High expression of inducible nitric oxide synthase correlates with intestinal inflammation of interleukin-2-deficient mice.

abstract：:Mouse models with targeted deletion of the genes encoding the enzyme 25-hydroxyvitamin D 1alpha-hydroxylase [1alpha(OH)ase], and the vitamin D receptor (VDR), have provided considerable insight into the regulation of mineral and skeletal physiology by 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. Dietary manipulation induce...

journal_title：Annals of the New York Academy of Sciences

authors： Goltzman D

更新日期：2010-03-01 00:00:00

abstract：:In his First Law (of thermodynamics), Clausius emphasized the equivalence of heat and work-conservation of energy was mentioned only indirectly. Today, the main emphasis is put on energy conservation, but the equivalence of heat and work has proven not only to be superfluous, but also highly destructive. Because of th...

journal_title：Annals of the New York Academy of Sciences

authors： Job G,Lankau T

更新日期：2003-05-01 00:00:00

abstract：:Lymphotoxin is a protein with a MW of 45,000 daltons derived from activated lymphocytes that kills target cells nonspecifically. Kinetic studies indicate that there is a lag period of about 4 hours before cytotoxicity becomes apparent, even at high concentrations of lymphotoxin. Therefore, the role of lymphotoxin in c...

journal_title：Annals of the New York Academy of Sciences

authors： Mayer MM,Gately MK,Okamoto M,Shin ML,Willoughby JB

更新日期：1979-01-01 00:00:00

abstract：:The endoplasmic reticulum (ER) is responsible for protein processing. In rapidly proliferating tumor cells, the ER tends to be overloaded with unfolded and misfolded proteins due to high metabolic demand. With the limited protein-folding capacity of the ER, tumor cells often suffer from more ER stress than do normal c...

journal_title：Annals of the New York Academy of Sciences

authors： Suh DH,Kim MK,Kim HS,Chung HH,Song YS

更新日期：2012-10-01 00:00:00

abstract：:In the present research, the relationship between various semantic memory functions and episodic odor memory across the adult life span is addressed. In contrast to earlier evidence that odors may be encoded and stored as unique, nonlinguistic whole percepts, the present work suggests that episodic odor information is...

journal_title：Annals of the New York Academy of Sciences

authors： Larsson M,Bäckman L

更新日期：1998-11-30 00:00:00

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00

abstract：:In adult Lurcher mice virtually all cerebellar Purkinje cells have degenerated as a direct consequence of mutant gene action, providing a natural model for studying the effect of cerebellar cortical lesions on the generation of compensatory eye movements. Lurcher mice possess both optokinetic (OKR) and vestibular (VOR...

journal_title：Annals of the New York Academy of Sciences

authors： Van Alphen AM,Schepers T,Luo C,De Zeeuw CI

更新日期：2002-12-01 00:00:00

abstract：:Lipogenesis occurs primarily in the liver, where dietary carbohydrates control the expression of key enzymes in glycolytic and lipogenic pathways. We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), is required for de novo fatty acid syn...

journal_title：Annals of the New York Academy of Sciences

authors： Glimcher LH,Lee AH

更新日期：2009-09-01 00:00:00

abstract：:The tumor suppressor p53 is a phosphoprotein barely detectable in the nucleus of normal cells. Upon cellular stress, particularly that induced by DNA damage, p53 can arrest cell cycle progression, thus allowing the DNA to be repaired; or it can lead to apoptosis. These functions are achieved, in part, by the transacti...

journal_title：Annals of the New York Academy of Sciences

authors： Soussi T

更新日期：2000-06-01 00:00:00

abstract：:Membrane processes are receiving increasing attention in the scientific community and in industry because in many cases they offer a favorable alternative to processes that are not easy to achieve by conventional routes. In this context, membranes made with perfluorinated polymers are of particular interest because of...

journal_title：Annals of the New York Academy of Sciences

authors： Arcella V,Ghielmi A,Tommasi G

更新日期：2003-03-01 00:00:00

abstract：:Estrogens are represented by a diverse group of compounds. Within this large family of molecules are tissue-selective estrogens that have been classified as selective estrogen receptor modulators (SERMs). These compounds are characterized by the fact that they exhibit both estrogen agonist and antagonist activity depe...

journal_title：Annals of the New York Academy of Sciences

authors： Komm BS,Lyttle CR

更新日期：2001-12-01 00:00:00

abstract：:Murine schistosomiasis mansoni is a parasitic disease in which flukes living in the portal vein of the host produce ova that deposit in the liver and intestines. In these organs, ova release antigens that induce chronic, focal granulomatous inflammation. IFN-gamma is an inflammatory cytokine important in macrophage ac...

journal_title：Annals of the New York Academy of Sciences

authors： Weinstock JV,Elliott D

更新日期：1998-05-01 00:00:00

abstract：:Aging is the outcome of the contest between chemistry and biology in living systems. Chronic, cumulative chemical modifications compromise the structure and function of biomolecules throughout the body. Proteins with long life spans serve as cumulators of exposure to chemical damage, which is detectable in the form of...

journal_title：Annals of the New York Academy of Sciences

authors： Baynes JW

更新日期：2002-04-01 00:00:00

abstract：:Very recently, we identified two distinct mesenchymal stem cell (MSC) subsets in primary bone marrow (BM) that differ in their expression pattern (CD271(bright)MSCA-1(dim)CD56(+) and CD271(bright)MSCA-1(bright)CD56(-)) and morphology as well as in their clonogenic and differentiation capacity. Here we analyzed the cel...

journal_title：Annals of the New York Academy of Sciences

authors： Bühring HJ,Treml S,Cerabona F,de Zwart P,Kanz L,Sobiesiak M

更新日期：2009-09-01 00:00:00

abstract：:Whole body exposure of rabbits to microwave radiation causes a decrease in ascorbic acid in the lens. In our study, rabbit lenses maintained in culture medium (37 degrees C) were exposed to either pulsed or continuous wave S-band radiation for 10-15 min at power densities between 0 and 200 mW/cm-2. Total ascorbic acid...

journal_title：Annals of the New York Academy of Sciences

authors： Weiter JJ,Finch ED,Schulz W,Frattali V

更新日期：1975-02-28 00:00:00

abstract：:This brief review is designed to highlight the limitations of our knowledge given the difficulties in simulating the in vivo condition in models established in vitro and ex vivo. Despite this uncertainty, mounting evidence indicates that the GPIIb-IIIa receptor mediates crucial platelet functions and that control over...

journal_title：Annals of the New York Academy of Sciences

authors： Coller BS

更新日期：1987-01-01 00:00:00

abstract：:Results obtained from projects in which self-organizing musical structures spontaneously arise through electrical interface between the brain and generative musical systems are surveyed. This provides a springboard for examining important paradigm shifts taking place in our thinking about what musical forms can be and...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenboom D

更新日期：2003-11-01 00:00:00

abstract：:Olivary fibers express CGRP-LI until the nest phase of their development and never in the next postnatal steps, that is, the "capuchon" stage. Together with other results presented in this volume regarding the postnatal development of CGRP binding sites in the cerebellar cortex, these immunohistologic findings suggest...

journal_title：Annals of the New York Academy of Sciences

authors： Morara S,Rosina A,Provini L

更新日期：1992-06-30 00:00:00

abstract：:In two experiments, musically trained and untrained adults were tested on their ability to match spoken utterances with their tonal analogues (tone sequences that retained the pitch and temporal patterns of the utterances). In both cases, musical training was associated with superior performance, indicating an enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Thompson WF,Schellenberg EG,Husain G

更新日期：2003-11-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a serious, chronic condition that, without early recognition and treatment, leads to progressive right heart failure and death. The dual endothelin receptor antagonist macitentan was designed through a deliberate discovery process to maximize endothelin-axis blockade while impr...

journal_title：Annals of the New York Academy of Sciences

authors： Selej M,Romero AJ,Channick RN,Clozel M

更新日期：2015-11-01 00:00:00

abstract：:Bipolar disorder is a chronic, recurrent illness that ranks among the top 10 causes of disability in the developed world. As the illness progresses, major depressive episodes increasingly predominate. However, few treatment options are available that have demonstrated efficacy in the treatment of bipolar depression, e...

journal_title：Annals of the New York Academy of Sciences

authors： Loebel A,Xu J,Hsu J,Cucchiaro J,Pikalov A

更新日期：2015-11-01 00:00:00

abstract：:Unfortunately, all of the problems of the hemophiliac have not been solved by the availability of concentrated factor VIII products. Patients still are faced with the crippling effects of arthritis, problems with employment, problems with ignorance (both medical and lay), and an increased risk of premature death even ...

journal_title：Annals of the New York Academy of Sciences

authors： Breckenridge RT

更新日期：1975-01-20 00:00:00

abstract：:The resolution of antibiotic-ribosomal subunit complexes and antibacterial-protein complexes at the atomic level has provided new insights into modifications of clinically relevant antimicrobials and provided new classes that target the protein cellular apparatus. New chemistry platforms that use fragment-based drug d...

journal_title：Annals of the New York Academy of Sciences

authors： Sutcliffe JA

更新日期：2011-12-01 00:00:00

abstract：:The behavior of neurons in the basal ganglia is severely disrupted in Parkinson's disease (PD). In nonhuman parkinsonian primate models, the disturbance in neurons in basal ganglia output structures include increased firing, bursting, an augmented synchrony, correlated activity, and a tendency towards loss of specific...

journal_title：Annals of the New York Academy of Sciences

authors： Hamani C,Lozano AM

更新日期：2003-06-01 00:00:00

abstract：:The distinction between episodic and semantic memory has become very popular since it was first proposed by Tulving in 1972. So far, very few neuropsychological, psychophysical, and imaging studies have related to the mnemonic aspects of music, notably on the long-term memory features, and practically nothing is known...

journal_title：Annals of the New York Academy of Sciences

authors： Platel H

更新日期：2005-12-01 00:00:00

abstract：:Several reports indicate the presence of infection with Anaplasma phagocytophila in Europe. The first case with confirmed human granulocytic ehrlichiosis was reported from Slovenia in 1997. By 2002, 13 patients have been discovered in a prospective study on the etiology of febrile illnesses occurring within six weeks ...

journal_title：Annals of the New York Academy of Sciences

authors： Lotric-Furlan S,Petrovec M,Avsic-Zupanc T,Strle F

更新日期：2003-06-01 00:00:00

abstract：:The Balb/c mice were infected with Coxiella burnetii and samples of blood and major organs from the infected mice were collected on days 1 to 14 after infection. The DNAs extracted from the samples were detected by a developed real-time quantitative PCR specific for C. burnetii and high loads of C. burnetii were found...

journal_title：Annals of the New York Academy of Sciences

authors： Zhang J,Wen B,Chen M,Zhang J,Niu D

更新日期：2005-12-01 00:00:00

abstract：:Deposition of amyloid beta protein in the brain is the major pathological feature of Alzheimer's disease. Amyloid beta protein is generated from beta-amyloid precursor protein by beta-secretase and gamma-secretase. Proteolytic processing of amyloid precursor protein at the beta site by BACE1 is essential to generate a...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou W,Qing H,Tong Y,Song W

更新日期：2004-12-01 00:00:00

abstract：:This paper describes the flight experiment, supporting ground science, and the design rationale for a project on spaceflight holography investigation in a virtual apparatus (SHIVA). SHIVA is a fundamental study of particle dynamics in fluids in microgravity. Gravitation effects and steady Stokes drag often dominate th...

journal_title：Annals of the New York Academy of Sciences

authors： Trolinger JD,L'Esperance D,Rangel RH,Coimbra CF,Witherow WK

更新日期：2004-11-01 00:00:00

abstract：:In rats, arginine vasopressin augments bradycardia associated with baroreflex activation. We investigated whether modulation of peripheral cardiac parasympathetic nerve function by AVP may play a role in this effect. To accomplish this we utilized an in vivo model with which we previously demonstrated both adrenergic ...

journal_title：Annals of the New York Academy of Sciences

authors： Pardini BJ,Lund DD,Schmid PG

更新日期：1993-07-22 00:00:00