The effects of PACAP on insulin secretion and glucose disposal are altered by adrenalectomy in mice.

abstract：:Most of the plasma suppressive activity was associated with alpha 2M in both normal subjects and cancer patients. alpha 2M binding to physiological levels of proteases was associated with an increase in the ability to suppress lymphocyte reactivity in the TEEM test. alpha 2M binding to proteases released a peptide tha...

journal_title：Annals of the New York Academy of Sciences

authors： Alomran A,Shenton BK,Donnelly PK,Francis DM,Proud G,Taylor RM

更新日期：1983-01-01 00:00:00

abstract：:The characteristics of about 2,000 Japanese sarcoidosis cases collected by the Japan Sarcoidosis Committee during the 10-yr period, 1963-1972, were chronological increase with decreasing infectious diseases (represented by tuberculosis), north-to-south decline in sarcoidosis incidence in accordance with the Oxford Atl...

journal_title：Annals of the New York Academy of Sciences

authors： Hosoda Y,Hiraga Y,Odaka M,Yangawa H,Ito Y,Shiegematsu I,Chiba Y

更新日期：1976-01-01 00:00:00

abstract：:The fatty acid (FA) compositions of liver and skeletal muscle structural lipids, overall phospholipids and phosphatidylcholine, and triglycerides (TG) were determined in the hereditary hypertriglyceridemic (HTG) rat, a nonobese animal model of the insulin resistance syndrome. Four groups of HTG rats and four groups of...

journal_title：Annals of the New York Academy of Sciences

authors： Bohov P,Seböková E,Gasperíková D,Langer P,Klimes I

更新日期：1997-09-20 00:00:00

abstract：:The autonomic nervous system (ANS) plays a role in a wide range of somatic and mental diseases. Whereas the role of the ANS in the regulation of the cardiovascular system seems evident, its role in the regulation of other systems associated with allostasis is less clear. Using a model of neurovisceral integration we d...

journal_title：Annals of the New York Academy of Sciences

authors： Thayer JF,Sternberg E

更新日期：2006-11-01 00:00:00

abstract：:Rapid cooling of small samples is necessary both to cryofixation for electron microscopy and to vitrification for cryopreservation. Several effects on the cooling rates of small samples quenched into liquid nitrogen were studied, including the diameter of samples, the subcooling of liquid nitrogen, the quenching speed...

journal_title：Annals of the New York Academy of Sciences

authors： Cao Q,Hua TC

更新日期：1998-09-11 00:00:00

abstract：:Consumers of marijuana typically feel a strong, compulsive desire to consume food. Although past research revealed that the CB1 cannabinoid receptor is a potent regulator of food intake, the functional presence of neuronal CB2 cannabinoid receptors in the brain has been controversial. The role of CB2 receptors in food...

journal_title：Annals of the New York Academy of Sciences

authors： Onaivi ES,Carpio O,Ishiguro H,Schanz N,Uhl GR,Benno R

更新日期：2008-10-01 00:00:00

abstract：:The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane α-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGP...

journal_title：Annals of the New York Academy of Sciences

authors： Liebscher I,Ackley B,Araç D,Ariestanti DM,Aust G,Bae BI,Bista BR,Bridges JP,Duman JG,Engel FB,Giera S,Goffinet AM,Hall RA,Hamann J,Hartmann N,Lin HH,Liu M,Luo R,Mogha A,Monk KR,Peeters MC,Prömel S,Ressl S,Sc

更新日期：2014-12-01 00:00:00

abstract：:Antigen-specific proliferative responses of peripheral blood T cells are widely used in humans to study the T cell compartment. However, responses to autoantigens are often weak and poorly reproducible. Here we show, using a test recall antigen (tetanus toxoid), that absolute levels of proliferation, minimally detecta...

journal_title：Annals of the New York Academy of Sciences

authors： Narendran P,Elsegood K,Leech NJ,Dayan CM

更新日期：2002-04-01 00:00:00

abstract：:In this paper we first present methods and preliminary results of pilot surveys of "serious" mental retardation (IQ less than or equal to 55); the surveys included screening and diagnostic components and were carried out in the less-developed world. Next we discuss two problems raised by these surveys: one is the diag...

journal_title：Annals of the New York Academy of Sciences

authors： Stein Z,Durkin M,Belmont L

更新日期：1986-01-01 00:00:00

abstract：:Cytokines are powerful mediators of biologic responses in the CNS and may contribute to cellular injury in pathophysiologic states. In order to better understand the actions of cytokines in the intact mammalian CNS, a transgenic approach was employed that targeted the expression of different cytokines to astrocytes in...

journal_title：Annals of the New York Academy of Sciences

authors： Campbell IL

更新日期：1998-05-01 00:00:00

abstract：:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Obrenovitch TP

更新日期：2001-06-01 00:00:00

abstract：:Thiazolidinediones improve glycemic control by reducing insulin resistance. Some studies have demonstrated that troglitazone had a preventative effect on diabetes in NOD (non-obese diabetic) mice. One of the mechanisms proposed for the prevention of diabetes by thiazolidinediones is an effect on T-helper 1/T-helper 2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Shigihara T,Okubo Y,Kanazawa Y,Oikawa Y,Shimada A

更新日期：2006-10-01 00:00:00

abstract：:Two major methodological problems that impact clinical research in endometriosis are the absence of a low-cost, highly reliable method for diagnosing endometriosis and the possibility that endometriosis is actually multiple different diseases that we have not yet been able to differentiate. Animal models of endometrio...

journal_title：Annals of the New York Academy of Sciences

authors： Barbieri RL,Missmer S

更新日期：2002-03-01 00:00:00

abstract：:Understanding how the gulf between prokaryotic and eukaryotic cellular design arose is a major challenge. The viral eukaryogenesis (VE) hypothesis addresses the challenge of eukaryotic origins by suggesting the first eukaryotic cell was a multimember consortium consisting of a viral ancestor of the nucleus, an archaea...

journal_title：Annals of the New York Academy of Sciences

authors： Bell PJ

更新日期：2009-10-01 00:00:00

abstract：:Developmental robustness, the capacity to stay "on track" despite the myriad vicissitudes that inevitably plague a developing organism, is, I argue, a prerequisite for natural selection and key to our understanding of the evolution of developmental processes. But how is such robustness achieved? And how can we reconci...

journal_title：Annals of the New York Academy of Sciences

authors： Keller EF

更新日期：2002-12-01 00:00:00

abstract：:The Knockout Mouse Project (KOMP) Repository archives and distributes vectors, embryonic stem cell clones, frozen germplasm, and live mutant mice for 8,500 knockout genes. Here, we describe the creation and functions of the KOMP Repository. ...

journal_title：Annals of the New York Academy of Sciences

authors： Lloyd KC

更新日期：2011-12-01 00:00:00

abstract：:The search for molecules on the surface of mammalian sperm that are responsible for the binding of sperm to the zona pellucida has led to the identification of a number of different surface proteins. Different experimental approaches have been used to identify these proteins and the strength of the evidence for their ...

journal_title：Annals of the New York Academy of Sciences

authors： Myles DG,Primakoff P

更新日期：1991-01-01 00:00:00

abstract：:The membrane domain of the Na(+)/Ca(2+) exchanger (NCX) contains two conserved internal repeat sequences, designated the alpha-1 and alpha-2 repeats. We have studied the topological disposition of residues in the alpha repeats and a neighboring region by substituted cysteine accessibility scanning as well as the funct...

journal_title：Annals of the New York Academy of Sciences

authors： Shigekawa M,Iwamoto T,Uehara A,Kita S

更新日期：2002-11-01 00:00:00

abstract：:The principal modulators of the hypothalamic-pituitary-adrenal (HPA) axis are corticotropin-releasing hormone (CRH) and arginine-vasopressin (AVP). Corticotropin-releasing hormone is not exclusively produced in the hypothalamus. Its presence has been demonstrated at peripheral inflammatory sites. Ovulation and luteoly...

journal_title：Annals of the New York Academy of Sciences

authors： Mastorakos G,Ilias I

更新日期：2003-11-01 00:00:00

abstract：:Here we describe the AddNeuroMed multicenter magnetic resonance imaging (MRI) study for longitudinal assessment in Alzheimer's disease (AD). The study is similar to a faux clinical trial and has been established to assess longitudinal MRI changes in AD, mild cognitive impairment (MCI), and healthy control subjects usi...

journal_title：Annals of the New York Academy of Sciences

authors： Simmons A,Westman E,Muehlboeck S,Mecocci P,Vellas B,Tsolaki M,Kłoszewska I,Wahlund LO,Soininen H,Lovestone S,Evans A,Spenger C,AddNeuroMed Consortium.

更新日期：2009-10-01 00:00:00

abstract：:Mammalian spermatogenesis is a complex developmental process. Spermatozoa, like ova, are uniquely capable of supporting embryonic development. Our approach to understanding this process is to identify genes whose developmental pattern of expression suggests that they may play a role in spermatogenesis. Experiments on ...

journal_title：Annals of the New York Academy of Sciences

authors： Duggal RN,Zakeri ZF,Ponzetto C,Wolgemuth DJ

更新日期：1987-01-01 00:00:00

abstract：:Adult animals that had been subjected to a single prolonged episode of maternal deprivation (MD) [24 h, postnatal day (PND) 9-10] show long-term behavioral alterations that resemble specific symptoms of schizophrenia. Moreover, at adolescence MD rats showed depressive-like behavior and altered motor responses. Accordi...

journal_title：Annals of the New York Academy of Sciences

authors： De la Fuente M,Llorente R,Baeza I,De Castro NM,Arranz L,Cruces J,Viveros MP

更新日期：2009-02-01 00:00:00

abstract：:Since NTS neurons receive synaptic input from many sensory modalities, it is crucial to understand the neuronal mechanisms involved in synaptic processing. We have proposed that GABA-containing neurons in the NTS are the primary target for somatic afferent fibers activated by skeletal muscle contraction. In our model,...

journal_title：Annals of the New York Academy of Sciences

authors： Potts JT

更新日期：2001-06-01 00:00:00

abstract：:In a placebo-controlled double-blinded study, the effect of 8 weeks of grape juice was compared to the effect of isocaloric placebo juice. Volunteers with a systolic blood pressure > 130 mmHg and diastolic blood pressure > 90 mmHg were recruited. A total of 40 healthy subjects were randomized to receive isocaloric jui...

journal_title：Annals of the New York Academy of Sciences

authors： Park YK,Lee SH,Park E,Kim JS,Kang MH

更新日期：2009-08-01 00:00:00

abstract：:TT virus (TTV) is a recently described circular DNA virus of about 3.8 kb, which is related to the circoviridae viruses. It is commonly detected in healthy subjects and no association with any specific disease has been established. TTV was initially thought to be hepatotropic, but subsequent reports have shown that it...

journal_title：Annals of the New York Academy of Sciences

authors： Zhong S,Yeo W,Tang MW,Lin XR,Mo F,Ho WM,Hui P,Johnson PJ

更新日期：2001-09-01 00:00:00

abstract：:The past three decades of clinical disappointments in treating stroke must compel us to rethink our strategy. Given the enormous complexity of the clinical disease, the "one size fits all" approach to stroke treatment is unlikely to succeed. The effective treatment of stroke aimed at reversing ischemic injury will req...

journal_title：Annals of the New York Academy of Sciences

authors： Joshi S,Agarwal S

更新日期：2010-06-01 00:00:00

abstract：:The complex dielectric properties of canine skeletal muscles were measured at 25 degrees C during ischemia in the frequency range from 50 Hz to 200 MHz. The dielectric spectrum of skeletal muscle shows an alpha-dispersion below 1 kHz and a beta-dispersion with a relaxation frequency of about 100 kHz. The alpha-dispers...

journal_title：Annals of the New York Academy of Sciences

authors： Schäfer M,Kirlum HJ,Schlegel C,Gebhard MM

更新日期：1999-04-20 00:00:00

abstract：:The disturbances in the balance of pro- and antifibrinolytic activity, as observed in AAA and obesity, respectively, have considerable potential for influencing both intra- and extravascular fibrinolytic events and may be causally related to the development of vascular disease. For example, the wall of the aortic athe...

journal_title：Annals of the New York Academy of Sciences

authors： Samad F,Schneiderman J,Loskutoff D

更新日期：1997-04-15 00:00:00

abstract：:This literature review of contemporary mentoring delineates mentoring definitions and anchors these with explanatory discourse. Select empirical studies spanning 1983-2019 were analyzed, with a focus on education across grade levels. Alternative mentoring issues, types, and applications, also located, are integral to ...

journal_title：Annals of the New York Academy of Sciences

authors： Mullen CA,Klimaitis CC

更新日期：2021-01-01 00:00:00

abstract：:The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, together with advances in methods for structural characterization, has enabled the key structural features of the relaxin family of peptides responsible for biological activity to be defined....

journal_title：Annals of the New York Academy of Sciences

authors： Tregear GW,Bathgate RA,Hossain MA,Lin F,Zhang S,Shabanpoor F,Scott DJ,Ma S,Gundlach AL,Samuel CS,Wade JD

更新日期：2009-04-01 00:00:00