Expression of the growth arrest specific genes in rat embryonic fibroblasts undergoing senescence.

abstract：:Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the f...

journal_title：Annals of the New York Academy of Sciences

authors： Kohanski RA,Deeks SG,Gravekamp C,Halter JB,High K,Hurria A,Fuldner R,Green P,Huebner R,Macchiarini F,Sierra F

更新日期：2016-12-01 00:00:00

abstract：:MRI is a robust technology that allows for superior contrast of muscles, tissues, and bones within the body, which enables visualization of soft tissue pathology that cannot be seen with CT or plain film radiography. In order to appreciate the subtle (and sometimes not so subtle) intricacies of MRI, one must have a ba...

journal_title：Annals of the New York Academy of Sciences

authors： Khanna S,Crues JV 3rd

更新日期：2009-02-01 00:00:00

abstract：:Progression of the cell cycle is controlled by activating and inhibiting cellular factors. The delicate balance between these positive- and negative-acting regulators warrants proper cell cycle progression in normal cells and facilitates cellular response to a variety of stress stimuli. The increased activity of the p...

journal_title：Annals of the New York Academy of Sciences

authors： Wesierska-Gadek J,Krystof V

更新日期：2009-08-01 00:00:00

abstract：:Understanding the predictive relationships between climate variability and coccidioidomycosis is of great importance for the development of an effective public health decision-support system. Preliminary regression-based climate modeling studies have shown that about 80% of the variance in seasonal coccidioidomycosis ...

journal_title：Annals of the New York Academy of Sciences

authors： Comrie AC,Glueck MF

更新日期：2007-09-01 00:00:00

abstract：:To test whether the development of emotional resilience is a function of sensitive caregiving and child negative affect, we tested the joint contributions of 7-month maternal sensitivity and infant negative affect to the prediction of 33-month emotional resilience across the first 3 years of life. The aims of this stu...

journal_title：Annals of the New York Academy of Sciences

authors： Conway AM,McDonough SC

更新日期：2006-12-01 00:00:00

abstract：:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary disease characterized by recurrent transient ischemic attacks, strokes, and vascular dementia. Various mutations in the Notch3 gene cause the disease, whereas the mechanism of how they cause the di...

journal_title：Annals of the New York Academy of Sciences

authors： Abe K,Murakami T,Matsubara E,Manabe Y,Nagano I,Shoji M

更新日期：2002-11-01 00:00:00

abstract：:Aberrant cell cycle activity and DNA damage have been observed in neurons in association with various neurodegenerative conditions. While there is strong evidence for a causative role for these events in neurotoxicity, it is unclear how they are triggered and why they are toxic. Here, we introduce a brief background o...

journal_title：Annals of the New York Academy of Sciences

authors： Kim D,Tsai LH

更新日期：2009-07-01 00:00:00

abstract：:The Cervico-ocular reflex (COR), which depends on proprioceptive afferents from neck muscles to the vestibular nucleus, makes little contribution to the stabilization of gaze in humans. If labyrinthine function is lost because of disease, however, the COR may increase in gain and assume greater importance in generatin...

journal_title：Annals of the New York Academy of Sciences

authors： Carmona S,Nieto D

更新日期：2005-04-01 00:00:00

abstract：:Young songbirds memorize a tutor song and use the memory trace as a template to shape their own song by auditory feedback. Major issues in birdsong research include the neural sites and mechanisms for song memory and auditory feedback. The brain song control system contains neurons with both premotor and auditory func...

journal_title：Annals of the New York Academy of Sciences

authors： Konishi M

更新日期：2004-06-01 00:00:00

abstract：:Current evidence from genetic and epidemiological studies supports the view that Alzheimer's disease (AD) is a heterogeneous disorder. While the disease is pathologically defined by the presence of specified lesions in form of amyloid plaques and neurofibrillary tangles within the parenchyma, other features of patholo...

journal_title：Annals of the New York Academy of Sciences

authors： Cohen DL,Hedera P,Premkumar DR,Friedland RP,Kalaria RN

更新日期：1997-09-26 00:00:00

abstract：:Recent studies have shown that cirazoline, an alpha 1-adrenoceptor agonist, has greater affinity than do other imidazoline or guanidinium compounds at imidazoline recognition sites. In this report we used [3H]cirazoline as a probe to characterize imidazoline recognition sites present in membrane homogenates of rat bra...

journal_title：Annals of the New York Academy of Sciences

authors： Angel I,Le Rouzic M,Pimoule C,Graham D,Arbilla S

更新日期：1995-07-12 00:00:00

abstract：:Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically "seal" the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial...

journal_title：Annals of the New York Academy of Sciences

authors： Schulzke JD,Fromm M

更新日期：2009-05-01 00:00:00

abstract：:In this review, we discuss how neuropsychological impairments in visual selection can inform us about how selection normally operates. Using neuroanatomical and behavioral evidence on the disorders of neglect, extinction, and simultanagnosia, we propose functional and anatomical links between different aspects of visu...

journal_title：Annals of the New York Academy of Sciences

authors： Riddoch MJ,Chechlacz M,Mevorach C,Mavritsaki E,Allen H,Humphreys GW

更新日期：2010-03-01 00:00:00

abstract：:A method using laser-induced fluorescence (LIF) for in vivo cancer diagnosis of the esophagus is described. Autofluorescence of normal and malignant tissues was measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Measurement of the...

journal_title：Annals of the New York Academy of Sciences

authors： Vo-Dinh T,Panjehpour M,Overholt BF

更新日期：1998-02-09 00:00:00

abstract：:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Obrenovitch TP

更新日期：2001-06-01 00:00:00

abstract：:Previous studies, which included predominantly Caucasian populations, examined psychiatric and physical illness and associated suicide risk. We used a nationwide database to reassess the findings in an Asian population, and also analyzed the influence of different onset timing of psychiatric and physical illness and t...

journal_title：Annals of the New York Academy of Sciences

authors： Chang CF,Yeh MK,Chien WC,Chung CH,Li TT,Lai EC

更新日期：2020-02-01 00:00:00

abstract：:The aim of the study was to determine the IgG antibody response to spotted fever group Rickettsia (SFGR) R. conorii and R. slovaca, and its specificity and sensitivity in patients with DEBONEL/TIBOLA. A prospective study of 31 patients with DEBONEL was carried out from January 2001 to May 2004. The SFGR serology testi...

journal_title：Annals of the New York Academy of Sciences

authors： Santibáñez S,Ibarra V,Portillo A,Blanco JR,Martínez de Artola V,Guerrero A,Oteo JA

更新日期：2006-10-01 00:00:00

abstract：:During neuronal circuit formation, axons are guided to their targets by the help of axon guidance molecules, which are required for establishing functional circuits. A promising system to dissect the development and functionalities of neuronal circuitry is the spinal cord central pattern generator (CPG) for locomotion...

journal_title：Annals of the New York Academy of Sciences

authors： Vallstedt A,Kullander K

更新日期：2013-03-01 00:00:00

abstract：:Piracetam and structurally related nootropics are known to potentiate the anticonvulsant effects of antiepileptic drugs. It remains to be seen, however, whether these nootropics inhibit proconvulsant actions of many toxic agents including Ro 5-4864, a specific agonist for peripheral-type benzodiazepine receptors (PBR)...

journal_title：Annals of the New York Academy of Sciences

authors： Nakamoto Y,Shiotani T,Watabe S,Nabeshima T,Yoshii M

更新日期：2004-10-01 00:00:00

abstract：:"Vascular anomalies" represents a spectrum of vascular lesions, of unclear etiology and often with unpredictable behavior. Patients with vascular anomalies represent a unique population, in that they have focal aberrations of vascular development (in vascular malformations) or vascular proliferation (in hemangiomas). ...

journal_title：Annals of the New York Academy of Sciences

authors： Blei F

更新日期：2008-01-01 00:00:00

abstract：:"Module networks" are a framework to learn gene regulatory networks from expression data using a probabilistic model in which coregulated genes share the same parameters and conditional distributions. We present a method to infer ensembles of such networks and an averaging procedure to extract the statistically most s...

journal_title：Annals of the New York Academy of Sciences

authors： Michoel T,De Smet R,Joshi A,Marchal K,Van de Peer Y

更新日期：2009-03-01 00:00:00

abstract：:Social behavior in most human societies is characterized by the following of moral rules explicitly justified by religious belief systems. These systems constitute the diverse domain of human sacred values. Supernatural entities as founders or warranty of moral principles may be seen as a form of "conversation stopper...

journal_title：Annals of the New York Academy of Sciences

authors： Tófalvy T,Viciana H

更新日期：2009-06-01 00:00:00

abstract：:Intracerebral administration of the excitotoxin ibotenate to new-born mice induced white-matter lesions mimicking the periventricular leukomalacia occurring in human premature babies. In this model, co-injection of vasoactive intestinal peptide (VIP) prevented white-matter lesions. VIP did not prevent the initial appe...

journal_title：Annals of the New York Academy of Sciences

authors： Gressens P

更新日期：1999-01-01 00:00:00

abstract：:Neuroendocrine tumors are very heterogeneous, develop from a variety of tissues, and can be difficult to diagnose. Without the clinical manifestation of metastases, it is often difficult to characterize them as malignant. Even so-called completely (R0) resected tumors can spread clinically visible metastases within a ...

journal_title：Annals of the New York Academy of Sciences

authors： Koch CA,Gimm O,Vortmeyer AO,Al-Ali HK,Lamesch P,Ott R,Kluge R,Bierbach U,Tannapfel A

更新日期：2006-08-01 00:00:00

abstract：:Deprivation of sympathetic neurons of their physiological neurotrophic factor, nerve growth factor (NGF), leads to degeneration of soma and neurites, followed by loss of viability. The progression of degeneration and death are dependent upon macromolecular synthesis indicating an active participation of neuronal metab...

journal_title：Annals of the New York Academy of Sciences

authors： Deckwerth TL,Johnson EM Jr

更新日期：1993-05-28 00:00:00

abstract：:Mammalian spermatogenesis is a complex developmental process. Spermatozoa, like ova, are uniquely capable of supporting embryonic development. Our approach to understanding this process is to identify genes whose developmental pattern of expression suggests that they may play a role in spermatogenesis. Experiments on ...

journal_title：Annals of the New York Academy of Sciences

authors： Duggal RN,Zakeri ZF,Ponzetto C,Wolgemuth DJ

更新日期：1987-01-01 00:00:00

abstract：:Stereotactic core needle biopsy has proven to be an accurate technique for evaluation of mammographically detected microcalcification. The development of the Mammotome biopsy system has led many medical centers to use this vacuum-assisted device for the sampling of microcalcifications in mammographically detected nonp...

journal_title：Annals of the New York Academy of Sciences

authors： Faour I,Al-Salam S,El-Terifi H,El Taji H

更新日期：2008-09-01 00:00:00

abstract：:We have earlier shown that monkeys reared with daily alternating monocular occlusion for the first few months of life develop large horizontal strabismus, A/V patterns, dissociated vertical deviation (DVD), and dissociated horizontal deviation (DHD). Here, we present results from neurophysiological experiments that sh...

journal_title：Annals of the New York Academy of Sciences

authors： Das VE

更新日期：2011-09-01 00:00:00

abstract：:This paper is intended to serve as a traditional Tibetan medical response to advancements in basic longevity research, with particular attention to current models of caloric restriction. This is a complicated task, as Tibetan medicine traditionally approaches dietary modification from a radically different perspective...

journal_title：Annals of the New York Academy of Sciences

authors： Dakpa T,Dodson-Lavelle B

更新日期：2009-08-01 00:00:00

abstract：:Thymosin alpha 1, originally isolated as the compound responsible for reconstitution of immune function in thymectomized animal models, has enjoyed a wide-ranging clinical development program over the past decades, extending across multiple companies, indications, countries, and continents. This paper provides an over...

journal_title：Annals of the New York Academy of Sciences

authors： Tuthill C,Rios I,McBeath R

更新日期：2010-04-01 00:00:00