Abstract：
:There are multiple connections from the entorhinal cortex (EC) to the hippocampus that carry the information from the EC to the hippocampus. Layer II cells of the medial EC innervating the dentate gyrus (DG)-molecular layer possess K(+)-outward currents and inward rectifier currents that are potentially modulated by changes in intracellular second messengers. Layer II cells responded to synaptic stimulation with a rather flat input-output curve, and much stronger stimuli are required to generate action potentials in these neurons than in EC layer III cells. During repetitive stimulation at frequencies of 10 Hz and more, EC layer II cells respond with increased likelihood to generate action potentials. Two different NMDA conductances can be demonstrated in these neurons. A slow, less Mg, less voltage-dependent component is responsible for the transient depolarization between the fast and slow IPSP. A second group of neurons also projects to the DG. These are either pyramidal or nonpyramidal cells in the deep layers of the EC. At least part of these neurons also possess rhythmogenic properties. In contrast to layer II cells, layer III neurons have a steep input-output curve and show during repetitive synaptic activation a tendency to repolarize and to display long-lasting inhibitions dependent on GABAB-, atropine-, and naloxone-sensitive components. As a consequence, they are readily activated during low frequency stimulation, but project only a few action potentials to area CA1 initially during higher (more than 10 Hz) frequency synaptic stimulation.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Heinemann U,Schmitz D,Eder C,Gloveli Tdoi
10.1111/j.1749-6632.2000.tb06722.xsubject
Has Abstractpub_date
2000-06-01 00:00:00pages
112-26eissn
0077-8923issn
1749-6632journal_volume
911pub_type
杂志文章,评审abstract：:Dietary and human factors have been found to be the major factors influencing the bioavailability of micronutrients, such as provitamin A carotenoid (pVAC), iron, and zinc, in biofortified crops. Dietary factors are related to food matrix structure and composition. Processing can improve pVAC bioavailability by disrup...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/nyas.13301
更新日期：2017-02-01 00:00:00
abstract：:The purpose of this research is to investigate the fluoride contents in the chilies from southwest China and other countries in order to calculate the difference in fluoride levels in the fresh chilies. The standard method in China for analysis of fluoride in food (GB/T 5009.18-2003) was applied to determinate the flu...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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abstract：:Propagation and prolongation of rapid neuronal discharge underlies the epilepsies. However, episodic focal rapid neuronal discharges limited to discrete nuclei and pathways of the amygdala-hippocampal-septal-hypothalamic networks are the language of physiologic message systems for endocrine regulation and reproductive...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.1999.tb09288.x
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abstract：:A rabbit antimouse brain theta reagent was made specific for cells of the T lineage by absorption in vivo in nude mice. When used in double fluorescence together with an antimouse immunoglobulin reagent, four types of cells were found in spleen and lymph nodes of both normal and nude mice: Ig+thetaBr-, Ig-thetaBr+, Ig...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1975.tb29173.x
更新日期：1975-06-30 00:00:00
abstract：:This review has addressed the concern that the reduction of the risk of coronary heart disease and other cardiovascular disorders by means of reducing serum cholesterol levels might, at the same time, increase the risk of developing noncardiovascular conditions. This concern is justified because, at face value, prospe...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-17 00:00:00
abstract：:Every year thousands of young teenagers are afflicted with different types of cancer and receive gonadotoxic chemotherapy and radiotherapy regimens, causing depletion of germ cells in the gonads and premature gonadal failure. In this review, we discuss and outline the current strategies and the future directions of fe...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：1997-05-28 00:00:00
abstract：:The discovery of mtDNA types common to Asians and Amerinds (types A, B, C, and D) forced investigators to search for those nations of Asia which, though not considered the ancestors of the Amerinds, have retained a close genetic resemblance with them. We collected samples and studied the gene pools of the Turkic-speak...
journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：1993-05-28 00:00:00
abstract：:Tick burdens cause direct damage to hosts and transmit several disease agents, the majority of which are secreted into feeding lesions through tick salivary glands. Reduced incidence of naturally transmitted tick-borne diseases was recently observed among cattle immunized with tick salivary gland extracts (TSGE). The ...
journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1996.tb34443.x
更新日期：1996-01-17 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：2010-12-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
doi：10.1111/j.1749-6632.2009.05154.x
更新日期：2010-02-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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更新日期：2006-09-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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更新日期：2005-06-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.2000.tb06391.x
更新日期：2000-04-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1975.tb51092.x
更新日期：1975-01-31 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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更新日期：2000-06-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：2010-04-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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更新日期：2005-06-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：2004-06-01 00:00:00
abstract：:We found a novel genetic abnormality, heterozygous C-->T nucleotide substitution at position -1138 bp in the 5'-flanking region of the fibrinogen A alpha gene, in patients with hypofibrinogenemia. Luciferase reporter assay using the pGL3-basic vector and CHO cells indicates that the transcriptional activity of a vecto...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
abstract：:Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identi...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
abstract：:The Guillain Barré syndromes (GBS) are the world's leading cause of acute autoimmune neuromuscular paralysis. Understanding the pathophysiological events of GBS, and improving immunotherapies are fundamental to improving the clinical outcome. Recent research into GBS and the Miller Fisher syndrome (MFS) variant has fo...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章
doi：10.1111/j.1749-6632.1994.tb24712.x
更新日期：1994-02-28 00:00:00
abstract：:Studies in humans and in animal models have demonstrated that the receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal skeletal growth and maturation. Investigations were undertaken to address which consequences of vitamin D receptor deficiency are a direct result of impaired receptor-dependen...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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更新日期：2006-04-01 00:00:00
abstract：:The objective of this double-blind, placebo-controlled, dose-escalation study is to evaluate safety, tolerability, and enhancement on healing of thymosin beta-4 (Tbeta-4) administered topically in patients with venous ulcers. Three groups of patients, coming from 10 sites, 5 from Italy and 5 from Poland, will be enrol...
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2007-09-01 00:00:00
