Combination of nucleoside analogues tiazofurin and ribavirin downregulates experimental autoimmune encephalomyelitis.

Abstract:

:The effect of combined treatment with ribavirin and tiazofurin on the development of experimental autoimmune encephalomyelitis, the best characterized animal model for human autoimmune disease multiple sclerosis, was investigated. The disease was induced in highly susceptible Dark Agouti rats with spinal cord homogenate in complete Freund's adjuvant. Although ribavirin or tiazofurin alone reduced the clinical and histopathological signs of experimental autoimmune encephalomyelitis, the combination of drugs achieved the same effect with significantly lower doses.

journal_name

Ann N Y Acad Sci

authors

Lavrnja I,Stojkov D,Peković S,Subasic S,Mostarica-Stojković M,Stosic-Grujicić S,Nedeljković N,Medic-Mijacević L,Rakić L,Stojiljkovi M

doi

10.1196/annals.1342.047

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

392-5

eissn

0077-8923

issn

1749-6632

pii

1048/1/392

journal_volume

1048

pub_type

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