Effect of curcumin treatment on protein phosphorylation in K562 cells.

Abstract:

:Deregulation of signaling pathways is a common feature observed in human cancers and other diseases. Therefore, there is a strong need for compounds that are able to modulate or inactivate upregulated signaling events. Natural compounds extracted from plants have long been used and still present a dynamic domain in the research of new therapeutic tools. Among those molecules, curcumin was already described for its antioxidative, anti-inflammatory, and antiseptic properties. Many actions of curcumin target proteins and kinases implicated in the signaling pathways. However, the effects described depend on the treatment conditions used, as well as the cell line studied, and these features vary strongly from one study to the other. During this work, we evaluated the effect of one curcumin treatment (20 muM, 48 h) on the phosphorylation of a number of proteins and kinases in the human chronic myelogenous leukemia cell line K562. These results allow to compare the results obtained in one condition on various proteins.

journal_name

Ann N Y Acad Sci

authors

Blasius R,Dicato M,Diederich M

doi

10.1196/annals.1397.041

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

377-87

eissn

0077-8923

issn

1749-6632

pii

1095/1/377

journal_volume

1095

pub_type

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