Evidence for altered monoamine activity and emotional and cognitive disturbance in marmoset monkeys exposed to early life stress.

abstract：:Pregnant female Sprague-Dawley rats were injected with either 40 mg/kg (-)cocaine hydrochloride or an equivalent volume of 0.9% saline, subcutaneously (s.c.), once daily from gestational day 12 (GD 12) to GD 21. Gestational cocaine exposure had no effect on maternal weight gain, length of gestation, birthweight, fetal...

journal_title：Annals of the New York Academy of Sciences

authors： Choi SJ,Mazzio E,Soliman KF

更新日期：1998-05-30 00:00:00

abstract：:A radioimmunoassay method (RIA) with specific antisera for human and rat alpha fetoprotein (AFP) was used to study the evolution of AFP levels in humans and rats, respectively, throughout the life span. Sera of 66 rats, aged 3-70 weeks, as well as sera of 201 clinically well children, 192 healthy blood donors, and 16...

journal_title：Annals of the New York Academy of Sciences

authors： Masseyeff R,Gilli J,Krebs B,Calluaud A,Bonet C

更新日期：1975-08-22 00:00:00

abstract：:Much has been learned during the past decade about the specific retinoid-binding proteins that exist in plasma, and in the intracellular compartment in a number of tissues. Vitamin A is mobilized from liver stores and transported in plasma in the form of the lipid alcohol retinol, bound to a specific transport protein...

journal_title：Annals of the New York Academy of Sciences

authors： Goodman DS

更新日期：1981-02-27 00:00:00

abstract：:West Nile virus (WNV) caused disease outbreaks in Israel in the 1950s and the late 1970s. In 1998 an outbreak of WNV in goose farms and evidence of infection in dead migratory birds were reported. Consequently, human diagnostic services for WNV were resumed, including virus isolation, serology, and RT-PCR. Risk factor...

journal_title：Annals of the New York Academy of Sciences

authors： Bin H,Grossman Z,Pokamunski S,Malkinson M,Weiss L,Duvdevani P,Banet C,Weisman Y,Annis E,Gandaku D,Yahalom V,Hindyieh M,Shulman L,Mendelson E

更新日期：2001-12-01 00:00:00

abstract：:Significant advances have been made over the past few years concerning the cellular and molecular events underlying neuron death. Recently, it is becoming increasingly clear that some of genes induced during cerebral ischemia may actually serve to rescue the cell from death. However, the injured cell may not be capabl...

journal_title：Annals of the New York Academy of Sciences

authors： Yenari MA,Dumas TC,Sapolsky RM,Steinberg GK

更新日期：2001-06-01 00:00:00

abstract：:A significant body of research links individual differences in symbolic numerical abilities, such as arithmetic, to number sense, the neurobiological system used to approximate and manipulate quantities without language or symbols. However, recent findings from cognitive neuroscience challenge this influential theory....

journal_title：Annals of the New York Academy of Sciences

authors： Wilkey ED,Ansari D

更新日期：2020-03-01 00:00:00

abstract：:The adult respiratory distress syndrome (ARDS) is not confined only to late shock states but is a typical finding in intoxications with such oxidizing agents as O3, NO2, chlorate, or paraquat. Under experimental conditions, alpha-tocopherol in a high enteric dosage (2 x 50 mg/kg) was able to prevent alterations of pul...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf HR,Seeger HW

更新日期：1982-01-01 00:00:00

abstract：:Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role ...

journal_title：Annals of the New York Academy of Sciences

authors： Broeckaert F,Clippe A,Knoops B,Hermans C,Bernard A

更新日期：2000-01-01 00:00:00

abstract：:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Does common genetic variation at human TH alter autonomic activity and predispose to cardiovascular disease? We undertook systematic polymorphism discovery at the TH locus, and then tested variants for contributions to sympathetic fun...

journal_title：Annals of the New York Academy of Sciences

authors： Rao F,Zhang L,Wessel J,Zhang K,Wen G,Kennedy BP,Rana BK,Das M,Rodriguez-Flores JL,Smith DW,Cadman PE,Salem RM,Mahata SK,Schork NJ,Taupenot L,Ziegler MG,O'Connor DT

更新日期：2008-12-01 00:00:00

abstract：:In the popular and widely used Atkins diet, the body burns fat as its main fuel. This process produces ketosis and hence increased levels of beta-hydroxybutyrate (BOB) acetoacetate (AcAc) and its by-products acetone and acetol. These products are potential precursors of the glycotoxin methylglyoxal. Since methylglyoxa...

journal_title：Annals of the New York Academy of Sciences

authors： Beisswenger BG,Delucia EM,Lapoint N,Sanford RJ,Beisswenger PJ

更新日期：2005-06-01 00:00:00

abstract：:Transcriptional profiling and functional genomics experiments using E11.5 metanephros organ cultures from Ahr(-/-) and Ahr(+/+) have shown that aryl hydrocarbon receptor (AHR) transcription factor is involved in the regulation of mesenchymal-to-epithelial transition (MET) during nephrogenesis. This response is mediate...

journal_title：Annals of the New York Academy of Sciences

authors： Ramos KS

更新日期：2006-09-01 00:00:00

abstract：:CDP-choline was given to patients with Alzheimer's disease (AD) at a daily dose of 1000 mg/day p.o. for one month. This compound slightly improved mental performance, tended to reduce theta activity in fronto-temporal regions, increasing alpha power in occipital areas, and enhanced cerebrovascular perfusion by increas...

journal_title：Annals of the New York Academy of Sciences

authors： Cacabelos R,Caamaño J,Gómez MJ,Fernández-Novoa L,Franco-Maside A,Alvarez XA

更新日期：1996-01-17 00:00:00

abstract：:In order to better understand the enhancing effects of lowered oxygen (O2) tension on the growth in vitro of granulocyte-macrophage progenitor cells (CFU-GM), the effects of oxidizing species derived from molecular O2 were assessed on CFU-GM. Low density or nonadherent low density normal human bone marrow cells were p...

journal_title：Annals of the New York Academy of Sciences

authors： Broxmeyer HE,Cooper S,Gabig T

更新日期：1989-01-01 00:00:00

abstract：:The effect of DHEA administration on the age-associated decline in immunity against influenza vaccine was studied. Increased humoral response was observed in 16- and 24-month-old mice immunized by live A/PR/8/34 (H1N1) influenza virus following DHEA treatment (a single injection adjacent to immunization). Furthermore,...

journal_title：Annals of the New York Academy of Sciences

authors： Danenberg HD,Ben-Yehuda A,Zakay-Rones Z,Friedman G

更新日期：1995-12-29 00:00:00

abstract：:With the progressive aging of the world's population, immunosenescence is rapidly becoming a clinical concern as it accounts for a higher incidence of severe infections and poor response to vaccines. To identify nutritional approaches that may counteract immunosenescence is of obvious importance in clinical practice. ...

journal_title：Annals of the New York Academy of Sciences

authors： Freeman SL,Fisher L,German JB,Leung PS,Prince H,Selmi C,Naguwa SM,Gershwin ME

更新日期：2010-03-01 00:00:00

abstract：:Bone marrow cells of various animal species and the human produce a group of bioregulatory peptides called myelopeptides (MPs). A highly purified myelopeptide (MP) fraction and some individual molecules have been isolated from the supernatant of the porcine bone marrow cell culture by successive gel chromatography and...

journal_title：Annals of the New York Academy of Sciences

authors： Petrov RV

更新日期：1993-06-23 00:00:00

abstract：:We have been interested in the consequences of foreign DNA insertion into established mammalian genomes and have initially studied this problem in adenovirus type 12 (Ad12)-transformed cells or in Ad12-induced hamster tumors. Since integrates are frequently methylated de novo, it appears that they might be modified by...

journal_title：Annals of the New York Academy of Sciences

authors： Doerfler W,Hohlweg U,Müller K,Remus R,Heller H,Hertz J

更新日期：2001-09-01 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is an increasingly popular noninvasive neuromodulatory tool in the fields of cognitive and clinical neuroscience and psychiatry. It is an inexpensive, painless, and safe brain-stimulation technique that has proven to be effective in modulating cognitive and sensory-percep...

journal_title：Annals of the New York Academy of Sciences

authors： Sellaro R,Nitsche MA,Colzato LS

更新日期：2016-04-01 00:00:00

abstract：:Astronomers and physicists of diverse interest are teaming up to study enigmatic cosmic phenomena, such as the life cycle of black holes. A "disruptive innovation" is about to emerge during the next decade: Advanced gravitational-wave observatories. The emergence of gravitational-wave physics as a viable observational...

journal_title：Annals of the New York Academy of Sciences

authors： Márka S

更新日期：2012-07-01 00:00:00

abstract：:The authors present a multifactorial model for the development of acquired immunodeficiency syndrome (AIDS) in homosexual men. It is posited that there is no specific AIDS agent; rather, AIDS is conceptualized as the result of an interaction of the known or likely effects of repeated exposures to specific environment...

journal_title：Annals of the New York Academy of Sciences

authors： Sonnabend JA,Witkin SS,Purtilo DT

更新日期：1984-01-01 00:00:00

abstract：:We examined the role of I1-imidazoline (I1-IR) receptors in control of airway function, by testing the effects of systemic administration of the I1-IR agonist moxonidine on reflex responses of tracheal smooth muscle (TSM) tone to either lung deflation or mechanical stimulation of intrapulmonary rapidly adapting recept...

journal_title：Annals of the New York Academy of Sciences

authors： Haxhiu MA,Dreshaj IA,McFadden CB,Erokwu BO,Ernsberger P

更新日期：1999-06-21 00:00:00

abstract：:The behavior of neurons in the basal ganglia is severely disrupted in Parkinson's disease (PD). In nonhuman parkinsonian primate models, the disturbance in neurons in basal ganglia output structures include increased firing, bursting, an augmented synchrony, correlated activity, and a tendency towards loss of specific...

journal_title：Annals of the New York Academy of Sciences

authors： Hamani C,Lozano AM

更新日期：2003-06-01 00:00:00

abstract：:Contemporary management of atrial fibrillation imposes many challenges, particularly in the setting of our aging population. In addition to well-recognized consequences, such as stroke and mortality, emerging evidence relates atrial fibrillation to elevated risk of dementia, posing further therapeutic challenges. As t...

journal_title：Annals of the New York Academy of Sciences

authors： Chinitz JS,Castellano JM,Kovacic JC,Fuster V

更新日期：2012-04-01 00:00:00

abstract：:It is often proposed that quinolinic acid (QUIN) contributes to the pathophysiology of neuroinflammation because this kynurenine pathway metabolite is a selective agonist of N-methyl-D-aspartate (NMDA) receptors, and both its brain tissue and cerebrospinal fluid concentrations increase markedly with inflammation. Howe...

journal_title：Annals of the New York Academy of Sciences

authors： Obrenovitch TP

更新日期：2001-06-01 00:00:00

abstract：:The clinical, epidemiological, and therapeutic aspects of 15 patients with Mediterranean spotted fever (MSF), admitted to the Internal Medicine Department of the General Hospital of Sitia (southeastern Crete, Greece) between December 2000 and July 2003, were studied. Diagnosis was made on the basis of clinical signs a...

journal_title：Annals of the New York Academy of Sciences

authors： Germanakis A,Psaroulaki A,Gikas A,Tselentis Y

更新日期：2006-10-01 00:00:00

abstract：:Tight junctions (TJs) regulate paracellular barriers and claudins (Cld) form the backbone of TJ strands. To elucidate the molecular mechanism of claudin polymer formation, TJs were reconstituted by claudin transfection of TJ-free HEK293 cells. Therewith, typical TJ stands can be found at cell-cell contacts. In additio...

journal_title：Annals of the New York Academy of Sciences

authors： Rossa J,Lorenz D,Ringling M,Veshnyakova A,Piontek J

更新日期：2012-06-01 00:00:00

abstract：:Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spine...

journal_title：Annals of the New York Academy of Sciences

authors： Wallace M,Frankfurt M,Arellanos A,Inagaki T,Luine V

更新日期：2007-02-01 00:00:00

abstract：:Although the hippocampus expresses nicotinic acetylcholine receptors (nAChRs) and receives cholinergic innervation, the functional roles of these receptors are not completely understood. Our results indicated that presynaptic nAChRs mediated a calcium influx that enhanced the release of both glutamate and GABA. Fura-2...

journal_title：Annals of the New York Academy of Sciences

authors： Radcliffe KA,Fisher JL,Gray R,Dani JA

更新日期：1999-04-30 00:00:00

abstract：:Tocopherols are known to undergo metabolism to phytyl chain-shortened metabolites excreted in urine. We sought to characterize the pathway, including associated enzymes, involved in this biotransformation. We previously found that human hepatoblastoma (HepG2) cultures metabolized tocopherols to their corresponding sho...

journal_title：Annals of the New York Academy of Sciences

authors： Parker RS,Sontag TJ,Swanson JE,McCormick CC

更新日期：2004-12-01 00:00:00

abstract：:Advanced glycation end products (AGEs) are the result of a nonenzymatic reaction of reducing sugars with primary amino groups of proteins (Maillard reaction). They accumulate in various tissues in the course of aging. Because AGEs induce protein cross-links and oxidative stress (radicals) within cells and tissues, the...

journal_title：Annals of the New York Academy of Sciences

authors： Simm A,Bartling B,Silber RE

更新日期：2004-06-01 00:00:00