997.tb48460.x

    authors: Grammas P,Botchlet TR,Moore P,Weigel PH

    更新日期:1997-09-26 00:00:00

  • Reproductive aging: theoretical perspectives, mechanisms, nonhuman models, and health correlates.

    abstract::Every 365.2421999 days--more or less--the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/j.1749-6632.2010.05700.x

    authors: Haaga J,O'Connor K,Weinstein M,Wise P

    更新日期:2010-08-01 00:00:00

  • Mechanisms of hypothalamic-pituitary-adrenal axis stimulation by immune signals in the adult rat.

    abstract::Immune stimulation increases the activity of the HPA axis, a phenomenon directly or indirectly mediated through cytokines. We have used two models, the peripheral administration of endotoxin (LPS) or turpentine-induced tissue injury to show that corticotropin-releasing factor (CRF) and vasopressin (VP), hypothalamic p...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09582.x

    authors: Turnbull AV,Lee S,Rivier C

    更新日期:1998-05-01 00:00:00

  • Studies of Ca2+ release from sarcoplasmic reticulum.

    abstract::Our studies of Ca2+ release have shown that three classes of compounds--quercetin, which inhibits Ca2+ release by reversal of the Ca2+ pump, H+ ionophores and DCCD, which affect proton gradients, and lipophilic anions, which act to oppose a separation of membrane surface charges--all have potential in probing the mech...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1982.tb25769.x

    authors: MacLennan DH,Shoshan V,Wood DS

    更新日期:1982-01-01 00:00:00

  • Genetic responses to free radicals. Homeostasis and gene control.

    abstract::Gene regulation mechanisms have evolved allowing cells to finetune the level of "endogenous" oxidative stress and to cope with increased free radicals from external sources. Levels of H2O2 are tightly controlled in E. coli by OxyR, which is activated by H2O2 to increase scavenging activities and limit H2O2 generation ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2000.tb06177.x

    authors: González-Flecha B,Demple B

    更新日期:2000-01-01 00:00:00

  • Dispersion and surface characteristics of nanosilica suspensions.

    abstract::Nanofluids consisting of nanometer-sized particles dispersed in base liquids are known to be effective in extending the saturated boiling regime and critical heat flux in pool boiling. The heat transfer characteristics of nanosilica suspensions with particle sizes of 10 and 20 nm in pool boiling with a suspended heati...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.04334.x

    authors: Kumar R,Milanova D

    更新日期:2009-04-01 00:00:00

  • Sex steroids and human behavior: prenatal androgen exposure and sex-typical play behavior in children.

    abstract::Gonadal hormones, particularly androgens, direct certain aspects of brain development and exert permanent influences on sex-typical behavior in nonhuman mammals. Androgens also influence human behavioral development, with the most convincing evidence coming from studies of sex-typical play. Girls exposed to unusually ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1286.026

    authors: Hines M

    更新日期:2003-12-01 00:00:00

  • Identification of carcinogenic agents and primary prevention of cancer.

    abstract::During the annual Ramazzini Days, the Mayor of Carpi confers the Ramazzini Award on scientists deemed by the Collegium Ramazzini to have made outstanding contributions to furthering the aims of Bernardino Ramazzini in safeguarding public health. Dr. Lorenzo Tomatis was the Ramazzini Award recipient in 2005, and the pr...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1371.039

    authors: Tomatis L

    更新日期:2006-09-01 00:00:00

  • Reducing emissions from deforestation and forest degradation (REDD+): game changer or just another quick fix?

    abstract::Reducing emissions from deforestation and forest degradation (REDD+) provides financial compensation to land owners who avoid converting standing forests to other land uses. In this paper, we review the main opportunities and challenges for REDD+ implementation, including expectations for REDD+ to deliver on multiple ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06306.x

    authors: Venter O,Koh LP

    更新日期:2012-02-01 00:00:00

  • Effect of saiboku-to (TJ-96) on bronchial asthma. Induction of glucocorticoid receptor, beta-adrenaline receptor, IgE-Fc epsilon receptor expression and its effect on experimental immediate and late asthmatic reaction.

    abstract::A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 ag...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1993.tb35918.x

    authors: Nakajima S,Tohda Y,Ohkawa K,Chihara J,Nagasaka Y

    更新日期:1993-06-23 00:00:00

  • Tight-junctional modification as the basis of osmotic opening of the blood-brain barrier.

    abstract::Osmotic opening of the blood-brain barrier (BBB) most likely is mediated by modification of interendothelial tight junctions, subsequent to shrinkage of cerebrovascular endothelial cells, and not by stimulation of transendothelial vesicular transport or by channel formation. This paper summarizes evidence for this con...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1986.tb27155.x

    authors: Rapoport SI,Robinson PJ

    更新日期:1986-01-01 00:00:00

  • Tight junctions: molecular structure meets function.

    abstract::Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically "seal" the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/j.1749-6632.2009.04925.x

    authors: Schulzke JD,Fromm M

    更新日期:2009-05-01 00:00:00

  • Analysis of Xenopus melanotrope cell size and POMC-gene expression.

    abstract::Flow cytometry was used to separate Xenopus melanotrope cells according to their size. The cells were then submitted to real-time RT-PCR to determine the level of POMC-gene expression. The results show a positive correlation between cell size and gene expression for cells from black-background (but not white-backgroun...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1327.040

    authors: Corstens GJ,Roubos EW,Jenks BG,Van Erp PE

    更新日期:2005-04-01 00:00:00

  • Structure of the type II collagen gene.

    abstract::In summary, the exon/intron structure of the chicken type II collagen gene is identical with that of the chicken alpha 2(I) collagen gene and differs at only one known position from the human and mouse alpha 1(I) genes. However, the chicken type II gene is different from the chicken alpha 2(I) gene in that it is consi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb51161.x

    authors: Upholt WB,Strom CM,Sandell LJ

    更新日期:1985-01-01 00:00:00

  • Regulation of angiogenesis by controlling VEGF receptor.

    abstract::The endothelial cells cultured in collagen gel caused upregulation of KDR expression, which resulted in an increase in tube formation. Endothelial cells exposed to high glucose (33 mmol/l) for 30 days increased the tube formation induced by VEGF, but not by serum and bFGF. Immunohistochemical study showed that KDR exp...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06315.x

    authors: Murota SI,Onodera M,Morita I

    更新日期:2000-05-01 00:00:00

  • Cellular and molecular aspects of thymic T-cell education in neuroendocrine self principles. Implications for autoimmunity.

    abstract::Thymic epithelial and nurse cells from different species express a repertoire of neuroendocrine polypeptide precursors. This repertoire exerts a dual role in T-lymphocyte selection according to their status either as cryptocrine signals or as neuroendocrine self-antigens of the peptide sequences that are processed fro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb09572.x

    authors: Geenen V,Martens H,Vandersmissen E,Achour I,Kecha O,Franchimont D

    更新日期:1998-05-01 00:00:00

  • Alternative treatments for adults with attention-deficit hyperactivity disorder (ADHD).

    abstract::A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05788.x

    authors: Arnold LE

    更新日期:2001-06-01 00:00:00

  • Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome.

    abstract::A four- to fivefold overexpression of the gene for the Alzheimer beta/A4 amyloid precursor protein (APP) in individuals with Down's Syndrome (DS) appears to be responsible for the fifty year earlier onset of Alzheimer's disease (AD) pathology in DS compared to the normal population. It is therefore likely that a dereg...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb23035.x

    authors: Beyreuther K,Pollwein P,Multhaup G,Mönning U,König G,Dyrks T,Schubert W,Masters CL

    更新日期:1993-09-24 00:00:00

  • Evolutionary genetics of the melanocortin-1 receptor in vertebrates.

    abstract::The molecular genetic basis of adaptive change in phenotype is a major outstanding issue in evolutionary biology. Evolutionary change in coat and plumage color is a promising system for making progress in this field. Most notably, recent work on the molecular genetic basis of hair and feather color has identified seve...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2003.tb03194.x

    authors: Mundy NI,Kelly J,Theron E,Hawkins K

    更新日期:2003-06-01 00:00:00

  • Combinatorial control of ATF4-dependent gene transcription in osteoblasts.

    abstract::Osteoblast-specific gene transcription requires interaction between bone cell-specific transcription factors and more widely expressed transcriptional regulators. This is particularly evident for the basic domain-leucine zipper factor activating transcription factor 4 (ATF4), whose activity can be enhanced or inhibite...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2011.06197.x

    authors: St-Arnaud R,Hekmatnejad B

    更新日期:2011-11-01 00:00:00

  • Neuroprotection trek--the next generation: the measurement is the message.

    abstract::Animal trials of many pharmacological neuroprotective agents have been quite successful, whereas trials in humans have been uniformly disappointing. A major difference between laboratory research in animals and clinical research in humans is the amount and/or quality of data obtained. The goal of this presentation is ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1344.001

    authors: Andrews RJ

    更新日期:2005-08-01 00:00:00

  • Structure and macromolecular organization of type VI collagen.

    abstract::Collagen VI is a large, disulfide-bonded protein complex which is widely distributed in connective tissue. The constituent polypeptide chains (Mr = 110,000-140,000) consist of collagenous and noncollagenous segments, are degraded to chains of about half the size when collagen VI is solubilized by pepsin, and assemble ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb51154.x

    authors: Engel J,Furthmayr H,Odermatt E,von der Mark H,Aumailley M,Fleischmajer R,Timpl R

    更新日期:1985-01-01 00:00:00