Abstract:
:We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in susceptibility to hypertrophy and heart failure, along with a significant reduction in E-C coupling gain. While global knockout of the exchanger in mice is embryonic-lethal, conditional knockout mice live to adulthood. Cardiac function is surprisingly normal in seven-week-old mice, but E-C coupling gain is apparently increased. Thus, genetic modification of exchanger expression has a major influence on E-C coupling.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Goldhaber JI,Henderson SA,Reuter H,Pott C,Philipson KDdoi
10.1196/annals.1341.011subject
Has Abstractpub_date
2005-06-01 00:00:00pages
122-6eissn
0077-8923issn
1749-6632pii
1047/1/122journal_volume
1047pub_type
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