Partial opioids. Medications for the treatment of pain and drug abuse.

abstract：:Although it is now well established that imidazoline receptors and alpha 2-adrenoceptors are discrete entities with distinct endogenous ligands, the two receptor classes apparently have several common features. While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidin...

journal_title：Annals of the New York Academy of Sciences

authors： Hieble JP,Ruffolo RR Jr

更新日期：1995-07-12 00:00:00

abstract：:The aim of the article was to use prospectively collected data on people with type 1 diabetes to examine which routinely collected clinical measures predict the development of peripheral neuropathy in people with type 1 diabetes. Within the Newcastle Diabetes Services, structured data collection at an annual review ha...

journal_title：Annals of the New York Academy of Sciences

authors： Sibal L,Law HN,Gebbie J,Home P

更新日期：2006-11-01 00:00:00

abstract：:In order to identify rate and stability of remission induced by low-dose prednisone comedication in early rheumatoid arthritis (RA), we evaluated patients with early RA (<1 year) who were randomized to receive (P) or not (non-P) low-dose prednisone in association with step-up disease-modifying antirheumatic drug thera...

journal_title：Annals of the New York Academy of Sciences

authors： Todoerti M,Scirè CA,Boffini N,Bugatti S,Montecucco C,Caporali R

更新日期：2010-04-01 00:00:00

abstract：:The quantitative analysis of nerve growth dynamics is critical to our understanding of nerve development and regeneration, but only recently has a quantitative framework begun to emerge to help define key objectives and to direct experimental measurements towards achieving this goal. Conceptually, the framework center...

journal_title：Annals of the New York Academy of Sciences

authors： Buettner HM

更新日期：1994-11-30 00:00:00

abstract：:It is well known that women with breast cancer who undergo therapies beyond the surgical intervention (adjuvant chemotherapy, hormone therapy, or both) often suffer from the lack of estrogen, manifesting as climacteric symptoms in either treated premenopausal or postmenopausal women. Although HRT (hormone replacement ...

journal_title：Annals of the New York Academy of Sciences

authors： Xydakis AM,Sakkas EG,Mastorakos G

更新日期：2006-12-01 00:00:00

abstract：:Within the past few years, developmental scientists have switched their attention from the study of DNA sequencing to the epigenetic state of the genome. Studying epigenetics could present the key to understanding gene expression changes without altering the basic structure of DNA. For example, the blastocyst, trophec...

journal_title：Annals of the New York Academy of Sciences

authors： Palini S,De Stefani S,Scala V,Dusi L,Bulletti C

更新日期：2011-03-01 00:00:00

abstract：:A recent study based on the SPoARC effect (spatial position association response codes) showed that culture heavily shapes cognition and more specifically the way thought is organized; when Western adults are asked to keep in mind a sequence of colors, they mentally organize them from left to right, whereas right-to-l...

journal_title：Annals of the New York Academy of Sciences

authors： Guida A,Mosinski F,Cipora K,Mathy F,Noël Y

更新日期：2020-10-01 00:00:00

abstract：:The overall goal of this study is to unravel the role(s) played by glial cell line-derived neurotrophic factor (GDNF) in the fate of spermatogonial stem cells. There is great interest in the biology of spermatogonial stem cells, or A(single) spermatogonia, because of their importance in the treatment of infertility, t...

journal_title：Annals of the New York Academy of Sciences

authors： Braydich-Stolle L,Nolan C,Dym M,Hofmann MC

更新日期：2005-12-01 00:00:00

abstract：:Both hereditary and environmental factors influence the risk of cancer. Four risk categories, or oncodemes, can exist for a particular kind of cancer, depending upon the presence of neither, one, or both factors: (1) spontaneous, or background; (2) hereditary; (3) environmental; (4) interactive. In the second, mutatio...

journal_title：Annals of the New York Academy of Sciences

authors： Knudson AG

更新日期：1997-12-29 00:00:00

abstract：:Previous studies reported that constitutive androstane receptor (CAR) does not transactivate phenobarbital responsive unit (PBRU)2C1luciferase reporter gene in COS cells in which endogenous CYP2B1 gene is not induced with PB. In order to understand molecular mechanism(s) whereby PBRU is transactivated, this article de...

journal_title：Annals of the New York Academy of Sciences

authors： Min G

更新日期：2006-12-01 00:00:00

abstract：:Collagen VI is a large, disulfide-bonded protein complex which is widely distributed in connective tissue. The constituent polypeptide chains (Mr = 110,000-140,000) consist of collagenous and noncollagenous segments, are degraded to chains of about half the size when collagen VI is solubilized by pepsin, and assemble ...

journal_title：Annals of the New York Academy of Sciences

authors： Engel J,Furthmayr H,Odermatt E,von der Mark H,Aumailley M,Fleischmajer R,Timpl R

更新日期：1985-01-01 00:00:00

abstract：:Hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis is often observed in association with and even prior to the onset of major depression. It is presently unclear (1) which molecular and cellular processes contribute to hyperactivity of parvocellular hypothalamic neurons (key regulators of the HPA system) an...

journal_title：Annals of the New York Academy of Sciences

authors： Joëls M,Verkuyl JM,Van Riel E

更新日期：2003-12-01 00:00:00

abstract：:Acetogens utilize the acetyl-CoA Wood-Ljungdahl pathway as a terminal electron-accepting, energy-conserving, CO(2)-fixing process. The decades of research to resolve the enzymology of this pathway (1) preceded studies demonstrating that acetogens not only harbor a novel CO(2)-fixing pathway, but are also ecologically ...

journal_title：Annals of the New York Academy of Sciences

authors： Drake HL,Gössner AS,Daniel SL

更新日期：2008-03-01 00:00:00

abstract：:G3139 is an 18mer phosphorothioate oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA. Because of the ability of this antisense construct to downregulate the expression of Bcl-2 mRNA and protein, it has entered phase III clinical trials in a number of human cancers, including advanced melanoma. ...

journal_title：Annals of the New York Academy of Sciences

authors： Benimetskaya L,Lai JC,Khvorova A,Wu S,Miller P,Stein CA

更新日期：2005-11-01 00:00:00

abstract：:Cyclosporin A (CsA) is an immunosuppressive drug commonly given to transplant patients. Its application is accompanied by severe side effects related to calcium, among them hypertension and nephrotoxicity. The Na+/Ca2+ exchanger (NCX) is a major calcium regulator expressed in the surface membrane of all excitable and ...

journal_title：Annals of the New York Academy of Sciences

authors： Rahamimoff H,Elbaz B,Alperovich A,Kimchi-Sarfaty C,Gottesman MM,Lichtenstein Y,Eskin-Shwartz M,Kasir J

更新日期：2007-03-01 00:00:00

abstract：:Neuroimaging research suggests that cerebral white matter (WM) integrity, as reflected in fractional anisotropy (FA) via diffusion tensor imaging (DTI), is decreased in older adults, especially in the prefrontal regions of the brain. Behavioral investigations of cognitive functioning suggest that some aspects of cogni...

journal_title：Annals of the New York Academy of Sciences

authors： Marks BL,Madden DJ,Bucur B,Provenzale JM,White LE,Cabeza R,Huettel SA

更新日期：2007-02-01 00:00:00

abstract：:The injury to vascular endothelium seen in severe bacterial infection may be mediated by neutrophil-derived enzymes. Neutrophil adhesion to endothelium, a prerequisite for this process, is mediated sequentially by the leukocyte adhesion molecules L-selectin and the beta 2 integrins, including CD11b/CD18. We have explo...

journal_title：Annals of the New York Academy of Sciences

authors： Finn A,Strobel S,Levin M,Klein N

更新日期：1994-05-28 00:00:00

abstract：:In response to infection or effective vaccination, naive antigen-specific CD8+ T cells undergo a dramatic highly orchestrated activation process. Initial encounter with an appropriately activated antigen-presenting cell leads to blastogenesis and an exponential increase in antigen-specific CD8+ T cell numbers. Simulta...

journal_title：Annals of the New York Academy of Sciences

authors： Obar JJ,Lefrançois L

更新日期：2010-01-01 00:00:00

abstract：:Bisphosphonates are widely used in the management of metastatic disease to bone and in diseases of altered bone turnover. Recently, multiple-case series and retrospective studies have established a relationship between necrotic bone lesions localized to the jaw and the use of chronic bisphosphonate therapy. This condi...

journal_title：Annals of the New York Academy of Sciences

authors： Ruggiero SL

更新日期：2011-02-01 00:00:00

abstract：:In this experiment, we investigated the influence of the photoperiod upon androgen receptor (AR) distribution and steroid concentrations in ovaries of 21-day-old bank vole females. Sections (6 mum) were assayed immunohistochemically. ARs were localized in the nuclei of granulosa cells. The strongest immunoreaction was...

journal_title：Annals of the New York Academy of Sciences

authors： Galas J,Slomczynska M,Kwasnik A

更新日期：2005-04-01 00:00:00

abstract：:Peripheral administration of lipopolysaccharide (LPS) in an amount that produces acute stress has been found to affect the catecholamine systems in the brain. Acute peripheral LPS administration activated norepinephrine (NE) metabolism in the locus ceruleus (LC). Approximately 40% of murine LC neurons project to the o...

journal_title：Annals of the New York Academy of Sciences

authors： Ota A,Mori K,Kaneko YS,Nakashima A,Nagatsu I,Nagatsu T

更新日期：2008-12-01 00:00:00

abstract：:In this note epistemological problems in general theories about living systems are considered; in particular, the question of hidden connections between different areas of experience, such as folk biology and scientific biology, and hidden connections between central concepts of theoretical biology, such as function, ...

journal_title：Annals of the New York Academy of Sciences

authors： Emmeche C

更新日期：2000-01-01 00:00:00

abstract：:Low- and high-frequency cortical oscillations play an important role in speech processing. Low-frequency neural oscillations in the delta (<4 Hz) and theta (4-8 Hz) bands entrain to the prosodic and syllabic rates of speech, respectively. Theta band neural oscillations modulate high-frequency neural oscillations in th...

journal_title：Annals of the New York Academy of Sciences

authors： Lizarazu M,Lallier M,Molinaro N

更新日期：2019-10-01 00:00:00

abstract：:The clinical significance of lymphocytic esophagitis (LyE), which is characterized by the prominence of peripapillary intraepithelial lymphocytes (IELs) without significant granulocytosis, remains poorly understood. During the last few years, plausible clinical correlates and novel approaches for stratification of LyE...

journal_title：Annals of the New York Academy of Sciences

authors： Lisovsky M,Westerhoff M,Zhang X

更新日期：2016-10-01 00:00:00

abstract：:We have evaluated different behavioral parameters in ICR (CD1) female mice of three different ages (38-39 weeks: mature; 62 weeks: late mature; 90 weeks: old), and addressed the effects of an enriched housing condition. We employed the following battery of tests: Holeboard, open field, elevated plus-maze (EPM), and fo...

journal_title：Annals of the New York Academy of Sciences

authors： Zambrana C,Marco EM,Arranz L,de Castro NM,Viveros MP,de la Fuente M

更新日期：2007-04-01 00:00:00

abstract：:The monoaminergic and cholinergic systems are implicated in different forms of behavioral arousal that can be dissected in terms of their forebrain targets and the nature of the behavioral processes they modulate in distinct regions. Thus, evidence in rats with selective neurochemical manipulations tested behaviorally...

journal_title：Annals of the New York Academy of Sciences

authors： Robbins TW,Granon S,Muir JL,Durantou F,Harrison A,Everitt BJ

更新日期：1998-06-21 00:00:00

abstract：:An inactive form of erythrocyte CA I was found in patients with primary aldosteronism. The levels of CA I in the patients were within the normal range: however, the specific esterase activity of CA I from three patients was in the range of 0.12-0.26 u/mg CA I (normal control: 0.66 +/- 0.1 u/mg CA I). In one subject, w...

journal_title：Annals of the New York Academy of Sciences

authors： Kondo T,Taniguchi N,Hirano T,Kawakami Y

更新日期：1984-01-01 00:00:00

abstract：:In this brief review, we introduce some major themes in the regulation of energy, lipid, and glucose metabolism by the central nervous system (CNS). Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with ...

journal_title：Annals of the New York Academy of Sciences

authors： Nogueiras R,Tschöp MH,Zigman JM

更新日期：2008-04-01 00:00:00

abstract：:In this short review, we have described studies that have identified Arg415 in the Ca2+ release channel as a residue that influences channel sensitivity to Ca2+ induced Ca2+ release, rate of Ca2+ release, and channel closing. We have also described studies that confirm Dr. Numa's predictions that residues 4246-4267, 4...

journal_title：Annals of the New York Academy of Sciences

authors： MacLennan DH,Chen SR

更新日期：1993-12-20 00:00:00

abstract：:Our earlier studies of translation have led us to a specific numeric coding of nucleotides (A = 0, C = 1, G = 2, and U = 3)--that is, a quaternary numeric system; to ordering of digrams and codons (read right to left: .yx and Z.yx) as ordinal numbers from 000 to 111; and to seek hypothetic transformation of mRNA to 20...

journal_title：Annals of the New York Academy of Sciences

authors： Damjanović ZM,Rakocević MM

更新日期：2005-06-01 00:00:00