Analysis of absorption enhancers in epithelial cell models.

Abstract:

:A variety of chemical compounds are currently being discussed as novel drug delivery strategies. One promising strategy is to selectively open the paracellular pathway of epithelia for the passage of macromolecules. A prerequisite for this effect is a rapid and reversible action of these compounds, to allow a marked translocation of a drug, but also to avoid unwanted adverse effects, such as the translocation of noxious agents. Bioactive molecules that elevate paracellular permeability include Ca(2+) chelators, bacterial toxins, and other compounds, some of which perturb the structural basis of epithelial barrier function--the tight junction. Within the tight junction, organ- and tissue-specific barrier properties are determined mainly by claudins. The majority of members of the claudin protein family seal the paracellular pathway. This paper focuses on recent approaches concerning absorption-enhancing effects, with regard to selectivity and mechanism.

journal_name

Ann N Y Acad Sci

authors

Rosenthal R,Heydt MS,Amasheh M,Stein C,Fromm M,Amasheh S

doi

10.1111/j.1749-6632.2012.06562.x

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

86-92

eissn

0077-8923

issn

1749-6632

journal_volume

1258

pub_type

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