Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms.

abstract：:In type 1 diabetes mellitus (T1DM), the frequency of antibodies against insulin (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell antigens (ICA) vary with human leukocyte antigen (HLA) composition of the patient. IAA, IA2 autoantibodies, and ICA are increased in DQ8 positives; GAD65 antib...

journal_title：Annals of the New York Academy of Sciences

authors： Gupta M,Graham J,McNeeny B,Zarghami M,Landin-Olsson M,Hagopian WA,Palmer J,Lernmark A,Sanjeevi CB

更新日期：2006-10-01 00:00:00

abstract：UNLABELLED:This article suggests eight high-level concepts that can promote convergence by identifying analogies across fields of science and engineering. CONSERVATION: Many properties are conserved, through symmetries, parity laws, and feedback-regulated stabilities in complex adaptive systems. INDECISION: Inconsisten...

journal_title：Annals of the New York Academy of Sciences

authors： Bainbridge WS

更新日期：2006-12-01 00:00:00

abstract：:A cardinal feature of neurons is the morphological polarity of neurons with serious functional implications. Typically, a neuron has a single axon and several dendrites. Neuronal polarity is essential for the unidirectional signal flow from somata or dendrites to axons in neurons. The initial event in establishing a p...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshimura T,Arimura N,Kaibuchi K

更新日期：2006-11-01 00:00:00

abstract：:Deregulation of signaling pathways is a common feature observed in human cancers and other diseases. Therefore, there is a strong need for compounds that are able to modulate or inactivate upregulated signaling events. Natural compounds extracted from plants have long been used and still present a dynamic domain in th...

journal_title：Annals of the New York Academy of Sciences

authors： Blasius R,Dicato M,Diederich M

更新日期：2007-01-01 00:00:00

abstract：:The human endometrium is an extremely sensitive target for steroid hormones. During the menstrual cycle, this tissue undergoes dynamic changes that are reflected on the surface morphology of the epithelium and that can be followed by scanning electron microscopy. The morphologic changes peak at the midsecretory phase,...

journal_title：Annals of the New York Academy of Sciences

authors： Nikas G,Makrigiannakis A,Hovatta O,Jones HW Jr

更新日期：2000-01-01 00:00:00

abstract：:In recent years calcium channel blockers have emerged as a new class of antiarrhythmic agents for the control of certain supraventricular and ventricular arrhythmias. Electrophysiologically, they are heterogeneous but their main action is mediated through a depressant effect on the slow calcium channel in cardiac musc...

journal_title：Annals of the New York Academy of Sciences

authors： Nademanee K,Singh BN

更新日期：1988-01-01 00:00:00

abstract：:Obesity has various deleterious effects on health largely associated with metabolic abnormalities including abnormal glucose and lipid homeostasis that are associated with vascular injury and known cardiac, renal, and cerebrovascular complications. Advanced age is also associated with increased adiposity, decreased le...

journal_title：Annals of the New York Academy of Sciences

authors： Lee EB

更新日期：2011-12-01 00:00:00

abstract：:When cells are deprived of iron, their growth is invariably inhibited. However, the mechanism involved remains largely unclear. Recently, we have reported that subcytotoxic concentration of deferoxamine mesylate (DFO), an iron chelator, specifically inhibited transition of Chang cell, a normal hepatocyte cell line, fr...

journal_title：Annals of the New York Academy of Sciences

authors： Yoon YS,Cho H,Lee JH,Yoon G

更新日期：2004-04-01 00:00:00

abstract：:Locomotion control uses proprioceptive, visual, and vestibular signals. Previously, we analyzed the visual contribution with visual motion stimulation in roll while participants kept their heads in a normal upright orientation. In this study we applied the same visual disturbance in a head-upright and a nose-down cond...

journal_title：Annals of the New York Academy of Sciences

authors： Bardins S,Schneider E

更新日期：2009-05-01 00:00:00

abstract：:There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampus. Layer II cells of the medial EC innervating the dentate gyrus (DG)-molecular layer possess K(+)-outward currents and inward rectifier currents that are potentially modulated by c...

journal_title：Annals of the New York Academy of Sciences

authors： Heinemann U,Schmitz D,Eder C,Gloveli T

更新日期：2000-06-01 00:00:00

abstract：:It is known that Delta(9)-tetrahydrocannabinol (THC), the major active ingredient of marijuana, can suppress reproductive function. Also, we reported previously that the endocannabinoid, anandamide (AEA), inhibited gonadotropin-releasing hormone (LHRH) release from medial basal hypothalamus (MBH) of male rats incubate...

journal_title：Annals of the New York Academy of Sciences

authors： Fernandez-Solari J,Prestifilippo JP,Bornstein SR,McCann SM,Rettori V

更新日期：2006-11-01 00:00:00

abstract：:The Dover sole was the species most often affected with eroded fins. Prevalence of the disease was highest on the Palos Verdes shelf, the site of a major municipal waste water discharge. Fin lesions in this species were characterized by a minimal inflammatory response and by the absence of associated microorganisms. T...

journal_title：Annals of the New York Academy of Sciences

authors： Sherwood MJ,Mearns AJ

更新日期：1978-09-29 00:00:00

abstract：:Antibodies to double-stranded desoxyribonucleic acid (dsDNA) and to the polymyositis/scleroderma (PM/Scl) complex are regarded as serological markers for systemic lupus erythematosus (SLE) and PM/Scl overlap syndrome, respectively. In a previous study, serum samples were identified that contained antibodies specific f...

journal_title：Annals of the New York Academy of Sciences

authors： Mahler M,Greidinger EL,Szmyrka M,Kromminga A,Fritzler MJ

更新日期：2007-08-01 00:00:00

abstract：:The effects of visual field changes and ocular hypertension on visual evoked potentials were investigated by photopic ERG and by luminance and pattern-reversal EPs on 116 glaucomatous and on 7 normal eyes. The problem was approached by way of four investigations: Firstly, which nerve structures are affected by glaucom...

journal_title：Annals of the New York Academy of Sciences

authors： Bartl G

更新日期：1982-01-01 00:00:00

abstract：:Glycoxidation and lipoxidation reactions contribute to the chemical modification of proteins during the Maillard reaction. Reactive oxygen species, produced during the oxidation of sugars and lipids in these processes, irreversibly oxidize proteins. Methionine is particularly susceptible to oxidation, yielding the oxi...

journal_title：Annals of the New York Academy of Sciences

authors： Brock JW,Cotham WC,Ames JM,Thorpe SR,Baynes JW

更新日期：2005-06-01 00:00:00

abstract：:Complete recovery of ischemic cardiac muscle after myocardial infarction is still an unresolved concern. In recent years, intensive research efforts have focused on mimicking the physical and biological properties of myocardium for cardiac repair. Here we show how heart regeneration approaches have evolved from cell t...

journal_title：Annals of the New York Academy of Sciences

authors： Soler-Botija C,Bagó JR,Bayes-Genis A

更新日期：2012-04-01 00:00:00

abstract：:The adult respiratory distress syndrome (ARDS) is not confined only to late shock states but is a typical finding in intoxications with such oxidizing agents as O3, NO2, chlorate, or paraquat. Under experimental conditions, alpha-tocopherol in a high enteric dosage (2 x 50 mg/kg) was able to prevent alterations of pul...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf HR,Seeger HW

更新日期：1982-01-01 00:00:00

abstract：:Invasive plants cause substantial economic and environmental damage throughout the world. However, eradication of most invasive species is impossible and, in some cases, undesirable. An alternative is to slow the spread of an invasive species, which can delay impacts or reduce their extent. We identify three main area...

journal_title：Annals of the New York Academy of Sciences

authors： Caplat P,Coutts S,Buckley YM

更新日期：2012-02-01 00:00:00

abstract：:The invariant nature of body situs within and across vertebrate species implies that a highly conserved pathway controls the specification of the left-right (L/R) axis. Situs-specific morphogenesis begins at the end of this pathway and leads to normal organ arrangement, also known as situs solitus. Occasionally, indiv...

journal_title：Annals of the New York Academy of Sciences

authors： Delhaas T,Decaluwe W,Rubbens M,Kerckhoffs R,Arts T

更新日期：2004-05-01 00:00:00

abstract：:Circadian and other rhythmic changes in biological susceptibility and response of organisms to a large variety of physical as well as chemical agents including medications and foods are rather common phenomena. Modern chronopharmacology investigates drug effects (a) as a function of biological timing and (b) upon para...

journal_title：Annals of the New York Academy of Sciences

authors： Reinberg AE

更新日期：1991-01-01 00:00:00

abstract：:Starling's law and the end-systolic pressure-volume relationship (ESPVR) reflect the effect of sarcomere length (SL) on the development of stress (sigma) and shortening by myocytes in the uniform ventricle. We show here that tetanic contractions of rat cardiac trabeculae exhibit a sigma-SL relationship at saturating [...

journal_title：Annals of the New York Academy of Sciences

authors： Ter Keurs HE,Shinozaki T,Zhang YM,Wakayama Y,Sugai Y,Kagaya Y,Miura M,Boyden PA,Stuyvers BD,Landesberg A

更新日期：2008-03-01 00:00:00

abstract：:A variety of chemical compounds are currently being discussed as novel drug delivery strategies. One promising strategy is to selectively open the paracellular pathway of epithelia for the passage of macromolecules. A prerequisite for this effect is a rapid and reversible action of these compounds, to allow a marked t...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenthal R,Heydt MS,Amasheh M,Stein C,Fromm M,Amasheh S

更新日期：2012-07-01 00:00:00

abstract：:We previously showed that pituitary adenylate cyclase-activating polypeptide (PACAP) potently stimulates insulin secretion in vivo in mice without altering glucose disposal. Such a combination of results would be explained if epinephrine released by PACAP counteracts the action of insulin and, therefore, that the gluc...

journal_title：Annals of the New York Academy of Sciences

authors： Ahrén B,Filipsson K

更新日期：2000-01-01 00:00:00

abstract：:A variety of different isoforms of mammalian voltage-gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart. All of these channels have been expressed in exogenous systems, and all o...

journal_title：Annals of the New York Academy of Sciences

authors： Goldin AL

更新日期：1999-04-30 00:00:00

abstract：:Patients with probable Alzheimer's disease were either stimulated with a continuous visual recognition task (n = 18) or with a continuous auditory recognition task during PET measurement with 18 FDG. The PET scanner was a Siemens CTI, ECAT EXACT with 5 mm transaxial and 6 mm axial resolution. The global stimulation ef...

journal_title：Annals of the New York Academy of Sciences

authors： Kessler J,Ghaemi M,Mielke R,Herholz K,Heiss WD

更新日期：1996-01-17 00:00:00

abstract：:In order to better understand the enhancing effects of lowered oxygen (O2) tension on the growth in vitro of granulocyte-macrophage progenitor cells (CFU-GM), the effects of oxidizing species derived from molecular O2 were assessed on CFU-GM. Low density or nonadherent low density normal human bone marrow cells were p...

journal_title：Annals of the New York Academy of Sciences

authors： Broxmeyer HE,Cooper S,Gabig T

更新日期：1989-01-01 00:00:00

abstract：:Newly molted Boophilus microplus females obtained in a laboratory at 30 degrees C and environmental relative humidity (RH) were employed. An original device was used to hold ticks during feeding. Three groups of 15 ticks each were created: unfed, fed with heparinized blood, and fed with defibrinated blood. Ticks were ...

journal_title：Annals of the New York Academy of Sciences

authors： de la Vega R,Díaz G,Finlay L

更新日期：2000-01-01 00:00:00

abstract：:The treatment of substance use disorders has always been challenging because multiple neurotransmitters mediate addiction. However, with smoking being the leading cause of preventable death and the recent opioid epidemic in the United States, the search for novel solutions becomes more imperative. In this review, we d...

journal_title：Annals of the New York Academy of Sciences

authors： Xu A,Kosten TR

更新日期：2020-03-08 00:00:00

abstract：:Age-associated alterations in the mitochondrial electron transport system (ETS) may lead to free radical generation and contribute to aging. The complexes of the ETS were screened spectrophotometrically in gastrocnemius of young (10 month) as well as older (20 and 26 month) B6C3F1 female mice fed an ad libitum (AL) di...

journal_title：Annals of the New York Academy of Sciences

authors： Feuers RJ

更新日期：1998-11-20 00:00:00

abstract：:The availability of immunodeficient mice engrafted with functional human immune systems and islets permits in vivo study of human diabetes without putting patients at risk. ...

journal_title：Annals of the New York Academy of Sciences

authors： Greiner DL,Brehm MA,Hosur V,Harlan DM,Powers AC,Shultz LD

更新日期：2011-12-01 00:00:00