Biological activity of relaxin in porcine milk.

abstract：:We review the effects of two transcription factor decoy oligonucleotides on apoptosis of human osteoclasts (OCs). The first decoy molecule was designed to inhibit nuclear factor kappa-B (NF-kappaB) binding to target sequence, the second to increase estrogen receptor (ER) alpha expression. We found that both decoy mole...

journal_title：Annals of the New York Academy of Sciences

authors： Piva R,Penolazzi L,Zennaro M,Bianchini E,Magri E,Borgatti M,Lampronti I,Lambertini E,Tavanti E,Gambari R

更新日期：2006-12-01 00:00:00

abstract：:After successful marrow transplantation (BMT) iron overload remains an important cause of morbidity in Thalassemia. After BMT, patients have normal erythropoiesis capable of producing a hyperplastic response to phlebotomy so that this procedure can be contemplated as a method of mobilizing iron from overloaded tissues...

journal_title：Annals of the New York Academy of Sciences

authors： Angelucci E,Muretto P,Lucarelli G,Ripalti M,Baronciani D,Erer B,Galimberti M,Annibali M,Giardini C,Gaziev D,Rapa S,Polchi P

更新日期：1998-06-30 00:00:00

abstract：:Most risk assessments assume uncertainty may be decomposed into variability and incertitude. Language is often overlooked as a source of uncertainty, but linguistic uncertainty may be pervasive in workshops, committees, and other face-to-face language-based settings where it can result in misunderstanding and arbitrar...

journal_title：Annals of the New York Academy of Sciences

authors： Carey JM,Burgman MA

更新日期：2008-04-01 00:00:00

abstract：:The alteration of oligosaccharide structures through genetic manipulation of glycosyltransferase activities is now a reality. It is apparent that this technique has greater consequences on oligosaccharide structure when an exogenous enzyme is introduced into cells, and in particular when this enzyme is responsible for...

journal_title：Annals of the New York Academy of Sciences

authors： Youakim A,Shur BD

更新日期：1994-11-30 00:00:00

abstract：:Members of the steroid receptor superfamily, like other transcription factors, can function as transcriptional inducers as well as repressors of transcription. The mechanisms by which repression is achieved seem to be specific for the factors and [table: see text] regulatory sequences involved. Many and perhaps all of...

journal_title：Annals of the New York Academy of Sciences

authors： Renkawitz R

更新日期：1993-06-11 00:00:00

abstract：:We present our achievements in the synthesis and application of multifunctionalized, cross-linked, polystyrene microspheres, which remarkably and quite generally are taken up by all cell types studied to date. Importantly, the nature of these synthetic beads allows multistep solid-phase chemistry and the ability to bi...

journal_title：Annals of the New York Academy of Sciences

authors： Sánchez-Martín RM,Alexander L,Bradley M

更新日期：2008-01-01 00:00:00

abstract：:Angiogenesis is a prerequisite for tumor expansion and metastasis. The angiogenic potential of the heparin-binding growth factors acidic fibroblast growth factor (FGF) and basic FGF has been demonstrated in various publications. We studied the inhibitory effects of suramin and the polysulfated heparinoids pentosan pol...

journal_title：Annals of the New York Academy of Sciences

authors： Zugmaier G,Favoni R,Jaeger R,Rosen N,Knabbe C

更新日期：1999-01-01 00:00:00

abstract：UNLABELLED:Hepatocarcinogenesis is a multistep process characterized by hepatocyte inflammation, regeneration, and proliferation. These changes are believed to depend on the aberrant expression of various tumor suppressor genes, oncogenes and growth factors. Several studies have shown the involvement of cyclooxygenase-...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Ingrao S,Soresi M,Florena AM,La Spada E,Sandonato L,D'Alessandro N,Cervello M,Montalto G

更新日期：2009-02-01 00:00:00

abstract：:Targeted depletion of immune cells expressing the interleukin-2 (IL-2) receptor can exacerbate inflammatory bowel disease (IBD) through elimination of regulatory T (Treg) cells, or ameliorate its course by depletion of cytotoxic cells. To answer this question we used a fusion protein composed of IL-2 and caspase-3 (IL...

journal_title：Annals of the New York Academy of Sciences

authors： Sagiv Y,Kaminitz A,Lorberboum-Galski H,Askenasy N,Yarkoni S

更新日期：2009-09-01 00:00:00

abstract：:First we remind general considerations concerning biodiversity on earth and particularly the loss of genetic biodiversity that seems irreversible whether its origin is directly or indirectly linked to human activities. Urgent and considerable efforts must be made from now on to cataloge, understand, preserve, and enha...

journal_title：Annals of the New York Academy of Sciences

authors： Maillard JC,Gonzalez JP

更新日期：2006-10-01 00:00:00

abstract：:We propose a model for signaling events induced by fluid shear stress that incorporates many of the features discussed in this paper (FIG. 4). First, heterotrimeric G-proteins, as well as a small G-proteins, are activated by flow. Indeed, a G protein appears to be required for ERK1/2 activation by flow because ERK1/2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Ishida T,Takahashi M,Corson MA,Berk BC

更新日期：1997-04-15 00:00:00

abstract：:Males and females rarely have identical evolutionary interests over reproduction, and when the fitness of both sexes is dependent upon paternity outcomes, sexual conflict over fertilization is inevitable. In internal fertilizers, the female tract is a formidable selective force on the number and integrity of sperm tha...

journal_title：Annals of the New York Academy of Sciences

authors： Firman RC

更新日期：2018-06-01 00:00:00

abstract：:In electrical impedance cardiography, Kubicek's formula is often used to measure stroke volume from thoracic impedance variations synchronously to heart activity. To calculate stroke volume from impedance variations, the so-called outflow problem should be adequately solved. This outflow problem refers to the joint ca...

journal_title：Annals of the New York Academy of Sciences

authors： Faes TJ,Raaijmakers E,Meijer JH,Goovaerts HG,Heethaar RM

更新日期：1999-04-20 00:00:00

abstract：:Fifty-eight contributors from 12 European and 2 American sarcoidosis centers have collaborated in a survey to define many questions concerning the use of 67Ga lung scan in sarcoidosis. The new quantitative scoring methods based on digital evaluation seem better in detecting lung activity. In 20.1% of untreated patient...

journal_title：Annals of the New York Academy of Sciences

authors： Rizzato G,Blasi A

更新日期：1986-01-01 00:00:00

abstract：:The endometrium acquires the ability to implant the developing embryo within a specific time window, termed the "receptive phase." During this period, the endometrium undergoes pronounced structural and functional changes induced by the ovarian steroids, estrogen and progesterone, which prepare it to be receptive to i...

journal_title：Annals of the New York Academy of Sciences

authors： Bagchi IC,Li Q,Cheon YP

更新日期：2001-09-01 00:00:00

abstract：:The primate orbitofrontal cortex (OFC) is often treated as a single entity, but architectonic and connectional neuroanatomy indicate that it has distinguishable parts. Nevertheless, few studies have attempted to dissociate the functions of its subregions. Here we review findings from recent neuropsychological and neur...

journal_title：Annals of the New York Academy of Sciences

authors： Rudebeck PH,Murray EA

更新日期：2011-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a complex clinical entity. In contrast to previously limited diagnostic definitions, it is now apparent that COPD is a clinically and biologically heterogeneous disease process, overlapping with other airways diseases like chronic asthma. As such, symptomatic response to...

journal_title：Annals of the New York Academy of Sciences

authors： Rooney C,Sethi T

更新日期：2015-06-01 00:00:00

abstract：:There is growing interest in the use of statins, HMG-CoA reductase inhibitors, for treating specific neurodegenerative diseases (e.g., cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis) and possibly traumatic brain injury. Neither is there a consensus on the efficacy of statins in t...

journal_title：Annals of the New York Academy of Sciences

authors： Wood WG,Eckert GP,Igbavboa U,Müller WE

更新日期：2010-06-01 00:00:00

abstract：:The molecular archaeology of the mutation spectra of tumor suppressor genes generates hypotheses concerning the etiology and molecular pathogenesis of human cancer. The spectrum of somatic mutations in the p53 gene implicates environmental carcinogens and both endogenous agents and processes in the etiology of human c...

journal_title：Annals of the New York Academy of Sciences

authors： Hussain SP,Hollstein MH,Harris CC

更新日期：2000-01-01 00:00:00

abstract：:The endocannabinoid system, through the cannabinoid receptor CB1, is involved in the modulation of adaptive responses to environmental conditions. However, little is known about the role of the cannabinergic system, particularly CB1 receptor expression, in relation to the effects induced by xenoestrogens concerning th...

journal_title：Annals of the New York Academy of Sciences

authors： Palermo FA,Angelini M,Cottone E,Virgili M,Franzoni MF,Mosconi G,Polzonetti-Magni AM

更新日期：2009-04-01 00:00:00

abstract：:To date, the precise etiology of inflammatory bowel disease (IBD) remains largely unknown; however, it is well accepted that IBD results from a dysregulated mucosal immune response to environmental factors in genetically susceptible hosts. The primary defect, in at least a subpopulation of IBD patients, may be due to ...

journal_title：Annals of the New York Academy of Sciences

authors： Reuter BK,Pizarro TT

更新日期：2009-05-01 00:00:00

abstract：:In the early 1970s carbohydrates (CHOs) were believed to induce overconsumption and excess fat deposition. They are now perceived to protect against these consequences. This paper evaluates the evidence for this change of interpretation by considering (1) the energy content of CHOs, (2) the energetic efficiency with w...

journal_title：Annals of the New York Academy of Sciences

authors： Stubbs RJ,Prentice AM,James WP

更新日期：1997-05-23 00:00:00

abstract：:It has been proposed that spacetime should be regarded as an evolving block universe, bounded to the future by the present time, which continually extends to the future. This future boundary is defined at each time by measuring proper time along Ricci eigenlines from the start of the universe. A key point, then, is th...

journal_title：Annals of the New York Academy of Sciences

authors： Ellis GF

更新日期：2014-10-01 00:00:00

abstract：:Comparative studies of proteins often face the problem of distinguishing a true orthologue (species homologue) from a paralogue (a gene duplicate). This identification task is particularly challenging for endocrine peptides and neuropeptides because they are short and usually have several invariant positions. For some...

journal_title：Annals of the New York Academy of Sciences

authors： Larhammar D,Sundström G,Dreborg S,Daza DO,Larsson TA

更新日期：2009-04-01 00:00:00

abstract：:Alternative splicing of RNA transcripts is a general characteristic for NCX genes in mammals, mollusks, and arthropods. Among the family of three NCX genes in mammals, the NCX1 gene contains six exons, namely, A, B, C, D, E, and F, that make up the alternatively spliced region. Studies of the NCX1 gene transcripts sug...

journal_title：Annals of the New York Academy of Sciences

authors： Schulze DH,Polumuri SK,Gille T,Ruknudin A

更新日期：2002-11-01 00:00:00

abstract：:Access to food is essential to optimal development and function in children and adults. Food security, food insecurity, and hunger have been defined and a U.S. Food Security Scale was developed and is administered annually by the Census Bureau in its Current Population Survey. The eight child-referenced items now make...

journal_title：Annals of the New York Academy of Sciences

authors： Cook JT,Frank DA

更新日期：2008-01-01 00:00:00

abstract：:The computation of ITD begins with preservation of the phase angle of spectral components by eighth-nerve fibers and by cells of the nucleus magnocellularis. At the level of the nucleus laminaris, the difference in phase angle of corresponding spectral components in the left and right ears is extracted. At the next le...

journal_title：Annals of the New York Academy of Sciences

authors： Takahashi TT

更新日期：1989-01-01 00:00:00

abstract：:A well-controlled local immune response is needed for recovery from CNS injury, and autoimmune T cells play a key role in mediating this response. Autoimmunity, at least in the context of the CNS, is the body's fighting force against self-derived destructive compounds, and "tolerance to self" (traditionally though mis...

journal_title：Annals of the New York Academy of Sciences

authors： Schwartz M,Kipnis J

更新日期：2005-06-01 00:00:00

abstract：:Liquid membrane reactors are well known for metal extraction. This technology may also be applied to the immobilization of enzymes in enzyme emulsions. The use of liquid membrane reactors for enzymatic bioconversions has several advantages in comparison to solid membrane reactors and conventional immobilization techni...

journal_title：Annals of the New York Academy of Sciences

authors： Scheper T,Makryaleas K,Nowottny C,Likidis Z,Tsikas D,Schügerl K

更新日期：1987-01-01 00:00:00

abstract：:In the pituitary of mammals, the GnRH receptor (GnRHR) plays crucial roles in the neuroendocrine control of reproductive function. This receptor is specifically expressed by the gonadotrope cells scattered among the five other endocrine cell types constituting the anterior pituitary; it is also expressed in other orga...

journal_title：Annals of the New York Academy of Sciences

authors： Schang AL,Counis R,Magre S,Bleux C,Granger A,Ngô-Muller V,Chenut MC,Ishaq M,Cohen-Tannoudji J,Laverrière JN

更新日期：2011-03-01 00:00:00