Neuroregulation of human nasal mucosa.

Abstract:

:Multiple subsets of nociceptive, parasympathetic, and sympathetic nerves innervate human nasal mucosa. These play carefully coordinated roles in regulating glandular, vascular, and other processes. These functions are vital for cleaning and humidifying ambient air before it is inhaled into the lungs. The recent identification of distinct classes of nociceptive nerves with unique patterns of transient receptor potential sensory receptor ion channel proteins may account for the polymodal, chemo- and mechanicosensitivity of many trigeminal neurons. Modulation of these families of proteins, excitatory and inhibitory autoreceptors, and combinations of neurotransmitters introduces a new level of complexity and subtlety to nasal innervation. These findings may provide a rational basis for responses to air-temperature changes, culinary and botanical odorants ("aromatherapy"), and inhaled irritants in conditions as diverse as allergic and nonallergic rhinitis, occupational rhinitis, hyposmia, and multiple chemical sensitivity.

journal_name

Ann N Y Acad Sci

authors

Baraniuk JN,Merck SJ

doi

10.1111/j.1749-6632.2009.04481.x

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

604-9

eissn

0077-8923

issn

1749-6632

pii

NYAS04481

journal_volume

1170

pub_type

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