Immunofluorescence studies of a possible prethymic T-cell differentiation in congenitally athymic (nude) mice.

abstract：:The receptive field of a direction-selective unit of any type consists of an excitatory center 3 degrees -5 degrees in size, a near inhibitory surround and a far surround upon which illumination exerts an influence for both spontaneous activity and specific cell response. ...

journal_title：Annals of the New York Academy of Sciences

authors： Golovkin M,Gorbunov V,Maximova E,Maximov V

更新日期：2005-06-01 00:00:00

abstract：:Propagation and prolongation of rapid neuronal discharge underlies the epilepsies. However, episodic focal rapid neuronal discharges limited to discrete nuclei and pathways of the amygdala-hippocampal-septal-hypothalamic networks are the language of physiologic message systems for endocrine regulation and reproductive...

journal_title：Annals of the New York Academy of Sciences

authors： Stevens JR

更新日期：1999-06-29 00:00:00

abstract：:It is well established for both rat and man that the total testosterone concentration within the testis is far higher than that in serum. We know for the rat that intratesticular testosterone can be reduced by 50-60% without an adverse effect on spermatogenesis but that the required intratesticular testosterone concen...

journal_title：Annals of the New York Academy of Sciences

authors： Jarow JP,Zirkin BR

更新日期：2005-12-01 00:00:00

abstract：:Pentazocine and cyclazocine are two benzomorphans that were synthesized by the late Sydney Archer in 1962. These benzomorphans were synthesized as part of an effort to develop analgesics with little or no abuse potential. Pentazocine is used as an analgesic, often in individuals who have sever pain or in those who hav...

journal_title：Annals of the New York Academy of Sciences

authors： Bidlack JM,McLaughlin JP,Wentland MP

更新日期：2000-01-01 00:00:00

abstract：:There is increasing evidence that food is an important factor that influences and shapes the composition and configuration of the gut microbiota. Most studies have focused on macronutrients (fat, carbohydrate, protein) in particular and their effects on the gut microbiota. Although the microbiota can synthesize differ...

journal_title：Annals of the New York Academy of Sciences

authors： Biesalski HK

更新日期：2016-05-01 00:00:00

abstract：:Newly molted Boophilus microplus females obtained in a laboratory at 30 degrees C and environmental relative humidity (RH) were employed. An original device was used to hold ticks during feeding. Three groups of 15 ticks each were created: unfed, fed with heparinized blood, and fed with defibrinated blood. Ticks were ...

journal_title：Annals of the New York Academy of Sciences

authors： de la Vega R,Díaz G,Finlay L

更新日期：2000-01-01 00:00:00

abstract：:New approaches to the treatment of pulmonary arterial hypertension (PH) have increased symptomatic relief and prolonged survival. PH is a common sequela of the hemoglobinopathies, but the use of standard oral treatment options is limited because of toxicity and poor effectiveness. Sildenafil citrate is a selective and...

journal_title：Annals of the New York Academy of Sciences

authors： Derchi G,Forni GL

更新日期：2005-01-01 00:00:00

abstract：:Human speech perception seems to involve the ability to recognize groupings of speech sounds rather than component phonemes, and to distinguish between permuted orders of items within sequences as holistic entities. Humans can use this Holistic Pattern Recognition (HPR) not only with speech and music, but also with se...

journal_title：Annals of the New York Academy of Sciences

authors： Warren RM

更新日期：1976-01-01 00:00:00

abstract：:The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, together with advances in methods for structural characterization, has enabled the key structural features of the relaxin family of peptides responsible for biological activity to be defined....

journal_title：Annals of the New York Academy of Sciences

authors： Tregear GW,Bathgate RA,Hossain MA,Lin F,Zhang S,Shabanpoor F,Scott DJ,Ma S,Gundlach AL,Samuel CS,Wade JD

更新日期：2009-04-01 00:00:00

abstract：:While the ovaries are the principal source of systemic estrogen in the premenopausal nonpregnant woman, other sites of estrogen biosynthesis are present throughout the body and these become the major sources of estrogen beyond menopause. These extragonadal sources of estrogen are small, but may play an important, thou...

journal_title：Annals of the New York Academy of Sciences

authors： Simpson ER,Clyne C,Speed C,Rubin G,Bulun S

更新日期：2001-12-01 00:00:00

abstract：:Different estrogen-3-sulfates (estrone-3-sulfate, estradiol-3-sulfate, and estriol-3-sulfate) can provoke important biologic responses in different mammary cancer cell lines; there is a significant increase in progesterone receptor. However, no significant effect was observed with estrogen-17-sulfates. The reason for ...

journal_title：Annals of the New York Academy of Sciences

authors： Pasqualini JR,Gelly C,Nguyen BL

更新日期：1990-01-01 00:00:00

abstract：:A major challenge in systems biology is to evaluate the feasibility of a biological research project prior to its realization. Since experiments are animals-, cost- and time-consuming, approaches allowing researchers to discriminate alternative hypotheses with a minimal set of experiments are highly desirable. Given a...

journal_title：Annals of the New York Academy of Sciences

authors： Maiwald T,Kreutz C,Pfeifer AC,Bohl S,Klingmüller U,Timmer J

更新日期：2007-12-01 00:00:00

abstract：:As a result of intensive investigation, particularly in the pharmaceutical industry, a number of potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists have been discovered. The structure activity relationship studies that led to the discovery of these mGluR5 antagonists are presented in t...

journal_title：Annals of the New York Academy of Sciences

authors： Carroll FI

更新日期：2008-10-01 00:00:00

abstract：:In this study, we analyzed the effect of Bcl-2 overexpression, an important anti-apoptotic protein, by using two hypothalamic cell lines, GT1-7puro or GT1-7bcl-2. 3-Nitropropionic acid (3-NP) mediated a dose-dependent decrease in cell viability in GT1-7puro cells, as determined by following the MTT (3-(4,5-dimethylthi...

journal_title：Annals of the New York Academy of Sciences

authors： Brito O,Almeida S,Oliveira CR,Rego AC

更新日期：2003-12-01 00:00:00

abstract：:In this paper, I have introduced and solved a simple deterministic model of eye tracking that produces rich dynamical behavior. Some of its main features, notably the existence of a chaotic regime, are reminiscent of the anomalies reported in smooth pursuit eye tracking experiments with schizophrenia patients. By obta...

journal_title：Annals of the New York Academy of Sciences

authors： Huberman BA

更新日期：1987-01-01 00:00:00

abstract：:Gastrointestinal peptides play important roles regulating feeding and energy homeostasis. Most gastrointestinal peptides including glucagon like peptide-1, peptide YY, amylin, and oxytomodulin are anorectic, and only ghrelin is an orexigenic peptide. Ghrelin increases appetite, modulates energy balance, suppresses inf...

journal_title：Annals of the New York Academy of Sciences

authors： Ueno H,Shiiya T,Nakazato M

更新日期：2010-07-01 00:00:00

abstract：:The therapeutic value of thymectomy for myasthenia is still questioned although it retains an important place among management modalities that strive for sustained remission. Questions derive from uncertainty as to appropriate timing, variable extent of resection and quantitation of response. Forty-seven patients, fol...

journal_title：Annals of the New York Academy of Sciences

authors： Penn AS,Jaretzki A 3rd,Wolff M,Chang HW,Tennyson V

更新日期：1981-01-01 00:00:00

abstract：:Tight and adherens junctions play critical roles in the barrier, adhesion, and signaling functions of epithelial and endothelial cells. How the molecular organization of these junctions is tuned to the widely diverse physiological requirements of each tissue type is not well understood. Here, we address this question ...

journal_title：Annals of the New York Academy of Sciences

authors： Vasileva E,Sluysmans S,Bochaton-Piallat ML,Citi S

更新日期：2017-10-01 00:00:00

abstract：:The vertebrate neuromuscular junction (NMJ) is a "tripartite" synapse, composed of three cellular elements: the presynaptic nerve terminal, the postsynaptic specialization, and synapse-associated glial cells, called perisynaptic Schwann cells (PSCs; also called terminal Schwann cells). During development, PSCs grow be...

journal_title：Annals of the New York Academy of Sciences

authors： Feng Z,Ko CP

更新日期：2008-01-01 00:00:00

abstract：:Most research on reading skill acquisition in deaf individuals has been conducted from the perspective of a hearing child learning to read. This approach may limit our understanding of how a deaf child approaches the task of learning to read and successfully acquires reading skills. An alternative approach is to consi...

journal_title：Annals of the New York Academy of Sciences

authors： Dye MW,Hauser PC,Bavelier D

更新日期：2008-12-01 00:00:00

abstract：:Long-term exposure to cadmium (Cd) induces perturbation of kidney proximal tubular epithelial cells. Mitochondrial dysfunction in renal cortical cells may contribute to the pathogenesis of Cd-induced nephropathy. In this study, we examined the accumulation of mitochondrial DNA (mtDNA) with a large deletion and cellula...

journal_title：Annals of the New York Academy of Sciences

authors： Takaki A,Jimi S,Segawa M,Iwasaki H

更新日期：2004-04-01 00:00:00

abstract：:Electroporation was used to transform the methylotrophic bacterium Methylobacterium extorquens with broad-host-range plasmid pLA2917, which contains a gene specifying resistance to kanamycin. Plasmid DNA was introduced into M. extorquens in the presence of an electric pulse, and kanamycin-resistant transformants were ...

journal_title：Annals of the New York Academy of Sciences

authors： Ueda S,Matsumoto S,Shimizu S,Yamane T

更新日期：1991-12-27 00:00:00

abstract：:Previous research on development of the Xenopus olfactory bulb from our laboratory has shown that mitral cells begin to differentiate after olfactory axons make contact with the olfactory bulb, and the number of olfactory axons is correlated with the number of mitral cells throughout development. In embryos, removal o...

journal_title：Annals of the New York Academy of Sciences

authors： Burd GD,Sein V

更新日期：1998-11-30 00:00:00

abstract：:Studies of musical abilities in dementia have for the most part been rather general assessments of abilities, for instance, assessing retention of music learned premorbidly. Here, we studied patients with dementias with contrasting cognitive profiles to explore specific aspects of music cognition under challenge. Pati...

journal_title：Annals of the New York Academy of Sciences

authors： Halpern AR,Golden HL,Magdalinou N,Witoonpanich P,Warren JD

更新日期：2015-03-01 00:00:00

abstract：:The incidence of autoimmune diseases is higher in females than in males. In both sexes, adrenal hormones, that is, glucocorticoids, dehydroepiandrosterone (DHEA), and androgens, are inadequately low in patients when compared to healthy controls. Hormonally active androgens are anti-inflammatory, whereas estrogens are ...

journal_title：Annals of the New York Academy of Sciences

authors： Schmidt M,Naumann H,Weidler C,Schellenberg M,Anders S,Straub RH

更新日期：2006-06-01 00:00:00

abstract：:From the time Dan was 12 years old to the present, he always was the explorer of life. He was very fortunate in having an opportunity to see how life exists in several human societies around the world. His many professional foreign travels are presented. Dan went to a 1959 meeting in Argentina, to England in 1963, and...

journal_title：Annals of the New York Academy of Sciences

authors： Gilbert C,Gilbert RL

更新日期：2000-01-01 00:00:00

abstract：:The Sex combs reduced gene of the Antennapedia complex specifics the identities of the anterior thoracic and posterior head segments, including the primordium of the larval salivary gland. The Sex combs reduced transcription unit spans over 30 kb of genomic DNA, with another 40 kb of upstream cis-regulatory sequences....

journal_title：Annals of the New York Academy of Sciences

authors： Kennison JA,Vázquez M,Brizuela BJ

更新日期：1998-04-15 00:00:00

abstract：:Flow cytometers are instruments that can determine multiparameter data simultaneously and have a great potential in providing unique information about cells. To transfer this potential to the clinical laboratory, the development and the proper use of standards and calibrators are required to ensure comparability and r...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz A,Fernández-Repollet E

更新日期：1993-03-20 00:00:00

abstract：:Evidence is emerging that calcium-activated neutral proteinases (CANPs) not only participate in intracellular protein turnover but help to regulate the functional reorganization of cytoskeletal proteins in response to calcium and second-messenger stimulation. The high concentration of CANPs in certain neurons has sugg...

journal_title：Annals of the New York Academy of Sciences

authors： Nixon RA

更新日期：1989-01-01 00:00:00

abstract：:Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the past decade, somatic...

journal_title：Annals of the New York Academy of Sciences

authors： Kaipparettu BA,Ma Y,Wong LJ

更新日期：2010-07-01 00:00:00