Mendelian genetics of male infertility.

Abstract:

:Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infertile individual cannot be transmitted to the offspring, ensuring the maintenance of reproductive fitness of the species. However, with the advent of assisted reproductive techniques (ART), we are now able to overcome sterility and bypass nature's protective mechanisms that developed through evolution to prevent fertilization by defective or deficient sperm.

journal_name

Ann N Y Acad Sci

authors

Hwang K,Yatsenko AN,Jorgez CJ,Mukherjee S,Nalam RL,Matzuk MM,Lamb DJ

doi

10.1111/j.1749-6632.2010.05917.x

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

E1-E17

eissn

0077-8923

issn

1749-6632

journal_volume

1214

pub_type

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