Is PR3-ANCA formation initiated in Wegener's granulomatosis lesions? Granulomas as potential lymphoid tissue maintaining autoantibody production.

abstract：:The potential of a transdisciplinary research method--Quali-Quantitative Analysis (QQA)--for delivering better evidence for healthy aging is explored. Illustrative reviews from the literature on healthy aging are summarized, as are papers on methodology by Charles Ragin and colleagues. The evidence needs for healthy a...

journal_title：Annals of the New York Academy of Sciences

authors： Bell E

更新日期：2007-10-01 00:00:00

abstract：:The induction of ornithine decarboxylase (ODC) during G1 phase of the cell cycle appears to be universal and essential for cell cycle progression. This induction has been demonstrated in at least 23 cell types in response to various growth stimuli. Further, specific inhibitors of ODC added to several of these cell lin...

journal_title：Annals of the New York Academy of Sciences

authors： Russell DH,Haddox MK

更新日期：1981-02-27 00:00:00

abstract：:Human epidemiologic studies provide convincing evidence that dietary patterns practiced during adulthood are important contributors to age-related cognitive decline and dementia risk. Diets high in fat, especially trans and saturated fats, adversely affect cognition, while those high in fruits, vegetables, cereals, an...

journal_title：Annals of the New York Academy of Sciences

authors： Parrott MD,Greenwood CE

更新日期：2007-10-01 00:00:00

abstract：:Rapid advances in the biomedical sciences are producing new means of intervention against many of the major tropical diseases. The discovery of new drugs, vaccines and diagnostic tests, however, is only the first, though important, step down an often long and difficult road to their effective deployment in disease con...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PG

更新日期：1989-01-01 00:00:00

abstract：:Both orbital and attitude dynamics employ the method of variation of parameters. In a non-perturbed setting, the coordinates (or the Euler angles) are expressed as functions of the time and six adjustable constants called elements. Under disturbance, each such expression becomes ansatz, the "constants" being endowed w...

journal_title：Annals of the New York Academy of Sciences

authors： Efroimsky M

更新日期：2005-12-01 00:00:00

abstract：:Language and music are human universals involving perceptually discrete elements organized in hierarchically structured sequences. The set of principles governing the combination of these structural elements into sequences is known as syntax. A violation of expectancies concerning syntactic regularities may be reflect...

journal_title：Annals of the New York Academy of Sciences

authors： Jentschke S,Koelsch S,Friederici AD

更新日期：2005-12-01 00:00:00

abstract：:Clostridium difficile infection, also known as C. difficile-associated diarrhea (CDAD), is the most common cause of nosocomial diarrhea, typically initiated by the use of broad-spectrum antibiotics that disrupt gut flora, thereby allowing C. difficile to proliferate. It is an increasing cause of morbidity and mortalit...

journal_title：Annals of the New York Academy of Sciences

authors： Sears P,Ichikawa Y,Ruiz N,Gorbach S

更新日期：2013-07-01 00:00:00

abstract：:The Ca2+-pump ATPase of human RBC membranes appears to be exquisitely sensitive to a variety of amphipathic molecules. The acidic protein calmodulin (CaM) activates the enzyme some three- to fivefold with an apparent Kd of approximately 1-5 nM. A variety of other amphipathic anions, such as acidic phospholipids, free ...

journal_title：Annals of the New York Academy of Sciences

authors： Vincenzi FF

更新日期：1982-01-01 00:00:00

abstract：:High concentrations of glucose induce insulin resistance and impair insulin secretion in a manner that mirrors type 2 diabetes, a phenomenon known as glucose toxicity. High concentrations of hexosamines mimic these effects, leading to the hypothesis that cells use hexosamine flux as a glucose- and satiety-sensing path...

journal_title：Annals of the New York Academy of Sciences

authors： Cooksey RC,McClain DA

更新日期：2002-06-01 00:00:00

abstract：:Hantaviruses belong to the Bunyaviridae family. While usually hosted by wild mammals, they are potentially pathogenic for humans, and several serologically distinct groups associated with different syndromes have been identified. Yet, investigations have mostly been conducted where human infections by hantaviruses con...

journal_title：Annals of the New York Academy of Sciences

authors： Henttonen H,Buchy P,Suputtamongkol Y,Jittapalapong S,Herbreteau V,Laakkonen J,Chaval Y,Galan M,Dobigny G,Charbonnel N,Michaux J,Cosson JF,Morand S,Hugot JP

更新日期：2008-12-01 00:00:00

abstract：:Although smell loss has several potential etiologies (e.g., head trauma, allergic rhinitis, and enlarged adenoids) that are common among children, studies evaluating the prevalence of olfactory dysfunction in the pediatric population are rare. Several challenges confront the clinician or researcher hoping to evaluate ...

journal_title：Annals of the New York Academy of Sciences

authors： Dalton P,Mennella JA,Cowart BJ,Maute C,Pribitkin EA,Reilly JS

更新日期：2009-07-01 00:00:00

abstract：:The purpose of the Big Data to Knowledge initiative is to develop methods for discovering new knowledge from large amounts of data. However, if the resulting knowledge is so large that it resists comprehension, referred to here as Big Knowledge (BK), how can it be used properly and creatively? We call this secondary c...

journal_title：Annals of the New York Academy of Sciences

authors： Perl Y,Geller J,Halper M,Ochs C,Zheng L,Kapusnik-Uner J

更新日期：2017-01-01 00:00:00

abstract：:Although it is now well established that imidazoline receptors and alpha 2-adrenoceptors are discrete entities with distinct endogenous ligands, the two receptor classes apparently have several common features. While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidin...

journal_title：Annals of the New York Academy of Sciences

authors： Hieble JP,Ruffolo RR Jr

更新日期：1995-07-12 00:00:00

abstract：:Most ecological economists believe that the transition to a steady-state economy is necessary to ensure ecological sustainability and to maximize a nation's economic welfare. While some observers agree with the necessity of the steady-state economy, they are nonetheless critical of the suggestion made by ecological ec...

journal_title：Annals of the New York Academy of Sciences

authors： Lawn P

更新日期：2011-02-01 00:00:00

abstract：:In keeping with the inflammatory paradigm of abdominal aortic aneurysm (AAA) pathophysiology, in vitro studies suggest that aneurysms secrete the proinflammatory cytokine interleukin-6 (IL-6). Circulating IL-6 levels are higher in patients with AAA with elevated circulating IL-6 an independent risk factor for cardiova...

journal_title：Annals of the New York Academy of Sciences

authors： Dawson J,Cockerill G,Choke E,Loftus I,Thompson MM

更新日期：2006-11-01 00:00:00

abstract：:The classic cardiac research programs revolved around measurable properties such as pressures, work done, vascular blood flow, electrical propagation, and other such parameters that defined the global heart functions in health and decease. Consistently, the first Henry Goldberg Workshop, held in Haifa in 1984, focused...

journal_title：Annals of the New York Academy of Sciences

authors： Beyar R

更新日期：2005-06-01 00:00:00

abstract：:Rapamycin (RAPA), an inhibitor of mTORC signaling, has been shown to extend life span in mice and other organisms. Recently, animal and human studies have suggested that inhibition of mTORC signaling can alleviate or prevent the development of cardiomyopathy. In view of this, we used a murine model of type 2 diabetes ...

journal_title：Annals of the New York Academy of Sciences

authors： Reifsnyder PC,Ryzhov S,Flurkey K,Anunciado-Koza RP,Mills I,Harrison DE,Koza RA

更新日期：2018-04-01 00:00:00

abstract：:Release of the amyloid precursor protein (APP) of Alzheimer's disease from Swiss 3T3 fibroblasts was stimulated in a concentration-dependent manner by phorbol 12-myristate 13-acetate. In fibroblasts overexpressing protein kinase C alpha (PKC alpha), the EC50 for this response was 7 nM, while in control cells the EC50 ...

journal_title：Annals of the New York Academy of Sciences

authors： Slack BE,Nitsch RM,Livneh E,Kunz GM Jr,Eldar H,Wurtman RJ

更新日期：1993-09-24 00:00:00

abstract：:Adaptive co-evolution of mammals and bacteria has led to the establishment of complex commensal communities on mucosal surfaces. In spite of having available a wealth of immune-sensing and effector mechanisms capable of triggering inflammation in response to microbial intrusion, mucosal immune cells establish an intim...

journal_title：Annals of the New York Academy of Sciences

authors： Cerutti A,Cols M,Gentile M,Cassis L,Barra CM,He B,Puga I,Chen K

更新日期：2011-11-01 00:00:00

abstract：:Musical enculturation is a complex, multifaceted process that includes the development of perceptual processing specialized for the pitch and rhythmic structures of the musical system in the culture, understanding of esthetic and expressive norms, and learning the pragmatic uses of music in different social situations...

journal_title：Annals of the New York Academy of Sciences

authors： Trainor LJ,Marie C,Gerry D,Whiskin E,Unrau A

更新日期：2012-04-01 00:00:00

abstract：:How can people adaptively analyze and "work through" negative feelings without ruminating? This paper will briefly review findings from an integrative program of research, which suggests that a critical factor determining whether people's attempts to adaptively reason about negative experiences succeed or fail is the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kross E

更新日期：2009-06-01 00:00:00

abstract：UNLABELLED:Hepatocarcinogenesis is a multistep process characterized by hepatocyte inflammation, regeneration, and proliferation. These changes are believed to depend on the aberrant expression of various tumor suppressor genes, oncogenes and growth factors. Several studies have shown the involvement of cyclooxygenase-...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Ingrao S,Soresi M,Florena AM,La Spada E,Sandonato L,D'Alessandro N,Cervello M,Montalto G

更新日期：2009-02-01 00:00:00

abstract：:Methamphetamine (METH) is one of the major drugs of abuse that is postulated to cause neurotoxicity by depleting dopamine (DA) and its metabolites, high-affinity DA uptake sites, and the activity of tyrosine hydroxylase. The present study was undertaken to investigate whether the relatively selective, neuronal nitric ...

journal_title：Annals of the New York Academy of Sciences

authors： Ali SF,Itzhak Y

更新日期：1998-05-01 00:00:00

abstract：:Mitochondrial dysfunction is a common characteristic of all neurodegenerative diseases. However, the cause of this dysfunction remains a mystery. Here, we discuss the potential role of mitochondrial fission and fusion in the onset and progression of neurodegenerative diseases. Specifically, we propose that an imbalanc...

journal_title：Annals of the New York Academy of Sciences

authors： Knott AB,Bossy-Wetzel E

更新日期：2008-12-01 00:00:00

abstract：:The 1,4-dihydropyridine-sensitive voltage-gated Ca2+ channel is widely distributed in excitable cells. The channel and its several associated drug binding sites are known to be up- and downregulated by a variety of homologous and heterologous influences including membrane depolarization. The neurosecretory GH4C1 cell ...

journal_title：Annals of the New York Academy of Sciences

authors： Liu J,Rutledge A,Triggle DJ

更新日期：1995-09-15 00:00:00

abstract：:The National Institutes of Health's Clinical and Translational Science Award (CTSA) program has had a profound impact on clinical research and training methods at the University of California, Davis (UC Davis). UC Davis was among the first 12 institutions to receive NIH funding for this award, and created its Clinical...

journal_title：Annals of the New York Academy of Sciences

authors： Kasim-Karakas S,Hyson D,Halsted C,van Loan M,Chedin E,Berglund L

更新日期：2010-03-01 00:00:00

abstract：:The human spatial orientation system is highly complex and nonlinear. It is difficult, therefore, to arrive at an unequivocal model of the underlying processing by merely combining the known elementary mechanisms ("bottom-up" approach); additional "top-down" concepts are required to narrow the choice between several f...

journal_title：Annals of the New York Academy of Sciences

authors： Mergner T,Becker W

更新日期：2003-10-01 00:00:00

abstract：:Hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis is often observed in association with and even prior to the onset of major depression. It is presently unclear (1) which molecular and cellular processes contribute to hyperactivity of parvocellular hypothalamic neurons (key regulators of the HPA system) an...

journal_title：Annals of the New York Academy of Sciences

authors： Joëls M,Verkuyl JM,Van Riel E

更新日期：2003-12-01 00:00:00

abstract：:Improved technology and medical advances have increased the lifespan for people with thalassemia. As thalassemia is no longer exclusively a pediatric blood disorder, consideration must now be given to transition planning from pediatric to adult care. The complexity of thalassemia disease, coupled with the changing fac...

journal_title：Annals of the New York Academy of Sciences

authors： Levine L,Levine M

更新日期：2010-08-01 00:00:00

abstract：:Genome architecture is well diversified among eukaryotes in terms of size and content, with many being radically shaped by ancient and ongoing genome conflicts with transposable elements (e.g., the large transposon-rich genomes common among plants). In ciliates, a group of microbial eukaryotes with distinct somatic an...

journal_title：Annals of the New York Academy of Sciences

authors： Maurer-Alcalá XX,Nowacki M

更新日期：2019-07-01 00:00:00