The pivotal role of iron in NF-kappa B activation and nigrostriatal dopaminergic neurodegeneration. Prospects for neuroprotection in Parkinson's disease with iron chelators.

abstract：:Although very few measurements have appeared in the open literature and there seems to be a controversy about the existence of the NDR phenomenon in molecules, the prospects of building such systems have attracted significant attention. In the work reported in this paper we used a model based on DFT calculations of th...

journal_title：Annals of the New York Academy of Sciences

authors： Simón-Manso Y,Gonzalez C,Mujica V,Aray Y,Marquez M

更新日期：2003-12-01 00:00:00

abstract：:The loop between transmembrane helices 6 and 7 (L6/7) of P-type ATPases has been suggested to be important for the functional linkage of ion binding and enzyme phosphorylation or to be a site of initial cation binding. To investigate the role of L6/7 in Na,K-ATPase, alanine substitutions were made for charged and cons...

journal_title：Annals of the New York Academy of Sciences

authors： Xu G,Farley RA,Kane DJ,Faller LD

更新日期：2003-04-01 00:00:00

abstract：:Rapid advances in the biomedical sciences are producing new means of intervention against many of the major tropical diseases. The discovery of new drugs, vaccines and diagnostic tests, however, is only the first, though important, step down an often long and difficult road to their effective deployment in disease con...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PG

更新日期：1989-01-01 00:00:00

abstract：:This review outlines the scientific rationale supporting the potential use of deep-brain electrical stimulation (DBS) in the central thalamus as a method to improve behavioral responsiveness following severe brain injury. Neurons within the central thalamus are selectively vulnerable to disconnection and dysfunction f...

journal_title：Annals of the New York Academy of Sciences

authors： Schiff ND

更新日期：2009-03-01 00:00:00

abstract：:Adaptive co-evolution of mammals and bacteria has led to the establishment of complex commensal communities on mucosal surfaces. In spite of having available a wealth of immune-sensing and effector mechanisms capable of triggering inflammation in response to microbial intrusion, mucosal immune cells establish an intim...

journal_title：Annals of the New York Academy of Sciences

authors： Cerutti A,Cols M,Gentile M,Cassis L,Barra CM,He B,Puga I,Chen K

更新日期：2011-11-01 00:00:00

abstract：:In this limited review, it has only been possible to highlight some of the more significant interactions of peptides with the blood-brain barrier. The literature has been reviewed extensively in recent years, and the major reviews are included in the references. Certainly one of the major outstanding problems is an el...

journal_title：Annals of the New York Academy of Sciences

authors： Begley DJ

更新日期：1994-10-31 00:00:00

abstract：:This paper represents a unique effort to elucidate the dynamics of two major types of politically motivated hostage takers. The data presented are derived from an ongoing research project that is gathering extensive interview and psychological test materials from prisoners convicted of politically motivated crimes, bo...

journal_title：Annals of the New York Academy of Sciences

authors： Knutson JN

更新日期：1980-01-01 00:00:00

abstract：:Basic fibroblast growth factor is a polypeptide belonging to a family of natural proteins also known as heparin-binding growth factors endowed with a pleiotropism of biological activities, the most striking of which are related to wound healing. Large quantities of recombinant human basic fibroblast growth factor (rh-...

journal_title：Annals of the New York Academy of Sciences

authors： Mazué G,Bertolero F,Jacob C,Sarmientos P,Roncucci R

更新日期：1991-01-01 00:00:00

abstract：:MRI is a robust technology that allows for superior contrast of muscles, tissues, and bones within the body, which enables visualization of soft tissue pathology that cannot be seen with CT or plain film radiography. In order to appreciate the subtle (and sometimes not so subtle) intricacies of MRI, one must have a ba...

journal_title：Annals of the New York Academy of Sciences

authors： Khanna S,Crues JV 3rd

更新日期：2009-02-01 00:00:00

abstract：:Amperometry is a powerful tool for studying the exocytotic process. Catecholamines released from a single secretory vesicle are oxidized by a carbon fiber microelectrode placed on a chromaffin cell membrane. This phenomenon can be recorded online as an amperometric signal. Each event of exocytosis is called a secretor...

journal_title：Annals of the New York Academy of Sciences

authors： Gomez JF,Brioso MA,Machado JD,Sanchez JL,Borges R

更新日期：2002-10-01 00:00:00

abstract：:The SERMs currently in clinical practice or in late stages of clinical development have been studied primarily for their effects on the breast, cardiovascular, bone, and reproductive systems. The effect of SERMs on the hypothalamic-pituitary-gonadal (HPG) axis has not been the primary focus of the studies conducted th...

journal_title：Annals of the New York Academy of Sciences

authors： Plouffe L Jr,Siddhanti S

更新日期：2001-12-01 00:00:00

abstract：:High demand of neoplastic tissues for glutamine (Gln) is met by its active transport across cell membranes. Chronic treatment with acrylamide in rodents is associated with an increased incidence of neoplasms, including astrocytomas. In this study, 24-h acrylamide treatment significantly increased the initial rate of l...

journal_title：Annals of the New York Academy of Sciences

authors： Wu Q,Sidoryk M,Mutkus L,Zielińska M,Albrecht J,Aschner M

更新日期：2005-08-01 00:00:00

abstract：:Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...

journal_title：Annals of the New York Academy of Sciences

authors： Conticello SG

更新日期：2012-09-01 00:00:00

abstract：:This paper will review our recent data relevant to the antioxidant effects of N-acetylserotonin (NAS), the immediate precursor of melatonin, the pineal gland indole. Mechanisms of the antioxidant effects of NAS might involve interaction with melatonin type 3 receptors and nonreceptor mechanisms such as stimulation of ...

journal_title：Annals of the New York Academy of Sciences

authors： Oxenkrug G

更新日期：2005-08-01 00:00:00

abstract：:Healthy CD45 KO mice show a Th2-type cytokine secretion profile in their small intestines. Dietary supplementation with human infant formula induced colitis and a shift toward a Th1-type profile, suggesting that diet can alter cytokine secretion. ...

journal_title：Annals of the New York Academy of Sciences

authors： Lópeza MC,Holmes N

更新日期：2004-12-01 00:00:00

abstract：:Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice...

journal_title：Annals of the New York Academy of Sciences

authors： Gerling IC,Ali C,Lenchik N

更新日期：2003-11-01 00:00:00

abstract：:The mechanisms controlling ATP generation in the transition from normal resting conditions to either high work states or ischemia are poorly understood. ATP generation depends upon compartmentation between the mitochondria and cytosol of metabolic pathways and key energy transfer species that cannot be easily assessed...

journal_title：Annals of the New York Academy of Sciences

authors： Zhou L,Yu X,Cabrera ME,Stanley WC

更新日期：2006-10-01 00:00:00

abstract：:A trial was carried out in alpacas (Lama pacos) and llamas (Lama glama) to determine the economic benefits of controlling both external and internal parasites by the use of ivermectin ("Ivomec," Merck Sharp & Dohme). After four months the treated male alpacas gained on average 3.1 kg more than the untreated males, and...

journal_title：Annals of the New York Academy of Sciences

authors： Windsor RS,Windsor RH,Teran M

更新日期：1992-06-16 00:00:00

abstract：:Pregnant female Sprague-Dawley rats were injected with either 40 mg/kg (-)cocaine hydrochloride or an equivalent volume of 0.9% saline, subcutaneously (s.c.), once daily from gestational day 12 (GD 12) to GD 21. Gestational cocaine exposure had no effect on maternal weight gain, length of gestation, birthweight, fetal...

journal_title：Annals of the New York Academy of Sciences

authors： Choi SJ,Mazzio E,Soliman KF

更新日期：1998-05-30 00:00:00

abstract：:Sensorineural hearing loss results from the degeneration of hair cells and/or auditory neurons in the cochlea of the inner ear. BDNF and NT-3 were shown to support survival of auditory neurons both in vitro and in vivo. Cochlea from P3-P4 rats were cultured as floating explants and hair cells in the organ of Corti wer...

journal_title：Annals of the New York Academy of Sciences

authors： Kuang R,Hever G,Zajic G,Yan Q,Collins F,Louis JC,Keithley E,Magal E

更新日期：1999-11-28 00:00:00

abstract：:Externally guided sensory-motor processes deteriorate with increasing age. Internally guided, for example, predictive, behavior usually helps to overcome sensory-motor delays. We studied whether predictive components of visuomotor transformation decline with age. We investigated smooth pursuit eye movements (SPEM) of ...

journal_title：Annals of the New York Academy of Sciences

authors： Sprenger A,Trillenberg P,Pohlmann J,Herold K,Lencer R,Helmchen C

更新日期：2011-09-01 00:00:00

abstract：:Developmental dyslexia is associated with problems in a range of linguistic and non-linguistic skills. Some of those problems have been attributed to dysfunction of the cerebellum and its associated neural systems. Two studies of cerebellar structure were undertaken by our group. In Study 1, white and grey matter volu...

journal_title：Annals of the New York Academy of Sciences

authors： Laycock SK,Wilkinson ID,Wallis LI,Darwent G,Wonders SH,Fawcett AJ,Griffiths PD,Nicolson RI

更新日期：2008-12-01 00:00:00

abstract：:Differentiation of specific epithelial cell lineages during development, as well as epithelial plasticity in response to heterologous cell-to-cell cross talk during adult life, accounts for the large variety of functions which are performed by the mucosal surfaces found in the human body. Among its functions, the dige...

journal_title：Annals of the New York Academy of Sciences

authors： Hamzaoui N,Pringault E

更新日期：1998-11-17 00:00:00

abstract：:The arterial baroreflex has two important functions. First, the arterial baroreflex is a negative feedback reflex that regulates arterial pressure around a preset value called a set or operating point. Second, the arterial baroreflex also establishes the prevailing systemic arterial pressure when the operating point i...

journal_title：Annals of the New York Academy of Sciences

authors： DiCarlo SE,Bishop VS

更新日期：2001-06-01 00:00:00

abstract：:Alterations in brain distribution of 11C-MAP, 14C-MAP, and 123I-IMP in MAP- and cocaine-sensitized animals were examined to investigate the mechanism involved in increased dopaminergic transmission and behavioral sensitization. First, a significant increase in 11C-MAP radioactivity in the striatum and hypothalamus was...

journal_title：Annals of the New York Academy of Sciences

authors： Numachi Y,Yoshida S,Inosaka T,Sato M,Mizugaki M,Kimura K,Hishinuma T

更新日期：1992-06-28 00:00:00

abstract：:This article focuses on the importance of social engagement and the behavioral and neurophysiological mechanisms that allow individuals to reduce psychological and physical distance. A model of social engagement derived from the Polyvagal Theory is presented. The model emphasizes phylogeny as an organizing principle a...

journal_title：Annals of the New York Academy of Sciences

authors： Porges SW

更新日期：2003-12-01 00:00:00

abstract：:Despite the high prevalence of adolescent smoking, few studies have examined nicotine sensitivity during this developmental period. In the present study we examined adolescent and adult rats' preference/aversion for a flavor previously paired with nicotine. Paired (nicotine + Kool-Aid) and unpaired (Kool-Aid) solution...

journal_title：Annals of the New York Academy of Sciences

authors： Wilmouth CE,Spear LP

更新日期：2004-06-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1)-positive patients in the late phase of infection develop AIDS dementia complex, an array of neurological complications that include extrapyramidal symptoms, cognitive impairments, and psychiatric disturbances. Brains of these patients exhibit brain injury. The HIV-1 envelope...

journal_title：Annals of the New York Academy of Sciences

authors： Bachis A,Mocchetti I

更新日期：2005-08-01 00:00:00

abstract：:Information from the vestibular nuclei ascending through the brainstem to the oculomotor and trochlear nuclei (NIII, NIV), the interstitial nucleus of Cajal (INC), the pretectum, or thalamus, is thought to be distributed in at least five different pathways. They include the medial longitudinal fasciculus (MLF), the as...

journal_title：Annals of the New York Academy of Sciences

authors： Zwergal A,Strupp M,Brandt T,Büttner-Ennever JA

更新日期：2009-05-01 00:00:00

abstract：:Indoor air pollution occurs as an undesirable consequence of urbanization, energy conservation, indoor bioaerosol contamination, and use of synthetic materials and new technologies, and has become a worldwide concern. It is important to comprehend not only the diversity of pollutant hazards but also to develop novel m...

journal_title：Annals of the New York Academy of Sciences

authors： Brooks BO,Aldrich FD,Utter GM,DeBroy JA,Schimke RD

更新日期：1992-04-30 00:00:00