p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and human risk assessment.

abstract：:Although much work has been done in the field of circulating DNA, no definitive information on sequencing data of total circulating DNA is available. Characterization of total circulating DNA by sequence analysis may give valuable information about the origin and function of these nucleic acid molecules. Circulating D...

journal_title：Annals of the New York Academy of Sciences

authors： van der Vaart M,Pretorius PJ

更新日期：2008-08-01 00:00:00

abstract：:In common marmoset monkeys (Callithrix jacchus, order Primates), infants aged 2-28 days were deprived of parental care for 30-120 min/day in order to investigate the long-term effects of this neglect-stress model on affect and cognition in a primate species. Basal morning levels of urinary cortisol across the first ye...

journal_title：Annals of the New York Academy of Sciences

authors： Pryce CR,Dettling A,Spengler M,Spaete C,Feldon J

更新日期：2004-12-01 00:00:00

abstract：:The production of nitric oxide (NO) emerges as an essential determinant in auto- and paracrine signaling. NO is known to be generated under inflammatory conditions, carcinogenesis, and circulatory shock. The large amount of NO produced in response to cytokines plays an important role in inflammatory conditions. Cycloo...

journal_title：Annals of the New York Academy of Sciences

authors： Shin JI,Lee YK,Kim YM,Hwang JT,Park OJ

更新日期：2007-01-01 00:00:00

abstract：:The accepted dogma has been that a single long-term hematopoietic stem cell (LT-HSC) can reconstitute all components of the immune system. However, our single-cell transfer studies have shown that highly purified LT-HSCs selectively fail to reconstitute B-1a cells in otherwise fully reconstituted hosts (i.e., LT-HSCs ...

journal_title：Annals of the New York Academy of Sciences

authors： Ghosn EE,Yang Y

更新日期：2015-12-01 00:00:00

abstract：:The following on proton pump inhibitors (PPIs) and chemoprevention in relation to Barrett's esophagus includes commentaries on 48-h pH monitoring, pH-impedence, bile acid testing, dyspepsia, long/short segment Barrett's esophagus, nonerosive reflux disease (NERD), functional heartburn, dual-release delivery PPIs, imme...

journal_title：Annals of the New York Academy of Sciences

authors： Richter JE,Penagini R,Tenca A,Pohl D,Dvorak K,Goldman A,Savarino E,Zentilin P,Savarino V,Watson JT,Wong RK,Pace F,Casini V,Peura DA,Herzig SJ,Kamiya T,Pelosini I,Scarpignato C,Armstrong D,DeVault KR,Bechi P,Tadd

更新日期：2011-09-01 00:00:00

abstract：:There is a significant increase in the percentage and absolute number of activated lymphocytes (OKT10+, IL2R1+) after ECT treatment of major depressive disorder. There is an acute decrease in the absolute number of total lymphocytes, T8+ and Leu11+ cells one hour after a single ECT. ...

journal_title：Annals of the New York Academy of Sciences

authors： Fischler B,Bocken R,Schneider I,De Waele M,Thielemans K,Derde MP

更新日期：1992-04-15 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is well known to protect delayed neuronal cell death in the brain of rodents. In order to investigate the neuroprotective action of PACAP in the retina, we examined the effects of PACAP on kainic acid (KA)-induced neurotoxicity in the rat retina. Many ganglion...

journal_title：Annals of the New York Academy of Sciences

authors： Seki T,Nakatani M,Taki C,Shinohara Y,Ozawa M,Nishimura S,Ito H,Shioda S

更新日期：2006-07-01 00:00:00

abstract：:Rats inoculated once with nicotinic acetylcholine receptor and adjuvants had two episodes of weakness, the first being acute and transient, starting on day 8, and remitting in a few days, the second, chronic, progressive, and appearing after day 20. In the acute phase, the compound action potential and twitch evoked ...

journal_title：Annals of the New York Academy of Sciences

authors： Lambert EH,Lindstrom JM,Lennon VA

更新日期：1976-01-01 00:00:00

abstract：:Epidemiological observations, clinical mechanistic studies, and basic laboratory research suggest that estrogen therapy is associated with beneficial cardiovascular effects in postmenopausal women. Estrogen has a multitude of biological effects that may account for this apparent benefit (which remains to be proved in ...

journal_title：Annals of the New York Academy of Sciences

authors： Blum A,Cannon RO 3rd

更新日期：2001-12-01 00:00:00

abstract：:Elevated circulating levels of glucocorticoids are associated with psychiatric symptoms across several different conditions. It remains unknown if this hormonal abnormality is a cause or an effect of the psychiatric conditions. For example, the hypercortisolemia observed in a subset of patients with depression may hav...

journal_title：Annals of the New York Academy of Sciences

authors： Wolkowitz OM,Burke H,Epel ES,Reus VI

更新日期：2009-10-01 00:00:00

abstract：:The ocular motor system provides several advantages for studying the brain, including well-defined populations of neurons that contribute to specific eye movements. Generation of rapid eye movements (saccades) depends on excitatory burst neurons (EBN) and omnipause neurons (OPN) within the brainstem, both types of cel...

journal_title：Annals of the New York Academy of Sciences

authors： Eggers SD,Horn AK,Roeber S,Härtig W,Nair G,Reich DS,Leigh RJ

更新日期：2015-04-01 00:00:00

abstract：:Post-polio syndrome (PPS) describes the clinical onset of progressive muscular weakness many years after survival of acute paralytic poliomyelitis, often in muscle groups clinically unaffected by the original disease process. Prior pathologic descriptions of this often disabling, but not usually fatal, syndrome have b...

journal_title：Annals of the New York Academy of Sciences

authors： Miller DC

更新日期：1995-05-25 00:00:00

abstract：:Plasticity is a fundamental property of the neural system controlling breathing. One frequently studied model of respiratory plasticity is long-term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH). pLTF arises from spinal plasticity, increasing respiratory motor output through a ...

journal_title：Annals of the New York Academy of Sciences

authors： Dale-Nagle EA,Hoffman MS,MacFarlane PM,Satriotomo I,Lovett-Barr MR,Vinit S,Mitchell GS

更新日期：2010-06-01 00:00:00

abstract：:The entorhinal cortex, subiculum, and hippocampus have been regions of great interest in both clinical and neuropathological investigations of schizophrenia. Postmortem studies have identified numerous abnormalities, although many remain controversial or unconfirmed. Among the cellular and molecular neuropathological ...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold SE

更新日期：2000-06-01 00:00:00

abstract：:Alcohol suppresses reproduction in humans, monkeys, and small rodents by suppressing release of luteinizing hormone (LH). The major action is on the hypothalamus to decrease release of LH-releasing hormone (LHRH). The release of LHRH is controlled by nitric oxide (NO) as determined by in vivo and in vitro experiments....

journal_title：Annals of the New York Academy of Sciences

authors： Rettori V,McCann SM

更新日期：1998-05-01 00:00:00

abstract：:Clumps of corona cells were separated from oocytes at the moment of fertilization control and were subsequently processed and cut into 1-mu sections to study their general morphologic patterns. This study revealed an extensive phagocytosis of spermatozoa by corona cells. Clumps of mural granulosa cells of comparable s...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnenborg R,Gordts S,Ongkowidjojo R,Brosens I

更新日期：1985-01-01 00:00:00

abstract：:Major trauma, shock, sepsis, and other conditions can lead to the acute respiratory distress syndrome (ARDS), which may progress to the highly lethal multiple organ dysfunction syndrome (MODS). Although a number of therapeutic strategies have been initiated, their success has been limited largely due to an incomplete ...

journal_title：Annals of the New York Academy of Sciences

authors： Deitch EA

更新日期：2010-10-01 00:00:00

abstract：:Indirect evidence, including neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-neurotoxicity by nitric oxide synthase (NOS) inhibitors and resistance of transgenic animals deficient in NOS, is controversial. We have reviewed evidence in favor of oxidative stress during the development of MPTP...

journal_title：Annals of the New York Academy of Sciences

authors： Mohanakumar KP,Thomas B,Sharma SM,Muralikrishnan D,Chowdhury R,Chiueh CC

更新日期：2002-05-01 00:00:00

abstract：:Hematopoietic growth factors are glycoproteins of 15-70 kDa. Although much clinical success has been obtained using recombinant proteins produced in mammalian cell lines and in microbial fermentation processes, the full-length polypeptides necessarily are expensive to produce, require parenteral administration, and in...

journal_title：Annals of the New York Academy of Sciences

authors： Kaushansky K

更新日期：2001-06-01 00:00:00

abstract：:Data show that specifically chelating lysosomal redox-active iron can prevent most H(2)O(2)-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage b...

journal_title：Annals of the New York Academy of Sciences

authors： Kurz T,Leake A,von Zglinicki T,Brunk UT

更新日期：2004-06-01 00:00:00

abstract：:Henry Kandrup wrote prolifically on the problem of relaxation of stellar systems. His picture of relaxation was significantly more refined than the standard description in terms of phase mixing and violent relaxation. In this article, I summarize Henry's work in this and related areas. ...

journal_title：Annals of the New York Academy of Sciences

authors： Merritt D

更新日期：2005-06-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Does common genetic variation at human TH alter autonomic activity and predispose to cardiovascular disease? We undertook systematic polymorphism discovery at the TH locus, and then tested variants for contributions to sympathetic fun...

journal_title：Annals of the New York Academy of Sciences

authors： Rao F,Zhang L,Wessel J,Zhang K,Wen G,Kennedy BP,Rana BK,Das M,Rodriguez-Flores JL,Smith DW,Cadman PE,Salem RM,Mahata SK,Schork NJ,Taupenot L,Ziegler MG,O'Connor DT

更新日期：2008-12-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) now enables precise visualization of the mechanical state of the living human orbit. Resulting insights have motivated histological re-examination of human and simian orbits, providing abundant consistent evidence for the active pulley hypothesis, a re-formulation of ocular motor physi...

journal_title：Annals of the New York Academy of Sciences

authors： Demer JL

更新日期：2002-04-01 00:00:00

abstract：:The Na,K-ATPase gamma subunit is present primarily in kidney as two splice variants, gammaa and gammab, which differ only at their extracellular N-termini. Two distinct effects of gamma are seen in biochemical Na,K-ATPase assays of mammalian (HeLa) cells transfected with gammaa or gammab, namely, (i) a decrease in K'(...

journal_title：Annals of the New York Academy of Sciences

authors： Blostein R,Pu HX,Scanzano R,Zouzoulas A

更新日期：2003-04-01 00:00:00

abstract：:Morphogenesis in the animal kingdom is closely coupled with the intracellular synthesis and the extracellular deposition of collagen. These morphogenetically important events involve multiple steps which begin in compartments inside the cell and continue in compartments outside the cell. The movement of matrix compone...

journal_title：Annals of the New York Academy of Sciences

authors： Birk DE,Trelstad RL

更新日期：1985-01-01 00:00:00

abstract：:Mustard gas (sulfur mustard, SM), a highly vesicating chemical warfare agent, was first deployed in warfare in 1917 and recently during the Iraq-Iran war (1980s) and Syrian conflicts (2000s); however, the threat of exposure from stockpiles and old artillery shells still looms large. Whereas research has been long ongo...

journal_title：Annals of the New York Academy of Sciences

authors： Mishra N,Raina K,Agarwal R

更新日期：2020-12-10 00:00:00

abstract：:Pharmacological actions of methamphetamine (METH) and phencyclidine (PCP) are different, but both of them can induce similar psychiatric disorders including abuse, intoxication, withdrawal, and psychotic symptoms like those of schizophrenia. These mental disorders are caused not only by their direct pharmacological ef...

journal_title：Annals of the New York Academy of Sciences

authors： Ouchi Y,Kubota Y,Ito C

更新日期：2004-10-01 00:00:00

abstract：:Though several studies show that genetic factors influence individual differences in musical engagement, aptitude, and achievement, no study to date has investigated whether specialization among musically active individuals in terms of choice of instrument and genre is heritable. Using a large twin cohort, we explored...

journal_title：Annals of the New York Academy of Sciences

authors： Mosing MA,Ullén F

更新日期：2018-05-09 00:00:00

abstract：:Thiazolidinediones improve glycemic control by reducing insulin resistance. Some studies have demonstrated that troglitazone had a preventative effect on diabetes in NOD (non-obese diabetic) mice. One of the mechanisms proposed for the prevention of diabetes by thiazolidinediones is an effect on T-helper 1/T-helper 2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Shigihara T,Okubo Y,Kanazawa Y,Oikawa Y,Shimada A

更新日期：2006-10-01 00:00:00

abstract：:Familial British dementia (FBD) is a disorder characterized by the presence of amyloid deposits in cerebral blood vessels and brain parenchyma coexisting with neurofibrillary tangles in limbic areas. The amyloid subunit (ABri) is a 4 kDa fragment of a 266 amino acid type II single-spanning transmembrane precursor prot...

journal_title：Annals of the New York Academy of Sciences

authors： Ghiso J,Vidal R,Rostagno A,Miravalle L,Holton JL,Mead S,Révész T,Plant G,Frangione B

更新日期：2000-01-01 00:00:00