Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified mice.

Abstract:

:We have created genetically altered mice to investigate how expression of the Na(+)-Ca(2+) exchange protein alters excitation-contraction (E-C) coupling. Whereas low levels of exchanger overexpression have minimal effects on E-C coupling properties, high levels of overexpression in homozygous animals results in susceptibility to hypertrophy and heart failure, along with a significant reduction in E-C coupling gain. While global knockout of the exchanger in mice is embryonic-lethal, conditional knockout mice live to adulthood. Cardiac function is surprisingly normal in seven-week-old mice, but E-C coupling gain is apparently increased. Thus, genetic modification of exchanger expression has a major influence on E-C coupling.

journal_name

Ann N Y Acad Sci

authors

Goldhaber JI,Henderson SA,Reuter H,Pott C,Philipson KD

doi

10.1196/annals.1341.011

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

122-6

eissn

0077-8923

issn

1749-6632

pii

1047/1/122

journal_volume

1047

pub_type

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