Nicotinic modulation of glutamate and GABA synaptic transmission of hippocampal neurons.

abstract：:Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Kellehear A,Kripal JJ,Leary L

更新日期：2014-11-01 00:00:00

abstract：:Advances in understanding the epidemiology of endometriosis have lagged behind other diseases because of methodologic problems related to disease definition and control selection. Nevertheless, a better picture of the epidemiology of endometriosis has emerged over the past few decades. Prevalence estimates of the dise...

journal_title：Annals of the New York Academy of Sciences

authors： Cramer DW,Missmer SA

更新日期：2002-03-01 00:00:00

abstract：:R-Apomorphine (APO) the catechol-derived dopamine D1-D2 receptor agonist has been shown to be highly potent iron chelator and radical scavenger and inhibitor of membrane lipid peroxidation in vitro, in vivo and in cell culture employing PC12 cells. Its potency has been compared to the prototype iron chelator desferrio...

journal_title：Annals of the New York Academy of Sciences

authors： Youdim MB,Grünblatt E,Mandel S

更新日期：1999-01-01 00:00:00

abstract：:We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in suscep...

journal_title：Annals of the New York Academy of Sciences

authors： Goldhaber JI,Henderson SA,Reuter H,Pott C,Philipson KD

更新日期：2005-06-01 00:00:00

abstract：:Recent studies have reported an association between exposure to childhood abuse or neglect and alterations in brain structure or function. One limitation of these studies is that they are correlational and do not provide evidence of a cause-effect relationship. Preclinical studies on the effects of exposure to early l...

journal_title：Annals of the New York Academy of Sciences

authors： Teicher MH,Tomoda A,Andersen SL

更新日期：2006-07-01 00:00:00

abstract：:Gypsy/Ty3 retrotransposons, a group of long terminal repeat retrotransposons related to vertebrate retroviruses, are found in the genome of many fungi, plants, and animals. Although multiple families of such retroelements are present in fish, active Gypsy/Ty3 retrotransposons have all been eliminated from the lineage ...

journal_title：Annals of the New York Academy of Sciences

authors： Volff JN

更新日期：2009-10-01 00:00:00

abstract：:A meta-analysis of 14 clinical studies with RRR- or all-rac-alpha-tocopherol (83,800 subjects) was performed to evaluate whether RRR and all-rac differ in cardiovascular efficacy based on those clinical endpoints that are most consistently documented in the publications of the studies. Odds ratios of treatment versus ...

journal_title：Annals of the New York Academy of Sciences

authors： Kraemer K,Koch W,Hoppe PP

更新日期：2004-12-01 00:00:00

abstract：:Ischemia and reperfusion injure the heart, as manifested by myocardial infarction, postischemic ventricular functional dysfunctions, arrhythmias, and cardiomyocyte apoptosis. Hearts can be adapted to ischemic-reperfusion injury by subjecting them to non-lethal cyclic episodes of short-term ischemia and reperfusion. Th...

journal_title：Annals of the New York Academy of Sciences

authors： Maulik N,Sasaki H,Galang N

更新日期：1999-06-30 00:00:00

abstract：:About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of...

journal_title：Annals of the New York Academy of Sciences

authors： Pistollato F,Masias M,Agudo P,Giampieri F,Battino M

更新日期：2019-05-01 00:00:00

abstract：:Pulmonary sarcoidosis is a disease characterized by increased numbers of T lymphocytes within the alveolar structures and the consequent spontaneous release of a variety of mediators relevant to the pathogenesis of this disorder. This phenomenon is associated with a different expansion of the T cell subpopulations pre...

journal_title：Annals of the New York Academy of Sciences

authors： Rossi GA,Sacco O,Cosulich E,Balbi B,Risso A,Ravazzoni C

更新日期：1986-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGF-R) has been implicated in the growth of endometrial cancer. In the present study, immunostaining of EGF-R was investigated in different endometrial cancer histotypes. For this purpose 34 surgical samples of primary endometrial carcinoma were studied using monoclonal anti-EGF-R ant...

journal_title：Annals of the New York Academy of Sciences

authors： Jasonni VM,Santini D,Amadori A,Ceccarelli C,Naldi S

更新日期：1994-09-30 00:00:00

abstract：:Nitric oxide (NO) is an important signaling molecule that is generated through the catalytic activity of nitric oxide synthase (NOS). In the brain, NO mediates neuronal survival, synaptic plasticity, vascular smooth muscle relaxation, and endothelial cell permeability. Previous studies demonstrated aberrant expression...

journal_title：Annals of the New York Academy of Sciences

authors： de la Monte SM,Sohn YK,Etienne D,Kraft J,Wands JR

更新日期：2000-04-01 00:00:00

abstract：:Insulin-related peptides (IRPs) from ganglions of mollusk, Anodonta cygnea, were purified and characterized (IRP1-IRP13) using insulin and insulin-like growth factor-I (IGF-I) radioreceptor test systems. The IRPs were able to bind to insulin and IGF-I receptors. Dose-dependent curve slopes indicated that most IRPs bin...

journal_title：Annals of the New York Academy of Sciences

authors： Shipilov VN,Shpakov AO,Rusakov YI

更新日期：2005-04-01 00:00:00

abstract：:In adult Lurcher mice virtually all cerebellar Purkinje cells have degenerated as a direct consequence of mutant gene action, providing a natural model for studying the effect of cerebellar cortical lesions on the generation of compensatory eye movements. Lurcher mice possess both optokinetic (OKR) and vestibular (VOR...

journal_title：Annals of the New York Academy of Sciences

authors： Van Alphen AM,Schepers T,Luo C,De Zeeuw CI

更新日期：2002-12-01 00:00:00

abstract：:There is growing interest in the use of statins, HMG-CoA reductase inhibitors, for treating specific neurodegenerative diseases (e.g., cerebrovascular disease, Parkinson's disease, Alzheimer's disease, multiple sclerosis) and possibly traumatic brain injury. Neither is there a consensus on the efficacy of statins in t...

journal_title：Annals of the New York Academy of Sciences

authors： Wood WG,Eckert GP,Igbavboa U,Müller WE

更新日期：2010-06-01 00:00:00

abstract：:Although it is now well established that imidazoline receptors and alpha 2-adrenoceptors are discrete entities with distinct endogenous ligands, the two receptor classes apparently have several common features. While the catecholamines stimulate alpha 2-adrenoceptors but not imidazoline receptors, agmatine, a guanidin...

journal_title：Annals of the New York Academy of Sciences

authors： Hieble JP,Ruffolo RR Jr

更新日期：1995-07-12 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune and chronic inflammatory disease characterized by plaques, areas of destroyed myelin sheaths in the CNS, which results in multiple disabilities for patients. In addition to demyelinated plaques, pathophysiological studies have shown "shadow plaques" that represent areas of part...

journal_title：Annals of the New York Academy of Sciences

authors： Filipović R,Zecević N

更新日期：2005-06-01 00:00:00

abstract：:In many scientific and technical applications, a three-dimensional (3D) object must be reconstructed, either to assist in understanding the object's structure or to ease its automatic handling and analysis. Volume reconstruction has been used in health care to diagnose, simulate, facilitate surgical planning, develop ...

journal_title：Annals of the New York Academy of Sciences

authors： Masero V,León-Rojas JM,Moreno J

更新日期：2002-12-01 00:00:00

abstract：:In recent years, vitamin D has been received increased attention due to the resurgence of vitamin D deficiency and rickets in developed countries and the identification of extraskeletal effects of vitamin D, suggesting unexpected benefits of vitamin D in health and disease, beyond bone health. The possibility of extra...

journal_title：Annals of the New York Academy of Sciences

authors： Christakos S,Hewison M,Gardner DG,Wagner CL,Sergeev IN,Rutten E,Pittas AG,Boland R,Ferrucci L,Bikle DD

更新日期：2013-05-01 00:00:00

abstract：:We created a toolbox of recombinant, microbial lipases, which allows us in combination with a lipase database to choose among the overexpressed lipases the most appropriate for a specific application and to improve it further via mutagenesis. By systematic comparison of geometry and properties of the scissile fatty ac...

journal_title：Annals of the New York Academy of Sciences

authors： Schmidt-Dannert C,Pleiss J,Schmid RD

更新日期：1998-12-13 00:00:00

abstract：:Accelerated atherosclerosis occurs in patients with type III hyperlipoproteinemia and familial hypercholesterolemia. These genetic disorders focus attention on specific types of lipoproteins as being responsible for the development of accelerated coronary artery heart disease. The accumulation of chylomicron remnants ...

journal_title：Annals of the New York Academy of Sciences

authors： Weisgraber KH,Innerarity TL,Rall SC Jr,Mahley RW

更新日期：1990-01-01 00:00:00

abstract：:A host of missense mutations in muscle nicotinic receptor subunits have been identified as the cause of congenital myasthenic syndromes (CMS). Two classes of CMS phenotypes have been identified: slow channel myasthenic syndromes (SCCMSs) and fast channel myasthenic syndromes (FCCMSs). Although both have similar phenot...

journal_title：Annals of the New York Academy of Sciences

authors： Sine SM,Wang HL,Ohno K,Shen XM,Lee WY,Engel AG

更新日期：2003-09-01 00:00:00

abstract：:The public health implications of reducing or preventing the excess increase in blood pressure and the acquisition of obesity during childhood years are important. Many children with high blood pressure, particularly those who are initially obese or become obese as young adults and those with excess left ventricular m...

journal_title：Annals of the New York Academy of Sciences

authors： Mahoney LT,Lauer RM,Lee J,Clarke WR

更新日期：1991-01-01 00:00:00

abstract：:Trichostatin A (TSA), an inhibitor of the eukaryotic cell cycle and an inducer of morphological reversion of transformed cells, inhibits histone deacetylase (HDAC) at nanomolar concentrations. Recently, trapoxin, oxamflatin, and FR901228, antitumor agents structurally unrelated to TSA, were found to be potent HDAC inh...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshida M,Horinouchi S

更新日期：1999-01-01 00:00:00

abstract：:Most risk assessments assume uncertainty may be decomposed into variability and incertitude. Language is often overlooked as a source of uncertainty, but linguistic uncertainty may be pervasive in workshops, committees, and other face-to-face language-based settings where it can result in misunderstanding and arbitrar...

journal_title：Annals of the New York Academy of Sciences

authors： Carey JM,Burgman MA

更新日期：2008-04-01 00:00:00

abstract：:We have previously shown that bone marrow will seed and proliferate in normal recipients. Transfusion of 50 million cells on each of 4 or 5 consecutive days, a total of 200-250 million cells, resulted in the recipient's marrow being 20-40% of donor origin. The present paper reported on the marked enhancement of prolif...

journal_title：Annals of the New York Academy of Sciences

authors： Brecher G,Mulcahy K,Tjio JH,Raveché E

更新日期：1985-01-01 00:00:00

abstract：:In biochemical and immunocytochemical comparisons of adhering junctions of different epithelia, we have observed differences in molecular composition not only between the intermediate filament-attached desmosomes and the actin filaments-anchoring adherens junctions but also between desmosomes of different tissues and ...

journal_title：Annals of the New York Academy of Sciences

authors： Borrmann CM,Mertens C,Schmidt A,Langbein L,Kuhn C,Franke WW

更新日期：2000-01-01 00:00:00

abstract：:The prevalence of obesity is rapidly increasing in the United States, particularly among women. Approximately 60-70% of hypertension in adults may be directly attributed to obesity. In addition, maternal obesity is a major risk factor for hypertensive disorders during pregnancy. The underlying mechanisms for the assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Fu Q

更新日期：2019-10-01 00:00:00

abstract：:Opsoclonus-myoclonus syndrome (OMS) is a rare neurologic disorder comprising the main symptoms of eye-movement disturbances, muscle jerks, and severe ataxia. In children and adults, some cases are associated with a tumor as a paraneoplastic syndrome, whereas in children the paraneoplastic form is almost exclusively as...

journal_title：Annals of the New York Academy of Sciences

authors： Kirsten A,Beck S,Fühlhuber V,Kaps M,Kreutz T,Korfei M,Schmitt S,Preissner KT,Blaes F

更新日期：2007-09-01 00:00:00

abstract：:We isolated a eugenol-degrading bacterium, Pseudomonas fluorescens E118. This strain produced a novel enzyme, eugenol dehydrogenase, which catalyzes the conversion of eugenol into coniferyl alcohol. The enzyme was purified from the eugenol-induced cells of P. fluorescens E118. The purified enzyme appeared to be homoge...

journal_title：Annals of the New York Academy of Sciences

authors： Furukawa H,Nagasawa T

更新日期：1998-12-13 00:00:00